Radiology and Oncology最新文献

{"title":"The influence of catheter type, the number of sutures and patients' age on percutaneous nephrostomy displacement.","authors":"Dimitrij Kuhelj, Ana Sustersic, Urban Zdesar","doi":"10.2478/raon-2025-0037","DOIUrl":"https://doi.org/10.2478/raon-2025-0037","url":null,"abstract":"<p><strong>Background: </strong>Percutaneous nephrostomy displacement results in procedure failure, reducing quality of life in patients with hydronephrosis. Scarce data about factors influencing displacement led to evaluation of our data in order to give better insight into this topic.</p><p><strong>Patients and methods: </strong>Patients admitted for percutaneous nephrostomy (PCN) exchange between March 3^rd and October 3^rd 2023 were included in our prospective observational study aiming to determine possible factors influencing PCN displacement. Catheter type, number of sutures and patients' age over 70 years were analyzed. Descriptive statistics and Pearson's chi-square test were used; value less than 0.05 was determined as statistically significant.</p><p><strong>Results: </strong>We included 57 patients (35 males; mean age 71.4 years) in the study. Loop catheters with strings were implanted 58 times and without strings 17 times. Fixation was achieved by 55 single and by 20 double sutures. 17 PCN (22.7%) were displaced in designated period. The mean time from PCN implantation to exchange was 4.16 months. Neither catheter type, number of sutures or patients' age significantly influenced PCN displacement (chi-square 0.57, 0.34 and 0.61, respectively).</p><p><strong>Conclusions: </strong>No significant difference in PCN displacement between two types of catheters and the number of fixing sutures was detected. Elderly patients had similar rates of PCN displacements as younger ones. The most important causes of PCN displacement remained probably patients' activity and a care for PCN during months after the implantation. Proper patients' education and care of the PCN are possibly the keys for long-term success.</p>","PeriodicalId":21034,"journal":{"name":"Radiology and Oncology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cuproptosis-related gene <i>CEP55</i> as a biomarker of pancreatic adenocarcinoma via multi-omics techniques and experimental validation.","authors":"Riyuan Zhang, Zixia Xu, Yurui Zhuang, Yuzhe Shi, Ziyi Guo, Chong Chen","doi":"10.2478/raon-2025-0042","DOIUrl":"https://doi.org/10.2478/raon-2025-0042","url":null,"abstract":"<p><strong>Background: </strong>Background. Pancreatic adenocarcinoma (PAAD) is a malignancy with a very poor prognosis. The clinical significance of cuproptosis in PAAD combining single cell data with The Cancer Genome Atlas (TCGA) data is unclear.</p><p><strong>Materials and methods: </strong>In this study, we first identified gene modules associated with cuproptosis by performing single-cell analysis and weighted co-expression network analysis (WCGNA). According to TCGA data, Cox regression and LASSO regression analysis were used to establish prognostic models, and PAAD patients were divided into high-risk and low-risk groups according to cuproptosis-related risk score. Then 7 algorithms were used to evaluate cancer immune microenvironment, followed by the mutation analysis. The expression levels and prognostic significance of the 8 model genes were analysed using single-gene analysis, Kaplan-Meier survival plots, and quantitative PCR (qPCR) validation. Finally, the biological function of <i>CEP55</i> in PAAD was verified by in vitro experiments.</p><p><strong>Results: </strong>We identified cuproptosis-related genes (CRG) in PAAD by performing single-cell analysis and WCGNA, and constructed a cuproptosis-related prognostic model of PAAD by comprehensive bioinformatics analyses. Based on cuproptosis-related risk score, there were significant differences in survival time between two groups. We further constructed a cuproptosis-related risk score-based nomogram to accurately assess PAAD patient prognosis. Immune infiltration analysis revealed that PAAD samples with higher cuproptosis-related scores exhibited significantly lower immune infiltration levels, which may mechanistically underlie their poorer clinical outcomes. Furthermore, the high-risk group had a higher mutation rate of the same mutated gene, which means that they are more likely to benefit from immunotherapy. Finally, we identified that <i>CEP55</i> was significantly overexpressed in PAAD and correlated with poor patient prognosis. In vitro knockdown of <i>CEP55</i> effectively suppressed proliferation and invasion capabilities in pancreatic cancer cell lines.