Romanian Journal of Military Medicine最新文献_第2页

Lynch Syndrome – An Overview of the Worldwide Management of This Silent Killer Within Our Genes 林奇综合征--世界范围内对这种基因内无声杀手的管理概览

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Romanian Journal of Military Medicine Pub Date : 2023-10-01 DOI: 10.55453/rjmm.2023.126.5.6

O. Voinea, A. E. Ranetti, Lucian G. Eftimie, Adrian V. Dumitru, Teodor I. Constantin, A. Mirică

{"title":"Lynch Syndrome – An Overview of the Worldwide Management of This Silent Killer Within Our Genes","authors":"O. Voinea, A. E. Ranetti, Lucian G. Eftimie, Adrian V. Dumitru, Teodor I. Constantin, A. Mirică","doi":"10.55453/rjmm.2023.126.5.6","DOIUrl":"https://doi.org/10.55453/rjmm.2023.126.5.6","url":null,"abstract":"\"Lynch syndrome, also known as hereditary non-polyposis cancer syndrome, represents the most common autosomal dominant genetic predisposition for the early onset development of several malignancies. Nearly three decades ago, the discovery of microsatellite instability, a distinctive feature of pathogenic variants within genes encoding mismatch repair proteins, marked a significant leap forward in understanding cancer biology and the underlying spectrum of cancers triggered by these mutations – typical of Lynch syndrome. In recent years, a new treatment paradigm, using immune checkpoint inhibitors, as well as preventive measures has drastically improved the survival rates. Identifying individuals with an inherent predisposition to cancer, through diagnostic protocols followed by personalized screening and treatment algorithms, holds the potential to mitigate premature cancer-related fatalities as well as preventable mortality. It is estimated that only a limited number of patients have been diagnosed, underscoring the importance of implementing specific screening programs for early detection of malignancies to which these patients are susceptible. This article aims to underline the importance of a national protocol tailored to guide a Western-inspired practice for Lynch syndrome patient management, the main aim of the Romanian Society for Lynch Syndrome, by providing an overview of similar initiatives throughout the world.\"","PeriodicalId":21298,"journal":{"name":"Romanian Journal of Military Medicine","volume":"34 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139326229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lynch Syndrome: Approach from the Gastroenterologist’s Point of View 林奇综合征：从消化内科医生的角度看问题

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Romanian Journal of Military Medicine Pub Date : 2023-10-01 DOI: 10.55453/rjmm.2023.126.5.4

Livia Ș. Drăgan, Cristian Gheorghe

{"title":"Lynch Syndrome: Approach from the Gastroenterologist’s Point of View","authors":"Livia Ș. Drăgan, Cristian Gheorghe","doi":"10.55453/rjmm.2023.126.5.4","DOIUrl":"https://doi.org/10.55453/rjmm.2023.126.5.4","url":null,"abstract":"\"Colorectal cancer is one of the main causes of death by cancer in the European Union and in Romania. Lynch Syndrome is an autosomal dominant inherited disease that affects around 3% of all colorectal cancer patients, defined by mutations in the mismatch repair genes (MLH1, MSH2, MSH6, PMS2). Aside from the high risk for colorectal cancer (CRC), they exhibit a high risk for endometrial cancer, ovarian cancer, gastric cancer, pancreatic cancer, brain cancer, small bowel cancer, and sebaceous gland cancer. Diagnosis is often made by the gastroenterologist, usually when he meets a young patient with symptoms suggesting the presence of a colonic tumor and a family history of CRC. The role of the gastroenterologist is to investigate the best practices in order to have an early diagnosis and to prevent interval cancers according to the newest guidelines or other gastrointestinal tract tumors associated with Lynch Syndrome. Registries play an important role in the optimal surveillance of these particular categories of patients and should be put into place in every country. They will allow clinicians to have a better understanding of the disease and a more standardized quality of care for them.\"","PeriodicalId":21298,"journal":{"name":"Romanian Journal of Military Medicine","volume":"26 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139325690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overview of the Genetic Aspects of Lynch Syndrome 林奇综合征遗传学概述

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Romanian Journal of Military Medicine Pub Date : 2023-10-01 DOI: 10.55453/rjmm.2023.126.5.3

Silvia N. Rădulescu

{"title":"Overview of the Genetic Aspects of Lynch Syndrome","authors":"Silvia N. Rădulescu","doi":"10.55453/rjmm.2023.126.5.3","DOIUrl":"https://doi.org/10.55453/rjmm.2023.126.5.3","url":null,"abstract":"\"Lynch syndrome (LS) is one of the most common inherited cancer predisposition syndromes and the most important cause of hereditary colorectal and endometrial cancers. It is inherited in an autosomal dominant pattern, caused by a pathogenic germline variant in one of the mismatch repair (MMR) genes (MLH1, MSH2, MSH6, or PMS2), which encode proteins responsible for maintaining genome stability. A defective MMR system confers an elevated risk of developing certain types of cancer, at a younger age than in the general population and at a high rate of multiple primary neoplasia. Lynch syndrome is not just one disease, but a collection of different subtypes of underlying molecular aspects with specific clinical implications. A better understanding of these subgroup profiles could offer better care for each patient, leading to more personalized risk-reduction and surveillance strategies. Lynch syndrome is a frequent but yet underdiagnosed condition that needs multidisciplinary increased awareness for correct diagnosis and management. The aim of this review is to provide a summary of available literature data on the genetic aspects of Lynch syndrome together with geno-type-phenotype correlations and its clinical implications in the detection, genetic counseling, genetic testing, risk stratification, and management of this condition.\"","PeriodicalId":21298,"journal":{"name":"Romanian Journal of Military Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139328761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emotional Regulation Strategies in Lynch Syndrome Diagnosis Psychological Adjustment – A Review 林奇综合征诊断心理适应中的情绪调节策略--综述

