Rheumatology最新文献

{"title":"Risk prediction model for relapse of anti-synthetase syndrome- associated interstitial lung disease in Japanese multicentre MYKO cohort study.","authors":"Shogo Matsuda,Takuya Kotani,Katsumasa Oe,Daisuke Nishioka,Chifumi Akiyama,Mahiro Yamamoto,Takayasu Suzuka,Ran Nakashima,Hideaki Tsuji,Tsuneo Sasai,Yasuhiro Nohda,Tsuneyasu Yoshida,Yoichi Nakayama,Yuto Nakakubo,Atsubumi Ogawa,Kazuma Yoshida,Keisuke Hirobe,Yuki Aitani,Yudai Koshida,Hirofumi Miyake,Tohru Takeuchi","doi":"10.1093/rheumatology/keaf469","DOIUrl":"https://doi.org/10.1093/rheumatology/keaf469","url":null,"abstract":"OBJECTIVESThis study aimed to establish a risk prediction model for the relapse of anti-synthetase syndrome-associated interstitial lung disease (ASyS-ILD).METHODSPatients diagnosed with ASyS-ILD and treated with prednisolone and calcineurin inhibitors as remission induction therapy were enrolled in the Japanese multicentre MYKO cohort. We followed up on patients who experienced relapse of ASyS-ILD after remission induction therapy, and examined the risk factors for predicting relapse by comparing initial clinical and laboratory findings.RESULTSOf 487 patients diagnosed with idiopathic inflammatory myopathies between 1991 and 2024, 101 patients with ASyS-ILD were included. Tacrolimus was used by 81.2% of patients and 18.8% used ciclosporin as calcineurin inhibitors for a remission induction therapy. Thirty-nine patients (38.6%) relapsed ASyS-ILD during a median follow-up of 4.3 years, and 5-year relapse rate was 45.1%. Multivariate Cox regression analyses showed that the presence of acute/subacute ILD and a lower % forced vital capacity (FVC) on admission were independently identified as risk factors for relapse in patients with ASyS-ILD. Using the receiver operating curve analysis, %FVC ≤77% was determined as the cut-off levels for indicating a poor prognosis. The 5-year relapse rate was significantly higher in patients with acute/subacute ILD, % FVC ≤77% than in those without these parameters. A risk-prediction model (RPM) based on these parameters can stratify patients into low-, moderate-, and high-risk ILD relapse groups.CONCLUSIONOur multicentre cohort study showed that the RPM model using the presence of acute/subacute ILD and %FVC values was a useful tool for stratifying risk of ASyS-ILD relapse.","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":"39 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ulcerative heliotrope rash in anti-MDA5-positive dermatomyositis.","authors":"Wenhan Huang,Lin Tang","doi":"10.1093/rheumatology/keaf470","DOIUrl":"https://doi.org/10.1093/rheumatology/keaf470","url":null,"abstract":"","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":"163 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new characteristıc of systemic lupus erythematosus: subclinical vein involvement-an in-depth biochemical and imaging study.","authors":"Derya Yildirim,Abdulsamet Erden,Nemat Ibrahimkhanli,Elena Elefante,Rahime Duran,Handenur Koc Kanik,Riza Can Kardas,Ibrahim Vasi,Hazan Karadeniz,Mahinur Cerit,Halit Nahit Sendur,Marta Mosca,Hamit Kucuk,Mehmet Akif Ozturk,Abdurrahman Tufan","doi":"10.1093/rheumatology/keaf468","DOIUrl":"https://doi.org/10.1093/rheumatology/keaf468","url":null,"abstract":"OBJECTIVESSystemic lupus erythematosus (SLE) is a heterogeneous autoimmune disorder often complicated by vascular events, with or without antiphospholipid antibody syndrome (APS). This study aimed to explore subclinical venous involvement in SLE using biochemical and imaging modalities, focusing on vein wall thickness (VWT) and inflammation-related biomarkers.METHODSIn this cross-sectional study, 68 SLE patients were categorized based on antiphospholipid antibody (APA) status and clinical APS. Results were compared with 22 rheumatoid arthritis (RA) patients and 20 healthy controls. Serum levels of P-selectin, growth differentiation factor 15 (GDF15), and citrullinated histone 3 (CH3) were measured using ELISA. Ultrasonographic assessments evaluated VWT at bilateral jugular veins, femoral veins, portal vein and femoral artery. Correlations and predictors of vascular changes were analyzed statistically.RESULTSVWT was significantly increased in SLE patients compared with both control groups (p< 0.001), regardless of APA and APS status. Serum P-selectin, GDF15, and CH3 levels were elevated in SLE-APS patients. GDF15 levels correlated positively with VWT, and increased portal vein wall thickness was independently associated with thrombosis. Biomarkers showed significant associations with APS, suggesting their role as indicators of prothrombotic states. No significant associations were found between vascular parameters and disease activity score.CONCLUSIONSubclinical venous involvement appears to be a novel vascular feature of SLE, reflected by increased vein wall thickness (VWT) and its association with thrombosis and biomarkers. Increased portal vein thickness may indicate vascular risk. Whether these changes result from inflammation or vascular remodeling remains unclear, but their presence irrespective of disease activity highlights their clinical relevance.","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":"33 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel pathogenic variant in PSTPIP1 highlights the diversity of PSTPIP1-associated disorders.","authors":"Nastaran Farajzadeh, Clément Triaille, Blandine Monjarret, Simon Lamothe, Fabien Touzot, Guilhem Cros","doi":"10.1093/rheumatology/keaf466","DOIUrl":"10.1093/rheumatology/keaf466","url":null,"abstract":"","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel pathogenic variant in PSTPIP1 highlights the diversity of PSTPIP1-associated disorders.","authors":"Nastaran Farajzadeh,Clément Triaille,Blandine Monjarret,Simon Lamothe,Fabien Touzot,Guilhem