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Reviews in Analytical Chemistry最新文献

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Chemometrical analysis of fingerprints for the detection of counterfeit and falsified medicines 用于检测假药和伪造药品的指纹化学计量分析
IF 4.3 3区 化学
Reviews in Analytical Chemistry Pub Date : 2016-12-01 DOI: 10.1515/revac-2016-0013
D. Custers, P. Courselle, S. Apers, E. Deconinck
{"title":"Chemometrical analysis of fingerprints for the detection of counterfeit and falsified medicines","authors":"D. Custers, P. Courselle, S. Apers, E. Deconinck","doi":"10.1515/revac-2016-0013","DOIUrl":"https://doi.org/10.1515/revac-2016-0013","url":null,"abstract":"Abstract Counterfeit medicines pose a major threat to public health worldwide. These pharmaceuticals are mostly manufactured without respecting Good Manufacturing Practices. Moreover, they are not subjected to any form of quality control, and therefore their safety, efficacy, and quality cannot be guaranteed. Extensive research on counterfeit medicines has already been performed and published in literature. This review aims at providing an updated overview of the use of fingerprints and subsequent multivariate (chemometrical) data analysis in the field of counterfeit medicine detection. Fingerprinting could be a useful tool in the analysis of counterfeit medicines because it generates a holistic view of a sample, rather than focusing on specific and predefined characteristics, such as identification and quantification of present active pharmaceutical ingredients. This review first provides an introduction into the counterfeiting problem. Next, the concept of fingerprinting and the basic principles of chemometrics are explained, followed by a description of the successful application of fingerprints in the field of Pharmacognosy. The last part of this review provides an overview describing the use of fingerprints in counterfeit medicine research.","PeriodicalId":21090,"journal":{"name":"Reviews in Analytical Chemistry","volume":"104 1","pages":"145 - 168"},"PeriodicalIF":4.3,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87589888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Electrochemical aptasensors for detection of small molecules, macromolecules, and cells 用于检测小分子、大分子和细胞的电化学适体传感器
IF 4.3 3区 化学
Reviews in Analytical Chemistry Pub Date : 2016-12-01 DOI: 10.1515/revac-2016-0009
Kun Han, Tao（刘涛） Liu, Yuanhong Wang, Peng Miao
{"title":"Electrochemical aptasensors for detection of small molecules, macromolecules, and cells","authors":"Kun Han, Tao（刘涛） Liu, Yuanhong Wang, Peng Miao","doi":"10.1515/revac-2016-0009","DOIUrl":"https://doi.org/10.1515/revac-2016-0009","url":null,"abstract":"Abstract Aptamers are a kind of special nucleic acids that have the ability to bind various targets (e.g. small molecules, macromolecules, and cells) with high affinity and specificity. As a type of efficient recognition component in analytical designs and applications, aptamers have gained intense achievements in the designs of biosensors. Especially, the past few years have witnessed the fast development of electrochemical aptasensors. In this mini-review, we summarize recent progresses in electrochemical biosensors based on aptamers. Different targets and the corresponding detection principles are introduced. The methods to enhance detectable signals are mentioned including the employment of nanomaterials. Also, some possible limitations and future perspectives are discussed.","PeriodicalId":21090,"journal":{"name":"Reviews in Analytical Chemistry","volume":"3 1","pages":"201 - 211"},"PeriodicalIF":4.3,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75985757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Separation and characterization of environmental nano- and submicron particles 环境纳米和亚微米颗粒的分离与表征
IF 4.3 3区 化学
Reviews in Analytical Chemistry Pub Date : 2016-12-01 DOI: 10.1515/revac-2016-0006
M. Ermolin, P. Fedotov
