Restorative Dentistry & Endodontics最新文献

{"title":"Effects of different calcium-silicate based materials on fracture resistance of immature permanent teeth with replacement root resorption and osteoclastogenesis.","authors":"Gabriela Leite de Souza,&nbsp;Gabrielle Alves Nunes Freitas,&nbsp;Maria Tereza Hordones Ribeiro,&nbsp;Nelly Xiomara Alvarado Lemus,&nbsp;Carlos José Soares,&nbsp;Camilla Christian Gomes Moura","doi":"10.5395/rde.2023.48.e21","DOIUrl":"https://doi.org/10.5395/rde.2023.48.e21","url":null,"abstract":"<p><strong>Objectives: </strong>This study evaluated the effects of Biodentine (BD), Bio-C Repair (BCR), and mineral trioxide aggregate (MTA) plug on the fracture resistance of simulated immature teeth with replacement root resorption (RRR) and <i>in vitro</i>-induced osteoclastogenesis.</p><p><strong>Materials and methods: </strong>Sixty bovine incisors simulating immature teeth and RRR were divided into 5 groups: BD and BCR groups, with samples completely filled with the respective materials; MTA group, which utilized a 3-mm apical MTA plug; RRR group, which received no root canal filling; and normal periodontal ligament (PL) group, which had no RRR and no root canal filling. All the teeth underwent cycling loading, and compression strength testing was performed using a universal testing machine. RAW 264.7 macrophages were treated with 1:16 extracts of BD, BCR, and MTA containing receptor activator of nuclear factor-kappa B ligand (RANKL) for 5 days. RANKL-induced osteoclast differentiation was assessed by staining with tartrate-resistant acid phosphatase. The fracture load and osteoclast number were analyzed using 1-way ANOVA and Tukey's test (α = 0.05).</p><p><strong>Results: </strong>No significant difference in fracture resistance was observed among the groups (<i>p ></i> 0.05). All materials similarly inhibited osteoclastogenesis (<i>p ></i> 0.05), except for BCR, which led to a lower percentage of osteoclasts than did MTA (<i>p <</i> 0.0001).</p><p><strong>Conclusions: </strong>The treatment options for non-vital immature teeth with RRR did not strengthen the teeth and promoted a similar resistance to fractures in all cases. BD, MTA, and BCR showed inhibitory effects on osteoclast differentiation, with BCR yielding improved results compared to the other materials.</p>","PeriodicalId":21102,"journal":{"name":"Restorative Dentistry & Endodontics","volume":"48 2","pages":"e21"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/25/ed/rde-48-e21.PMC10240096.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9589933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful nonsurgical treatment of type II dens invaginatus with 5 root canals using a self-adjusting file: a case report.","authors":"George Táccio de Miranda Candeiro,&nbsp;Antônio Sérgio Teixeira de Menezes,&nbsp;Ana Carolina Saldanha de Oliveira,&nbsp;Flávio Rodrigues Ferreira Alves","doi":"10.5395/rde.2023.48.e17","DOIUrl":"https://doi.org/10.5395/rde.2023.48.e17","url":null,"abstract":"<p><p>The present report describes the endodontic treatment of an Oehlers type II dens invaginatus in a maxillary lateral incisor with 5 root canals, an extremely rare condition. Apical periodontitis and related symptoms were noted. Cone-beam computed tomography was used to aid the diagnosis, reveal tooth morphology, and assist in canal location. The pulp chamber was carefully accessed, and the root canals were explored under magnification. All root canals were prepared with an R25 Reciproc Blue system and sodium hypochlorite (NaOCl) irrigation. After initial preparation, a self-adjusting file (SAF) with NaOCl and ethylenediaminetetraacetic acid was used to complement the disinfection. Additionally, calcium hydroxide medication was applied. Vertical compaction was used to fill the canals with a calcium silicate-based endodontic sealer and gutta-percha. After 12 months, the patient exhibited healing of the periapical region, absence of symptoms, and normal dental function. In conclusion, this nonsurgical treatment protocol was successful in promoting the cure of apical periodontitis. Both complementary disinfection with an SAF and use of calcium hydroxide medication should be considered when choosing the best treatment approach for dens invaginatus with very complex anatomy.</p>","PeriodicalId":21102,"journal":{"name":"Restorative Dentistry & Endodontics","volume":"48 2","pages":"e17"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/51/17/rde-48-e17.PMC10240087.