Rheumatology最新文献

{"title":"Is antimalarial use associated with a reduced risk of LN in patients with SLE? Results from an inception cohort-based study.","authors":"Fadi Kharouf,JuanPablo DiazMartinez,Pankti Mehta,Dafna D Gladman,Laura P Whittall Garcia,Zahi Touma","doi":"10.1093/rheumatology/keaf482","DOIUrl":"https://doi.org/10.1093/rheumatology/keaf482","url":null,"abstract":"OBJECTIVESAntimalarials are a cornerstone in managing SLE and are associated with multiple favourable disease outcomes. This study explored whether antimalarial use is associated with a reduced risk of incident LN in SLE patients.METHODSWe included SLE patients from an inception cohort with no prior history of LN, followed prospectively at regular intervals. The relationship between the exposure (cumulative duration of antimalarial exposure in years) and the outcome (development of LN, as indicated by new-onset proteinuria attributed to lupus activity by clinical judgement and recorded in the SLEDAI-2K sheet) was characterized using a time-dependent univariable Cox proportional hazards model to estimate the overall effect. Adjusted multivariable Cox regression was also employed to estimate the risk of LN, incorporating clinically relevant variables.RESULTSThe study included 674 inception SLE patients, with a median baseline age of 33.6 years (interquartile range [IQR]: 24.9-45.4). One hundred and fifty-four patients (22.8%) developed SLE-related new-onset proteinuria, indicating LN, with a median time to event of 3.6 years [IQR: 0.9-8.8]. Cumulative duration of antimalarial exposure was not significantly associated with a lower risk of LN, either in the unadjusted univariable model estimating the overall effect (hazard ratio [HR]: 0.98; 95% CI: 0.94-1.02, P = 0.25) or in the adjusted multivariable model (HR: 0.96; 95% CI: 0.92-1.00, P = 0.08). This finding was also corroborated in a sensitivity analysis of patients with serologically active SLE (HR: 0.97; 95% CI: 0.92-1.02).CONCLUSIONAntimalarial use is not significantly associated with a reduced risk of incident LN in SLE patients.","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":"77 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145089882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammation assessment in psoriatic arthritis via optical spectral transmission: correlations with clinical markers and musculoskeletal ultrasound.","authors":"Konstantinos Triantafyllias, Stefanie Liverakos, Xenofon Baraliakos, Andreas Schwarting","doi":"10.1093/rheumatology/keaf480","DOIUrl":"https://doi.org/10.1093/rheumatology/keaf480","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the value of optical spectral transmission (OST) in detecting joint inflammation in patients with psoriatic arthritis (PsA) and to evaluate correlations of OST with musculoskeletal ultrasound (US) and clinical disease activity markers.</p><p><strong>Methods: </strong>OST and clinical examinations were performed on the finger (metacarpophalangeal, proximal-interphalangeal, distal-interphalangeal) and wrist joints of patients with PsA and healthy controls. A subset of patients was additionally examined via musculoskeletal US. OST differences in the two groups were statistically assessed and the diagnostic performance of OST was evaluated by Receiver-Operating-Characteristics (ROC). Additionally, associations between OST values and clinical, laboratory, as well as US activity markers were examined through correlation analyses and linear regression.</p><p><strong>Results: </strong>A total of 3,000 joints from 100 PsA patients were examined using OST and compared to 3,000 joints from 100 controls. OST was significantly higher in the PsA group compared to the control group (15.76 vs. 10.24; p<0.001). ROC (PsA vs. controls) revealed a very good diagnostic OST performance by an area-under-the-curve of 0.848 (95%-CI 0.795-0.900; p<0.001), with a sensitivity of 0.89 and specificity of 0.71 for an OST cut-off of 12.75. Among patients, OST correlated moderately with Joint-Power-Doppler- (rho=0.412; p=0.015) and Grey-Scale-US (rho=0.419; p=0.014), respectively. Moreover, significant OST correlations with CRP (rho=0.232; p=0.021), ''Disease-Activity-in-Psoriatic-Arthritis (DAPSA)'' (rho=0.215; p=0.032) and \"Disease-Activity-Score-28 (DAS28)\" (rho=0.23; p=0.021) were found.</p><p><strong>Conclusion: </strong>OST associated significantly with clinical, US and laboratory disease activity markers in patients with PsA. Furthermore, OST could reliably differentiate between sonographically inflamed and non-inflamed joints in patients with PsA.