Radiochimica Acta最新文献_第4页

Synthesis, MTT assay, 99m-Technetium radiolabeling, biodistribution evaluation of radiotracer and in vitro magnetic resonance imaging study of P,N-doped graphene quantum dots as a new multipurpose imaging nano-agent 作为新型多用途成像纳米试剂的 P,N 掺杂石墨烯量子点的合成、MTT 试验、99m-锝放射性标记、放射性示踪剂的生物分布评估和体外磁共振成像研究

IF 1.8 3区化学

Radiochimica Acta Pub Date : 2024-05-24 DOI: 10.1515/ract-2023-0180

Morteza Mollazadeh, A. Fakhari, T. Mortezazadeh, F. B. Mofrad, Ali Jamali Nazarie

{"title":"Synthesis, MTT assay, 99m-Technetium radiolabeling, biodistribution evaluation of radiotracer and in vitro magnetic resonance imaging study of P,N-doped graphene quantum dots as a new multipurpose imaging nano-agent","authors":"Morteza Mollazadeh, A. Fakhari, T. Mortezazadeh, F. B. Mofrad, Ali Jamali Nazarie","doi":"10.1515/ract-2023-0180","DOIUrl":"https://doi.org/10.1515/ract-2023-0180","url":null,"abstract":"\u0000 In this study, a new nano-structure, N,P-doped graphene quantum dots (N,P-GQDs), were synthesized as multipurpose imaging agent for performing scintigraphy and magnetic resonance imaging (MRI). Some standard characterization methods were used to identify the nano-structure. In vitro cytotoxicity evaluation using MTT assay revealed that N,P-GQDs nanoparticles had no significant cytotoxicity after 24 and 48 h against normal (MCF-10A) and cancerous (MCF 7) human breast cell line in concentration up to 200 μg/mL. The N,P-GQDs were radiolabeled with Technetium-99m as 99mTc-(N,P-GQDs) and the radiochemical purity was assayed by ITLC concluding RCP ≥ 95 %. The passing of 99mTc-(N,P-GQDs) through 0.1 µm filter demonstrated that 70.8 % of particles were <0.1 µm. In order to perform scintigraphy, the 99mTc-(N,P-GQDs) were injected to female healthy Wistar rats. The results showed that the radio-complex was captured and eliminated just by kidneys. Moreover, in vitro T1-weighted phantom MRI imaging showed that the N,P-GQDs have proper relaxivity in comparison to Dotarem® as a clinically available contrast agent. The results showed that the N,P-GQDs have potential to be considered as a novel and encouraging agent for both molecular MRI and nuclear medicine imagings.","PeriodicalId":21167,"journal":{"name":"Radiochimica Acta","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141099969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kinetic evaluation of the uranyl peroxide synthetic route on morphology 过氧化铀合成路线对形态的动力学评估

IF 1.8 3区化学

Radiochimica Acta Pub Date : 2024-05-16 DOI: 10.1515/ract-2024-0277

Erik C. Abbott, Logan D. Gibb, Cody A. Nizinski, Elijah W. Allen, Hiram E. E. O’Connor, Luther W. McDonald IV

