Rheumatology最新文献

{"title":"Comment on: Gout incidence in metformin versus sodium-glucose co-transporter-2 inhibitor users: a retrospective cohort study.","authors":"Shih-Wei Lai","doi":"10.1093/rheumatology/keaf261","DOIUrl":"https://doi.org/10.1093/rheumatology/keaf261","url":null,"abstract":"","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leg edema in systemic sclerosis: uncovering fasciitis and myositis as key underlying causes.","authors":"Shiri Keret,Merav Lidar,Aniela Shouval,Abid Awisat,Alaa Sawaed,Noa Nemesh,Lisa Kaly,Itzhak Rosner,Michael Rozenbaum,Nina Boulman,Gleb Slobodin,Doron Rimar","doi":"10.1093/rheumatology/keaf274","DOIUrl":"https://doi.org/10.1093/rheumatology/keaf274","url":null,"abstract":"","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":"19 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144114294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Gout incidence in metformin versus sodium-glucose co-transporter-2 inhibitor users: A retrospective cohort study: Reply.","authors":"Masaki Hatano,Akira Okada,Hideo Yasunaga","doi":"10.1093/rheumatology/keaf262","DOIUrl":"https://doi.org/10.1093/rheumatology/keaf262","url":null,"abstract":"","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":"32 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the relevance of the 2024 BSR systemic sclerosis guideline to juvenile systemic sclerosis.","authors":"Clare E Pain,Hanna Lythgoe,Emily Willis,Sunil Sampath,Samundeeswari Deepak,Kathryn S Torok,Phuoc H Duong,Shahin Moledina,Juliana Silva,Clarissa Pilkington,Eslam Al-Abadi,Christopher P Denton","doi":"10.1093/rheumatology/keaf249","DOIUrl":"https://doi.org/10.1093/rheumatology/keaf249","url":null,"abstract":"","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":"18 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis revealed HLA susceptibility markers in ANCA-associated vasculitis and its clinical sub-types","authors":"Harinder Singh, Koustav Maiti, Sohini Saha, Sabyasachi Senapati","doi":"10.1093/rheumatology/keaf265","DOIUrl":"https://doi.org/10.1093/rheumatology/keaf265","url":null,"abstract":"Objectives ANCA-associated vasculitis (AAV) is a group of systemic autoimmune diseases affecting small blood-vessels. Class-II HLA genes often reported as major genetic determinants. We conducted a systematic review and meta-analysis to evaluate the susceptibility conferred by HLA genes in AAV and five sub-types i.e. PR3+AAV, MPO+AAV, Granulomatosis with polyangiitis (GPA), Microscopic polyangiitis (MPA) and Eosinophilic granulomatosis with polyangiitis (EGPA). Methods Relevant articles were retrieved until March 2024, from electronic databases using appropriate keywords. Eligible studies were included following inclusion-exclusion criteria. Funnel plots, Newcastle-Ottawa Scale and GRADE tools were used to evaluate the quality of evidence and research findings. Statistical analyses were performed by RevMan 5.4.1. The meta-odds ratio and Z test p-value were considered to check the HLA associations. Results Meta-analysis of HLA-alleles identified 30 significant associations with AAV and its sub-types of which 17 withstood Bonferroni corrections. rs9277554-C from HLA-DPB1 (Meta-OR = 3.92(3.27–4.69)), rs1049072-A from HLA-DQB1 (Meta-OR = 1.39(1.27–1.52)) and rs9277341-C from HLA-DPA1 (Meta-OR = 0.41(0.03–0.57)) were significantly associated (p < 0.00001) with AAV and GPA respectively. DRB1*09:01 was significantly (p < 0.00001) predisposing allele in AAV (Meta-OR = 1.72(1.46–2.03)) and MPO+AAV (Meta-OR = 1.65(1.41–1.93)) and MPA (Meta-OR = 1.75(1.41–2.19)). Significant association (p ≤ 0.0005) was also observed for DPB1*01:01 (Meta-OR = 0.38(0.24–0.62)) and DRB1*11:01 (Meta-OR = 2.11(1.39–3.20)) for AAV and MPA respectively. Sensitivity analysis identified additional significant (p ≤ 0.001) predisposing alleles DPB1*04:01 and DPB1*02:01 in AAV and more than one sub-types. Conclusion Multiple alleles from HLA-DRB1 and DPB1 were found to provide predisposition to AAV and sub-types. Predisposition by DPB1*04:01 and protection