</p>","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should we be attempting to stop treatment in patients with JIA who are in remission?","authors":"Ethan S Sen,Clare E Pain,A V Ramanan","doi":"10.1093/rheumatology/keaf477","DOIUrl":"https://doi.org/10.1093/rheumatology/keaf477","url":null,"abstract":"","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":"35 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145025743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Transition of clinical remission rates with molecular targeted therapies in rheumatoid arthritis in Japan: reply.","authors":"Satoshi Kubo,Yoshiya Tanaka","doi":"10.1093/rheumatology/keaf472","DOIUrl":"https://doi.org/10.1093/rheumatology/keaf472","url":null,"abstract":"","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":"32 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145025595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of hand function impairment on daily life of patients with systemic sclerosis: a qualitative study.","authors":"Mark Greveling, Stefano Rodolfi, Nora El Bardai, Christopher P Denton, Voon H Ong, Nick Jeffrie S-Owen, Rita Schriemer, Lieke Tweehuysen, Julia Spierings","doi":"10.1093/rheumatology/keaf476","DOIUrl":"https://doi.org/10.1093/rheumatology/keaf476","url":null,"abstract":"<p><strong>Objectives: </strong>Many patients with systemic sclerosis (SSc) experience impaired hand function, yet the precise nature and impact of this impairment remains unclear. In this study, we explored the determinants of hand function impairment in SSc from a patient perspective and its impact on daily life. Additionally, we identified unmet care needs related to hand function impairment.</p><p><strong>Methods: </strong>Adult patients with SSc were included from the University Medical Centre Utrecht, the Netherlands, and Royal Free Hospital London, United Kingdom (UK). Face-to-face semi-structured interviews were conducted, transcribed verbatim, and coded. Thematic analysis was performed to identify key themes. Hand function was evaluated using the modified Hand Mobility in Scleroderma (mHAMIS) and the Cochin Hand Function Scale (CHFS).</p><p><strong>Results: </strong>Thirty-three patients were included (N = 18 in the Netherlands, N = 15 in the UK). Three main themes were identified: symptoms, impact, and (un)met needs. The symptoms theme captures the broad range of medical and functional complaints, often co-occurring and leading to significant hand function impairment. The impact theme describes how these symptoms limited daily activities, employment, and leisure, and contributed to emotional distress and social isolation. The (un)met needs theme highlights varied coping strategies and experiences with care. While participants felt that patient education was sufficient when healthcare professionals addressed hand impairment, many reported a lack of tailored support and insufficient recognition of hand-related problems.</p><p><strong>Conclusion: </strong>Hand function impairment in SSc profoundly affects patients' daily lives and well-being. Addressing this unmet need requires greater clinical awareness and more personalised and symptom-specific management strategies.</p>","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global burden of osteoarthritis in middle-aged adults (40-59 years): estimates from the global burden of disease 2021 study.","authors":"Tingxuan Tang,Changyu Liu,Libo Zhao,Tian Ma,Chenghao Gao,Jiawei Jiang,Zixing Shu,Yuan Xiong,Chengjia Liu,Xuying Sun,Yuanli Zhu,Hao Zhu,Jun Xiao","doi":"10.1093/rheumatology/keaf475","DOIUrl":"https://doi.org/10.1093/rheumatology/keaf475","url":null,"abstract":"OBJECTIVESOsteoarthritis (OA) is a leading cause of chronic pain and disability worldwide, traditionally viewed as a disease of aging. However, emerging evidence highlights its increasing prevalence among middle-aged adults (40-59 years), a population critical to socioeconomic stability. This study is designed to assess the burden of OA among middle-aged adults.METHODSData were sourced from the GBD Study 2021. Incidence, prevalence and YLDs of OA were calculated in middle-aged adults from 1990 to 2021. Variability in OA burden was examined by SDI and geographical region. Incidence was forecast to 2050 using the GBD Foresight Visualization tool.RESULTSIncident cases of OA among middle-aged adults increased by 123.7%, from 11.8 million in 1990-26.4 million in 2021. ∼56.5% of incident cases and 37.9% of prevalent cases occur within middle-aged group, underscoring its critical burden. Middle-aged population experienced 70% and 331% higher incident cases compared with elderly population (>60 years) and younger population (30-39 years), respectively. The highest incidence YLDs were observed in the high-income region. A significant positive association was found between OA burden and SDI. By 2050, the age-standardized incident rate of OA in middle-aged population is projected to increase by 10.2%, with hand OA showing the largest rise.CONCLUSIONThis study underscores the growing burden of OA among middle-aged adults, a population that has been historically underrepresented in OA research. The findings highlight the urgent need to prioritize prevention strategies. Early intervention could significantly delay disease progression and alleviate the future burden.","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":"15 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145025597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Transition