Radiology and Oncology最新文献

{"title":"The role of focal adhesion kinase in bladder cancer: translation from <i>in vitro</i> to <i>ex vivo</i> human urothelial carcinomas.","authors":"Gaja Markovic, Natasa Resnik, Aleksandar Janev, Dasa Zupancic, Gasper Grubelnik, Marusa Debeljak, Maja Cemazar, Tanja Jesenko, Masa Omerzel, Tomaz Smrkolj, Mateja Erdani Kreft","doi":"10.2478/raon-2025-0052","DOIUrl":"10.2478/raon-2025-0052","url":null,"abstract":"<p><strong>Background: </strong>Focal adhesion kinase (FAK), a cytoplasmic tyrosine kinase, plays a crucial role in focal adhesion turnover by interfacing between the extracellular space, transmembrane integrins, and actin filaments. Its significance for the progression of several malignancies, including bladder cancer, has been well-documented. However, its precise role and the implications of its inhibition in bladder cancer tissues and urothelial <i>in vitro</i> models has not been fully explored. This study examined FAK expression and function in human bladder cancer biopsies and <i>in vitro</i> bladder cancer models.</p><p><strong>Materials and methods: </strong><i>Ex vivo</i> analyses were performed using reverse transcription-quantitative PCR (qRT-PCR), western blotting, and immunohistochemistry to compare FAK expression between bladder cancer tissues and adjacent normal tissues. <i>In vitro</i>, FAK expression was assessed in low-grade (LG) human non-invasive papilloma urothelial cell line RT4 for NMIBC (Ta), high-grade (HG) human muscle-invasive cancer urothelial cell line T24 for MIBC (T2) and normal porcine urothelial (NPU) cells using qRT-PCR and western blotting, as well as flow cytometry for the quantification of FAK-positive RT4 and T24 cells. The role of FAK in cancer cell survival was explored <i>in vitro</i> using microRNA (miRNA) to silence FAK expression. Additionally, we used FAK inhibitors PND-1186, PF-573228 and defactinib to investigate the effects of FAK inhibition on normal compared to cancerous bladder urothelial cells.</p><p><strong>Results: </strong><i>Ex vivo</i> analyses demonstrated significantly higher FAK expression in bladder cancer tissues compared to adjacent normal tissues. Similarly, <i>in vitro</i> analyses showed significantly higher FAK expression in RT4 and T24 cells than NPU cells. Silencing FAK using anti-FAK plasmids led to increased caspase-3-mediated apoptosis of RT4 and T24 cells and growth reduction of stably transfected T24 cells. Importantly, based on cell viability assays, treatment with 100 μM defactinib for 2 hours per day on 3 consecutive days was identified as a clinically relevant regimen. Under this treatment, the viability of differentiated NPU cells remained high at 108.4 ± 17.1%, while the viability of 2-day RT4 and 2-day T24 cells was drastically reduced to 4.1 ± 2.7% and 7.6 ± 2.9%, respectively.</p><p><strong>Conclusions: </strong>To our knowledge, this is the first report demonstrating the role of FAK and its inhibition across both normal and cancerous bladder urothelial models. This study highlights the critical role of FAK in the progression of human bladder cancer and establishes a foundation for exploring FAK inhibition as a potential therapeutic approach in bladder cancer treatment.</p>","PeriodicalId":21034,"journal":{"name":"Radiology and Oncology","volume":"59 3","pages":"349-367"},"PeriodicalIF":2.2,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12441887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The implementation of a robotic surgical platform for the treatment of patients with malignant or pre-malignant pancreatic tumors at the University Medical Center Ljubljana.","authors":"Miha Petric, Patricio Marcelo Polanco, Jan Grosek, Ales Tomazic, Blaz Trotovsek, Bostjan Plesnik","doi":"10.2478/raon-2025-0051","DOIUrl":"10.2478/raon-2025-0051","url":null,"abstract":"<p><strong>Background: </strong>Robotic platforms are increasingly employed in the field of minimally invasive pancreatic surgery. It is essential to develop an innovative method that ensures both safety and efficacy, producing outcomes comparable to those of established treatment modalities. Implementation process should incorporate surgical science, education, local implementation, and non-technical skills. In our study, we describe the safe implementation of a robotic platform in pancreatic surgery within our medical institution.</p><p><strong>Patients and methods: </strong>We analysed prospectively collected data from the first ten consecutive robotic-assisted distal pancreatectomies (RDP) and pancreatoduodenectomies (RPD). Due to nature of the study basic statistical analysis were performed.