{"title":"Separation and characterization of environmental nano- and submicron particles","authors":"M. Ermolin, P. Fedotov","doi":"10.1515/revac-2016-0006","DOIUrl":"https://doi.org/10.1515/revac-2016-0006","url":null,"abstract":"Abstract The investigation of environmental nano- and submicron particles is needed for the assessment of their impact on the environment and human health as well as for understanding various natural and anthropogenic processes. Nano- and submicron particles have an increased mobility, may serve as a “carrier” for toxic and nutrient substances, and hence are of particular interest. So far, there is a lack of knowledge about source, behavior, fate, and toxicity of environmental nano- and submicron particles. This article is focused on the separation and characterization methods, which are currently used for their investigation. The application of sedimentation, centrifugation, membrane filtration, and field- and flow-based techniques to the separation of nano- and submicron particles are discussed. The advantages and limitations of the techniques are briefly summarized. Among characterization/analysis methods, a special attention is given to electron microscopy, light scattering as well as atomic absorption spectroscopy, optical emission, and mass spectrometry.","PeriodicalId":21090,"journal":{"name":"Reviews in Analytical Chemistry","volume":"45 1","pages":"185 - 199"},"PeriodicalIF":4.3,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74294578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Capillary electrophoresis-integrated immobilized enzyme reactors 毛细管电泳-一体化固定化酶反应器
IF 4.3 3区 化学
Reviews in Analytical Chemistry Pub Date : 2016-09-01 DOI: 10.1515/revac-2016-0003
Xiaoxia Liu, Jiqing Yang, Li Yang
{"title":"Capillary electrophoresis-integrated immobilized enzyme reactors","authors":"Xiaoxia Liu, Jiqing Yang, Li Yang","doi":"10.1515/revac-2016-0003","DOIUrl":"https://doi.org/10.1515/revac-2016-0003","url":null,"abstract":"Abstract Online enzyme assay based on capillary electrophoresis (CE) offers several advantages for the assay, such as low consumption of samples, easy automation of all steps, and less requirement of sample work-up. As a widely used approach for online enzyme assay, CE-integrated immobilized enzyme microreactor (IMER) has been applied in almost all aspects of enzyme assays during the past two decades, including evaluation of the enzymatic activity and kinetics, screening of inhibitor, investigation of enzyme-mediated metabolic pathways, and proteome analysis. In a CE-integrated IMER, enzyme is bound to the capillary surface or a suitable carrier attached to the capillary and substrates/products of the enzymatic reaction are separated and online detected by CE at downstream of the capillary. Enzymatic reactions can be viewed as interaction between the stationary phase (immobilized enzyme) and the mobile phase (substrate(s)/co-enzyme(s) solution), in analogy to the well-known separation technique, capillary electrochromatography. From this point of view, CE-integrated IMERs can be categorized into open tubular capillary IMER, monolithic IMER, and packed capillary IMER. In this review, we have surveyed, analyzed, and discussed advances on fabrication techniques of the three categories of CE-integrated IMERs for online assays involving various enzymes in the past two decades (1992–2015). Some recent studies using microfluidic-based IMERs for enzyme assays have also been reviewed.","PeriodicalId":21090,"journal":{"name":"Reviews in Analytical Chemistry","volume":"89 1","pages":"115 - 131"},"PeriodicalIF":4.3,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82513292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
Molecularly imprinting: a tool of modern chemistry for analysis and monitoring of phenolic environmental estrogens 分子印迹:分析和监测酚类环境雌激素的现代化学工具
IF 4.3 3区 化学
Reviews in Analytical Chemistry Pub Date : 2016-07-01 DOI: 10.1515/revac-2016-0005
Xiaoyu Xie, Yusi Bu, Sicen Wang
{"title":"Molecularly imprinting: a tool of modern chemistry for analysis and monitoring of phenolic environmental estrogens","authors":"Xiaoyu Xie, Yusi Bu, Sicen Wang","doi":"10.1515/revac-2016-0005","DOIUrl":"https://doi.org/10.1515/revac-2016-0005","url":null,"abstract":"Abstract Phenolic environmental estrogen (PEE) is one of the most common endocrine disrupting chemicals whose interference with the normal function of the endocrine system in animals and humans raised concern to their potential impact on wildlife and humans health. Research on PEEs calls for a high selectivity analytical methods. Molecularly imprinted polymers (MIPs) are synthetic polymers having a predetermined selectivity for a given analyte, or group of structurally related compounds, which make them ideal materials to be used in analysis of PEEs. During the past few years, a huge amount of papers have been published dealing with the use of MIPs in the analysis of PEEs. In this review, we focus on the recent applications of MIPs to analyze PEEs. We describe the preparation of MIPs and discuss different methods of polymerization. We highlight the latest applications of MIPs in the analysis of PEEs, including nanomaterial MIPs as sorbent for solid-phase extraction and MIPs as electrochemical sensors. This review provides a good platform for the analysis and monitoring of PEEs in complicated matrixes and offers suggestions for future success in the field of MIPs.","PeriodicalId":21090,"journal":{"name":"Reviews in Analytical Chemistry","volume":"11 1","pages":"87 - 97"},"PeriodicalIF":4.3,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82258886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Recent strategies to minimise fouling in electrochemical detection systems 电化学检测系统中最小化污垢的最新策略
