Regulation of trophoblast invasion: the role of matrix metalloproteinases.

Reviews in obstetrics & gynecology Pub Date : 2012-01-01
Jia-Yu Zhu, Zhan-Jun Pang, Yan-Hong Yu
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Abstract

Pregnancy success is determined by a complex progress that includes trophoblast invasion and placentation. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are metal-dependent endopeptidases capable of degrading extracellular matrix, and appear to play a critical role in trophoblast invasion. This article reviews in detail the role of MMPs, TIMPs, and their regulators in the mechanism of trophoblast invasion in early human pregnancy.

基质金属蛋白酶对滋养细胞侵袭的调控作用。
妊娠成功是由一个复杂的过程决定的,包括滋养细胞侵袭和胎盘。基质金属蛋白酶(MMPs)和金属蛋白酶的组织抑制剂(TIMPs)是金属依赖性的内肽酶,能够降解细胞外基质,在滋养细胞侵袭中起关键作用。本文就MMPs、TIMPs及其调控因子在人类妊娠早期滋养细胞侵袭机制中的作用作一综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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