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9589935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of endodontic retreatment using WaveOne Primary files in reciprocating and rotary motions.","authors":"Patricia Marton Costa,&nbsp;Renata Maíra de Souza Leal,&nbsp;Guilherme Hiroshi Yamanari,&nbsp;Bruno Cavalini Cavenago,&nbsp;Marco Antônio Húngaro Duarte","doi":"10.5395/rde.2023.48.e15","DOIUrl":"https://doi.org/10.5395/rde.2023.48.e15","url":null,"abstract":"<p><strong>Objectives: </strong>This study evaluated the efficiency of WaveOne Primary files (Dentsply Sirona) for removing root canal fillings with 2 types of movement: reciprocating (RCP) and continuous counterclockwise rotation (CCR).</p><p><strong>Materials and methods: </strong>Twenty mandibular incisors were prepared with a RCP instrument (25.08) and filled using the Tagger hybrid obturation technique. The teeth were retreated with a WaveOne Primary file and randomly allocated to 2 experimental retreatment groups (<i>n</i> = 10) according to movement type: RCP and CCR. The root canals were emptied of filling material in the first 3 steps of insertion, until reaching the working length. The timing of retreatment and procedure errors were recorded for all samples. The specimens were scanned before and after the retreatment procedure with micro-computed tomography to calculate the percentage and volume (mm³) of the residual filling material. The results were statistically evaluated using paired and independent <i>t</i>-tests, with a significance level set at 5%.</p><p><strong>Results: </strong>No significant difference was found in the timing of filling removal between the groups, with a mean of 322 seconds (RCP) and 327 seconds (CCR) (<i>p</i> < 0.05). There were 6 instrument fractures: 1 in a RCP motion file and 5 in continuous rotation files. The volumes of residual filling material were similar (9.94% for RCP and 15.94% for CCR; <i>p</i> > 0.05).</p><p><strong>Conclusions: </strong>The WaveOne Primary files used in retreatment performed similarly in both RCP and CCR movements. Neither movement type completely removed the obturation material, but the RCP movement provided greater safety.</p>","PeriodicalId":21102,"journal":{"name":"Restorative Dentistry & Endodontics","volume":"48 2","pages":"e15"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b2/a5/rde-48-e15.PMC10240093.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9589932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of CBCT parameters on image quality and the diagnosis of vertical root fractures in teeth with metallic posts: an <i>ex vivo</i> study.","authors":"Larissa Pereira Lagos de Melo,&nbsp;Polyane Mazucatto Queiroz,&nbsp;Larissa Moreira-Souza,&nbsp;Mariana Rocha Nadaes,&nbsp;Gustavo Machado Santaella,&nbsp;Matheus Lima Oliveira,&nbsp;Deborah Queiroz Freitas","doi":"10.5395/rde.2023.48.e16","DOIUrl":"https://doi.org/10.5395/rde.2023.48.e16","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to evaluate the influence of peak kilovoltage (kVp) and a metal artifact reduction (MAR) tool on image quality and the diagnosis of vertical root fracture (VRF) in cone-beam computed tomography (CBCT).</p><p><strong>Materials and methods: </strong>Twenty single-rooted human teeth filled with an intracanal metal post were divided into 2 groups: control (<i>n</i> = 10) and VRF (<i>n</i> = 10). Each tooth was placed into the socket of a dry mandible, and CBCT scans were acquired using a Picasso Trio varying the kVp (70, 80, 90, or 99), and the use of MAR (with or without). The examinations were assessed by 5 examiners for the diagnosis of VRF using a 5-point scale. A subjective evaluation of the expression of artifacts was done by comparing random axial images of the studied protocols. The results of the diagnoses were analyzed using 2-way analysis of variance and the Tukey <i>post hoc</i> test, the subjective evaluations were compared using the Friedman test, and intra-examiner reproducibility was evaluated using the weighted kappa test (α = 5%).</p><p><strong>Results: </strong>The kVp and MAR did not influence the diagnosis of VRF (<i>p</i> > 0.05). According to the subjective classification, the 99 kVp protocol with MAR demonstrated the least expression of artifacts, while the 70 kVp protocol without MAR led to the most artifacts.</p><p><strong>Conclusions: </strong>Protocols with higher kVp combined with MAR improved the image quality of CBCT examinations. However, those factors did not lead to an improvement in the diagnosis of VRF.