</p><p><strong>Results: </strong>The mean operating time was 211minutes (±49.4) for RDP and 365 minutes (±69.6) for RPD, with blood loss 330 mL for RDP and 195 mL for RPD. Hospital stay was 8.7 days (±3.9) in RDP and 7.9 days (±3.9) in RPD. One patient (10%) in the RDP group developed clinically relevant postoperative pancreatic fistula (CR-POPF) and delayed gastric emptying (DGE). The mean tumour size was 31 mm (±9.8) in the RDP and 27 mm (±7.5) in the RPD. The mean number of lymph nodes harvested was 6 (0-24) in the RDP and 15 (6-22) in the RPD. The R0 resection rate was 60% in the RDP and 70% in the RPD.</p><p><strong>Conclusions: </strong>Robotic surgical technology can be safely and effectively integrated into a clinical setting. This integration should be facilitated through a well-established training program and curriculum. Nonetheless, patient selection is important, especially in the early phases of robotic program development.</p>","PeriodicalId":21034,"journal":{"name":"Radiology and Oncology","volume":"59 3","pages":"425-434"},"PeriodicalIF":2.2,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12441891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the impact of waste co-incineration at the Anhovo cement plant (Slovenia) on the regional cancer burden.","authors":"Vesna Zadnik, Mojca Birk, Teja Oblak, Maja Jurtela, Sonja Tomsic, Katarina Lokar, Ana Mihor, Nika Bric, Miran Mlakar, Amela Duratovic Konjevic, Tina Zagar","doi":"10.2478/raon-2025-0050","DOIUrl":"10.2478/raon-2025-0050","url":null,"abstract":"<p><strong>Background: </strong>This epidemiological study aims to assess the cancer risk potentially associated with environmental exposure resulting from cement production and waste co-incineration at the Anhovo cement plant in Western Slovenia and to develop a strong and reliable methodological framework for the long-term surveillance of environmentally related cancer risks in small geographical areas.</p><p><strong>Materials and methods: </strong>We integrated all the available data sources: cancer cases from the population-based Slovenian Cancer Registry; background population; and available measurements on exposure to air PM₁₀ particles and chromium (Cr) in the soil in the municipality of Kanal and the wider Goriška region. Relative risks of cancer in small geographical areas were estimated using Bayesian hierarchical spatial models and the population attributable fractions of the modelled risk factors were calculated. The point source analysis compared the cancer risk near the cement plant to that in more distant areas.</p><p><strong>Results: </strong>The analysis did not reveal any excess cancer incidence in the area of the Anhovo cement plant or an association with the PM₁₀ particles and Cr in the soil. The incidence of mesothelioma remains high in the region, but stable in the last two decades.</p><p><strong>Conclusions: </strong>In view of the environmental pollution caused by either historical cement production or the potential impact of current waste co-incineration activities in Kanal, we strongly recommend that a follow-up epidemiological study be carried out in the next 10 to 20 years. The methodological framework established in the present study provides a foundation for the ongoing surveillance of the cancer burden in the region.</p>","PeriodicalId":21034,"journal":{"name":"Radiology and Oncology","volume":"59 3","pages":"412-424"},"PeriodicalIF":2.2,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12441888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation-induced impairment of skeletal muscle regeneration.","authors":"Maja Cemazar, Mihaela Jurdana","doi":"10.2478/raon-2025-0048","DOIUrl":"10.2478/raon-2025-0048","url":null,"abstract":"<p><strong>Background: </strong>Radiotherapy is a cornerstone of treatment for various cancers, but often causes collateral damage to surrounding healthy tissue, including skeletal muscle. Ionizing radiation leads to oxidative stress and inflammation, which impairs the regenerative capacity of muscle tissue. Irradiation reduces the number and functionality of satellite cells and disrupts the tightly regulated processes of myogenesis and tissue remodelling. In addition, irradiation alters the muscle microenvironment by promoting fibrosis and vascular damage, which further impedes effective regeneration. Cytokine signalling pathways are also dysregulated following irradiation, contributing to impaired activation and differentiation of satellite cells.