Reumatismo最新文献

{"title":"Intimate partner violence in reproductive-age and pregnant-postpartum women with autoimmune rheumatic diseases: a comparative cross-sectional study.","authors":"Mara Alejandra Ponce-Santillán, Anahí Carrazco-Chapa, Andres Manuel Ortiz-Rios, Maria Eugenia Corral-Trujillo, Jesus Alberto Cardenas-de la Garza, Cassandra Michele Skinner-Taylor, Dionicio Angel Galarza-Delgado, Lorena Perez-Barbosa","doi":"10.4081/reumatismo.2025.1850","DOIUrl":"10.4081/reumatismo.2025.1850","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to describe the frequency of intimate partner violence (IPV) in reproductive-age women and pregnant-postpartum women with autoimmune rheumatic diseases (ARDs) and compare it with those without ARDs (controls).</p><p><strong>Methods: </strong>A descriptive, cross-sectional, and comparative study was conducted among pregnant-postpartum patients and reproductive-age women (18-45 years) with and without ARDs who attended the Hospital Universitario in Monterrey, Mexico, and answered the survey Hurt-Insult-Threaten-Scream (HITS) scale in the validated Spanish version, from June 2023 to May 2024.</p><p><strong>Results: </strong>A total of 120 women were included: 60 with ARDs and 60 controls. In both groups, 30 patients were reproductive-age women and 30 were pregnant-postpartum women. A total of 44 (36%) women reported being victims of IPV. No significant differences were found in reported IPV between the control group and the group of women with ARDs (n=21, 35% vs. n=23, 38%, p=0.85). There was no statistically significant difference between the ARD group compared to the control group in the HITS score (p=0.537), nor between the pregnant-postpartum subgroups (p=0.356) or the reproductive-age subgroups (p=0.972). These findings indicate that IPV rates did not significantly differ by ARD status or reproductive stage in this sample.</p><p><strong>Conclusions: </strong>Nearly one in every three women experienced IPV, but our research showed that there was no difference in the frequency of IPV between the ARD group and the control group. Pregnant and postpartum women were more likely to report IPV than women of reproductive age. These findings highlight that IPV is a significant concern for all women in Mexico and the need for increased attention and support for them.</p>","PeriodicalId":21222,"journal":{"name":"Reumatismo","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paratenon effusion of the Achilles tendon: a rare finding.","authors":"Raphael Micheroli, Vincenzo Ricci, Ondřej Naňka, Giorgio Tamborrini","doi":"10.4081/reumatismo.2025.1845","DOIUrl":"https://doi.org/10.4081/reumatismo.2025.1845","url":null,"abstract":"<p><p>We present a case of Achilles tendon swelling and pain related to paratenon effusion. Further ultrasound assessment showed no evidence of acute enthesitis, although a nonspecific degenerative enthesophyte was present. Our case study presents a rare instance of paratenonitis involving effusion into the paratenon lumen. Paratenonitis has a non-specific etiology. Recent findings suggest that paratenonitis plays a role not only in cases of mechanical injury and in patients with spondyloarthritis but also in individuals at risk of developing rheumatoid arthritis. Further studies have shown that the paratenon surrounding the extensor tendons consists of a lining layer formed by fibroblasts. However, more research is needed to characterize these fibroblasts and compare them to those found in the synovium.</p>","PeriodicalId":21222,"journal":{"name":"Reumatismo","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144966990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sedentary behavior and physical activity preferences in patients with knee osteoarthritis: insights from a cross-sectional study.","authors":"Samya Ez-Zaoui, Hanan Rkain, Sara Bahloul, Fatine Kronbi, Rahma Honsali, Sara Farih, Imane Bensghir, Nada Benzine, Hind L'heri, Loubna Lammaghi, Latifa Tahiri, Najia Hajjaj-Hassouni, Fadoua Allali","doi":"10.4081/reumatismo.2025.1736","DOIUrl":"https://doi.org/10.4081/reumatismo.2025.1736","url":null,"abstract":"<p><strong>Objective: </strong>Osteoarthritis (OA) is a prevalent condition associated with significant disability, particularly affecting mobility and daily activities. Sedentary behavior is common among individuals with knee OA, influenced by factors such as pain, functional limitations, and sociocultural aspects. Despite the benefits of physical activity in managing knee OA, many patients remain sedentary. Understanding factors contributing to sedentary behavior and patients' preferences regarding physical activity is crucial for effective intervention. This cross-sectional study aimed to assess the level of physical activity among Moroccan patients with knee OA, identify factors associated with sedentary behavior, and explore patients' expectations and preferences regarding physical activity.