</p>","PeriodicalId":21102,"journal":{"name":"Restorative Dentistry & Endodontics","volume":"48 2","pages":"e16"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f5/20/rde-48-e16.PMC10240088.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9595283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of medium or high concentrations of in-office dental bleaching gel on the human pulp response in the mandibular incisors.","authors":"Douglas Augusto Roderjan,&nbsp;Rodrigo Stanislawczuk,&nbsp;Diana Gabriela Soares,&nbsp;Carlos Alberto de Souza Costa,&nbsp;Michael Willian Favoreto,&nbsp;Alessandra Reis,&nbsp;Alessandro D Loguercio","doi":"10.5395/rde.2023.48.e12","DOIUrl":"https://doi.org/10.5395/rde.2023.48.e12","url":null,"abstract":"<p><strong>Objectives: </strong>The present study evaluated the pulp response of human mandibular incisors subjected to in-office dental bleaching using gels with medium or high concentrations of hydrogen peroxide (HP).</p><p><strong>Materials and methods: </strong>The following groups were compared: 35% HP (HP35; <i>n</i> = 5) or 20% HP (HP20; <i>n</i> = 4). In the control group (CONT; <i>n</i> = 2), no dental bleaching was performed. The color change (CC) was registered at baseline and after 2 days using the Vita Classical shade guide. Tooth sensitivity (TS) was also recorded for 2 days post-bleaching. The teeth were extracted 2 days after the clinical procedure and subjected to histological analysis. The CC and overall scores for histological evaluation were evaluated by the Kruskal-Wallis and Mann-Whitney tests. The percentage of patients with TS was evaluated by the Fisher exact test (α = 0.05).</p><p><strong>Results: </strong>The CC and TS of the HP35 group were significantly higher than those of the CONT group (<i>p</i> < 0.05) and the HP20 group showed an intermediate response, without significant differences from either the HP35 or CONT group (<i>p</i> > 0.05). In both experimental groups, the coronal pulp tissue exhibited partial necrosis associated with tertiary dentin deposition. Overall, the subjacent pulp tissue exhibited a mild inflammatory response.</p><p><strong>Conclusions: </strong>In-office bleaching therapies using bleaching gels with 20% or 35% HP caused similar pulp damage to the mandibular incisors, characterized by partial necrosis, tertiary dentin deposition, and mild inflammation.</p>","PeriodicalId":21102,"journal":{"name":"Restorative Dentistry & Endodontics","volume":"48 2","pages":"e12"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/61/3f/rde-48-e12.PMC10240089.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9592683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of CTHRC1 on odontogenic differentiation and angiogenesis in human dental pulp stem cells.","authors":"Jong-Soon Kim,&nbsp;Bin-Na Lee,&nbsp;Hoon-Sang Chang,&nbsp;In-Nam Hwang,&nbsp;Won-Mann Oh,&nbsp;Yun-Chan Hwang","doi":"10.5395/rde.2023.48.e18","DOIUrl":"https://doi.org/10.5395/rde.2023.48.e18","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to determine whether collagen triple helix repeat containing-1 (CTHRC1), which is involved in vascular remodeling and bone formation, can stimulate odontogenic differentiation and angiogenesis when administered to human dental pulp stem cells (hDPSCs).</p><p><strong>Materials and methods: </strong>The viability of hDPSCs upon exposure to CTHRC1 was assessed with the WST-1 assay. CTHRC1 doses of 5, 10, and 20 µg/mL were administered to hDPSCs. Reverse-transcription polymerase reaction was used to detect dentin sialophosphoprotein, dentin matrix protein 1, vascular endothelial growth factor, and fibroblast growth factor 2. The formation of mineralization nodules was evaluated using Alizarin red. A scratch wound assay was conducted to evaluate the effect of CTHRC1 on cell migration. Data were analyzed using 1-way analysis of variance followed by the Tukey <i>post hoc</i> test. The threshold for statistical significance was set at <i>p</i> < 0.05.</p><p><strong>Results: </strong>CTHRC1 doses of 5, 10, and 20 µg/mL had no significant effect on the viability of hDPSCs. Mineralized nodules were formed and odontogenic markers were upregulated, indicating that CTHRC1 promoted odontogenic differentiation. Scratch wound assays demonstrated that CTHRC1 significantly enhanced the migration of hDPSCs.</p><p><strong>Conclusions: </strong>CTHRC1 promoted odontogenic differentiation and mineralization in hDPSCs.