Cros","doi":"10.1093/rheumatology/keaf466","DOIUrl":"https://doi.org/10.1093/rheumatology/keaf466","url":null,"abstract":"","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":"24 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144960276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myeloid-derived suppressor cells and monocytes are biomarkers of the clinical phenotype and activity of psoriatic disease","authors":"Jennifer T Balderas-Miranda, Jiram Torres-Ruiz, Guillermo A Guaracha-Basañez, Beatriz Alcalá-Carmona, Yatzil Reyna-Juárez, María José Ostos-Prado, Guillermo Juarez-Vega, Nancy R Mejía-Domínguez, Silvia Méndez-Flores, Virgina Pascual Ramos, Diana Gómez-Martín","doi":"10.1093/rheumatology/keaf465","DOIUrl":"https://doi.org/10.1093/rheumatology/keaf465","url":null,"abstract":"Objectives To assess the relation between the proportion of myeloid-derived suppressor cells (MDSCs), monocyte subsets, and the clinical phenotypes and disease activity of psoriatic disease (PsD), including psoriasis (PsO) and psoriatic arthritis (PsA). Methods We carried out a cross-sectional study including 47 patients with PsD and 10 age and sex-paired healthy controls. Using multiparametric flow cytometry, we evaluated the granulocytic (G) and monocytic (M) MDSCs, classical, intermediate and non-classical monocytes in peripheral blood. We compared these cell populations according to the clinical features, phenotype of PsD, and treatment groups. We evaluated their capability to predict disease activity measured by Psoriasis Area and Severity Index (PASI) and Disease Activity in Psoriatic Arthritis (DAPSA) by multivariate logistic and linear regressions. Results In comparison to healthy donors, PsD patients displayed lower mature G-MDSCs (5.88% vs 60.97%), increased M-MDSCs (0.62% vs 0.02%), decreased expression of arginase-1 and PDL1, and expansion of non-classical monocytes (12.2% vs 4.68%). Increased mature G-MDSCs and decreased arginase-1 expression were seen in patients with cutaneous features. G-MDSCs were associated with cutaneous disease activity (PASI (β 5.05, p= 0.05)), whilst non-classical monocytes were related to active PsA (DAPSA (β 0.68, p= 0.004)), highlighting their potential as disease activity biomarkers. Conclusion In PsD, G-MDSCs relate to cutaneous disease activity, whereas non-classical monocytes correlate with musculoskeletal features, highlighting their role as potential biomarkers of disease activity in PsD. Further prospective studies addressing the function of these cell subtypes would confirm their relationship with PsD activity status.","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":"83 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Venous thromboembolism in patients with lupus nephritis: frequency and risk factors—a cohort study","authors":"Fadi Kharouf, Pankti Mehta, Qixuan Li, Dafna D Gladman, Laura P Whittall Garcia, Zahi Touma","doi":"10.1093/rheumatology/keaf464","DOIUrl":"https://doi.org/10.1093/rheumatology/keaf464","url":null,"abstract":"Objectives Venous thromboembolism (VTE) is a known complication of systemic lupus erythematosus (SLE), yet there is a lack of high-quality studies specifically focused on lupus nephritis (LN). This study aimed to assess the frequency of VTE in patients with LN and identify risk factors for its development. Methods We included patients with biopsy-proven LN from a prospective observational cohort followed between 1970 and 2024. The primary outcome, VTE occurring after the onset of LN, was monitored longitudinally, and the time to the first event was calculated. Time-varying univariable and multivariable cause-specific Cox proportional hazards models were used to identify factors associated with the first VTE, with death considered a competing risk. Results A total of 324 patients were included, with a mean age of 34.2 years [IQR: 25.9–43.0] at LN onset. Over a long-term follow-up period of 9.9 years [IQR: 5.0–16.4], 30 patients (9.3%) developed VTE, with a total of 34 events. The median time to the first event from LN onset of 4.4 years [IQR, 0.1, 14.1]. Most events were isolated (86.7%), including 19 deep vein thromboses (DVTs, 59.4%), 5 pulmonary embolisms (PEs), and 2 events involving other venous beds. In the multivariable model, the following factors were independently associated with the development of VTE: the SLEDAI-2K score (HR = 1.05, 95% CI: 1.01–1.10) and proteinuria level (HR = 1.26, 95% CI: 1.08–1.47). Conclusions VTE can complicate the course of LN at any stage. Disease activity and proteinuria are the primary risk factors for its development.","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":"25 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Gout incidence in metformin versus sodium-glucose co-transporter-2 inhibitor users: a retrospective cohort study.","authors":"Shih-Wei Lai","doi":"10.1093/rheumatology/keaf261","DOIUrl":"10.1093/rheumatology/keaf261","url":null,"abstract":"","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":" ","pages":"5196"},"PeriodicalIF":4.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timely or too late? An Indian study on delays in systemic lupus erythematosus diagnosis.","authors":"Vineeta Shobha","doi":"10.1093/rheumatology/keaf463","DOIUrl":"https://doi.org/10.1093/rheumatology/keaf463","url":null,"abstract":"","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":"29 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144960293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hospitalized with fever: worthy of serum ferritin.","authors":"Ian Harrowell, Randy Q Cron, Athimalaipet V Ramanan","doi":"10.1093/rheumatology/keaf294","DOIUrl":"10.1093/rheumatology/keaf294","url":null,"abstract":"","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":" ","pages":"4872-4873"},"PeriodicalIF":4.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}