Revista Brasileira de Hematologia e Hemoterapia最新文献

{"title":"Plasma cell leukemia with t(11;14)(q13;q32) simulating lymphoplasmacytic lymphoma – a diagnostic challenge solved by flow cytometry","authors":"Aleyde Diniz Loureiro , Matheus Vescovi Gonçalves , Maura Rosário Valério Ikoma , Maria Regina Regis Silva , Gisele Wally Braga Colleoni , Maria de Lourdes Chauffaille , Mihoko Yamamoto","doi":"10.1016/j.bjhh.2016.10.001","DOIUrl":"10.1016/j.bjhh.2016.10.001","url":null,"abstract":"","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 1","pages":"Pages 66-69"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2016.10.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34791698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myelodysplasia and acute myeloid leukemia fifteen years after high-dose cyclophosphamide in a child with severe aplastic anemia","authors":"José Carlos Jaime-Pérez, Liliana Nataly Guerra-Leal, Olga Graciela Cantú-Rodríguez, David Gómez-Almaguer","doi":"10.1016/j.bjhh.2016.06.003","DOIUrl":"10.1016/j.bjhh.2016.06.003","url":null,"abstract":"","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 1","pages":"Pages 57-59"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2016.06.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34791699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Red cell autoantibody mimicking anti-C specificity: a rare manifestation","authors":"Rajeswari Subramaniyan, Mangalakumar Veerasamy","doi":"10.1016/j.bjhh.2016.11.002","DOIUrl":"10.1016/j.bjhh.2016.11.002","url":null,"abstract":"","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 1","pages":"Pages 91-92"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2016.11.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34791707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cholelithiasis and its complications in sickle cell disease in a university hospital","authors":"Raquel Alves Martins,&nbsp;Renato Santos Soares,&nbsp;Fernanda Bernadelli De Vito,&nbsp;Valdirene de Fátima Barbosa,&nbsp;Sheila Soares Silva,&nbsp;Helio Moraes-Souza,&nbsp;Paulo Roberto Juliano Martins","doi":"10.1016/j.bjhh.2016.09.009","DOIUrl":"10.1016/j.bjhh.2016.09.009","url":null,"abstract":"<div><h3>Introduction</h3><p>The clinical manifestations of sickle cell disease are related to the polymerization of hemoglobin S. The chronic hemolysis caused by this condition often causes the formation of gallstones that can migrate and block the common bile duct leading to acute abdomen.</p></div><div><h3>Objective</h3><p>This study aimed to evaluate the profile of patients with sickle cell disease and cholelithiasis.</p></div><div><h3>Methods</h3><p>Patients with sickle cell disease were separated into groups according to the presence or absence of cholelithiasis. Socioepidemiological and clinical characteristics, such as gender, age, use of hydroxyurea and the presence of other hemoglobinopathies were researched in the medical records of patients.</p></div><div><h3>Results</h3><p>A hundred and seven patients with sickle cell anemia were treated at the institution. Of these, 27 (25.2%) had cholelithiasis. The presence of cholelithiasis was higher in the 11–29 age group than in younger than 11 years and over 29 years. No association was found for the presence of cholelithiasis with gender, use of hydroxyurea or type of hemoglobinopathy (hemoglobin SS, hemoglobin SC or sickle beta-thalassemia). Sixteen of the patients had to be submitted to cholecystectomy with 14 of the surgeries being performed by laparoscopy. Complications were observed in three patients and one patient died for reasons unrelated to the surgery.</p></div><div><h3>Conclusion</h3><p>A quarter of patients with sickle cell disease had gallstones, more commonly in the 11- to 29-year age range. Patients should be monitored from childhood to prevent cholelithiasis with preoperative, intra-operative and postoperative care being crucial to reduce the risk of complications in these patients.</p></div>","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 1","pages":"Pages 28-31"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2016.09.009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34791798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Administration of all-trans retinoic acid through enteral tubes in acute promyelocytic leukemia: the handling of cytotoxic agents and clinical benefits","authors":"Lucas Miyake Okumura,&nbsp;Patrícia Carvalho Baruel Okumura,&nbsp;Cleni Veroneze","doi":"10.1016/j.bjhh.2016.11.001","DOIUrl":"10.1016/j.bjhh.2016.11.001","url":null,"abstract":"","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 1","pages":"Pages 86-88"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2016.11.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34791704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary myeloid neoplasms: bone marrow cytogenetic and histological features may be relevant to prognosis","authors":"Roberta Sandra da Silva Tanizawa ,&nbsp;Maria Claudia Nogueira Zerbini ,&nbsp;Ricardo Rosenfeld ,&nbsp;Cristina Aiko Kumeda ,&nbsp;Raymundo Soares Azevedo ,&nbsp;Sheila Aparecida Coelho Siqueira ,&nbsp;Elvira Deolinda Rodrigues Pereira Velloso","doi":"10.1016/j.bjhh.2016.09.015","DOIUrl":"10.1016/j.bjhh.2016.09.015","url":null,"abstract":"<div><h3>Background</h3><p>Secondary myeloid neoplasms comprise a group of diseases arising after chemotherapy, radiation, immunosuppressive therapy or from aplastic anemia. Few studies have addressed prognostic factors in these neoplasms.</p></div><div><h3>Method</h3><p>Forty-two patients diagnosed from 1987 to 2008 with secondary myeloid neoplasms were retrospectively evaluated concerning clinical, biochemical, peripheral blood, bone marrow aspirate, biopsy, and immunohistochemistry and cytogenetic features at diagnosis as prognostic factors. The International Prognostic Scoring System was applied. Statistical analysis employed the Kaplan–Meier method, log-rank and Fisher's exact test.