Revista Brasileira de Hematologia e Hemoterapia最新文献

{"title":"Stathmin 1 expression in plasma cell neoplasms","authors":"João Agostinho Machado-Neto , Fernando Vieira Pericole , Fernando Ferreira Costa , Fabiola Traina , Sara Teresinha Olalla Saad","doi":"10.1016/j.bjhh.2017.02.005","DOIUrl":"10.1016/j.bjhh.2017.02.005","url":null,"abstract":"","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 2","pages":"Pages 183-185"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2017.02.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35056633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interleukin-10 haplotypes are not associated with acute cerebral ischemia or high-risk transcranial Doppler in a newborn cohort of 395 children with sickle cell anemia","authors":"André Rolim Belisário ,&nbsp;Rahyssa Rodrigues Sales ,&nbsp;Nayara Evelin Toledo ,&nbsp;Cibele Velloso-Rodrigues ,&nbsp;Célia Maria Silva ,&nbsp;Marcos Borato Viana","doi":"10.1016/j.bjhh.2016.09.017","DOIUrl":"10.1016/j.bjhh.2016.09.017","url":null,"abstract":"<div><h3>Background</h3><p>The etiology of stroke, a severe complication of sickle cell anemia, involves inflammatory processes. However, the pathogenetic mechanisms are unknown. The aim of this study was to evaluate the influence of interleukin-10 polymorphisms and haplotypes on the risk of acute cerebral ischemia and high-risk transcranial Doppler in 395 children with sickle cell anemia from the state of Minas Gerais, Brazil.</p></div><div><h3>Methods</h3><p>Interleukin-10 haplotypes were determined by polymerase chain reaction-restriction fragment length polymorphism and sequencing. The outcomes studied were acute cerebral ischemia and high-risk transcranial Doppler. Clinical data were retrieved from the children's records.</p></div><div><h3>Results</h3><p>There was no statistically significant difference in the frequencies of polymorphisms and haplotypes between children with and without acute cerebral ischemia or children with or without high-risk transcranial Doppler. These data are consistent with a previous report that showed an absence of association between interleukin-10 plasma levels and high-risk transcranial Doppler velocity in children with sickle cell anemia.</p></div><div><h3>Conclusion</h3><p>Interleukin-10 haplotypes were not associated with the risk of acute cerebral ischemia or high-risk transcranial Doppler velocity in children with sickle cell anemia from the state of Minas Gerais, Brazil.</p></div>","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 2","pages":"Pages 108-114"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2016.09.017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35057142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Foxo3 gene expression and oxidative status in beta-thalassemia minor subjects","authors":"Sandra Stella Lazarte ,&nbsp;María Eugenia Mónaco ,&nbsp;Magdalena María Terán,&nbsp;Ana Cecilia Haro,&nbsp;Miryam Emilse Ledesma Achem,&nbsp;Blanca Alicia Issé","doi":"10.1016/j.bjhh.2017.01.005","DOIUrl":"10.1016/j.bjhh.2017.01.005","url":null,"abstract":"<div><h3>Background</h3><p>Oxidative stress may aggravate symptoms of hemolytic anemias such as beta-thalassemia. FoxO3 activation results in resistance to oxidative stress in fibroblasts and neuronal cell cultures.</p></div><div><h3>Objective</h3><p>The purpose of this research was to study <em>FoxO3</em> gene expression and oxidative status in beta-thalassemia minor individuals.</p></div><div><h3>Methods</h3><p>Sixty-three subjects (42 apparently healthy individuals and 21 with beta-thalassemia minor) were analyzed at the Universidad Nacional de Tucumán, Argentina, between September 2013 and June 2014. A complete blood count, hemoglobin electrophoresis in alkaline pH and hemoglobin A₂ levels were quantified. Moreover, thiobarbituric acid reactive species, erythrocyte catalase activity and iron status were evaluated. Beta-thalassemia mutations were determined by real-time polymerase chain reaction. <em>FoxO3</em> gene expression was investigated by real-time reverse transcription-polymerase chain reaction using mononuclear cells from peripheral blood.</p></div><div><h3>Results</h3><p>Subjects were grouped as children (≤12 years), and adult women and men. The analysis of erythrocyte catalase activity/hemoglobin ratio revealed a significant difference (<em>p</em>-value &lt;0.05) between healthy and beta-thalassemia minor adults, but no significant difference was observed in the thiobarbituric acid reactive species levels and <em>FoxO3</em> gene expression (<em>p</em>-value &gt;0.05). Thiobarbituric acid reactive species and the erythrocyte catalase activity/hemoglobin ratio were not significantly different on comparing the type of beta-thalassemia mutation (β⁰ or β⁺) present in carriers.</p></div><div><h3>Conclusions</h3><p>The lack of systemic oxidative imbalance demonstrated by thiobarbituric acid reactive species is correlated to the observation of normal <em>FoxO3</em> gene expression in mononuclear cells of peripheral blood. However, an imbalanced antioxidant state was shown by the erythrocyte catalase activity/hemoglobin ratio in beta-thalassemia minor carriers. It would be necessary to study <em>FoxO3</em> gene expression in reticulocytes to elucidate the role of <em>FoxO3</em> in this pathology.</p></div>","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 2","pages":"Pages 115-121"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2017.01.