Resuscitation最新文献

{"title":"Temporal Dynamics of Neural Synchrony and Complexity of Auditory EEG Responses in Post-Hypoxic Ischemic Coma.","authors":"Sigurd L Alnes, Florence M Aellen, Thomas Rusterholz, Andria Pelentritou, Matthias Hänggi, Andrea O Rossetti, Frédéric Zubler, Marzia De Lucia, Athina Tzovara","doi":"10.1016/j.resuscitation.2025.110531","DOIUrl":"https://doi.org/10.1016/j.resuscitation.2025.110531","url":null,"abstract":"<p><p>The capacity to integrate information across brain regions and sufficient diversity of neural activity is necessary for consciousness. In patients in a post-hypoxic ischemic coma, the integrity of the auditory processing network is indicative of chances of regaining consciousness. However, our understanding of how measures of integration and differentiation of auditory responses manifest across time of coma is limited. We investigated the temporal evolution of neural synchrony of auditory-evoked electroencephalographic (EEG) responses, measured via their phase-locking value (PLV), and of their neural complexity in unconscious post-hypoxic ischemic comatose patients. Our results show that the PLV was predictive of chances to regain consciousness within the first 40 hours post-cardiac arrest, while its predictive value diminished over subsequent time after coma onset. This was due to changing trajectories of PLV over time of coma for non-survivors, while survivors had stable PLV. The complexity of EEG responses was not different between patients who regained consciousness and those who did not, but it significantly diminished over time of coma, irrespective of the patient's outcome. Our findings provide novel insights on the optimal temporal window for assessing auditory functions in post-hypoxic ischemic coma. They are of particular importance for guiding the implementation of quantitative techniques for prognostication and contribute to an evolving understanding of neural functions within the acute comatose state.</p>","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":" ","pages":"110531"},"PeriodicalIF":6.5,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increasing CPR awareness in Europe through EURO 2024: Lessons from \"Get Trained Save Lives.","authors":"Carsten Lott, Zoran Bahtijarević, Peter Klomp, Evert Verhagen, Jan Van Dooren, Federico Semeraro","doi":"10.1016/j.resuscitation.2025.110532","DOIUrl":"https://doi.org/10.1016/j.resuscitation.2025.110532","url":null,"abstract":"","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":" ","pages":"110532"},"PeriodicalIF":6.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Interventions in Prehospital and In-hospital Settings and Outcomes for Out-of-Hospital Cardiac Arrest Patients Meeting the Termination of Resuscitation Rule in Japan: A Nationwide Database Study (The JAAM-OHCA Registry).","authors":"Tadaharu Shiozumi, Tasuku Matsuyama, Norihiro Nishioka, Takeyuki Kiguchi, Tetsuhisa Kitamura, Bon Ohta, Taku Iwami","doi":"10.1016/j.resuscitation.2025.110530","DOIUrl":"https://doi.org/10.1016/j.resuscitation.2025.110530","url":null,"abstract":"<p><strong>Background: </strong>Out-of-hospital cardiac arrest (OHCA) is a global health burden with low survival rates. The termination of resuscitation (TOR) rule, widely adopted internationally, aims to preserve dignity, optimize resources, and protect healthcare providers. However, prehospital TOR is not implemented in Japan, presenting legal and practical challenges. This study analyzes temporal trends in prehospital and in-hospital interventions for OHCA patients with poor predicted outcomes.</p><p><strong>Methods: </strong>This retrospective study analyzed data from the Japanese Association for Acute Medicine Out-of-Hospital Cardiac Arrest (JAAM-OHCA) registry (June 2014- December 2021). Adult OHCA patients with medical causes were included if they fulfilled all the advanced life support (ALS) TOR rule criteria: unwitnessed arrest, no return of spontaneous circulation, no bystander-initiated cardiopulmonary resuscitation, and no automated external defibrillator use or defibrillation. Prehospital and in-hospital interventions were evaluated.</p><p><strong>Results: </strong>Among 11,334 patients meeting the inclusion criteria, 2,447 received all three ALS interventions (advanced airway management, intravenous access, and epinephrine administration). Over time, in-hospital interventions, including endotracheal intubation (56%) and epinephrine administration (82%), decreased, while advanced therapies, including coronary angiography, extracorporeal membrane oxygenation, and targeted temperature management, remained rare (<1%). The median time to TOR after hospital arrival shortened to 18 minutes. In contrast, prehospital epinephrine administration increased, while advanced airway management and intravenous access decreased.</p><p><strong>Conclusions: </strong>OHCA patients who met TOR rule showed a decrease in in-hospital interventions. Further efforts are warranted to avoid futile medical treatments and promote patient-centered care.