Respiratory carePub Date : 2024-08-26DOI: 10.4187/respcare.12283
Madeline X Zhang, Reinout A Bem, Tom Huijgen, Rozalinde Klein-Blommert, Daniel Bonn, Cees J M van Rijn
{"title":"The effect of decoupling humidity control on aerosol drug delivery during HFNC for infants.","authors":"Madeline X Zhang, Reinout A Bem, Tom Huijgen, Rozalinde Klein-Blommert, Daniel Bonn, Cees J M van Rijn","doi":"10.4187/respcare.12283","DOIUrl":"https://doi.org/10.4187/respcare.12283","url":null,"abstract":"<p><strong>Background: </strong>Aerosol therapy is commonly used during treatment with high-flow nasal cannula (HFNC) in the intensive care unit (ICU). Heated humidification inside the HFNC tubing circuit leads to unwanted condensation, which may greatly limit the efficiency of drug delivery. In this study, we aimed to investigate whether a novel humidification system, which decouples temperature and humidity control, can improve the delivered dose.</p><p><strong>Methods: </strong>In a bench study setup, fluorescein sodium solution was nebulized using a vibrating-mesh nebulizer in an infant HFNC circuit to measure the delivered dose, with a conventional versus a novel decoupled humidifier. The deposition of fluorescein inside each breathing circuit component and a final collection filter at the end of the nasal cannula was collected and quantified with a UV-vis spectrometer. Droplet sizes at different sections of the breathing circuit were measured by laser diffraction. Three air flow rates: 5, 10 and 15 L/min, and two nebulizer positions: (1) at the humidifier and (2) after the inspiratory tube, were tested.</p><p><strong>Results: </strong>The delivered dose decreased with increasing flow rate for the conventional setup and was higher when the nebulizer was placed after the inspiratory tube. Turning off the conventional humidifier 10 minutes before and during nebulization did not improve the delivered dose. The decoupled humidifier achieved a significantly higher (p = .002) delivered dose than the conventional setup. The highest delivered dose obtained by the decoupled humidifier was 62.4% when the nebulizer was placed after the humidifier, while the highest dose obtained for the conventional humidifier was 36.3% by placing the nebulizer after the inspiratory tube.</p><p><strong>Conclusions: </strong>In this bench study, we found that the delivered dose for an infant HFNC nebulization setup could be improved significantly by decoupling temperature and humidity control inside the HFNC circuit, as it reduced drug deposition inside the breathing circuit.</p>","PeriodicalId":21125,"journal":{"name":"Respiratory care","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Respiratory carePub Date : 2024-08-24DOI: 10.4187/respcare.11670
Chen Yun Goh, Herng Lee Tan, Yi-Jyun Ma, Apollo Bugarin Aguilan, Wen Cong Lee, Anuradha P Menon, Yee Hui Mok, Judith Ju-Ming Wong
{"title":"High-Risk Extubation Readiness Testing for Children With Cardiac Critical Illness.","authors":"Chen Yun Goh, Herng Lee Tan, Yi-Jyun Ma, Apollo Bugarin Aguilan, Wen Cong Lee, Anuradha P Menon, Yee Hui Mok, Judith Ju-Ming Wong","doi":"10.4187/respcare.11670","DOIUrl":"10.4187/respcare.11670","url":null,"abstract":"<p><strong>Background: </strong>A protocolized extubation readiness test (ERT), including a spontaneous breathing trial (SBT), is recommended for patients who are intubated. This quality-improvement project aimed to improve peri-extubation outcomes by using a high-risk ERT protocol in intubated cardiac patients in addition to a standard-risk protocol.</p><p><strong>Methods: </strong>After baseline data collection, we implemented a standard-risk ERT protocol (pressure support plus PEEP), followed by a high-risk ERT protocol (PEEP alone) in cardiac subjects who were intubated. The primary outcome, a composite of extubation failure and rescue noninvasive respiratory support, was compared between phases. Ventilator duration and use of postextubation respiratory support were balancing measures.</p><p><strong>Results: </strong>A total of 213 cardiac subjects who were intubated were studied, with extubation failure and rescue noninvasive respiratory support occurring in 10 of 213 (4.7%) and 8 of 213 (3.8%), respectively. We observed a reduction in the composite outcome among the 3 consecutive phases (5/29 [17.2%], 10/110 [9.1%] vs 3/74 [4.1%]; <i>P</i> = .10), but this did not reach statistical significance. In the logistic regression model when adjusting for admission type, the high-risk ERT protocol was associated with a significant reduction of the composite outcome (adjusted odds ratio 0.20, 95% CI 0.04-0.091; <i>P</i> = .037), whereas the standard-risk ERT protocol was not (adjusted odds ratio 0.48, 95% CI 0.15-1.53; <i>P</i> = .21). This was not accompanied by a longer ventilator duration (2.0 [1.0, 3.0], 2.0 [1.0-4.0], vs adjusted odds ratio 2.0 [95% [1.0-6.0]; <i>P</i> = .99) or an increased use of planned noninvasive respiratory support (10/29 [35.5%], 35/110 [31.8%], vs 25/74 [33.8%]; <i>P</i> > .99).