Revista Virtual de Química最新文献_第10页

Municipal Solid Waste as Source of Renewable Energy in Brazil: Current Overview and Future Perspectives 巴西城市固体废物作为可再生能源的来源:当前概况和未来展望

Revista Virtual de Química Pub Date : 2022-01-01 DOI: 10.21577/1984-6835.20210093

Karen de Souza do Prado, Christian Cuello Barrios, Anderson Pires Fernandes, Jane Maria Faulstich de Paiva

引用次数: 2

A Chemical Approach on Drugs that are Under Evaluation as Potential COVID-19’s Treatment 新冠肺炎潜在治疗药物评估的化学方法

Revista Virtual de Química Pub Date : 2022-01-01 DOI: 10.21577/1984-6835.20220061

Jessica S. Pizzo, Patricia D. S. Santos, Carlos R. Senes, Victor H. M. Cruz, Patrícia M. Souza, Matheus C. de Castro, Oscar O. Santos-Junior, Jesuí V. Visentainer

{"title":"A Chemical Approach on Drugs that are Under Evaluation as Potential COVID-19’s Treatment","authors":"Jessica S. Pizzo, Patricia D. S. Santos, Carlos R. Senes, Victor H. M. Cruz, Patrícia M. Souza, Matheus C. de Castro, Oscar O. Santos-Junior, Jesuí V. Visentainer","doi":"10.21577/1984-6835.20220061","DOIUrl":"https://doi.org/10.21577/1984-6835.20220061","url":null,"abstract":"A novel SARS-CoV-2 coronavirus, the virus responsible for COVID-19, is a public health emergency of international concern since this infection spreads quickly through human-to-human transmission. Several drugs are being studied by researchers worldwide as an effective antiviral agent against this coronavirus. Therefore, most studies are focusing on drugs that have been already used earlier on the treatment of other diseases. Therapies under investigation include azithromycin, chloroquine, hydroxychloroquine, remdesivir, lopinavir/ritonavir, and favipiravir. Remdesivir is the only Food and Drug Administrationapproved drug for the use in adult and pediatric patients (>12 years old) for the treatment of this disease requiring hospitalization. In this context, the present review summarizes information about these drugs highlighting the chemical standpoint, such as physical-chemical and molecular characteristics, toxicity, history, and main applications, since knowledge about these substances is essential to assist the search for an appropriate treatment.","PeriodicalId":21315,"journal":{"name":"Revista Virtual de Química","volume":"116 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86031967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioactive Natural Products from the Symbiotic Association of Bees and Bacteria 来自蜜蜂和细菌共生协会的生物活性天然产物

Revista Virtual de Química Pub Date : 2022-01-01 DOI: 10.21577/1984-6835.20230011

Carolina A. de Oliveira, Gabriela Toninato de Paula, M. Pupo

引用次数: 0

Application of Agricultural Waste from Main Brazilian Crops as Adsorbent for Wastewater Treatment 巴西主要作物农业废弃物吸附剂在废水处理中的应用

Revista Virtual de Química Pub Date : 2022-01-01 DOI: 10.21577/1984-6835.20230017

Kaline C. Vasconcelos, Sabryna G. Alencar, Daniele V. Vich, Leonardo M. T. M. Oliveira, Vanderson B. Bernardo, José Leandro da S. Duarte

引用次数: 0

Evaluation of Powdered Chia Mucilage as an Iron Ore Dust Suppressor and Use of Chia Oil, Unfit for Consumption, in the Production of Biodiesel 奇亚籽浆液粉末状铁矿抑尘剂的评价及不宜消费的奇亚籽油在生物柴油生产中的应用

Revista Virtual de Química Pub Date : 2022-01-01 DOI: 10.21577/1984-6835.20220072

Lucas de Almeida Gama, C. Spadetto, Carla Santana Francisco, Sergio Henriques Saraiva, Eloi Alves da Silva Filho

引用次数: 0

Evaluation of Proteins with Intrinsic Disorder from the DisProt Database: Concepts, Biological Importance and Peculiar Characteristics 从DisProt数据库中评价具有内在紊乱的蛋白质:概念、生物学重要性和特有特性

Revista Virtual de Química Pub Date : 2022-01-01 DOI: 10.21577/1984-6835.20220008

Stephanny M. Alves de Souza, Theo L. F. de Souza

{"title":"Evaluation of Proteins with Intrinsic Disorder from the DisProt Database: Concepts, Biological Importance and Peculiar Characteristics","authors":"Stephanny M. Alves de Souza, Theo L. F. de Souza","doi":"10.21577/1984-6835.20220008","DOIUrl":"https://doi.org/10.21577/1984-6835.20220008","url":null,"abstract":"The intrinsic disorder (ID) consists of a feature present in an extensive group of proteins in its totality (IDPs) or only in regions (IDRs). Such feature provides a series of peculiar behaviors that differs from those presented for globular proteins. They are characterized by the absence of a well-defined tridimensional structure, owning high flexibility and conformational entropy, which enables a structural plasticity. In this work, we perform an investigation of different issues involving proteins with ID available in the DisProt database, as well as an extensive literature search to gather information that can help to expand the knowledge about this important group of proteins. Proteins with ID are observed in all kingdoms of life from the simplest to the most complex organisms, where they become more present. They participate of the most diverse biological process, acting mainly in process involving signaling, where the ability to adopt different conformations and bind to different partners becomes fundamental. The ID in proteins is also responsible for the development of diseases and its peculiar structural features bring with them the challenge of developing drugs able to act in these proteins. Different techniques can be applied to analyze structural features presented by these proteins, such as the absence or low structural content, possibility of structural gain, large volume, high solvent exposure and flexibility. With this work, we seek to bring a set of information from the most varied topics involving proteins with ID that can help in the theme disclosure.","PeriodicalId":21315,"journal":{"name":"Revista Virtual de Química","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82240234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Moringa oleifera Lam. Seeds Potential as an Adsorbent Material for Soybean Oil Bleaching 辣木的评价。种子作为大豆油漂白吸附材料的潜力