</p>","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":" ","pages":"110530"},"PeriodicalIF":6.5,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"There may be more to this than meets the eye: Hospital performance and racial disparities in neurological outcome after out-of-hospital cardiac arrest.","authors":"Robert Larribau, Antoine Sigaux","doi":"10.1016/j.resuscitation.2025.110527","DOIUrl":"https://doi.org/10.1016/j.resuscitation.2025.110527","url":null,"abstract":"","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":" ","pages":"110527"},"PeriodicalIF":6.5,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring Intra-Arrest Transport in Out-of-Hospital Cardiac Arrest: A Methodological Study of Registry-Compatible Definitions.","authors":"Judah A Kreinbrook, Joshua M Kimbrell, Dheuris Rodriguez, Jacob Stebel, Maria Rampersaud, Brittany Kalosza, Dana Poke, Aditya C Shekhar, Andrew Miele, Brian Grunau, John Vega","doi":"10.1016/j.resuscitation.2025.110529","DOIUrl":"https://doi.org/10.1016/j.resuscitation.2025.110529","url":null,"abstract":"<p><strong>Introduction: </strong>For out-of-hospital cardiac arrest (OHCA) with refractory arrest, transport to hospital with ongoing cardiopulmonary resuscitation (CPR)-\"intra-arrest transport (IAT)\"-is a treatment option, however it may reduce resuscitation quality. Unfortunately, international registries do not measure IAT directly, but other variables may be used to estimate IAT. We compared three indirect definitions to a direct measurement of IAT.</p><p><strong>Methods: </strong>We included advanced life support-treated adult non-traumatic OHCA from a large metropolitan emergency medical services network (2021-2023). We reviewed prehospital records and cardiac monitor files to identify IAT, defined as CPR in progress at time of transport. We compared this to three indirect definitions, including transport prior to: (1) \"Any ROSC\"; (2) \"Sustained ROSC\" (≥20 minutes or present at ED); or, (3) \"Post-ROSC Vitals\" (1st blood pressure/12-lead ECG.) RESULTS: Of 1,269 cases, the median age was 71.0 (60.0-81.0), 523 (41%) were female, 128 (10%) had initial shockable rhythms, 336 (26) achieved ROSC on scene and were transported (75 of 200 [38%] with available data experienced rearrest on scene). Overall, 472 (37%, 95% CI: 34% - 40%) received IAT (direct definition). Indirect definitions of \"Any ROSC\", \"Sustained ROSC\", and \"Post-ROSC Vitals\" demonstrated sensitivity and specificities of 78.0%/100.0%, 98.5%/97.0%, and 82.4%/97.6%, respectively.</p><p><strong>Conclusion: </strong>Compared to a direct measurement of IAT, the indirect definition using \"Any ROSC\" demonstrated the lowest sensitivity; however, the definition using \"Sustained ROSC\" showed the highest sensitivity and specificity. These indirect definitions may support estimation of IAT within future research and quality initiatives.</p>","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":" ","pages":"110529"},"PeriodicalIF":6.5,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of AI tools for disseminating CPR guidelines: Implications for cardiac arrest education","authors":"Federico Semeraro,&nbsp;Marco Cascella,&nbsp;Jonathan Montomoli,&nbsp;Valentina Bellini,&nbsp;Elena Giovanna Bignami","doi":"10.1016/j.resuscitation.2025.110528","DOIUrl":"10.1016/j.resuscitation.2025.110528","url":null,"abstract":"","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":"208 ","pages":"Article 110528"},"PeriodicalIF":6.5,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the complexities of ECPR outcomes in infants with single ventricle physiology","authors":"Morgann Loaec,&nbsp;Ryan W. Morgan","doi":"10.1016/j.resuscitation.2025.110522","DOIUrl":"10.1016/j.resuscitation.2025.110522","url":null,"abstract":"","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":"207 ","pages":"Article 110522"},"PeriodicalIF":6.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted mild hypercapnia and acute kidney failure after cardiac arrest: Lessons from the TAME trial","authors":"Jean-Baptiste Lascarrou,&nbsp;Emmanuel Canet","doi":"10.1016/j.resuscitation.2025.110505","DOIUrl":"10.1016/j.resuscitation.2025.110505","url":null,"abstract":"","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":"207 ","pages":"Article 110505"},"PeriodicalIF":6.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Get that AED out! The circadian dilemma of public access defibrillation","authors":"Guglielmo Imbriaco,&nbsp;Jacopo Davide Giamello,&nbsp;Donatella Del Giudice,&nbsp;Federico Semeraro","doi":"10.1016/j.resuscitation.2025.110514","DOIUrl":"10.1016/j.resuscitation.2025.110514","url":null,"abstract":"","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":"207 ","pages":"Article 110514"},"PeriodicalIF":6.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143041663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rediscovery of acute lung injury in cardiac arrest: Breathing fresh air into a neglected component of the post-cardiac arrest syndrome","authors":"Willard W. Sharp,&nbsp;Lin Piao","doi":"10.1016/j.resuscitation.2025.110495","DOIUrl":"10.1016/j.resuscitation.2025.110495","url":null,"abstract":"","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":"207 ","pages":"Article 110495"},"PeriodicalIF":6.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}