Research communications in chemical pathology and pharmacology最新文献_第2页

Stimulation by hydrogen peroxide of L-arginine metabolism to L-citrulline coupled with nitric oxide synthesis in cultured endothelial cells. 过氧化氢刺激培养内皮细胞l -精氨酸代谢为l -瓜氨酸并结合一氧化氮合成。

Research communications in chemical pathology and pharmacology Pub Date : 1994-06-01

S Shimizu, Y Saitoh, T Yamamoto, K Momose

引用次数: 0

Is heat acclimation able to increase whole-body sensitivity to insulin? 热适应能增加全身对胰岛素的敏感性吗?

Research communications in chemical pathology and pharmacology Pub Date : 1994-06-01

J Nagasawa, Y Sato, H Yamashita, T Ookawara, T Kizaki, Y Habara, H Ohno

{"title":"Is heat acclimation able to increase whole-body sensitivity to insulin?","authors":"J Nagasawa, Y Sato, H Yamashita, T Ookawara, T Kizaki, Y Habara, H Ohno","doi":"","DOIUrl":"","url":null,"abstract":"The aim of the present study was to determine whether heat acclimation increases whole-body sensitivity to insulin. Male Wistar rats were kept at 34 degrees C for 2 weeks (HA group). Warm-acclimated rats (WA group) at 25 degrees C served as controls. The glucose infusion rate (GIR) was assessed as an index of in vivo insulin sensitivity, using a hyperinsulinemic euglycemic clamp technique. Moreover, the 125I-insulin binding capacity to purified insulin receptor preparations from m. gastrocnemius of rats after 1, 7, or 14 days of heat exposure was examined. Mean GIR values of HA group were slightly higher than those of WA group, but not significant. The great deviation of the HA group, however, appeared to exist. About half of HA rats showed markedly high GIR values (p < 0.01 vs. WA group). Mean GIR value of the remaining HA rats were significantly (p < 0.05) lower than those of the WA group. Likewise, the binding capacity to 125I-insulin was not significantly different among the periods of time of heat exposure, and the deviation went on increasing from 1 to 14 days. These results suggest that there is a wide individual difference between the changes in glucose metabolism under heat exposure. In view of such results, there appears to be a great need for further studies on the factors affecting the variation of insulin action.","PeriodicalId":21140,"journal":{"name":"Research communications in chemical pathology and pharmacology","volume":"84 3","pages":"375-8"},"PeriodicalIF":0.0,"publicationDate":"1994-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18935438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blood cytokine and complement levels in patients with sepsis. 脓毒症患者血液细胞因子和补体水平的变化。

Research communications in chemical pathology and pharmacology Pub Date : 1994-06-01 DOI: 10.1097/00024382-199505000-00172