{"title":"Kinetic evaluation of the uranyl peroxide synthetic route on morphology","authors":"Erik C. Abbott, Logan D. Gibb, Cody A. Nizinski, Elijah W. Allen, Hiram E. E. O’Connor, Luther W. McDonald IV","doi":"10.1515/ract-2024-0277","DOIUrl":"https://doi.org/10.1515/ract-2024-0277","url":null,"abstract":"\u0000 An important challenge in utilizing particle morphology in nuclear forensic or fuel fabrication applications is understanding why differences in morphologies are observed following varying processing conditions. This is often due to competition and interplay between thermodynamic and kinetic influences. To that end, some of the kinetic influences in the uranyl peroxide precipitation reaction were evaluated and compared to thermodynamic influences studied previously. Metastudtite (UO2O2·2H2O) was synthesized from solutions of uranyl nitrate or chloride, and the reaction time was varied from 100 s to 230 min enabling an evaluation of kinetic and thermodynamic influences. The metastudtite was then calcined to U3O8, and all materials were analyzed by powder X-ray diffraction (p-XRD) and scanning electron microscopy (SEM). Analysis by p-XRD confirmed the sample purity of metastudtite and U3O8. SEM images were analyzed using the Morphological Analysis for Materials (MAMA) software to measure the size and shape of the nanoparticles for a statistical comparison between materials. Metastudtite produced at shorter reaction times exhibited a kinetically controlled shape by forming smaller and rounder particles than metastudtite produced at longer reaction times. Metastudtite produced at the longer reaction times exhibited differences between the uranyl nitrate and uranyl chloride routes with the nitrate exhibiting a more angular and faceted morphology than the chloride. Overall, the control of the supersaturation ratio (S) played a significant role in determining the morphology of the metastudtite. Morphological differences between the U3O8 confirmed the role of nanoparticle agglomeration in forming larger sintered particles. The results help demonstrate the importance of understanding particle formation mechanisms in the long-term development of morphology in nuclear forensics or in developing advanced fuels with specific characteristics.","PeriodicalId":21167,"journal":{"name":"Radiochimica Acta","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140968343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytoremediation of radium contaminated soils: recent advances and prospects 镭污染土壤的植物修复：最新进展与前景

IF 1.8 3区化学

Radiochimica Acta Pub Date : 2024-05-13 DOI: 10.1515/ract-2023-0248

Jianlong Wang, Can Chen

{"title":"Phytoremediation of radium contaminated soils: recent advances and prospects","authors":"Jianlong Wang, Can Chen","doi":"10.1515/ract-2023-0248","DOIUrl":"https://doi.org/10.1515/ract-2023-0248","url":null,"abstract":"Radioactive radium (Ra) mainly comes from the mining and milling of uranium and other metal or non-metal mines, phosphate production and fertilizer use, production of oil and gas, coal combustion, wastewater treatment, and various wastes from the above activities, which is ubiquitous in the environment. Phytoremediation is a green and cheap remediation technology for metal/radionuclide-contaminated sites. Radium is often of particular interest and there are many literatures on parameters of Ra concentration in plants and transfer factors from soil to plant from a radiological impact assessment point of view. However, review articles on phytoremediation of Ra-polluted soil are relatively few. This review focused on radium-polluted soil phytoremediation, involving two main strategies of phytoextraction and phytostabilization, which covered the potential (hyper)accumulators for Ra, characteristics of Ra uptake from soil by plants, influencing factors, and phytostabilization application. In future research works, more attention should be paid to the deep insights and mechanism researches of Ra uptake/immobilization by plants. This review will deepen the understanding of the relationship of radium-soil-plants, and to enhance the potential application of phytoremediation as an alternative treatment technology for remediation of Ra-polluted soil site.","PeriodicalId":21167,"journal":{"name":"Radiochimica Acta","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140938131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The adsorption of U(VI) on chlorite: batch, modeling and XPS study U(VI)在绿泥石上的吸附：批处理、建模和 XPS 研究