IF 4.3 3区 化学
Reviews in Analytical Chemistry Pub Date : 2016-04-01 DOI: 10.1515/revac-2015-0008
Benjamin L. Hanssen, S. Siraj, D. Wong
{"title":"Recent strategies to minimise fouling in electrochemical detection systems","authors":"Benjamin L. Hanssen, S. Siraj, D. Wong","doi":"10.1515/revac-2015-0008","DOIUrl":"https://doi.org/10.1515/revac-2015-0008","url":null,"abstract":"Abstract Electrode fouling is a phenomenon that can severely affect the analytical characteristics of a technique or a sensor, such as sensitivity, detection limit, reproducibility, and overall reliability. Electrode fouling generally involves the passivation of an electrode surface by a fouling agent that forms an increasingly impermeable layer on the electrode, inhibiting the direct contact of an analyte of interest with the electrode surface for electron transfer. Some potential fouling agents include proteins, phenols, amino acids, neurotransmitters, and other biological molecules. Various antifouling strategies have been reported to reduce or eliminate electrode fouling. Most antifouling strategies exploit a protective layer or barrier on an electrode substrate to prevent the fouling agent from reaching the electrode surface. Although such strategies can be quite effective, they are inappropriate for systems in which the analyte itself is also the fouling agent. In such cases, other strategies must be used, including electrode surface modification and electrochemical activation. In this review, recent strategies to minimise and efforts to overcome electrode fouling across a diverse range of analytes and fouling agents will be presented.","PeriodicalId":21090,"journal":{"name":"Reviews in Analytical Chemistry","volume":"1 1","pages":"1 - 28"},"PeriodicalIF":4.3,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82802731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 167
Hyphenated differential mobility spectrometry for rapid separation and detection 用于快速分离和检测的连字符差分迁移度光谱法
IF 4.3 3区 化学
Reviews in Analytical Chemistry Pub Date : 2016-04-01 DOI: 10.1515/revac-2015-0017
Liu Yang, Qiang Han, S. Cao, Junchao Yang, Jiang Zhao, M. Ding
{"title":"Hyphenated differential mobility spectrometry for rapid separation and detection","authors":"Liu Yang, Qiang Han, S. Cao, Junchao Yang, Jiang Zhao, M. Ding","doi":"10.1515/revac-2015-0017","DOIUrl":"https://doi.org/10.1515/revac-2015-0017","url":null,"abstract":"Abstract This paper reviews hyphenated differential mobility spectrometry (DMS) technology. DMS is a type of ion mobility spectrometry (IMS) also called high-field asymmetric waveform IMS. It is widely used in the detection of chemical warfare agents, explosives, drugs, and volatile organic compounds. Stand-alone DMS analysis of complex mixtures in real-field applications is challenging. Hyphenated DMS can improve resolution for rapid separation and detection. This review focuses on hyphenated DMS, including gas chromatography-DMS, DMS-mass spectrometry (MS), DMS-IMS, IMS-DMS, and DMS-DMS, as well as their associated principles, applications, and research procedures. Key problems in hyphenated DMS are considered.","PeriodicalId":21090,"journal":{"name":"Reviews in Analytical Chemistry","volume":"94 1","pages":"29 - 40"},"PeriodicalIF":4.3,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79447169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Double electrode systems with microelectrode arrays for electrochemical measurements 电化学测量用微电极阵列双电极系统
IF 4.3 3区 化学
Reviews in Analytical Chemistry Pub Date : 2015-12-01 DOI: 10.1515/revac-2015-0012
Feng Zhu, B. Mao, Jiawei Yan