</p>","PeriodicalId":21102,"journal":{"name":"Restorative Dentistry & Endodontics","volume":"48 2","pages":"e18"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/68/a4/rde-48-e18.PMC10240092.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9595282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stem cell-derived exosomes for dentin-pulp complex regeneration: a mini-review.","authors":"Dina A Hammouda,&nbsp;Alaa M Mansour,&nbsp;Mahmoud A Saeed,&nbsp;Ahmed R Zaher,&nbsp;Mohammed E Grawish","doi":"10.5395/rde.2023.48.e20","DOIUrl":"https://doi.org/10.5395/rde.2023.48.e20","url":null,"abstract":"<p><p>This mini-review was conducted to present an overview of the use of exosomes in regenerating the dentin-pulp complex (DPC). The PubMed and Scopus databases were searched for relevant articles published between January 1, 2013 and January 1, 2023. The findings of basic <i>in vitro</i> studies indicated that exosomes enhance the proliferation and migration of mesenchymal cells, as human dental pulp stem cells, via mitogen-activated protein kinases and Wingless-Int signaling pathways. In addition, they possess proangiogenic potential and contribute to neovascularization and capillary tube formation by promoting endothelial cell proliferation and migration of human umbilical vein endothelial cells. Likewise, they regulate the migration and differentiation of Schwann cells, facilitate the conversion of M1 pro-inflammatory macrophages to M2 anti-inflammatory phenotypes, and mediate immune suppression as they promote regulatory T cell conversion. Basic <i>in vivo</i> studies have indicated that exosomes triggered the regeneration of dentin-pulp-like tissue, and exosomes isolated under odontogenic circumstances are particularly strong inducers of tissue regeneration and stem cell differentiation. Exosomes are a promising regenerative tool for DPC in cases of small pulp exposure or for whole-pulp tissue regeneration.</p>","PeriodicalId":21102,"journal":{"name":"Restorative Dentistry & Endodontics","volume":"48 2","pages":"e20"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/33/ca/rde-48-e20.PMC10240090.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9595286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dentinal tubule penetration of sodium hypochlorite in root canals with and without mechanical preparation and different irrigant activation methods.","authors":"Renata Aqel de Oliveira,&nbsp;Theodoro Weissheimer,&nbsp;Gabriel Barcelos Só,&nbsp;Ricardo Abreu da Rosa,&nbsp;Matheus Albino Souza,&nbsp;Rodrigo Gonçalves Ribeiro,&nbsp;Marcus Vinicius Reis Só","doi":"10.5395/rde.2023.48.e1","DOIUrl":"https://doi.org/10.5395/rde.2023.48.e1","url":null,"abstract":"<p><strong>Objectives: </strong>This study evaluated the dentinal penetration depth of 2.5% sodium hypochlorite (NaOCl) in root canals with and without preparation and different irrigant activation protocols.</p><p><strong>Materials and methods: </strong>Sixty-three bovine mandibular incisors were randomly allocated to 6 groups (<i>n</i> = 10): G1, preparation + conventional needle irrigation (CNI); G2, preparation + passive ultrasonic irrigation (PUI); G3, preparation + Odous Clean (OC); G4, no preparation + CNI; G5, no preparation + PUI; G6, no preparation + OC; and CG (negative control; <i>n</i> = 3). Samples were filled with crystal violet for 72 hours. Irrigant activation was performed. Samples were sectioned perpendicularly along the long axis, 3 mm and 7 mm from the apex. Images of the root thirds of each block were captured with a stereomicroscope and analyzed with an image analysis software. One-way analysis of variance, followed by the Tukey <i>post hoc</i> test, and the Student's <i>t</i>-test were used for data analysis, with a significance level of 5%.</p><p><strong>Results: </strong>The NaOCl penetration depth was similar when preparation was performed, regardless of the method of irrigation activation (<i>p</i> > 0.05). In the groups without preparation, G6 showed greater NaOCl penetration depth (<i>p</i> < 0.05). The groups without preparation had a greater NaOCl penetration depth than those with preparation (<i>p</i> = 0.0019).</p><p><strong>Conclusions: </strong>The NaOCl penetration depth was similar in groups with root canal preparation. Without root canal preparation, OC allowed deeper NaOCl penetration. The groups without preparation had greater NaOCl penetration than those undergoing root canal preparation.</p>","PeriodicalId":21102,"journal":{"name":"Restorative Dentistry & Endodontics","volume":"48 1","pages":"e1"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ee/64/rde-48-e1.PMC9982243.