</p><p><strong>Conclusions: </strong>There is evidence that factors such as melatonin and growth factors can improve muscle regeneration. Understanding the molecular and cellular mechanisms underlying the impairment of muscle regeneration after radiotherapy is crucial for the development of targeted strategies to mitigate side effects and improve patients' quality of life. Overall, the preservation and restoration of muscle function in irradiated tissue remains a critical challenge that requires multidisciplinary approaches.</p>","PeriodicalId":21034,"journal":{"name":"Radiology and Oncology","volume":"59 3","pages":"293-300"},"PeriodicalIF":2.2,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12441890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic variability of <i>HIF1A</i> and response to treatment with cisplatin in combination with pemetrexed or gemcitabine in patients with malignant mesothelioma.","authors":"Matic Setina, Eva Setina, Ziga Doljak, Katja Goricar, Vita Dolzan, Viljem Kovac","doi":"10.2478/raon-2025-0049","DOIUrl":"10.2478/raon-2025-0049","url":null,"abstract":"<p><strong>Background: </strong>Treatment of malignant mesothelioma (MM) still relies on chemotherapy with cisplatin in combination with pemetrexed or other drugs. Studies indicate that hypoxic conditions within tumour tissue may reduce responsiveness to cisplatin-based chemotherapy. Hypoxia-inducible factors (HIF) play an important role in regulation of cellular adaptation to hypoxia. The aim of our study was to investigate single nucleotide polymorphisms (SNPs) in the <i>HIF1A</i> gene coding for the regulatory alpha subunit (HIF-1A) and their role in the response to chemotherapy in patients with MM.</p><p><strong>Patients and methods: </strong>Our retrospective genetic association study included 234 patients with MM, who were treated with a combination of cisplatin/pemetrexed or cisplatin/gemcitabine at the Institute of Oncology Ljubljana between January 2001 and September 2018. Selected <i>HIF1A</i> SNPs (rs1154965, rs11549467, and rs2057482) were genotyped using the competitive allele-specific polymerase chain reaction (KASP). Additionally, we used a TaqMan assay for independent confirmation of rs11549465 genotyping results. The impact of the SNPs on response to chemotherapy was analysed using logistic regression. For survival analysis, we used the Kaplan-Meier method and Cox regression.</p><p><strong>Results: </strong>In heterozygotes with the <i>HIF1A</i> rs11549465 CT genotype, response to chemotherapy was significantly worse compared to homozygotes with the CC genotype, but only after adjustment for weight loss and CRP (RO_adj = 0.37; 95% CI = 0.14-0.97; P_adj = 0.044). <i>HIF1A</i> rs11549467 and rs2057482 were not associated with response to chemotherapy (all P > 0.05). None of the investigated SNPs were associated with progression-free survival or overall survival (all P > 0.05).</p><p><strong>Conclusions: </strong>Among the investigated <i>HIF1A</i> SNPs, only rs11549465 has showed association with a worse response to chemotherapy after the adjustment for clinical parameters. The findings of this study have improved our understanding of the role of <i>HIF1A</i> polymorphisms in MM and may offer valuable insights into their impact on other cancers as well.</p>","PeriodicalId":21034,"journal":{"name":"Radiology and Oncology","volume":"59 3","pages":"403-411"},"PeriodicalIF":2.2,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12441883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does volume change of the spleen correlate with the therapy response in uveal melanoma patients with liver metastases undergoing hepatic artery infusion chemotherapy?","authors":"Hannah Luisa Steinberg-Vorhoff, Marcel Drews, Marcel Opitz, Natalie van Landeghem, Luca Salhöfer, Mathias Holtkamp, Yan Li, Johannes Haubold, Jens Siveke, Heike Richly, Michael Forsting, Benedikt Michael Schaarschmidt, Sebastian Zensen","doi":"10.2478/raon-2025-0047","DOIUrl":"10.2478/raon-2025-0047","url":null,"abstract":"<p><strong>Background: </strong>Uveal melanoma (UM) patients with liver metastases often undergo hepatic artery infusion therapy (HAIC). Due to diffuse metastatic spread in the liver, patients often develop hepatomegaly and secondary, portal hypertension which may lead to splenomegaly. This study aimed to compare spleen volumetry and the change of spleen volume (SV) for the evaluation of HAIC treatment response.