by DPB1*02:01 were specific for AAV, PR3+AAV and GPA. Predisposition by DRB1*09:01 was observed among AAV, MPO+AAV and MPA.","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":"133 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NETs in the spotlight: exploring NETosis markers for tracking disease activity in IgA vasculitis","authors":"Vafa Guliyeva, Fatma Gül Demirkan, Erdem Bektaş, Rabia Deniz, Zeliha Emrence, Özlem Akgün, Selen Duygu Arık, Ayşenur Doğru, Ayşe Tanatar, Neslihan Abacı, Sema Sırma Ekmekci, Ahmet Gül, Nuray Aktay Ayaz","doi":"10.1093/rheumatology/keaf272","DOIUrl":"https://doi.org/10.1093/rheumatology/keaf272","url":null,"abstract":"Objectives The role of neutrophil extracellular traps (NETs) in immunoglobulin A vasculitis (IgAV) pathogenesis is emerging, with NETosis-associated markers potentially linked to disease activity. This study aimed to explore the relationship between NETosis biomarkers and IgAV disease phases. Methods A longitudinal study involving 33 pediatric IgAV patients and 26 healthy controls was conducted. Blood and urine samples were collected from healthy controls and patients during active and inactive disease phases. NETosis markers, including cell-free DNA (cf-DNA), neutrophil elastase (NE), myeloperoxidase (MPO), and citrullinated histone H3 (cit-H3) were measured using ELISA kits. Statistical analyses were conducted to compare differences for NETosis markers between groups and to evaluate correlations among variables using appropriate statistical tests. Results There was no significant difference in gender and age between the patient and control groups. The serum cf-DNA level was significantly higher in the active patient group compared with the control and inactive patient groups (p= 0.04; p= 0.04, respectively). In urine, MPO levels were significantly lower in the active phase of patients than controls (p= 0.009), while cit-H3 levels were higher in both active and inactive phases compared with controls (p= 0.01 and p= 0.03, respectively). A cf-DNA threshold of 935 ng/ml was identified, which achieved a sensitivity of 93% (correctly identifying 93% of active patients) and a specificity of 72% (correctly identifying 72% of healthy controls). Conclusion Elevated serum cf-DNA and urine cit-H3 suggest a potential role for NETosis in IgAV activity, highlighting these markers as potential indicators for disease monitoring. Further studies are warranted to establish standardized protocols for NETosis marker assessment in IgAV.","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":"57 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Fibrosis-4 Index (FIB-4) correlates with cardiovascular risk and insulin resistance in patients with rheumatoid arthritis.","authors":"Iván Ferraz-Amaro,Elena Heras-Recuero,Antonia de Vera-González,Alejandra González-Delgado,Alejandro Romo-Cordero,Adrián Quevedo-Rodríguez,Juan C Quevedo-Abeledo,Raquel Largo,Miguel Á González-Gay","doi":"10.1093/rheumatology/keaf263","DOIUrl":"https://doi.org/10.1093/rheumatology/keaf263","url":null,"abstract":"OBJECTIVESThe Fibrosis-4 index (FIB-4), a non-invasive tool for assessing liver fibrosis, has also been linked to cardiovascular (CV) risk in the general population. This connection is due to the association of chronic liver diseases, particularly fibrosis or non-alcoholic fatty liver disease, with systemic inflammation, metabolic syndrome, and atherosclerosis. In this study, we aimed to calculate the FIB-4 index in patients with rheumatoid arthritis (RA), a condition associated with increased CV disease risk. We then examined its association with disease characteristics and CV comorbidities, including lipid profile, subclinical carotid atherosclerosis, and insulin resistance indices.METHODSA total of 465 RA patients were recruited in this cross-sectional study. They underwent comprehensive evaluations, including disease-related features, complete lipid profile, anthropometric measurements, insulin resistance indices (using HOMA), metabolic syndrome criteria, and carotid ultrasound for