of clinical remission rates with molecular targeted therapies in rheumatoid arthritis in Japan: insights from FIRST registry.","authors":"Ichiro Yoshii,Naoya Sawada,Tatsumi Chijiwa","doi":"10.1093/rheumatology/keaf471","DOIUrl":"https://doi.org/10.1093/rheumatology/keaf471","url":null,"abstract":"","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":"87 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145025596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between anti-SSA/SSB antibody profiles and patient-reported outcomes in primary Sjögren's disease.","authors":"Marie Robert,Yann Nguyen,Rakiba Belkhir,Frédéric Desmoulins,Elisabeth Berge,Julien Henry,Pascale Chretien,Arnaud Hot,Gaetane Nocturne,Samuel Bitoun,Xavier Mariette,Raphaèle Seror","doi":"10.1093/rheumatology/keaf478","DOIUrl":"https://doi.org/10.1093/rheumatology/keaf478","url":null,"abstract":"","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":"13 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of hypertrophic pachymeningitis with neutrophil extracellular traps formation.","authors":"Koki Nakamura,Masatoshi Kanda,Yuki Hamakawa,Hidenori Amaike,Ken Nagahata,Hiroyuki Nakamura,China Washio,Yuka Nishibata,Sakiko Masuda,Akihiro Ishizu,Hiroki Takahashi","doi":"10.1093/rheumatology/keaf473","DOIUrl":"https://doi.org/10.1093/rheumatology/keaf473","url":null,"abstract":"","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":"53 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal involvement in very early and established systemic sclerosis: insights from the SPRING-SIR national Italian registry.","authors":"Francesco Bonomi,Cosimo Bruni,Silvia Peretti,Rossella De Angelis,Gianluigi Bajocchi,Dilia Giuggioli,Martina Orlandi,Giovanni Zanframundo,Rosario Foti,Giovanna Cuomo,Alarico Ariani,Edoardo Rosato,Gemma Lepri,Francesco Girelli,Valeria Riccieri,Elisabetta Zanatta,Silvia Laura Bosello,Ilaria Cavazzana,Francesca Ingegnoli,Maria De Santis,Fabio Cacciapaglia,Giuseppe Murdaca,Giuseppina Abignano,Pettiti Giorgio,Alessandra Della Rossa,Maurizio Caminiti,Anna Maria Iuliano,Giovanni Ciano,Lorenzo Beretta,Gianluca Bagnato,Ennio Lubrano,Ilenia De Andres,Luca Idolazzi,Marta Saracco,Cecilia Agnes,Corrado Campochiaro,Edoardo Cipolletta,Marco Fornaro,Federica Lumetti,Amelia Spinella,Luca Magnani,Giacomo De Luca,Veronica Codullo,Elisa Visalli,Carlo Iandoli,Antonietta Gigante,Greta Pellegrino,Erika Pigatto,Maria Grazia Lazzaroni,Enrico De Lorenzis,Gianna Mennillo,Marco Di Battista,Giuseppa Pagano-Mariano,Federica Furini,Licia Vultaggio,Simone Parisi,Clara Lisa Peroni,Gerolamo Bianchi,Enrico Fusaro,Gian Domenico Sebastiani,Marcello Govoni,Salvatore D'Angelo,Franco Cozzi,Franco Franceschini,Serena Guiducci,Lorenzo Dagna,Andrea Doria,Carlo Salvarani,Maria Antonietta D'Agostino,Florenzo Iannone,Clodoveo Ferri,Marco Matucci-Cerinic,Silvia Bellando Randone, ","doi":"10.1093/rheumatology/keaf457","DOIUrl":"https://doi.org/10.1093/rheumatology/keaf457","url":null,"abstract":"OBJECTIVESTo describe the prevalence of gastrointestinal (GI) symptoms in systemic sclerosis (SSc) and Very Early Diagnosis of SSc (VEDOSS), identify clinical and serological features associated with GI involvement, and explore a cranio-caudal pattern of symptom distribution, using data from the Italian SPRING-SIR registry.METHODSThis cross-sectional analysis included patients fulfilling 2013 ACR/EULAR SSc or VEDOSS criteria. GI involvement was defined as symptoms in at least one GI tract segment and categorized as upper and lower. Associations between GI involvement and clinical variables were assessed using logistic and ordinal regression models, adjusting for demographics, disease characteristics, and autoantibodies.RESULTSAmong 1917 SSc patients, 56% had GI symptoms, associated with longer disease duration, diffuse cutaneous SSc (dcSSc), interstitial lung disease (ILD), digital ulcers (DU), telangiectasias, and tobacco exposure. Extensive GI involvement correlated with more severe disease. Ordinal regression identified female sex, dcSSc, ILD, DU, telangiectasias, tobacco exposure, and anti-centromere antibodies as variables significantly associated with more extensive GI involvement. Disease duration did not show a significant association with GI symptom extent. Among 211 VEDOSS patients, 41.2% reported GI symptoms (mostly esophageal), significantly associated with puffy fingers, and dyspnea. Among VEDOSS, puffy fingers and anti-centromere antibodies were independent predictors of presence of esophageal symptoms.CONCLUSIONGI involvement in SSc is linked to more severe disease and longer disease duration. Disease duration resulted linked to the presence of GI symptoms rather than extent of GI involvement. Puffy fingers and anti-centromere antibodies may associate with presence of early esophageal symptoms in VEDOSS.","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":"42 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145003194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}