</p><p><strong>Conclusions: </strong>In this quality-improvement project, a high-risk ERT protocol was implemented with improvement in peri-extubation outcomes among cardiac subjects.</p>","PeriodicalId":21125,"journal":{"name":"Respiratory care","volume":" ","pages":"1108-1115"},"PeriodicalIF":2.4,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11349595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140871047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Respiratory carePub Date : 2024-08-24DOI: 10.4187/respcare.11726
Julie Di Maria, Sarah Hartley, Jonathan Levy, Isabelle Bossard, Laure Messirejean, Frédéric Lofaso, Djamel Bensmail, Hélène Prigent, Antoine Léotard
{"title":"Screening Strategies for Sleep-Disordered Breathing in Patients With Spinal Cord Injury in a Tertiary Care Rehabilitation Center.","authors":"Julie Di Maria, Sarah Hartley, Jonathan Levy, Isabelle Bossard, Laure Messirejean, Frédéric Lofaso, Djamel Bensmail, Hélène Prigent, Antoine Léotard","doi":"10.4187/respcare.11726","DOIUrl":"10.4187/respcare.11726","url":null,"abstract":"<p><strong>Background: </strong>Sleep-disordered breathing (SDB) is frequent in patients with spinal-cord injury (SCI). However, SDB is frequently underdiagnosed due to limited access to diagnostic testing and knowledge about the condition. Moreover, SDB heterogeneity (sleep apnea, obstructive sleep apnea or central sleep apnea and nocturnal alveolar hypoventilation) implies complex evaluation of both nocturnal respiratory effort and hypercapnia. The aim of this study was to compare different screening strategies for an SDB diagnosis in patients with SCI.</p><p><strong>Methods: </strong>This was a retrospective analysis of data from subjects with SCI followed up in a tertiary-care rehabilitation center with a specialized sleep unit. Subjective (questionnaires) and objective data (polysomnography [PSG]), [Formula: see text] extracted from the PSG, morning blood gases, and nocturnal transcutaneous CO<sub>2</sub> (P<sub>tcCO<sub>2</sub></sub> ) were collected and analyzed. A retrospective comparison of different strategies for SDB screening was carried out. Each strategy was compared (alone and in combination) with the standard of care for sleep apnea (PSG) and nocturnal alveolar hypoventilation (P<sub>tcCO<sub>2</sub></sub> ) diagnosis. The performance of the usual cutoff and visual analysis was studied.</p><p><strong>Results: </strong>Among 190 subjects with SCI who underwent a full night's PSG, data were available for 104 questionnaires and 162 with oximetry. Nocturnal alveolar hypoventilation was screened by P<sub>tcCO<sub>2</sub></sub> and blood gases in 52 subjects with SCI. Questionnaires (the modified Screening for Obstructive Sleep Apnea in Tetraplegia and the Epworth Sleepiness Scale) had poor performance for identifying sleep apnea and did not identify nocturnal alveolar hypoventilation. [Formula: see text] (oxygen desaturation index score ≥ 13) and visual analysis of [Formula: see text] were good at identifying sleep apnea but insufficient to identify nocturnal alveolar hypoventilation. Diurnal blood gases were poor predictors of nocturnal alveolar hypoventilation.</p><p><strong>Conclusions: </strong>Questionnaires were of limited use in subjects with SCI, but the oxygen desaturation index derived from oximetry performed well for sleep apnea screening. Both diurnal blood gases and oximetry visual analysis were insufficient for nocturnal alveolar hypoventilation screening. P<sub>tcCO<sub>2</sub></sub> monitoring should be mandatory and ideally combined with PSG given the heterogeneity of SDB phenotypes and associated sleep comorbidities of patients with SCI.</p>","PeriodicalId":21125,"journal":{"name":"Respiratory care","volume":" ","pages":"1116-1128"},"PeriodicalIF":2.4,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11349584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141420658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Respiratory carePub Date : 2024-08-24DOI: 10.4187/respcare.11400
Robert M DiBlasi, Rebecca J Engberg, Jonathan Poli, Kristen E Carlin, Niko Kontoudios, P Worth Longest, Masaki Kajimoto