intima-media thickness and carotid plaque detection. FIB-4 was calculated and categorized into low (<1.45), indeterminate (1.45-3.25) and high risk (>3.25) for fibrosis. A multivariable linear regression analysis was performed to examine the associations between the disease characteristics and FIB-4.RESULTSTwenty percent of RA patients had a FIB-4 score indicating indeterminate or high risk for hepatic fibrosis. FIB-4 was significantly associated with higher values of the cardiovascular risk calculator SCORE2 but not with carotid atherosclerosis. It was also significantly related to insulin resistance and metabolic syndrome. However, after multivariable analysis, FIB-4 did not correlate with RA disease characteristics, including disease activity.CONCLUSIONUp to 20% of RA patients show an abnormal FIB-4 index, which correlates with cardiovascular risk and insulin resistance.","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":"138 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term outcomes in lung transplant for anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody positive interstitial lung disease: a case series.","authors":"Judith Jade,Kun Huang,Fergus To","doi":"10.1093/rheumatology/keaf259","DOIUrl":"https://doi.org/10.1093/rheumatology/keaf259","url":null,"abstract":"","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":"55 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psoriatic arthritis flare incidence, definition and risk factors: a systematic review.","authors":"Batoul Hojeij,Gonul Hazal Koc,Jolanda Luime,Marijn Vis,Laura C Coates,Marc R Kok,Ilja Tchetverikov","doi":"10.1093/rheumatology/keaf247","DOIUrl":"https://doi.org/10.1093/rheumatology/keaf247","url":null,"abstract":"OBJECTIVESWe systematically reviewed the literature to identify the incidence of psoriatic arthritis (PsA) flare, criteria used to define it, and associated risk factors.METHODSDatabases of Embase, Medline ALL, Web of Science Core Collection and Cochrane Central Register of Controlled Trials were searched until September 2023, for original articles studying PsA flare. The Newcastle Ottawa scale was used to assess the quality of included studies.RESULTSFifty-four studies of cohort, cross-sectional, and clinical trial designs were included. Twelve studies assessed PsA flare rates, 28 assessed risk factors, and 44 defined flare. The prevalence of current flare ranged between 7%-50% (n = 8), while the incidence ranged between 10%-27% over 6 months (n = 3), and 22%-23% over 12 months (n = 2). Based on high-quality scoring, the current patient-reported flare was 10% (n = 1), while current physician-reported flare was 7% with 22%-23% incidence rate over 12 months (n = 2). Criteria used in flare definition could be grouped into seven categories, with disease activity scores (36%), patient-reported (39%) and physician-reported (30%) flare, and change in therapy (25%) being frequently used. Risk factors could be grouped into four categories: arthritis therapies, SARS-CoV, PsA features, and other. The factors showed limited or unclear evidence.CONCLUSIONThe current prevalence of flare ranged between 7%-10%, and the annual incidence was 22%-23%, based on high-quality scoring. Forty-four studies defined flare, revealing no consensus on a single flare definition, and highlighting the need for a standardized definition. No conclusions could be drawn on risk factors, highlighting the need for further research.PROSPERO REGISTRATIONCRD42024482657.","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":"25 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitivity and specificity of optical coherence tomography retinal imaging within a giant cell arteritis fast track clinic.","authors":"Matthew K Kenworthy,Ruolin Qin,Kylan Pathmanathan,Prathiba Ramakrishnan,Fred K Chen,Helen I Keen","doi":"10.1093/rheumatology/keaf245","DOIUrl":"https://doi.org/10.1093/rheumatology/keaf245","url":null,"abstract":"","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":"40 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}