IF 1.8 3区化学

Radiochimica Acta Pub Date : 2024-05-09 DOI: 10.1515/ract-2024-0278

Qiang Jin, Yuxiong Wang, Xin Zhao, Ye Fan, Xinya Diao, Zongyuan Chen, Zhijun Guo

{"title":"The adsorption of U(VI) on chlorite: batch, modeling and XPS study","authors":"Qiang Jin, Yuxiong Wang, Xin Zhao, Ye Fan, Xinya Diao, Zongyuan Chen, Zhijun Guo","doi":"10.1515/ract-2024-0278","DOIUrl":"https://doi.org/10.1515/ract-2024-0278","url":null,"abstract":"A mechanistic modelling of the adsorption processes onto individual minerals presenting in the near- and far-fields can greatly enhance the credibility of long-term safety assessments of granite-based geological repositories. In this study, the titration and U(VI) adsorption characteristics of chlorite, one of the major minerals of rock fractures, have been studied. Potentiometric titration curves at two ionic strengths (0.1 and 0.4 mol/L NaCl) are successfully interpreted by considering protonation/deprotonation reactions on generic edge sites (≡SOH) in the framework of a non-electrostatic surface complexation model (SCM). The adsorption of U(VI) on chlorite was reached after 24 h, the adsorption kinetics can be described by a pseudo-second-order model. A non-electrostatic SCM with three surface complexes (≡SOUO2 +, ≡SO(UO2)3(OH)5 and ≡SO(UO2)3(OH)7 2−) was set up based on pH edges of U(VI) at adsorption equilibrium in the absence of CO2. Additional, experimental data measured as a function of U(VI) concentration, solid-to-liquid ratio and carbonate concentration were well reproduced by the proposed model. Finally, parallel experiments were conducted using X-ray photoelectron spectroscopy (XPS) to analyze the variation of U(VI) surface species speciation at different pH values. The good agreement between SCM prediction and XPS analysis demonstrates the reliability of the model in predicting and quantifying the radionuclides retention by chlorite.","PeriodicalId":21167,"journal":{"name":"Radiochimica Acta","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140937955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of gamma, neutron, and proton interaction parameters of some immunotherapy drugs using EpiXs, NGCal, and PSTAR software 使用 EpiXs、NGCal 和 PSTAR 软件研究某些免疫疗法药物的伽马、中子和质子相互作用参数

IF 1.8 3区化学

Radiochimica Acta Pub Date : 2024-05-08 DOI: 10.1515/ract-2023-0255

Gangadharayya Hiremath, Vishwanath Singh, Narasimha Ayachit, Nagappa Badiger

{"title":"Study of gamma, neutron, and proton interaction parameters of some immunotherapy drugs using EpiXs, NGCal, and PSTAR software","authors":"Gangadharayya Hiremath, Vishwanath Singh, Narasimha Ayachit, Nagappa Badiger","doi":"10.1515/ract-2023-0255","DOIUrl":"https://doi.org/10.1515/ract-2023-0255","url":null,"abstract":"In proton therapy, the protons are used to destroy the cancer cells efficiently at the Bragg peak without much damage to normal cells. The protons can also produce neutrons, protons, and high-energy gamma rays through nuclear reactions with cancerous and healthy tissues as well as with beamline components. The effective observed dose in the therapy is enhanced due to the interaction of nuclear particles with cancerous tissues. Such nuclear particles can have several effects on drugs used in immunotherapy, such as immunotherapy in combination with proton therapy, which has been used to treat cancer. In the present investigations, the gamma, neutron, and protons interaction parameters of some immunotherapy drugs, such as dostarlimab, atezolizumab, ipilimumab, nivolumab, and pembrolizumab, are determined by using EpiXs, NGCal, and PSTAR software. It is found that the EBF and EABF for all selected immunotherapy drugs increase with increasing penetration depth, peaking at 100 keV. The peaking is more symmetric at a higher penetration depth of 40 mfp than at a lower one of 1 mfp. At lower energies of gamma photons, the EBF values increase exponentially, and at higher energies, they increase linearly with increasing penetration depth for all selected drugs. Mass attenuation factors are slightly higher for thermal neutrons than for fast neutrons for selected immunotherapeutic drugs, indicating that thermal neutrons more actively participate in these drugs than fast neutrons. The mass attenuation factor for both fast and thermal neutrons increases with increasing weight percentages of hydrogen and is found to be higher for thermal neutrons. This is the first study in the literature to investigate the radiation interaction parameters for immunotherapy drugs, and it is helpful in radiation therapy and dosimetry.","PeriodicalId":21167,"journal":{"name":"Radiochimica Acta","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140929251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges in the solution phase synthesis of PSMA-11 and PSMA-617: organic ligands for radiopharmaceutical preparations in prostate cancer medication 溶液相合成 PSMA-11 和 PSMA-617 的挑战：用于前列腺癌放射性药物制剂的有机配体

