Global burden of osteoarthritis in middle-aged adults (40-59 years): estimates from the global burden of disease 2021 study.

IF 4.4 2区医学 Q1 RHEUMATOLOGY

Rheumatology Pub Date : 2025-09-09 DOI:10.1093/rheumatology/keaf475

Tingxuan Tang,Changyu Liu,Libo Zhao,Tian Ma,Chenghao Gao,Jiawei Jiang,Zixing Shu,Yuan Xiong,Chengjia Liu,Xuying Sun,Yuanli Zhu,Hao Zhu,Jun Xiao

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引用次数: 0

Abstract

OBJECTIVES Osteoarthritis (OA) is a leading cause of chronic pain and disability worldwide, traditionally viewed as a disease of aging. However, emerging evidence highlights its increasing prevalence among middle-aged adults (40-59 years), a population critical to socioeconomic stability. This study is designed to assess the burden of OA among middle-aged adults. METHODS Data were sourced from the GBD Study 2021. Incidence, prevalence and YLDs of OA were calculated in middle-aged adults from 1990 to 2021. Variability in OA burden was examined by SDI and geographical region. Incidence was forecast to 2050 using the GBD Foresight Visualization tool. RESULTS Incident cases of OA among middle-aged adults increased by 123.7%, from 11.8 million in 1990-26.4 million in 2021. ∼56.5% of incident cases and 37.9% of prevalent cases occur within middle-aged group, underscoring its critical burden. Middle-aged population experienced 70% and 331% higher incident cases compared with elderly population (>60 years) and younger population (30-39 years), respectively. The highest incidence YLDs were observed in the high-income region. A significant positive association was found between OA burden and SDI. By 2050, the age-standardized incident rate of OA in middle-aged population is projected to increase by 10.2%, with hand OA showing the largest rise. CONCLUSION This study underscores the growing burden of OA among middle-aged adults, a population that has been historically underrepresented in OA research. The findings highlight the urgent need to prioritize prevention strategies. Early intervention could significantly delay disease progression and alleviate the future burden.

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中年人（40-59岁）骨关节炎的全球负担：来自2021年全球疾病负担研究的估计

骨关节炎（OA）是世界范围内慢性疼痛和残疾的主要原因，传统上被认为是一种衰老疾病。然而，新出现的证据表明，它在中年人（40-59岁）中越来越普遍，这一人群对社会经济稳定至关重要。本研究旨在评估中年OA患者的负担。方法数据来源于GBD研究2021。计算1990年至2021年中年人OA的发病率、患病率和YLDs。通过SDI和地理区域检查OA负担的变异性。使用GBD预见可视化工具预测到2050年的发病率。结果中年人OA发病率从1990年的1180万例增加到2021年的2640万例，增加了123.7%。~ 56.5%的发病病例和37.9%的流行病例发生在中年人群中，这是严重的负担。与老年人群（60 ~ 60岁）和年轻人群（30 ~ 39岁）相比，中年人群的发病率分别高出70%和331%。高收入地区的YLDs发病率最高。OA负担与SDI之间存在显著的正相关。预计到2050年，中年人群OA年龄标准化发病率将增长10.2%，其中手部OA增幅最大。结论：该研究强调了OA在中年人中日益增长的负担，这一人群在OA研究中一直未被充分代表。研究结果强调，迫切需要优先考虑预防战略。早期干预可以显著延缓疾病进展，减轻未来负担。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Rheumatology 医学-风湿病学

CiteScore

9.40

自引率

7.30%

发文量

1091

审稿时长

2 months

期刊介绍： Rheumatology strives to support research and discovery by publishing the highest quality original scientific papers with a focus on basic, clinical and translational research. The journal’s subject areas cover a wide range of paediatric and adult rheumatological conditions from an international perspective. It is an official journal of the British Society for Rheumatology, published by Oxford University Press. Rheumatology publishes original articles, reviews, editorials, guidelines, concise reports, meta-analyses, original case reports, clinical vignettes, letters and matters arising from published material. The journal takes pride in serving the global rheumatology community, with a focus on high societal impact in the form of podcasts, videos and extended social media presence, and utilizing metrics such as Altmetric. Keep up to date by following the journal on Twitter @RheumJnl.