{"title":"Aerosol Delivery Efficiency With High-Flow Nasal Cannula Therapy in Neonatal, Pediatric, and Adult Nasal Upper-Airway and Lung Models.","authors":"Robert M DiBlasi, Rebecca J Engberg, Jonathan Poli, Kristen E Carlin, Niko Kontoudios, P Worth Longest, Masaki Kajimoto","doi":"10.4187/respcare.11400","DOIUrl":"10.4187/respcare.11400","url":null,"abstract":"<p><strong>Background: </strong>High-flow nasal cannula (HFNC) systems employ different methods to provide aerosol to patients. This study compared delivery efficiency, particle size, and regional deposition of aerosolized bronchodilators during HFNC in neonatal, pediatric, and adult upper-airway and lung models between a proximal aerosol adapter and distal aerosol circuit chamber.</p><p><strong>Methods: </strong>A filter was connected to the upper airway to a spontaneously breathing lung model. Albuterol was nebulized using the aerosol adapter and circuit at different clinical flow settings. The aerosol mass deposited in the upper airway and lung was quantified. Particle size was measured with a laser diffractometer. Regional deposition was assessed with a gamma camera at each nebulizer location and patient model with minimum flow settings.</p><p><strong>Results: </strong>Inhaled lung doses ranged from 0.2-0.8% for neonates, 0.2-2.2% for the small child, and 0.5-5.2% for the adult models. Neonatal inhaled lung doses were not different between the aerosol circuit and adapter, but the aerosol circuit showed marginally greater lung doses in the pediatric and adult patient models. Impacted aerosols and condensation in the non-heated HFNC and aerosol delivery components contributed to the dispersion of coarse liquid droplets, high deposition (11-44%), and occlusion of the supine neonatal upper airway. In contrast, the upright pediatric and adult upper-airway models had minimal deposition (0.3-7.0%) and high fugitive losses (∼24%) from liquid droplets leaking out of the nose. The high impactive losses in the aerosol adapter (56%) were better contained than in the aerosol circuit, resulting in less cannula sputter (5% vs 22%), fewer fugitive losses (18% vs 24%), and smaller inhaled aerosols (5 µm vs 13 µm).</p><p><strong>Conclusions: </strong>The inhaled lung dose was low (1-5%) during HFNC. Approaches that streamline aerosol delivery are needed to provide safe and effective therapy to patients receiving aerosolized medications with this HFNC system.</p>","PeriodicalId":21125,"journal":{"name":"Respiratory care","volume":" ","pages":"1146-1160"},"PeriodicalIF":2.4,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11349594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141564222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Respiratory carePub Date : 2024-08-24DOI: 10.4187/respcare.12070
Kimberly S Wiles
{"title":"2023 Year in Review: Home Oxygen Therapy.","authors":"Kimberly S Wiles","doi":"10.4187/respcare.12070","DOIUrl":"10.4187/respcare.12070","url":null,"abstract":"<p><p>Long-term oxygen therapy (LTOT) is a treatment that involves the provision of supplemental oxygen to individuals with respiratory disease to correct hypoxemia in the post-acute care environment. Over 1.5 million adults in the United States use supplemental oxygen for various respiratory disorders. This paper explores literature published on LTOT from September 2022-September 2023. Upon the conclusion of this literature review, 4 distinct categories emerged. This paper highlights the significant findings associated with the 4 categories: supplemental oxygen and COVID-19, telemonitoring, LTOT equipment, and in-home high-flow nasal cannula.</p>","PeriodicalId":21125,"journal":{"name":"Respiratory care","volume":"69 9","pages":"1182-1188"},"PeriodicalIF":2.4,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11349592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Albuterol Delivery via In-Line Intrapulmonary Percussive Ventilation Superimposed on Invasive Ventilation in an Adult Lung Model.","authors":"Takashi Karashima, Yuka Mimura-Kimura, Yusuke Mimura","doi":"10.4187/respcare.11249","DOIUrl":"10.4187/respcare.11249","url":null,"abstract":"<p><strong>Background: </strong>Intrapulmonary percussive ventilation (IPV) is frequently used for airway clearance, together with delivery of aerosolized medications. Drug delivery via IPV alone increases with decreasing percussion frequency and correlates with tidal volume ([Formula: see text]), whereas drug delivery via IPV during invasive ventilation is not well characterized. We hypothesized that drug delivery via IPV-invasive ventilation would differ from IPV alone due to control of ventilation by invasive ventilation.