A. Mirică, Emil A. Ranetti, O. Voinea, I. Badarau, Raluca I. Papacocea, Diana L. Păun
{"title":"An Endocrine Perspective on Lynch Syndrome","authors":"A. Mirică, Emil A. Ranetti, O. Voinea, I. Badarau, Raluca I. Papacocea, Diana L. Păun","doi":"10.55453/rjmm.2023.126.5.5","DOIUrl":null,"url":null,"abstract":"\"Background: A germline mutation of the MisMatch Repairgene that causes a malfunctioning DNA system is the defining feature of the hereditary illness known as Lynch syndrome. This review will discuss the endocrine aspects of LS and highlight current advancements in the area. Methods: We searched the available literature of the last 10 years for terms such as endocrine tumors and LS. Our goal is to provide a summary of the most recent information available on the endocrine perspective in Lynch syndrome. Results: The hormonal chemoprevention methods cited are the use of combined oral contraceptives, the use of progestogen-releasing intrauterine devices, and the use of progesterone-only drugs. In addition, after surgical exclusion of the uterus and ovaries, a method frequently adopted for LS patients, it is necessary to start hormonal menopausal therapy, taking into account certain age-specific features. In addition, numerous LS-associated endocrine tumor types have been described. Conclusions: Many hormonal variants are available that are useful in the chemoprevention involved in the treatment of LS. Menopausal hormone therapy is imperative for LS patients who need it. Clinicians need to be aware of the possible association of certain types of aggressive endocrine cancers associated with LS.\"","PeriodicalId":21298,"journal":{"name":"Romanian Journal of Military Medicine","volume":null,"pages":null},"PeriodicalIF":0.1000,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Romanian Journal of Military Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.55453/rjmm.2023.126.5.5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
"Background: A germline mutation of the MisMatch Repairgene that causes a malfunctioning DNA system is the defining feature of the hereditary illness known as Lynch syndrome. This review will discuss the endocrine aspects of LS and highlight current advancements in the area. Methods: We searched the available literature of the last 10 years for terms such as endocrine tumors and LS. Our goal is to provide a summary of the most recent information available on the endocrine perspective in Lynch syndrome. Results: The hormonal chemoprevention methods cited are the use of combined oral contraceptives, the use of progestogen-releasing intrauterine devices, and the use of progesterone-only drugs. In addition, after surgical exclusion of the uterus and ovaries, a method frequently adopted for LS patients, it is necessary to start hormonal menopausal therapy, taking into account certain age-specific features. In addition, numerous LS-associated endocrine tumor types have been described. Conclusions: Many hormonal variants are available that are useful in the chemoprevention involved in the treatment of LS. Menopausal hormone therapy is imperative for LS patients who need it. Clinicians need to be aware of the possible association of certain types of aggressive endocrine cancers associated with LS."
背景MisMatch Repairgene 的种系突变会导致 DNA 系统功能失常,这是被称为林奇综合征的遗传性疾病的主要特征。本综述将讨论林奇综合征的内分泌问题,并重点介绍该领域的最新进展。研究方法我们搜索了过去 10 年中有关内分泌肿瘤和 LS 等术语的现有文献。我们的目标是提供林奇综合征内分泌方面的最新信息摘要。结果:所引用的激素化学预防方法包括使用复方口服避孕药、使用释放孕激素的宫内节育器和使用纯黄体酮药物。此外,LS 患者常采用的一种方法是手术切除子宫和卵巢,在手术切除后,有必要开始激素绝经治疗,同时考虑到某些年龄特征。此外,还描述了许多与LS相关的内分泌肿瘤类型。结论:有许多激素变体可用于治疗LS的化学预防。对于有需要的 LS 患者来说,绝经期激素治疗势在必行。临床医生需要意识到某些类型的侵袭性内分泌癌症可能与LS有关"。