IF 1.8 3区化学

Radiochimica Acta Pub Date : 2024-04-30 DOI: 10.1515/ract-2024-0280

K. S. Ajish Kumar, Anupam Mathur

{"title":"Challenges in the solution phase synthesis of PSMA-11 and PSMA-617: organic ligands for radiopharmaceutical preparations in prostate cancer medication","authors":"K. S. Ajish Kumar, Anupam Mathur","doi":"10.1515/ract-2024-0280","DOIUrl":"https://doi.org/10.1515/ract-2024-0280","url":null,"abstract":"Patient specific treatments for different cancers are currently being actively addressed through nuclear medicine. More recently, the identification of biomarker namely; prostate-specific membrane antigen (PSMA) expressed on the prostate cancer cell surface has been considered as a turning point in prostate cancer management using radiopharmaceuticals. In this treatment method, apart from radionuclide, organic ligands that target PSMA constitute an essential component. PSMA-11 and PSMA-617 are two important ligands that form the radiopharmaceuticals, [68Ga]Ga-PSMA-11, [177Lu]Lu-PSMA-617, which are currently powering the prostate cancer management, especially metastatic castration resistant prostate cancer (mCRPC) in most part of the world. Identification of efficient synthetic routes towards these highly expensive ligands is an important prerequisite to make this treatment modality more popular. In this account, the synthetic challenges that we circumvent during the solution phase synthesis of PSMA-11 and PSMA-617, through different chemical synthetic routes are demonstrated. Post-synthesis, both the ligands, PSMA-11 and PSMA-617 were successfully radiolabelled using 68Ga, and 177Lu, respectively, to generate corresponding labelled products [68Ga]Ga-PSMA-11, and [177Lu]Lu-PSMA-617, in good radiochemical purity.","PeriodicalId":21167,"journal":{"name":"Radiochimica Acta","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140833470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of radioactivity and radiological risk indices in the sediments of the Tam Giang-Cau Hai, Thi Nai, and Nai lagoons in the Center of Vietnam 评估越南中部 Tam Giang-Cau Hai、Thi Nai 和 Nai 湖沉积物中的放射性和放射性风险指数

IF 1.8 3区化学

Radiochimica Acta Pub Date : 2024-04-25 DOI: 10.1515/ract-2024-0271

D. H. Nhon, Nguyen Van Quan, Phan Son Hai, Bui Van Vuong, Nguyen Ngoc Anh, N. Đ. Ve, Hoang Thi Chien

引用次数: 0

Chromium sorption on synthetic and natural rock minerals with emphasis on speciation behavior and kinetic model using Cr51 铬在人工合成和天然岩石矿物上的吸附作用，重点是标本行为和使用 Cr51 的动力学模型