T. Takakuwa, S. Endo, H. Nakae, M. Kikuchi, N. Baba, K. Inada, M. Yoshida

{"title":"Blood cytokine and complement levels in patients with sepsis.","authors":"T. Takakuwa, S. Endo, H. Nakae, M. Kikuchi, N. Baba, K. Inada, M. Yoshida","doi":"10.1097/00024382-199505000-00172","DOIUrl":"https://doi.org/10.1097/00024382-199505000-00172","url":null,"abstract":"We measured serum levels of endotoxin, cytokines, and eicosanoids and investigated their relationship to serum complement levels in patients with sepsis. Serum endotoxin (Et) levels (5.3 +/- 2.4 pg/ml) were within the normal range, but levels of tumor necrosis factor-alpha (TNF-alpha, 114 +/- 104.94 pg/ml), interleukin 6 (IL-6, 86.7 +/- 50.9 pg/ml), interleukin 8 (IL-8, 86.8 +/- 49.7 pg/ml), type-II phospholipase A2 (type II PLA2, 211.3 +/- 193.9 ng/ml), leukotriene B4 (LTB4, 88.7 +/- 27.2 pg/ml), thromboxane B2 (TXB2, 58.7 +/- 50.9 pg/ml) and 6-keto-prostaglandin F1 alpha (PGF1 alpha, 21.0 +/- 11.0 pg/ml) levels were above normal. Levels of C3a (1088.4 +/- 83.8.7 ng/ml) and C4a (1951.5 +/- 1697.8 ng/ml) were also above normal; C3 (66.0 +/- 25.6 mg/dl) and C4 (23.6 +/- 5.3 mg/dl) were within the normal range, and C5a was lower than the detectable limit in all but one of the subjects. Serum TNF-alpha was significantly correlated with C3a (p < 0.001). Serum IL-6 had a significant negative correlation with C3 (p = 0.002) and C4 (p = 0.010). Type II PLA2 was significantly correlated with C3a (p < 0.001). There were no significant correlations between serum Et or IL-8 and serum C3, C4, C3a or C4a. Our findings suggest that increased levels of TNF-alpha, IL-6, and Type II PLA/ in patients with sepsis contribute to activation of the complement system.","PeriodicalId":21140,"journal":{"name":"Research communications in chemical pathology and pharmacology","volume":"17 1","pages":"291-300"},"PeriodicalIF":0.0,"publicationDate":"1994-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90381563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Inhibition of antigen-induced airway hyperresponsiveness in rats: effects of ozagrel (a thromboxane A2 synthase inhibitor) and of CV-3988 (a platelet activating factor antagonist). 抑制大鼠抗原诱导的气道高反应性:奥扎格雷尔(一种血栓素A2合成酶抑制剂)和CV-3988(一种血小板活化因子拮抗剂)的作用

Research communications in chemical pathology and pharmacology Pub Date : 1994-06-01

M Misawa, Y Chiba

{"title":"Inhibition of antigen-induced airway hyperresponsiveness in rats: effects of ozagrel (a thromboxane A2 synthase inhibitor) and of CV-3988 (a platelet activating factor antagonist).","authors":"M Misawa, Y Chiba","doi":"","DOIUrl":"","url":null,"abstract":"The effects of ozagrel, a thromboxane A2 (TXA2) synthase inhibitor, and CV-3988, a platelet activating factor (PAF) antagonist, was investigated on the repeatedly antigenic challenge-induced airway hyperresponsiveness (AHR) in rats. Rats were actively sensitized with DNP-Ascaris antigen and received 3 inhalations of antigen (challenges) or saline (sensitized control) every 48 hr. These animals were also pretreated with ozagrel (100 mg/kg, p.o., 30 min before), CV-3988 (3 mg/kg, i.v., 5 min before) or respective vehicle (water and saline, respectively) before each inhalation of antigen or saline. The in vivo airway responsiveness to cumulatively inhaled acetylcholine (ACh; 0.001-0.03%, each for 3 min) was measured 24 hr after the last inhalation of antigen or saline under anesthesia. A marked AHR was observed after repeated antigenic challenge when compared with the sensitized control group (5.5-9.5 times in order). This AHR was significantly, but partly, attenuated by pretreatment with ozagrel although this treatment alone had no effect on the airway responsiveness to inhaled ACh in sensitized control animals. On the other hand, CV-3988 had no inhibitory effect on this AHR. These findings suggest that TXA2, but not PAF, is one of the most important mediators participating in the pathogenesis of the antigen-induced AHR in rats.","PeriodicalId":21140,"journal":{"name":"Research communications in chemical pathology and pharmacology","volume":"84 3","pages":"341-9"},"PeriodicalIF":0.0,"publicationDate":"1994-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18935433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of the intracerebroventricular administration of ketamine on centrogenic arrhythmias in anesthetized rats. 脑室注射氯胺酮对麻醉大鼠心源性心律失常的影响。

Research communications in chemical pathology and pharmacology Pub Date : 1994-06-01

A Filippelli, B Cuparencu, M Falciani, V de Novellis, L Safta, V Arustei, F Rossi

引用次数: 0

Dynamics of hepatic collagen synthesis and intracellular degradation of newly synthesized collagen during chronic carbon tetrachloride-induced liver injury in rats. 慢性四氯化碳肝损伤大鼠肝胶原合成动态及新合成胶原细胞内降解。