手动加压对经胸阻抗的影响：猪和健康人类志愿者心室颤动期间的实时测量

IF 6.5 1区医学 Q1 CRITICAL CARE MEDICINE

Resuscitation Pub Date : 2025-07-18 DOI:10.1016/j.resuscitation.2025.110730

Aurora Magliocca, Giulia Merigo, Davide Zani, Francesca Fumagalli, Giuseppe Ristagno, UniMI-IRFMN Study Group, Daria De Giorgio, Chiara Crivellari, Cristina Dulama, Alessandra Rosati, Antonio Boccardo, Donatella De Zani, Davide Pravettoni

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引用次数: 0

摘要

心肺复苏过程中的手动压力增强（MPA）包括在休克递送过程中对除颤器施加向下的力，以减少经胸阻抗（TTI）并提高除颤成功率。这项转化研究是第一个直接和连续测量MPA对猪心室颤动模型和健康人类志愿者TTI影响的研究。当垫块应用于前侧位时，MPA显著降低TTI，即使在MPA释放后，TTI值仍然较低。这些发现支持了MPA作为提高除颤疗效的潜在策略的生理学原理，值得进一步研究其临床安全性。

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Effect of manual pressure augmentation on transthoracic impedance: a real-time measurement during ventricular fibrillation in pigs and in healthy human volunteers

Manual pressure augmentation (MPA) during cardiopulmonary resuscitation involves applying downward force on defibrillatory pads during shock delivery to reduce transthoracic impedance (TTI) and enhance defibrillation success. This translational study is the first to directly and continuously measure the effect of MPA on TTI in a porcine ventricular fibrillation model and in healthy human volunteers. MPA significantly reduced TTI when pads were applied in the anterior-lateral position, with values remaining lower even after MPA release. These findings support the physiological rationale for MPA as a potential strategy to improve defibrillation efficacy, warranting further investigation into its clinical safety.

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来源期刊

Resuscitation 医学-急救医学

CiteScore

12.00

自引率

18.50%

发文量

556

审稿时长

21 days

期刊介绍： Resuscitation is a monthly international and interdisciplinary medical journal. The papers published deal with the aetiology, pathophysiology and prevention of cardiac arrest, resuscitation training, clinical resuscitation, and experimental resuscitation research, although papers relating to animal studies will be published only if they are of exceptional interest and related directly to clinical cardiopulmonary resuscitation. Papers relating to trauma are published occasionally but the majority of these concern traumatic cardiac arrest.