Revista Virtual de Química Pub Date : 2022-01-01 DOI: 10.21577/1984-6835.20220006

Patrícia M. Souza, Marília B. Galuch, Ana P. Lopes, Jessica S. Pizzo, Matheus C. Castro, Victor H. M. da Cruz, Paulo R. Souza, Deiviti F. Impossetto, Rubia M. Suzuki, Jesuí V. Visentainer

{"title":"Assessment of Moringa oleifera Lam. Seeds Potential as an Adsorbent Material for Soybean Oil Bleaching","authors":"Patrícia M. Souza, Marília B. Galuch, Ana P. Lopes, Jessica S. Pizzo, Matheus C. Castro, Victor H. M. da Cruz, Paulo R. Souza, Deiviti F. Impossetto, Rubia M. Suzuki, Jesuí V. Visentainer","doi":"10.21577/1984-6835.20220006","DOIUrl":"https://doi.org/10.21577/1984-6835.20220006","url":null,"abstract":"During the refining process of vegetable oils, the removal of pigments occurs in the bleaching stage, in which oil-adsorbent agents are used. Although various types of adsorbent materials are commercially available, alternative bleaching agents are being constantly investigated to increase the efficiency of this step. This work used seeds of Moringa oleifera Lam. in natura and in the form of activated charcoal to remove chlorophyll from soybean oil. The techniques used for this purpose were infrared with Fourier transform (FTIR), thermogravimetric analysis (TGA), chlorophyll by ultraviolet-visible (UV-VIS) spectroscopy, titratable acidity, gas chromatography with a flame ionization detector (GC-FID), and direct infusion by electrospray ionization mass spectrometry in positive ion mode (ESI(+)-MS). The results obtained showed that the defatted seeds of Moringa did not have the potential to remove chlorophyll from the oil. Activated charcoal produced from seeds, on the other hand, was effective as a bleaching agent, removing 97.53% of the chlorophyll content of the treated soybean oil. Besides, the use of coal obtained from Moringa seeds did not significantly change the composition of fatty acids, therefore, the use of coal as Moringa seeds is indicated. As a result, the activated charcoal from Moringa seeds has the potential to be used during the refining process of soybean oil.","PeriodicalId":21315,"journal":{"name":"Revista Virtual de Química","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82357406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Revisiting Forbidden Drugs: Chemical and Pharmacological Perspectives Over Psychedelic Indoleamines and Entactogens as Promising Therapeutic Agents 重新审视违禁药物:从化学和药理学的角度看致幻剂吲哚胺和Entactogens是有前途的治疗药物

Revista Virtual de Química Pub Date : 2022-01-01 DOI: 10.21577/1984-6835.20220053

João Pedro Evangelista Ferreira, Stella Bortoli, Airton Vicente Pereira

引用次数: 1

OSMAC Strategy: An Affordable Method for the Discovery of New Microbial Compounds OSMAC策略:发现新的微生物化合物的一种经济实惠的方法

Revista Virtual de Química Pub Date : 2022-01-01 DOI: 10.21577/1984-6835.20220041

Raissa Rezende Ferreira, Jacqueline Santos Cruz, L. Hamerski

{"title":"OSMAC Strategy: An Affordable Method for the Discovery of New Microbial Compounds","authors":"Raissa Rezende Ferreira, Jacqueline Santos Cruz, L. Hamerski","doi":"10.21577/1984-6835.20220041","DOIUrl":"https://doi.org/10.21577/1984-6835.20220041","url":null,"abstract":"Natural products from microbial origin have always been an abundant source of structurally diversified secondary metabolites, which have been used in the pharmaceutical, agrochemical, and food industries. Furthermore, the biotechnological potential of microorganisms is huge however, the quickness to discover new bioactive secondary metabolites has been slowing down due to the use of the same conventional cultivation and isolation procedures. Genomic studies have been shown of the secondary metabolites production on microorganisms is underestimated, there are many essential gene clusters for the biosynthesis of different classes of compounds, but they are silenced under cultivation conditions. Thus, new approaches were developed to improve the production of new bioactive metabolites by activating the silenced genes. The OSMAC (One Strain Many Compounds) strategy has been a simple and effective approach to activate new metabolic pathways, and consequently the synthesis of new secondary metabolites. Thus, the paper briefly presents the main concepts of the OSMAC strategy to induce the production of secondary metabolites that are not expressed in conventional laboratory culture conditions, and thus favour the discovery of new microbial natural products.","PeriodicalId":21315,"journal":{"name":"Revista Virtual de Química","volume":"77 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73417032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural Sources and Synthetic of 2,3-Dihydrobenzofurans Derivatives: A Recent Approach 2,3-二氢苯并呋喃衍生物的天然来源及合成研究进展

Revista Virtual de Química Pub Date : 2022-01-01 DOI: 10.21577/1984-6835.20220139

Pâmella Silva Cordeiro, Amanda Rebelo, Victor Hugo Menezes Costa, Joel S. Reis, Vanessa Nascimento

引用次数: 0