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9412778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Buckling resistance, torque, and force generation during retreatment with D-RaCe, HyFlex Remover, and Mtwo retreatment files.","authors":"Yoojin Kim,&nbsp;Seok Woo Chang,&nbsp;Soram Oh","doi":"10.5395/rde.2023.48.e10","DOIUrl":"https://doi.org/10.5395/rde.2023.48.e10","url":null,"abstract":"<p><strong>Objectives: </strong>This study compared the buckling resistance of 3 nickel-titanium (NiTi) retreatment file systems and the torque/force generated during retreatment.</p><p><strong>Materials and methods: </strong>The buckling resistance was compared among the D-RaCe (DR2), HyFlex Remover, and Mtwo R25/05 retreatment systems. J-shaped canals within resin blocks were prepared with ProTaper NEXT X3 and obturated by the single-cone technique with AH Plus. After 4 weeks, 4 mm of gutta-percha in the coronal aspect was removed with Gates-Glidden drills. Retreatment was then performed using DR1 (size 30, 10% taper) followed by DR2 (size 25, 4% taper), HyFlex Remover (size 30, 7% taper), or Mtrwo R25/05 (size 25, 5% taper) (15 specimens in each group). Further apical preparation was performed with WaveOne Gold Primary. The clockwise torque and upward force generated during retreatment were recorded. After retreatment, resin blocks were examined using stereomicroscopy, and the percentage of residual filling material in the canal area was calculated. Data were analyzed using 1-way analysis of variance with the Tukey test.</p><p><strong>Results: </strong>The HyFlex Remover files exhibited the greatest buckling resistance (<i>p</i> < 0.05), followed by the Mtwo R25/05. The HyFlex Remover and Mtwo R25/05 files generated the highest maximum clockwise torque and upward force, respectively (<i>p</i> < 0.05). The DR1 and DR2 files generated the least upward force and torque (<i>p</i> < 0.05). The percentage of residual filling material after retreatment was not significantly different between file systems (<i>p</i> > 0.05).</p><p><strong>Conclusions: </strong>NiTi retreatment instruments with higher buckling resistance generated greater clockwise torque and upward force.</p>","PeriodicalId":21102,"journal":{"name":"Restorative Dentistry & Endodontics","volume":"48 1","pages":"e10"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d8/44/rde-48-e10.PMC9982244.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10849946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of endodontic sealer on postoperative pain: a network meta-analysis.","authors":"Cynthia Maria Chaves Monteiro,&nbsp;Ana Cristina Rodrigues Martins,&nbsp;Alessandra Reis,&nbsp;Juliana Larocca de Geus","doi":"10.5395/rde.2023.48.e5","DOIUrl":"https://doi.org/10.5395/rde.2023.48.e5","url":null,"abstract":"<p><p>This systematic review and network meta-analysis aimed to answer the following focused research question: \"Does the type of endodontic sealer affect the postoperative pain in patients who received endodontic treatment?\" Different databases and grey literature were surveyed. Only one randomized controlled trial were included. The risk of bias in the studies was evaluated by using the Cochrane Collaboration's tool. A random-effects meta-analysis was conducted to compare the risk and intensity of postoperative pain. The quality of the body of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation approach. Out of 11,601 studies, 15 remained for qualitative analyses and 12 for meta-analysis. Seven studies were classified at high risk of bias, and 8 studies raised some concerns. No significant differences between the endodontic materials were observed in the direct comparisons, both in risk and in intensity of postoperative pain (pairwise comparisons with 2 studies: I² = 0%; <i>p</i> > 0.05 and 8 studies: I² = 23%; <i>p</i> > 0.05, respectively). The certainty of the evidence was graded as low or moderate. There was no difference in the risk and intensity of postoperative pain after filling with different endodontic sealers. Further systematic reviews should be conducted.</p><p><strong>Trial registration: </strong>PROSPERO Identifier: CRD42020215314.</p>","PeriodicalId":21102,"journal":{"name":"Restorative Dentistry & Endodontics","volume":"48 1","pages":"e5"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a7/83/rde-48-e5.PMC9982236.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10849943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}