IF 0.3

Romanian Journal of Military Medicine Pub Date : 2023-10-01 DOI: 10.55453/rjmm.2023.126.5.2

M. Licu, C. G. Ionescu, F. Golu

引用次数: 0

Cardiotoxicity of Chemotherapy in Lynch Syndrome – A Literature Review 林奇综合征化疗的心脏毒性--文献综述

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Romanian Journal of Military Medicine Pub Date : 2023-10-01 DOI: 10.55453/rjmm.2023.126.5.1

Bogdan-Viorel Vîlceleanu, O. Voinea, C. Buzilă, Diana M. Ciobanu, Liviu Stan, S. I. Dumitrescu

引用次数: 0

An Endocrine Perspective on Lynch Syndrome 从内分泌角度看林奇综合征

IF 0.3

Romanian Journal of Military Medicine Pub Date : 2023-10-01 DOI: 10.55453/rjmm.2023.126.5.5

A. Mirică, Emil A. Ranetti, O. Voinea, I. Badarau, Raluca I. Papacocea, Diana L. Păun

{"title":"An Endocrine Perspective on Lynch Syndrome","authors":"A. Mirică, Emil A. Ranetti, O. Voinea, I. Badarau, Raluca I. Papacocea, Diana L. Păun","doi":"10.55453/rjmm.2023.126.5.5","DOIUrl":"https://doi.org/10.55453/rjmm.2023.126.5.5","url":null,"abstract":"\"Background: A germline mutation of the MisMatch Repairgene that causes a malfunctioning DNA system is the defining feature of the hereditary illness known as Lynch syndrome. This review will discuss the endocrine aspects of LS and highlight current advancements in the area. Methods: We searched the available literature of the last 10 years for terms such as endocrine tumors and LS. Our goal is to provide a summary of the most recent information available on the endocrine perspective in Lynch syndrome. Results: The hormonal chemoprevention methods cited are the use of combined oral contraceptives, the use of progestogen-releasing intrauterine devices, and the use of progesterone-only drugs. In addition, after surgical exclusion of the uterus and ovaries, a method frequently adopted for LS patients, it is necessary to start hormonal menopausal therapy, taking into account certain age-specific features. In addition, numerous LS-associated endocrine tumor types have been described. Conclusions: Many hormonal variants are available that are useful in the chemoprevention involved in the treatment of LS. Menopausal hormone therapy is imperative for LS patients who need it. Clinicians need to be aware of the possible association of certain types of aggressive endocrine cancers associated with LS.\"","PeriodicalId":21298,"journal":{"name":"Romanian Journal of Military Medicine","volume":"102 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139326197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk Factors for Urinary Colonization in Patients with Double J Catheters Implanted for Treating Obstructive Urolithiasis 双J型导尿管治疗梗阻性尿路结石患者尿路结肠癌的危险因素

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Romanian Journal of Military Medicine Pub Date : 2023-08-01 DOI: 10.55453/rjmm.2023.126.4.4

Mihai Vintilă, D. Spînu, D. Marcu, D. Mischianu, S. Nica

引用次数: 0

Validity of Photoplethysmography Mobile Analysis to Test the Autonomic Stress Status of Tactical Athletes 光容积脉搏波运动分析测试战术运动员自主应激状态的有效性

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Romanian Journal of Military Medicine Pub Date : 2023-08-01 DOI: 10.55453/rjmm.2023.126.4.20

A. C. Regueros, Á. Bustamante-Sánchez, V. Clemente-Suárez

{"title":"Validity of Photoplethysmography Mobile Analysis to Test the Autonomic Stress Status of Tactical Athletes","authors":"A. C. Regueros, Á. Bustamante-Sánchez, V. Clemente-Suárez","doi":"10.55453/rjmm.2023.126.4.20","DOIUrl":"https://doi.org/10.55453/rjmm.2023.126.4.20","url":null,"abstract":"\"Background: The effect of stress on sympathetic modulation measured by HRV has been studied in various population groups exposed to different stressors. HRV measurement tools are based on the electrocardiogram (ECG), portable tools such as POLAR V800, and recently photoplethysmography (PPG). The aim of this study was to analyze the validity of a PPG mobile app to measure HRV with a validated V800 system in a tactical athlete population. Methods HRV of 53 professional militaries were analyzed by POLAR V800 and an HRV Camera app with a smartphone during 5 min and 30 s protocol respectively. Results: The HRV values obtained by the PPG presented a significant negative significant correlation in the HRVI index, LF, HF, LF (n.u.), HF (n.u.), and a positive significant correlation in TINN index by the Polar V800 system with the application of a regression equation over the data obtained. Conclusions: HRV Camera PPG App 30s record analysis protocol could be applied using a regression formula depending on the HRV variables after the comparison with a standard 5-minute test conducted with a validated Polar V800. In future research, it is suggested to validate PPG protocols with longer durations.\"","PeriodicalId":21298,"journal":{"name":"Romanian Journal of Military Medicine","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49001247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Value of Electrocardiogram Algorithms Predicting Right Ventricular Outflow Tract Origin in the Era of Catheter Mapping 导管测绘时代右室流出道起源的心电图预测算法的价值