</p><p><strong>Methods: </strong>We conducted a survey involving 130 patients with knee OA. Information on sociodemographic characteristics, disease profile, physical activity levels using the International Physical Activity Questionnaire Short Form, barriers to physical activity, and preferences for educational interventions was collected.</p><p><strong>Results: </strong>The mean age of the patients was 59.9±10 years, with females comprising 84.6% of the sample. Sedentary behavior was prevalent in 69.2% of patients and was associated with factors such as age (p=0.005), lack of prior physical activity (p=0.01), knee pain (p=0.02), functional disability (p=0.01), socioeconomic factors (p=0.01), and non-recommendation of physical activity by rheumatologists (p=0.0001). Patients expressed preferences for outdoor physical activity (39.2%), gym-based exercise (30.8%), audiovisual support (80%), and participation in physical activity workshops (66.7%).</p><p><strong>Conclusions: </strong>Sedentary behavior is prevalent among knee OA patients. It is important to overcome this unhealthy lifestyle and to encourage the practice of physical activity in this population by combating barriers reported by patients.</p>","PeriodicalId":21222,"journal":{"name":"Reumatismo","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144874953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare in the rare: Kikuchi-Fujimoto disease associated with connective tissue disorders. A report of our experience.","authors":"Carmela Coccia, Gemma Lepri, Juela Levani, Silvia Bellando Randone, Serena Guiducci","doi":"10.4081/reumatismo.2025.1853","DOIUrl":"https://doi.org/10.4081/reumatismo.2025.1853","url":null,"abstract":"<p><p>Kikuchi-Fujimoto disease (KFD) is a rare and benign lymphadenopathy of unknown etiology. Usually, it is an isolated and self-limiting condition requiring no specific therapy; however, in some cases, it may be associated with an autoimmune disease. Here, we report three cases of KFD developing an associated autoimmune connective disorder: the first case presented with Sjögren's syndrome, and the other two had a diagnosis of systemic lupus erythematosus.</p>","PeriodicalId":21222,"journal":{"name":"Reumatismo","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144874952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful treatment of refractory tracheal stenosis complicating anti-neutrophil cytoplasm antibody-associated vasculitis with sirolimus.","authors":"Giorgio Buscetta, Antonino Palumbo, Chiara Rizzo, Giuliana Guggino","doi":"10.4081/reumatismo.2025.1851","DOIUrl":"https://doi.org/10.4081/reumatismo.2025.1851","url":null,"abstract":"<p><p>Laryngotracheal granulomatous inflammation is a clinical entity that may complicate either localized or systemic disorders. It can result in life-threatening airway compromise, requiring urgent medical or surgical intervention. We report the case of a patient presenting with recurrent tracheal stenosis secondary to anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis, refractory to conventional treatments. Despite multiple endoscopic dilatations and surgical resection of tracheal rings, disease control remained suboptimal. Introduction of sirolimus led to a sustained improvement of the stenotic lesion, as demonstrated by clinical and instrumental assessment. Sirolimus may be considered a valuable therapeutic option for severe subglottic inflammatory manifestations in ANCA-associated vasculitis.</p>","PeriodicalId":21222,"journal":{"name":"Reumatismo","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144874954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of tumor necrosis factor inhibitors during high-risk pregnancies in antiphospholipid syndrome: a clinical report of a patient with concomitant Takayasu arteritis and case-based review.","authors":"Liala Moschetti, Francesca Crisafulli, Francesca Regola, Rossana Orabona, Sofia Pitsigavdaki, Franco Franceschini, Laura Andreoli, Sonia Zatti, Angela Tincani","doi":"10.4081/reumatismo.2025.1835","DOIUrl":"https://doi.org/10.4081/reumatismo.2025.1835","url":null,"abstract":"<p><p>In the field of obstetric antiphospholipid syndrome (APS), studies in mouse models and case reports support the potential benefit of tumor necrosis factor-α inhibitors (TNF-i) in preventing pregnancy loss associated with APS. We present the case of a 36-year-old woman with a diagnosis of Takayasu arteritis who suffered