</p></div><div><h3>Results</h3><p>Twenty-three patients (54.8%) were male and the median age was 53.5 years (range: 4–88 years) at diagnosis of secondary myeloid neoplasms. Previous diseases included hematologic malignancies, solid tumors, aplastic anemia, autoimmune diseases and conditions requiring solid organ transplantations. One third of patients (33%) were submitted to chemotherapy alone, 2% to radiotherapy, 26% to both modalities and 28% to immunosuppressive agents. Five patients (11.9%) had undergone autologous hematopoietic stem cell transplantation. The median latency between the primary disease and secondary myeloid neoplasms was 85 months (range: 23–221 months). Eight patients were submitted to allogeneic hematopoietic stem cell transplantation to treat secondary myeloid neoplasms. Important changes in bone marrow were detected mainly by biopsy, immunohistochemistry and cytogenetics. The presence of clusters of CD117⁺ cells and p53⁺ cells were associated with low survival. p53 was associated to a higher risk according to the International Prognostic Scoring System. High prevalence of clonal abnormalities (84.3%) and thrombocytopenia (78.6%) were independent factors for poor survival.</p></div><div><h3>Conclusion</h3><p>This study demonstrated that cytogenetics, bone marrow biopsy and immunohistochemistry are very important prognostic tools in secondary myeloid neoplasms.</p></div>","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 1","pages":"Pages 4-12"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2016.09.015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34791800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated skin relapse of Philadelphia chromosome-positive acute lymphoblastic leukemia after allogeneic stem cell transplant","authors":"Masumi Ueda ,&nbsp;Carlos Silva ,&nbsp;Linda Baer ,&nbsp;Paolo F. Caimi ,&nbsp;Kevin Cooper ,&nbsp;Kord Honda ,&nbsp;Marcos de Lima","doi":"10.1016/j.bjhh.2016.11.003","DOIUrl":"10.1016/j.bjhh.2016.11.003","url":null,"abstract":"","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 1","pages":"Pages 77-79"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2016.11.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34791701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemophilic pseudotumor – a rare complication","authors":"Márcio Luís Duarte ,&nbsp;Élcio Roberto Duarte ,&nbsp;Edgard Brasil Solorzano","doi":"10.1016/j.bjhh.2016.10.002","DOIUrl":"10.1016/j.bjhh.2016.10.002","url":null,"abstract":"","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 1","pages":"Pages 84-85"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2016.10.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34791708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paradoxes of hematology: When the old disappears and the new does not arrive","authors":"Angelo Maiolino ,&nbsp;Belinda Pinto Simões ,&nbsp;Claudio Galvão de Castro Junior ,&nbsp;Dimas Tadeu Covas ,&nbsp;Gustavo dos Santos Fernandes ,&nbsp;Nelson Hamerschlak ,&nbsp;Teresa Cristina Cardoso Fonseca ,&nbsp;Vergilio Colturato","doi":"10.1016/j.bjhh.2017.01.001","DOIUrl":"10.1016/j.bjhh.2017.01.001","url":null,"abstract":"","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 1","pages":"Pages 1-3"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2017.01.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34791795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adult T-cell leukemia/lymphoma treatment in Bahia, Brazil","authors":"Pedro Dantas Oliveira ,&nbsp;Ítala Gomes ,&nbsp;Victor Hugo Gomes Souza ,&nbsp;Ernesto Cunha Pires ,&nbsp;Glória Bomfim Arruda ,&nbsp;Achiléa Bittencourt","doi":"10.1016/j.bjhh.2016.09.012","DOIUrl":"10.1016/j.bjhh.2016.09.012","url":null,"abstract":"<div><h3>Background</h3><p>Adult T-cell leukemia/lymphoma is a peripheral disease associated with human T-cell lymphotropic virus type 1. Treatment is carried out according to clinical type with watchful waiting being recommended for less aggressive types. Aggressive adult T-cell leukemia/lymphoma is generally treated with chemotherapy and/or antivirals. The objective of this study was to correlate the survival of patients diagnosed in Bahia, Brazil, with the therapeutic approaches employed and to evaluate what issues existed in their treatment processes.</p></div><div><h3>Methods</h3><p>Eighty-three adult T-cell leukemia/lymphoma patients (26 smoldering, 23 chronic, 16 acute, 13 lymphoma and five primary cutaneous tumoral) with available data were included in this study.</p></div><div><h3>Results</h3><p>Complete response was achieved in seven smoldering patients with symptomatic treatment, in two with chronic disease using antivirals/chemotherapy, in one with acute disease using antivirals and in one lymphoma using the LSG15 regimen [vincristine, cyclophosphamide, doxorubicin, and prednisolone (VCAP); doxorubicin, ranimustine, and prednisolone (AMP); and vindesine, etoposide, carboplatin, and prednisolone (VECP)]. Smoldering patients who received symptomatic treatment presented longer survival. Favorable chronic patients treated with antivirals presented longer survival compared to the unfavorable subtype. However, for the acute form, first-line chemotherapy was better, albeit without significance, than antivirals. Only one of the patients with lymphoma and primary cutaneous tumors responded.</p></div><div><h3>Conclusions</h3><p>Watchful waiting associated with phototherapy represents the best option for smoldering adult T-cell leukemia/lymphoma with survival in Bahia being superior to that described in Japan. There was a trend of better results with zidovudine/interferon-alpha in favorable chronic disease. Excellent results were achieved in the lymphoma type treated with the LSG15 protocol. Patients are diagnosed late probably due to lack of knowledge of adult T-cell leukemia/lymphoma by primary healthcare doctors and a Brazilian treatment protocol needs to be established.</p></div>","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 1","pages":"Pages 13-19"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2016.09.012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34791796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}