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35057143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional status and hyperglycemia in the peritransplant period: a review of associations with parenteral nutrition and clinical outcomes","authors":"Marina Verdi Schumacher ,&nbsp;Gustavo Adolpho Moreira Faulhaber","doi":"10.1016/j.bjhh.2016.09.016","DOIUrl":"10.1016/j.bjhh.2016.09.016","url":null,"abstract":"<div><p>Hematopoietic stem cell transplantation is an established treatment option for various hematological diseases. This therapy involves complex procedures and is associated with several systemic complications. Due to the toxic effects of the conditioning regimen used in allogeneic transplantations, patients frequently suffer from severe gastrointestinal complications and are unable to feed themselves properly. This complex clinical scenario often requires specialized nutritional support, and despite the increasing number of studies available, many questions remain regarding the best way to feed these patients. Parenteral nutrition has been traditionally indicated when the effects on gastrointestinal mucosa are significant; however, the true benefits of this type of nutrition in reducing clinical complications have been questioned. Hyperglycemia is a common consequence of parenteral nutrition that seems to be correlated to poor transplantation outcomes and a higher risk of infections. Additionally, nutrition-related pre-transplantation risk factors are being studied, such as impaired nutritional status, poorly controlled diabetes mellitus and obesity. This review aims to discuss some of these recent issues. A real case of allogeneic transplant was used to illustrate the scenario and to highlight the most important topics that motivated this literature review.</p></div>","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 2","pages":"Pages 155-162"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2016.09.016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35056626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sickle cell intrahepatic cholestasis unresponsive to exchange blood transfusion: a case report","authors":"Juliana Albano de Guimarães,&nbsp;Luciana Cristina dos Santos Silva","doi":"10.1016/j.bjhh.2017.02.006","DOIUrl":"10.1016/j.bjhh.2017.02.006","url":null,"abstract":"","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 2","pages":"Pages 163-166"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2017.02.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35056627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concomitant chronic myeloid leukemia and monoclonal B cell lymphocytosis – a very rare condition","authors":"Sara Duarte ,&nbsp;Sónia Campelo Pereira ,&nbsp;Élio Rodrigues ,&nbsp;Amélia Pereira","doi":"10.1016/j.bjhh.2017.02.004","DOIUrl":"10.1016/j.bjhh.2017.02.004","url":null,"abstract":"","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 2","pages":"Pages 167-169"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2017.02.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35056628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Idiopathic hypereosinophilic syndrome with 20 years of diagnostic delay","authors":"Miguel Pedro de Queiroz Neto,&nbsp;Fernando Antônio Galvão Gondim Filho","doi":"10.1016/j.bjhh.2016.11.008","DOIUrl":"10.1016/j.bjhh.2016.11.008","url":null,"abstract":"","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 2","pages":"Pages 170-174"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2016.11.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35056629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First observation of Hb Ullevaal [β78(EF2) Leu>Val] in Turkey","authors":"F. Sinem Hocaoglu-Emre ,&nbsp;Guven Yenmis ,&nbsp;Cengiz Yakicier","doi":"10.1016/j.bjhh.2016.09.013","DOIUrl":"10.1016/j.bjhh.2016.09.013","url":null,"abstract":"","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 1","pages":"Pages 63-65"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2016.09.013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34791697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous granulomatous reaction as the first manifestation of Hodgkin's lymphoma","authors":"Catarina Moreira ,&nbsp;Elisabete Rios ,&nbsp;Teresa Baudrier ,&nbsp;Filomena Azevedo","doi":"10.1016/j.bjhh.2016.11.004","DOIUrl":"10.1016/j.bjhh.2016.11.004","url":null,"abstract":"","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 1","pages":"Pages 70-72"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2016.11.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34791700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular and hematologic relapses in adult patients with acute promyelocytic leukemia: a cohort study","authors":"Ilana de França Azevedo ,&nbsp;Michelline Gomes Magalhães ,&nbsp;Fernanda Ribeiro Souto ,&nbsp;Washington Batista das Neves ,&nbsp;Fárida Coeli de Barros Correia Melo ,&nbsp;Eduardo Magalhães Rego ,&nbsp;Raul Antônio Morais Melo","doi":"10.1016/j.bjhh.2016.09.010","DOIUrl":"10.1016/j.bjhh.2016.09.010","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate factors predictive for relapse in a cohort of adult patients with acute promyelocytic leukemia monitored by molecular methods during consolidation and during at least one month of maintenance therapy.</p></div><div><h3>Methods</h3><p>The charts and laboratory data of 65 adult patients with acute promyelocytic leukemia treated according to the International Consortium on Acute Promyelocytic Leukemia 2006 protocol were reviewed. The identification of the <em>promyelocytic leukemia-retinoic acid receptor-alpha</em> gene rearrangement at diagnosis, post-induction, post-consolidation and during maintenance treatment was performed by qualitative and quantitative reverse transcription polymerase chain reaction.</p></div><div><h3>Results</h3><p>Eighty-nine patients were diagnosed with acute promyelocytic leukemia over a seven-year period and of these 65 were eligible for treatment with the protocol. Among the 45 patients who received consolidation and maintenance treatment, six (13%) relapsed, three of whom presented hematologic and three presented molecular relapse. The first relapses occurred at a median of 39 months. Relapsed patients were from all risk groups (low, intermediate and high) and both morphological types (M3 and M3variant) were found. Three of these patients are alive and in molecular remission after salvage treatment. There were no statistically significant differences regarding gender, age, risk group, morphology, promyelocytic leukemia breakpoint cluster region, use of all-trans retinoic acid, development of differentiation syndrome and number of days to complete remission between the patients who relapsed and those who did not.</p></div><div><h3>Conclusion</h3><p>Our results reinforce the importance of prolonged monitoring of acute promyelocytic leukemia patients using molecular methods to detect relapse early.</p></div>","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 1","pages":"Pages 46-51"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2016.09.010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34791801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}