IF 0.3

Romanian Journal of Military Medicine Pub Date : 2023-08-01 DOI: 10.55453/rjmm.2023.126.4.3

Raluca Sirbu Prisecaru, L. Riahi, M. Abagiu, O. Purcar, I. Manițiu

{"title":"Value of Electrocardiogram Algorithms Predicting Right Ventricular Outflow Tract Origin in the Era of Catheter Mapping","authors":"Raluca Sirbu Prisecaru, L. Riahi, M. Abagiu, O. Purcar, I. Manițiu","doi":"10.55453/rjmm.2023.126.4.3","DOIUrl":"https://doi.org/10.55453/rjmm.2023.126.4.3","url":null,"abstract":"Background: The 12-lead electrocardiogram (ECG) is an extremely useful tool for analyzing cardiac arrhythmias and numerous ECG algorithms have been developed to predict the origin of right ventricular outflow tract (RVOT) arrhythmias. Aim: To determine if using complex, time-consuming analysis, and difficult-to-memorize ECG algorithms is feasible and preferable before the ablation procedure when compared with the use of multipolar mapping catheter use during the ablation procedure. Methods: 47 consecutive patients admitted for radiofrequency catheter ablation of idiopathic PVC were included prospectively in this study. Of the algorithms selected for comparison, three have a memorable design and easy applicability (Dixit, Joshi, Pytkowski) and the fourth has a complex, detailed design and is more difficult to memorize (Zhang). Results: The greatest accuracy was observed for the algorithms proposed by Dixit and Pytkowski – 92. 3%. However, when the algorithms were compared for their accuracy, specificity, and sensitivity, no significant differences were found (p=0. 96). Conclusions: 3-D guided mapping using a conventional ablation catheter in a narrower, precise area of interest in the RVOT, based on ECG algorithms is not inferior compared to the multielectrode catheter mapping in the whole RVOT, in terms of mapping time, total procedural time, and radiofrequency application time.","PeriodicalId":21298,"journal":{"name":"Romanian Journal of Military Medicine","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47066777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Low-Doses Doxorubicin Effects in Mice Using Chromosomal Aberration Assay 用染色体畸变法评价小剂量阿霉素对小鼠的作用

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Romanian Journal of Military Medicine Pub Date : 2023-08-01 DOI: 10.55453/rjmm.2023.126.4.1

R. Costache, R. Nica, S. Nica, Robert M. Sionel, S. Spandole-Dinu, Oana Costianu, I. Radu, Mirela Oancea, Matei I. Nica, D. Cimponeriu, L. Berca

{"title":"Assessment of Low-Doses Doxorubicin Effects in Mice Using Chromosomal Aberration Assay","authors":"R. Costache, R. Nica, S. Nica, Robert M. Sionel, S. Spandole-Dinu, Oana Costianu, I. Radu, Mirela Oancea, Matei I. Nica, D. Cimponeriu, L. Berca","doi":"10.55453/rjmm.2023.126.4.1","DOIUrl":"https://doi.org/10.55453/rjmm.2023.126.4.1","url":null,"abstract":"\"The cytogenetic aberrations induced by doxorubicin (DOX) may be influenced by diet. Investigation regarding effects of low doses of DOX on chromosomal aberrations frequency in mice bone marrow. The study explored a possible relationship between diet, follow-up period, and cytostatic doses. Four mice groups received normal or high-fat (pork) diet. At the beginning of the 8th day mice from each group received a single intraperitoneal injection with DOX (dose range: 1.7-7.7 mg/kg b.w.) or isotonic saline solution (0.02 mL/g control mice). In the 10th (groups I, II) and 14th (groups III, IV) days from the beginning of the experiment, the mice were euthanized and chromosome aberrations were tested in bone marrow cells. The body weight of all mice who received DOX decreases, especially at higher doses. In the first three days post-injection, weight loss percentage was significantly influenced by DOX doses and/or type of diet (p<0.003). The interaction between the type of diet and DOX doses was not statistically significant in the follow-up period (p interactions >0.05). DOX doses were able to increase the frequency of chromosomal aberrations. DOX acts as a potent inductor of cytogenetic aberrations in bone marrow cells, regardless of the type of diet.\"","PeriodicalId":21298,"journal":{"name":"Romanian Journal of Military Medicine","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48431790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0