{"title":"Prevention of early-term deliveries: much ado about nothing?","authors":"Errol R Norwitz, James A Greenberg","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21170,"journal":{"name":"Reviews in obstetrics & gynecology","volume":"6 2","pages":"43-5"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861945/pdf/RIOG006002_0043.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31965339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Global endometrial ablation in the presence of essure® microinserts.","authors":"Diana Aldape, Scott G Chudnoff, Mark D Levie","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Abnormal uterine bleeding (AUB) affects 30% of women at some time during their reproductive years and is one of the most common reasons a woman sees a gynecologist. Many women are turning to endometrial ablation to manage their AUB. This article reviews the data relating to the available endometrial ablation techniques performed with hysteroscopic sterilization, and focuses on data from patients who had Essure® (Conceptus, San Carlos, CA) coils placed prior to performance of endometrial ablation. Reviewed specifically are data regarding safety and efficacy of these two procedures when combined. Data submitted to the US Food and Drug Administration for the three devices currently approved are reviewed, as well as all published case series. Articles included were selected based on a PubMed search for endometrial ablation (also using the brand names of the different techniques currently available), hysteroscopic sterilization, and Essure. </p>","PeriodicalId":21170,"journal":{"name":"Reviews in obstetrics & gynecology","volume":"6 2","pages":"80-8"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861947/pdf/RIOG006002_0080.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31973877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An In Vitro Diagnostic Multivariate Index Assay (IVDMIA) for Ovarian Cancer: Harvesting the Power of Multiple Biomarkers.","authors":"Zhen Zhang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In this review, OVA1® (Vermillion, Inc., Austin, TX), the first in vitro diagnostic multivariate index assay (IVDMIA) of protein biomarkers cleared by the US Food and Drug Administration (FDA), is used to explain the concept behind IVDMIA, the use of multiple markers to improve clinical performance of a diagnostic tool, and the key considerations in the development of IVDMIA.</p>","PeriodicalId":21170,"journal":{"name":"Reviews in obstetrics & gynecology","volume":"5 1","pages":"35-41"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349922/pdf/RIOG005001_0035.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30614429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Genetic testing for lynch syndrome, an inherited cancer of the bowel, endometrium, and ovary.","authors":"J Craig Strafford","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Genetic screening for the mismatch repair genes found in patients with Lynch syndrome leads to improvements in health outcomes among carriers and members of their family. Clinicians now have a simple and easily employed means of determining if an individual carries the genetic mutations found with Lynch syndrome. This article reviews the background and incidence of Lynch syndrome and presents screening criteria, including the use of Web-based algorithms to estimate the likelihood of an individual having inherited Lynch mutations. Comprehensive management plans based on individual risk and family history plus appropriate preventive measures are recommended. Primary care providers including obstetrician-gynecologists are encouraged to adopt a proactive, evidence-based approach to address patients and their relatives with Lynch syndrome.</p>","PeriodicalId":21170,"journal":{"name":"Reviews in obstetrics & gynecology","volume":"5 1","pages":"42-9"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349923/pdf/RIOG005001_0042.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30614430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Regulation of trophoblast invasion: the role of matrix metalloproteinases.","authors":"Jia-Yu Zhu, Zhan-Jun Pang, Yan-Hong Yu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Pregnancy success is determined by a complex progress that includes trophoblast invasion and placentation. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are metal-dependent endopeptidases capable of degrading extracellular matrix, and appear to play a critical role in trophoblast invasion. This article reviews in detail the role of MMPs, TIMPs, and their regulators in the mechanism of trophoblast invasion in early human pregnancy.</p>","PeriodicalId":21170,"journal":{"name":"Reviews in obstetrics & gynecology","volume":"5 3-4","pages":"e137-43"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594863/pdf/RIOG005003_e137.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31300620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Management of pregnant patients who refuse medically indicated cesarean delivery.","authors":"Neha A Deshpande, Corrina M Oxford","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The doctrine of informed refusal may become difficult to adhere to in obstetric practice, especially in situations in which the fetus's life is at risk. One rare yet potentially problematic situation of informed refusal is the case of a pregnant woman who refuses to undergo a medically indicated cesarean delivery that would ensure the well-being of her fetus. Although some would argue that patient autonomy takes precedence and the woman's informed refusal should be respected, others would argue that beneficence, justice, and doing no harm to the viable fetus should ethically overrule the refusal of a surgery. This article explores the profound conflict between maternal autonomy and the rights of the fetus, provides a framework to address when the two diverge, and poses suggestions for how providers can better navigate this dilemma.</p>","PeriodicalId":21170,"journal":{"name":"Reviews in obstetrics & gynecology","volume":"5 3-4","pages":"e144-50"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594862/pdf/RIOG005003_e144.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31301981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Large sacrococcygeal teratoma hindering vaginal delivery attempted at home.","authors":"Pallab Kumar Mistri, Bijan Patua, Hajekul Alam, Sailes Ray, Sanjoy Kumar Bhattacharyya","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Sacrococcygeal teratoma in fetus is rare. If it remains antenatally undiagnosed, it may cause sudden arrest of an otherwise uncomplicated vaginal delivery because of the tumor mass. This poses a challenge to obstetricians. In this era of widespread antenatal care, this type of complication is very rare; however, in such cases, if met unexpectedly, an urgent laparotomy followed by a reduction of the tumor mass might help in completion of the delayed delivery.</p>","PeriodicalId":21170,"journal":{"name":"Reviews in obstetrics & gynecology","volume":"5 2","pages":"65-8"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410504/pdf/RIOG005002_0065.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30813468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}