</p><p><strong>Patients and methods: </strong>In this study, 179 UM patients (mean age 64.8 ± 11.0y, 53% female) with liver metastases undergoing HAIC were included. Treatment response was analyzed by RECIST 1.1 and SV on CT imaging before and after first HAIC. The correlation of change in spleen and liver volume was analyzed with Spearman test. Overall survival (OS) was calculated as the time from the first HAIC to patient death using Kaplan-Meier test and multivariate analysis was performed for RECIST 1.1 and SV.</p><p><strong>Results: </strong>In the study population, OS was 13.8 months (95% CI 10.6-14.7 months). Change in SV before and after first HAIC was +4% (interquartile range [IQR] -4.0%-12.0%, p = 0.49) and showed a weak correlation with OS (r = -0.11, p = 0.18). UM patients with progressive disease (PD) according to RECIST 1.1 showed an increase in SV compared to patients with stable disease (SD) (p = 0.04). Compared to RECIST 1.1, SV was not significant prognostic factor that can identify a change in OS.</p><p><strong>Conclusions: </strong>In uveal melanoma patients with liver metastases undergoing HAIC, neither the change of SV nor splenomegaly could be identified as prognostic factors for OS.</p>","PeriodicalId":21034,"journal":{"name":"Radiology and Oncology","volume":"59 3","pages":"383-390"},"PeriodicalIF":2.2,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12441889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of MR cytometry methods in predicting immunohistochemical factor status and molecular subtypes of breast cancer.","authors":"Lei Wu, Fan Liu, Sisi Li, Xinyi Luo, Yishi Wang, Wen Zhong, Thorsten Feiweier, Junzhong Xu, Haihua Bao, Diwei Shi, Hua Guo","doi":"10.2478/raon-2025-0044","DOIUrl":"10.2478/raon-2025-0044","url":null,"abstract":"<p><strong>Background: </strong>First evaluation of the performance of MR cytometry incorporating transcytolemmal water exchange in predicting immunohistochemical factor status and molecular subtypes of breast cancer.</p><p><strong>Patients and methods: </strong>We prospectively enrolled 90 breast cancer patients in the study. For each participant, pulsed gradient spin-echo (PGSE) with diffusion time of 70 ms and oscillating gradient spin-echo (OGSE) diffusion-weighted imaging of 25 Hz and 50 Hz were performed on a 3T MRI scanner. Time-dependent apparent diffusion coefficients (ADC) and microstructural parameters including cell diameter <b><i>d</i></b> , intracellular volume fraction <b><i>v_in</i> </b> , water exchange rate constant <b><i>k_in</i> </b> , and apparent extracellular diffusivity <b><i>D_ex</i> </b> were calculated. Single- and multi-variable logistic regression analyses were performed to evaluate their performance in identifying immunohistochemistry (IHC) factor status and molecular subtypes. The area under the receiver operating characteristic curve (AUC) was computed.</p><p><strong>Results: </strong>The multi-variable regression models generated from MR cytometry-derived metrics provided higher AUC compared to those from time-dependent ADC metrics, <i>i.e</i>. 0.744 <i>vs</i>. 0.645 for estrogen receptor (ER), 0.727 <i>vs</i>. 0.688 for progesterone receptor (PR), 0.734 <i>vs</i>.0.623 for HER2, and 0.679 <i>vs</i>. 0.633 for Ki67, 0.751 <i>vs</i>. 0.644 for Triple-Negative Breast Cancer (TNBC), 0.819 <i>vs</i>. 0.765 for HER2-enriched, 0.730 <i>vs</i>. 0.659 for Luminal A, 0.633 <i>vs</i>. 0.633 for Luminal B. MR cytometry with transcytolemmal water exchange (JOINT and EXCHANGE) outperformed the original one with the impermeable model (IMPULSED) in predicting PR (0.727 <i>vs</i>. 0.705), HER2 (0.734 <i>vs</i>. 0.689), Ki67 (0.679 <i>vs</i>. 0.646), TNBC (0.751 <i>vs</i>. 0.748) and HER2-enriched (0.819 <i>vs</i>. 0.739), Luminal A (0.730 <i>vs</i>. 0.666), Luminal B (0.633 <i>vs</i>. 0.630).</p><p><strong>Conclusions: </strong>MR cytometry outperformed conventional ADC measurements in clinical breast cancer subtyping. Incorporating transcytolemmal water exchange further enhanced classification accuracy.</p>","PeriodicalId":21034,"journal":{"name":"Radiology and Oncology","volume":" ","pages":"337-348"},"PeriodicalIF":2.2,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12441884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of hub genes predicting sensitivity to neoadjuvant chemoradiation in locally advanced rectal cancer.","authors":"Qunye Zhao, Chuang Zhang, Xiaotain Zhang, Yanlong Liu, Binbin Cui","doi":"10.2478/raon-2025-0005","DOIUrl":"10.2478/raon-2025-0005","url":null,"abstract":"<p><strong>Background: </strong>Preoperative neoadjuvant chemoradiation (NACR) benefits disease control in most locally advanced rectal cancer (LARC) patients. However, effective biomarkers predicting response to NACR are still not accessible. This study aimed to find potential biomarkers to assess therapy response and susceptibility to LARC.