{"title":"Double electrode systems with microelectrode arrays for electrochemical measurements","authors":"Feng Zhu, B. Mao, Jiawei Yan","doi":"10.1515/revac-2015-0012","DOIUrl":"https://doi.org/10.1515/revac-2015-0012","url":null,"abstract":"Abstract Microelectrode arrays-based double electrode systems possess the property of diffusion layer overlapping between the two sets of electrodes. They have received increased attention in recent years in the field of electrochemistry and electroanalytical chemistry. This review introduces the fabrication, characterization, and applications of microelectrode arrays-based double electrode systems. The progress of photolithography enables and benefits microfabrication of the electrode systems with various geometries. As an essential step before electrochemical applications, various characterization methods are addressed to monitor the quality of the fabricated electrodes. Following that, applications as electrochemical sensors in generator-collector mode are discussed. Then, electrochemical sensors in bipolar mode, an interesting phenomenon existing in double electrode systems, are also introduced. Finally, applications of double electrode systems to the measurement of fundamentally electrochemical parameters are demonstrated.","PeriodicalId":21090,"journal":{"name":"Reviews in Analytical Chemistry","volume":"144 1","pages":"101 - 87"},"PeriodicalIF":4.3,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80414515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Proton pump inhibitors: recent developments in analytical methodologies 质子泵抑制剂:分析方法的最新发展
IF 4.3 3区 化学
Reviews in Analytical Chemistry Pub Date : 2015-10-01 DOI: 10.1515/revac-2014-0019
Mehul M. Patel, Satish D. Bhuva, Miketa M. Patel
{"title":"Proton pump inhibitors: recent developments in analytical methodologies","authors":"Mehul M. Patel, Satish D. Bhuva, Miketa M. Patel","doi":"10.1515/revac-2014-0019","DOIUrl":"https://doi.org/10.1515/revac-2014-0019","url":null,"abstract":"Abstract An extensive survey of the literature published in various analytical and pharmaceutical chemistry-related journals have been conducted, and the instrumental analytical methods that were developed and used for the determination of proton pump inhibitors in bulk drugs, formulations, and biological fluids have been reviewed. This review covers the time period from 1990 to 2011 during which 80 analytical methods, including all types of spectrophotometric and chromatographic techniques were reported. High-performance liquid chromatography (HPLC) with ultra violet (UV) detection was found to be the technique of choice for many workers, and more than 50 methods were based on liquid chromatography (LC) and ultra violet (UV). A critical analysis of the reported data was carried out and the present state of the art of the analytical techniques for the determination of omeprazole, esomeprazole, pantoprazole, rabeprazole, dexrabeprazole, tenatoprazole, lansoprazole, and dexlansoprazole is discussed.","PeriodicalId":21090,"journal":{"name":"Reviews in Analytical Chemistry","volume":"os8 1","pages":"29 - 43"},"PeriodicalIF":4.3,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88402270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Biosensing using hairpin DNA probes 利用发夹式DNA探针进行生物传感
IF 4.3 3区 化学
Reviews in Analytical Chemistry Pub Date : 2015-10-01 DOI: 10.1515/revac-2015-0010
Jiahao Huang, Jueqi Wu, Zhigang Li
{"title":"Biosensing using hairpin DNA probes","authors":"Jiahao Huang, Jueqi Wu, Zhigang Li","doi":"10.1515/revac-2015-0010","DOIUrl":"https://doi.org/10.1515/revac-2015-0010","url":null,"abstract":"Abstract Hairpin DNA probes (HDPs) are specially designed single-stranded DNA and have excellent sensing specificity. The past decade has witnessed the fast development of HDP-based biosensors due to the tremendous applications in biology, medicine, environmental science, and engineering. Their detectable targets include nucleic acids, proteins, small molecules, and metal ions. In this review, we summarize the recent progress in HDP-based biosensors by categorizing them into molecular beacon (MB)-based sensing in homogeneous systems and other HDP-based solid-state sensors. The basic design of MBs with diverse signaling pairs is introduced first. Then, various detectable targets and the detection principles of all HDP-based biosensors are extensively discussed. Furthermore, the methods for amplifying the response signal and improving the detection performance are covered. Finally, the limitations and possible solutions about the sensors are discussed.","PeriodicalId":21090,"journal":{"name":"Reviews in Analytical Chemistry","volume":"8 1","pages":"1 - 27"},"PeriodicalIF":4.3,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81034298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
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