from antiphospholipid antibody (aPL)-related thrombotic microangiopathy/probable catastrophic APS during her first pregnancy and who had a subsequent successful pregnancy while on treatment with certolizumab pegol (CZP), heparin, and low-dose aspirin. The report is followed by the literature review of published cases of APS or aPL-positive pregnancies treated with CZP or other TNF-i. A total of 20 pregnancies, including the one here presented, were reported in high-risk APS patients exposed to TNF-i, showing a favorable outcome in most pregnancies (80% live births, 69% absence of adverse pregnancy outcomes). Despite the limited available evidence, TNF-i could represent a promising option for high-risk patients in obstetric APS.</p>","PeriodicalId":21222,"journal":{"name":"Reumatismo","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144874955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with life quality, sleep quality, and depression in systemic sclerosis patients: a cross-sectional study from Iran.","authors":"Dena Mohamadzadeh, Shirin Assar, Zhovan Fatahi, Faraneh Farsad","doi":"10.4081/reumatismo.2025.1790","DOIUrl":"https://doi.org/10.4081/reumatismo.2025.1790","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to determine the prevalence and associated factors of depressive symptoms, poor sleep, and life quality among patients with systemic sclerosis (SSc).</p><p><strong>Methods: </strong>This was a cross-sectional study including 120 SSc patients. Demographic and clinical data were obtained. The Short Form Health Survey 36 (SF-36), Pittsburgh Sleep Quality Index (PSQI), and short form of the Beck Depression Questionnaire were used to evaluate life quality, sleep quality, and self-reported depressive symptoms, respectively. The obtained data were analyzed to identify the demographic and clinical risk associations for depressive symptoms, poor sleep, and life quality.</p><p><strong>Results: </strong>Of 120 participants, 108 patients (90%) were female. The mean age was 42.23 years, and the mean disease duration was 13.58 years. Most of the patients were married, unemployed, or housekeepers. Most of them had moderate economic conditions and tertiary education. The total scores of the SF-36 and PSQI questionnaires were 93.25±3.7 and 9.02±4.51, respectively, which showed good life quality but poor sleep quality. The prevalence of depressive symptoms was 44.16% (n=53), and most of them had mild to moderate depressive symptoms. The factors that correlated with life quality were occupational status and cough. The factors that negatively correlated with sleep quality were the presence of digital ulcers, cough, and dysphasia. The presence of cough, dyspnea, and gastroesophageal reflux disease was associated with depressive symptoms.</p><p><strong>Conclusions: </strong>Our study showed a high prevalence of poor sleep quality and depressive symptoms among SSc patients. We found that gastrointestinal symptoms, respiratory symptoms, and digital ulcers affected patients' life quality, sleep quality, and mental status. Our results also demonstrated that depression was correlated with poor sleep quality, and they were both risk factors for diminished life quality. Identification of these factors would help to make pharmacological and non-pharmacological interventions to improve the quality of life and sleep in SSc patients.</p>","PeriodicalId":21222,"journal":{"name":"Reumatismo","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of tramadol/paracetamol 75 mg/650 mg combination therapy for early-stage knee osteoarthritis: a retrospective observational study.","authors":"Alessandro Conforti, Cosimo Ruggiero, Nastasja Palombi, Filippo Messina, Marco Bonifacio, Linda Lucchetti, Marco Ruggiero, Giuseppe La Cava, Roberto Piazza, Mario Mangrella","doi":"10.4081/reumatismo.2025.1872","DOIUrl":"https://doi.org/10.4081/reumatismo.2025.1872","url":null,"abstract":"<p><strong>Objective: </strong>Knee osteoarthritis (KOA) is a progressive joint disorder that significantly impairs patients' quality of life. Effective long-term management of KOA remains challenging due to limited pharmacological options and associated adverse effects. This monocentric, retrospective observational study evaluated the efficacy and safety of a fixed-dose tramadol/paracetamol combination (75/650 mg) in alleviating pain in patients with grade I-II KOA according to the Kellgren-Lawrence classification.</p><p><strong>Methods: </strong>A total of 30 patients treated for 15 days were assessed using the Numerical Rating Scale for pain, the Western Ontario and McMaster Universities Osteoarthritis Index for functional impairment, and the Pittsburgh Sleep Quality Index for sleep quality.