</p><p><strong>Materials and methods: </strong>Differentially expressed genes (DEGs) between NACR-sensitive and resistant patients were screened using GEO database. STRING and Cytoscape were utilized to construct PPI networks and identify hub genes. Based on CIBERSORT, TCGA, GTEx, GSEA and ROC curves, the connections between hub genes and specific signaling pathways, immune cell infiltration, prognosis value and miRNA-transcription factor (TF)-target network were investigated. Human Protein Atlas (HPA) database was used to visualize hub gene expression in clinical samples.</p><p><strong>Results: </strong>We identified 2619 up- and 2466 down-regulated genes between NACR-sensitive and resistant patients. The up-regulated DEGs were searched for highly expressed genes in the NACR-resistant, TCGA and GTEx-related datasets compared to the NACR-sensitive group, yielding six hub genes (<i>RRM2, HNRNPL, EZH2, METTL1, NHP2L1 and ASF1B</i>). ROC curves demonstrated the predictive utility of the six genes in NACR sensitivity. Immune infiltration research revealed no significant relationship between NACR sensitivity and immune cell infiltration extent. The miRNA-TF-target network of hub genes was established. Finally, HPA database results showed that six genes were expressed at variable levels in rectal cancer patients.</p><p><strong>Conclusions: </strong>This study identified six hub genes (<i>RRM2, HNRNPL, EZH2, METTL1, NHP2L1 and ASF1B</i>) up-regulated in LARC and valuable for predicting patient susceptibility and response to NACR.</p>","PeriodicalId":21034,"journal":{"name":"Radiology and Oncology","volume":" ","pages":"435-449"},"PeriodicalIF":2.2,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12441892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Laser speckle contrast imaging of perfusion in oncological clinical applications: a literature review.","authors":"Rok Hren, Simona Kranjc Brezar, Urban Marhl, Gregor Sersa","doi":"10.2478/raon-2025-0045","DOIUrl":"10.2478/raon-2025-0045","url":null,"abstract":"","PeriodicalId":21034,"journal":{"name":"Radiology and Oncology","volume":" ","pages":"466"},"PeriodicalIF":2.2,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of catheter type, the number of sutures and patients' age on percutaneous nephrostomy displacement.","authors":"Dimitrij Kuhelj, Ana Sustersic, Urban Zdesar","doi":"10.2478/raon-2025-0037","DOIUrl":"https://doi.org/10.2478/raon-2025-0037","url":null,"abstract":"<p><strong>Background: </strong>Percutaneous nephrostomy displacement results in procedure failure, reducing quality of life in patients with hydronephrosis. Scarce data about factors influencing displacement led to evaluation of our data in order to give better insight into this topic.</p><p><strong>Patients and methods: </strong>Patients admitted for percutaneous nephrostomy (PCN) exchange between March 3^rd and October 3^rd 2023 were included in our prospective observational study aiming to determine possible factors influencing PCN displacement. Catheter type, number of sutures and patients' age over 70 years were analyzed. Descriptive statistics and Pearson's chi-square test were used; value less than 0.05 was determined as statistically significant.</p><p><strong>Results: </strong>We included 57 patients (35 males; mean age 71.4 years) in the study. Loop catheters with strings were implanted 58 times and without strings 17 times. Fixation was achieved by 55 single and by 20 double sutures. 17 PCN (22.7%) were displaced in designated period. The mean time from PCN implantation to exchange was 4.16 months. Neither catheter type, number of sutures or patients' age significantly influenced PCN displacement (chi-square 0.57, 0.34 and 0.61, respectively).</p><p><strong>Conclusions: </strong>No significant difference in PCN displacement between two types of catheters and the number of fixing sutures was detected. Elderly patients had similar rates of PCN displacements as younger ones. The most important causes of PCN displacement remained probably patients' activity and a care for PCN during months after the implantation. Proper patients' education and care of the PCN are possibly the keys for long-term success.</p>","PeriodicalId":21034,"journal":{"name":"Radiology and Oncology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}