</p><p><strong>Methods: </strong>An adult ventilator circuit was used for IPV-invasive ventilation. A normal or a diseased lung model was configured to airway resistance of 5 cm H<sub>2</sub>O/L/s and lung compliance of 100 mL/cm H<sub>2</sub>O or to airway resistance of 20 cm H<sub>2</sub>O/L/s and lung compliance of 50 mL/cm H<sub>2</sub>O, respectively. The ventilator settings were the following: pressure control continuous mandatory ventilation mode, 10 breaths/min; PEEP, 5 cm H<sub>2</sub>O; [Formula: see text], 0.21; inspiratory time, 1 s; no bias flow; and inspiratory pressure, 10 or 15 cm H<sub>2</sub>O for the normal or the diseased lung model, respectively, to reach [Formula: see text] 500 mL with IPV off. Albuterol nebulized from an IPV device was captured in a filter placed before the lung model and quantitated by spectrophotometry.</p><p><strong>Results: </strong>The maximum efficiency of albuterol delivery via IPV-invasive ventilation was not different from that via IPV alone (mean ± SD of loading dose, 3.7 ± 0.2% vs 4.2 ± 0.3%, respectively; <i>P</i> = .12). The mean ± SD albuterol delivery efficiency with IPV-invasive ventilation was lower for the diseased lung model versus the normal model (1.6 ± 0.3% vs 3.2 ± 0.5%; <i>P</i> < .001), which increased with decreasing percussion frequency. In contrast, the mean ± SD [Formula: see text] was lower for the normal lung model versus the diseased model (401 ± 14 mL vs 470 ± 11 mL; <i>P</i> < .001).</p><p><strong>Conclusions: </strong>Albuterol delivery via IPV-invasive ventilation was modulated by percussion frequency but was not increased with increasing [Formula: see text]. The delivery efficiency was not sufficiently high for clinical use, in part due to nebulizer retention and extrapulmonary deposition.</p>","PeriodicalId":21125,"journal":{"name":"Respiratory care","volume":" ","pages":"1092-1099"},"PeriodicalIF":2.4,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11349587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140306712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Respiratory carePub Date : 2024-08-24DOI: 10.4187/respcare.11599
Alaina C Berg, Erin Evans, Uche E Okoro, Vivian Pham, Tyler M Foley, Chloe Hlas, Justin D Kuhn, Boulos Nassar, Brian M Fuller, Nicholas M Mohr
{"title":"Respiratory Therapist-Driven Mechanical Ventilation Protocol Is Associated With Increased Lung Protective Ventilation.","authors":"Alaina C Berg, Erin Evans, Uche E Okoro, Vivian Pham, Tyler M Foley, Chloe Hlas, Justin D Kuhn, Boulos Nassar, Brian M Fuller, Nicholas M Mohr","doi":"10.4187/respcare.11599","DOIUrl":"10.4187/respcare.11599","url":null,"abstract":"<p><strong>Background: </strong>Mechanical ventilation is a common life-saving procedure but can lead to serious complications, including ARDS and oxygen toxicity. Nonadherence to lung-protective ventilation guidelines is common. We hypothesized that a respiratory therapist-driven mechanical ventilation bundle could increase adherence to lung-protective ventilation and decrease the incidence of pulmonary complications in the ICU.</p><p><strong>Methods: </strong>A respiratory therapist-driven protocol was implemented on August 1, 2018, in all adult ICUs of a Midwestern academic tertiary center. The protocol targeted low tidal volume, adequate PEEP, limiting oxygen, adequate breathing frequency, and head of the bed elevation. Adherence to lung-protective guidelines and clinical outcomes were retrospectively observed in adult subjects admitted to the ICU and on ventilation for ≥ 24 h between January 2011 and December 2019.</p><p><strong>Results: </strong>We included 666 subjects; 68.5% were in the pre-intervention group and 31.5% were in the post-intervention group. After adjusting for body mass index and intubation indication, a significant increase in overall adherence to lung-protective ventilation guidelines was observed in the post-intervention period (adjusted odds ratio 2.48, 95% CI 1.73-3.56). Fewer subjects were diagnosed with ARDS in the post-intervention group (adjusted odds ratio 0.22, 95% CI 0.08-0.65) than in the pre-intervention group. There was no difference in the incidence of ventilator-associated pneumonia, ventilator-free days, ICU mortality, or death within 1 month of ICU discharge.</p><p><strong>Conclusions: </strong>A respiratory therapist-driven protocol increased adherence to lung-protective mechanical ventilation guidelines in the ICU and was associated with decreased ARDS incidence.</p>","PeriodicalId":21125,"journal":{"name":"Respiratory care","volume":" ","pages":"1071-1080"},"PeriodicalIF":2.4,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11349598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141627533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Respiratory carePub Date : 2024-08-24DOI: 10.4187/respcare.11859