IF 1.8 3区化学

Radiochimica Acta Pub Date : 2024-04-23 DOI: 10.1515/ract-2023-0240

Ashraf A. El-Sayed

{"title":"Chromium sorption on synthetic and natural rock minerals with emphasis on speciation behavior and kinetic model using Cr51","authors":"Ashraf A. El-Sayed","doi":"10.1515/ract-2023-0240","DOIUrl":"https://doi.org/10.1515/ract-2023-0240","url":null,"abstract":"\u0000 The presence of chromate in the aquatic environment poses toxicity and pollution to the environment. Therefore, the needs to establish methods to get rid of this species is a must. The effect of different natural rock minerals; pyrite, magnetite, pyrrhotite, and wurtzite as constituent parts of the Earth’s crust can play a major role in waste treatment. The properties of those minerals towards the behavior of chromium (sorption) were studied under the effect of changes of pH and contact time to treat the waste solution of toxic chromate. The total chromium species in the reaction system was determined using Cr51 as a simpler, faster and more accurate analytical tools. Concerning the effect of types of minerals, the synthetic ones, the results indicated that pyrrhotite and wurtzite were highly effective for the removal of chromate with almost 100 % sorption capacity as it was pH-independent, despite the presence of a degree of reductive ability of both minerals. While, it was 99 % at pH 8.5 and 28 % at pH 3 for pyrite and magnetite, respectively, which was pH dependent. The equilibrium adsorption capacities for chromium adsorption were 0.34 ± 0.15, 0.028 ± 0.01 and 4.27 ± 1.3 mg/g mineral for natural minerals pyrite, magnetite and synthetic one pyrhotite, respectively. However, it was found 117.7 ± 10.9 mg/g for synthetic mineral wurtzite. These results can be attributed to the redox power of oxide and sulfide minerals; magnetite and, pyrite used. For kinetic studies of chromium (VI) adsorption, non linear model approved that the reaction could be described based on pseudo-second-order kinetics in such simulated environmental heterogeneous systems.","PeriodicalId":21167,"journal":{"name":"Radiochimica Acta","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140669783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insight on the properties of multi-walled carbon nanotubes reinforced nitrile rubber composites cured by ionizing radiation or peroxide: a comparative study 电离辐射或过氧化物固化的多壁碳纳米管增强丁腈橡胶复合材料性能透视：一项比较研究

IF 1.8 3区化学

Radiochimica Acta Pub Date : 2024-04-17 DOI: 10.1515/ract-2023-0244

Khaled F. El-Nemr, Hamdi Radi, Aman I. Khalaf, Eman M. Hamdy

引用次数: 0

Green synthesis of CdS/flaxseed mucilage nanocomposite films using gamma irradiation for packaging applications 利用伽马辐照绿色合成用于包装的 CdS/亚麻籽粘液纳米复合膜

IF 1.8 3区化学

Radiochimica Acta Pub Date : 2024-04-16 DOI: 10.1515/ract-2023-0251

Rehab Sokary, Heba A. Raslan, Rasha Mohammad Fathy

{"title":"Green synthesis of CdS/flaxseed mucilage nanocomposite films using gamma irradiation for packaging applications","authors":"Rehab Sokary, Heba A. Raslan, Rasha Mohammad Fathy","doi":"10.1515/ract-2023-0251","DOIUrl":"https://doi.org/10.1515/ract-2023-0251","url":null,"abstract":"The most common ways to produce nanoparticles are through chemical and physical processes, which can be expensive and environmentally hazardous. Using plant extracts (green synthesis) as reducing and capping agents is a simple, cost-effective, and environmentally friendly method of lowering the usage of dangerous chemicals in the synthesis of metal nanoparticles. This study covers the environmentally friendly synthesis of cadmium sulphide nanoparticles (CdS NPs) using a blend of flaxseed extracts (FM), polyvinyl alcohol (PVA), and chitosan (Cs). The composites are then exposed to gamma irradiation at doses of 20 kGy and 40 kGy. UV–VIS absorption spectroscopy, SEM, HRTEM, EDX, and FTIR were used to analyse the produced nanocomposite films. UV–Vis absorption spectra showed considerable surface Plasmon resonance (SPR) bands at 396–440 nm, indicating that CdS NPs had been successfully synthesized. A progressive red shift in wavelength was noted, along with the broadening of the absorption band as the irradiation dose increased. Transmission electron microscopy pictures revealed that the generated CdS nanostructures were dispersed as spherical nanoparticles with remarkable structural homogeneity. Tensile strength and elongation measurements of the films revealed that the inclusion of CdS NPs improved their mechanical properties. The addition of CdS NPs to the current blends limits biodegradation in soil. Thermal gravimetric analysis findings showed that CdS NPs included in FM/PVA films had improved thermal stability. The antimicrobial activities of the tested films were performed against Staphylococcus aureus, Escherichia coli, and Candida albicans. The results revealed that all of the films exhibited more antibacterial activity against S. aureus than the two others, with the highest activity observed in nanocomposites with a high concentration of CdS.","PeriodicalId":21167,"journal":{"name":"Radiochimica Acta","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140564247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0