</p><p><strong>Results: </strong>Results showed a 30% and 50% pain reduction in 86% and 43% of patients, respectively, alongside significant improvements in functional mobility and sleep quality. Adverse events, including nausea, itching, and sleepiness, occurred in 10% of patients and did not necessitate treatment discontinuation. Efficacy was consistent across demographic and clinical subgroups, possibly suggesting broad treatment applicability.</p><p><strong>Conclusions: </strong>While the findings could support tramadol/paracetamol as a safe and effective first-line therapy for KOA, reinforcing its role in optimizing KOA management strategies, limitations such as the small sample size and lack of a control group highlight the need for further research.</p>","PeriodicalId":21222,"journal":{"name":"Reumatismo","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of anifrolumab in reshaping the treatment landscape of extra-renal systemic lupus erythematosus.","authors":"Fulvia Ceccarelli, Matteo Piga, Alessandra Bortoluzzi, Laura Coladonato, Micaela Fredi, Daniele Mauro, Chiara Tani, Luca Iaccarino","doi":"10.4081/reumatismo.2025.1830","DOIUrl":"https://doi.org/10.4081/reumatismo.2025.1830","url":null,"abstract":"<p><strong>Objective: </strong>Systemic lupus erythematosus (SLE) is a multifaceted autoimmune disorder that typically requires management with immunosuppressive and anti-inflammatory treatments. The 2023 guidelines of the European Alliance of Associations for Rheumatology now recommend lowering maintenance glucocorticoid doses to ≤5 mg/day to reduce long-term health risks, a decrease from the previous 7.5 mg/day threshold set in 2019. To help achieve these reduced doses, early initiation of biologic therapies is suggested, even before conventional immunosuppressants. Belimumab and anifrolumab, the biologics currently approved for SLE treatment, have shown greater efficacy than placebo in clinical trials and similar safety profiles, supporting their use in achieving remission and enabling glucocorticoid tapering or discontinuation. This review evaluates the role of biologics, especially anifrolumab, in treating extra-renal SLE in Italy, using clinical scenarios to illustrate situations where early anifrolumab therapy could be beneficial.</p><p><strong>Methods: </strong>Hypothetical scenarios derived from clinical practice were examined to identify real-life contexts suitable for the early initiation of anifrolumab treatment.</p><p><strong>Results: </strong>Anifrolumab represents an effective therapeutic option for various extra-renal SLE patients. These include those who have failed to achieve or maintain remission with standard care, have contraindications to conventional immunosuppressants, are glucocorticoid-dependent, or experience mucocutaneous and musculoskeletal manifestations. Anifrolumab also offers potential benefits for patients planning pregnancy by promoting remission or low disease activity.</p><p><strong>Conclusions: </strong>Despite its recent approval and limited real-world evidence, anifrolumab has emerged as a promising therapeutic option for non-renal lupus. We hope this review will encourage further studies on the efficacy and safety of anifrolumab in real-life SLE patient cohorts.</p>","PeriodicalId":21222,"journal":{"name":"Reumatismo","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lucio phenomenon and antiphospholipid antibodies in leprosy mimicking rheumatologic disorders: a case report.","authors":"Rudy Hidayat, Johanda Damanik, Abirianty Priandani Araminta, Melani Marissa, Maria Angela Putri Maharani","doi":"10.4081/reumatismo.2025.1834","DOIUrl":"https://doi.org/10.4081/reumatismo.2025.1834","url":null,"abstract":"<p><p>Hansen's disease, also known as leprosy, is often termed \"the great imitator\" due to its diverse clinical presentations that can mimic various rheumatologic disorders. We present the case of a 34-year-old female who developed extensive purpuric rashes, initially raising suspicion of vasculitis. Laboratory investigations revealed triple-positive antiphospholipid antibodies. However, skin smears and histopathological examination confirmed a diagnosis of diffuse lepromatous leprosy complicated by Lucio phenomenon. This case highlights the importance of considering infectious etiologies, such as leprosy, in the differential diagnosis of vasculitis and rheumatologic diseases. Given the overlapping clinical features, a comprehensive patient history and careful interpretation of autoantibody tests are essential for achieving an accurate diagnosis.</p>","PeriodicalId":21222,"journal":{"name":"Reumatismo","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}