Lea Bergez, Gilles Jourdain, Azzedine Ayachi, Daniele De Luca
{"title":"Noise Produced by Various Respiratory Support Techniques During Neonatal Transportation: A Simulation Study.","authors":"Lea Bergez, Gilles Jourdain, Azzedine Ayachi, Daniele De Luca","doi":"10.4187/respcare.11859","DOIUrl":"10.4187/respcare.11859","url":null,"abstract":"","PeriodicalId":21125,"journal":{"name":"Respiratory care","volume":" ","pages":"1161-1164"},"PeriodicalIF":2.4,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11349590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140922685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Respiratory carePub Date : 2024-08-24DOI: 10.4187/respcare.11286
Ghaida Jabri, Farah Alotaibi, Amjad M Ahmed, Jesna Jose, Farhan Z Alenezi, Musharaf Sadat, Felwa Bin Humaid, Fahad Al-Hameed, Javed Memon, Kasim Al Khatib, Abdullah M Alsuayb, Mohammed AlObaidi, Mohammed Al Mutairi, Ahmad A Alanaizi, Fuad Alghamdi, Yaseen M Arabi
{"title":"Noninvasive Ventilation in Critically Ill Patients With Severe Acute Respiratory Infections.","authors":"Ghaida Jabri, Farah Alotaibi, Amjad M Ahmed, Jesna Jose, Farhan Z Alenezi, Musharaf Sadat, Felwa Bin Humaid, Fahad Al-Hameed, Javed Memon, Kasim Al Khatib, Abdullah M Alsuayb, Mohammed AlObaidi, Mohammed Al Mutairi, Ahmad A Alanaizi, Fuad Alghamdi, Yaseen M Arabi","doi":"10.4187/respcare.11286","DOIUrl":"10.4187/respcare.11286","url":null,"abstract":"<p><strong>Background: </strong>The objective of this study was to evaluate the association between noninvasive ventilation (NIV) compared with invasive ventilation and mortality in subjects with severe acute respiratory infection.</p><p><strong>Methods: </strong>This was a retrospective multi-center study of subjects with severe acute respiratory infection treated with ventilatory support between September 2012 and June 2018. We compared the 90-d mortality of subjects managed initially with NIV (NIV group) with those managed with invasive ventilation only (invasive ventilation group), adjusting by propensity score.</p><p><strong>Results: </strong>Of 383 subjects, 189 (49%) were in the NIV group and 194 (51%) were in the invasive ventilation group. Of the subjects initially treated with NIV, 117 (62%) were eventually intubated. Crude 90-d mortality was lower in the NIV group versus the invasive ventilation group (42 [22.2%] vs 77 [39.7%]; <i>P</i> < .001). After propensity score adjustment, NIV was associated with lower 90-d mortality than invasive ventilation (odds ratio 0.54, 95% CI 0.38-0.76; <i>P</i> < .001). The association of NIV with mortality compared with invasive ventilation was not different across the studied subgroups.</p><p><strong>Conclusions: </strong>In subjects with severe acute respiratory infection and acute respiratory failure, NIV was commonly used. NIV was associated with a lower 90-d mortality. The observed high failure rate suggests the need for further research to optimize patient selection and facilitate early recognition of NIV failure.</p>","PeriodicalId":21125,"journal":{"name":"Respiratory care","volume":" ","pages":"1138-1145"},"PeriodicalIF":2.4,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11349588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141311538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Respiratory carePub Date : 2024-08-24DOI: 10.4187/respcare.12014
Andrew G Miller, Palen M Mallory, Alexandre T Rotta
{"title":"Endotracheal Intubation Outside the Operating Room: Year in Review 2023.","authors":"Andrew G Miller, Palen M Mallory, Alexandre T Rotta","doi":"10.4187/respcare.12014","DOIUrl":"10.4187/respcare.12014","url":null,"abstract":"<p><p>Endotracheal intubation is a common lifesaving procedure that often is performed outside the operating room in a variety of clinical scenarios. Providers who perform intubation outside the operating room have variable degrees of training, skill development, and experience. A large number of studies were published in 2023 on the topic of intubations outside the operating room across a wide variety of settings and patient populations. Here, we review relevant papers on this topic published in 2023.</p>","PeriodicalId":21125,"journal":{"name":"Respiratory care","volume":" ","pages":"1165-1181"},"PeriodicalIF":2.4,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11349597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140922441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}