</p><p><strong>Conclusions: </strong>In this study, a novel prognostic model of PAAD was constructed to evaluate the prognosis and immune microenvironment of PAAD patients, and <i>CEP55</i> was identified as a central gene of PAAD. In vitro studies verified the biological function of <i>CEP55</i>, providing a new potential target for the treatment of PAAD.</p>","PeriodicalId":21034,"journal":{"name":"Radiology and Oncology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of ultrasound assessment of sarcopenia in patients with diffuse large B-cell lymphoma: a prospective study.","authors":"Teng Liu, Junjun Wan, Yangyang Liu, Jing Zhuo, Weijiang Fu","doi":"10.2478/raon-2025-0036","DOIUrl":"https://doi.org/10.2478/raon-2025-0036","url":null,"abstract":"<p><strong>Background: </strong>This study investigated the clinical utility of ultrasound in diagnosing sarcopenia in patients with diffuse large B-cell lymphoma (DLBCL), focusing on muscle mass, strength, and physical fitness.</p><p><strong>Patients and methods: </strong>A prospective analysis was conducted on 167 patients with DLBCL (88 with sarcopenia and 79 without). Muscle thickness (MT), cross-sectional area (CSA), and subcutaneous fat thickness (SFT) were measured using ultrasound at various anatomical sites. Diagnostic efficacy of muscle indices for sarcopenia was assessed using receiver operating characteristic (ROC) curves.</p><p><strong>Results: </strong>Patients with sarcopenia exhibited significant reductions in MT and CSA across multiple muscle groups, including biceps brachii (BB), vastus intermedius (VI), and rectus femoris (RF) (all p ≤ 0.001). ROC analysis identified RF-CSA as the most effective indicator of sarcopenia, with an area under the curve (AUC) of 0.87, a sensitivity of 86%, and a specificity of 83% at a critical value of 7.08 cm². Multivariate analysis revealed that reduced MT and CSA significantly increased the risk of sarcopenia after adjusting for age, gender, and physical performance.</p><p><strong>Conclusions: </strong>Ultrasound was a cost-effective and accessible diagnostic tool for identifying sarcopenia in DLBCL patients. Early detection through ultrasound can guide timely interventions and improve clinical outcomes.</p>","PeriodicalId":21034,"journal":{"name":"Radiology and Oncology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human papillomavirus (HPV) genotyping and prognostic value of HPV E4 protein and transcription factors NANOG and SOX11 in atypical p16 patchy squamous epithelium of cervix.","authors":"Maja Kebe Radulovic, Anja Ostrbenk, Mario Poljak, Margareta Strojan-Flezar","doi":"10.2478/raon-2025-0038","DOIUrl":"https://doi.org/10.2478/raon-2025-0038","url":null,"abstract":"<p><strong>Background: </strong>Immunohistochemical staining for p16 is used to differentiate precancerous cervical lesions in tissue samples, but the interpretation of patchy p16 expression remains challenging. We performed human papillomavirus (HPV) genotyping and evaluated immunohistochemical expression of HPV E4 protein - a marker for transient infections, stem cell transcription factor NANOG, and transcription factor SOX11 to detect possible high-grade squamous lesions in atypical p16 patchy squamous epithelium.</p><p><strong>Materials and methods: </strong>We analyzed 24 cervical tissue samples with atypical squamous epithelium and patchy p16 expression along with the following controls: 11 cases of atypical squamous epithelium with null p16 expression, 9 condylomas, 12 cases of cervical intraepithelial neoplasia (CIN) grade 1, 11 cases of CIN2, and 9 cases of CIN3. In addition, HPV genotyping of tissue and related cervical smears from up to two years prior to biopsy was performed. Immunohistochemical staining for Ki67, HPV E4, NANOG, and SOX11 was performed and compared with follow-up data.</p><p><strong>Results: </strong>High-risk HPV infection was detected in 6/24 cases with patchy p16 expression and HPV E4 was expressed in 1/24 cases with patchy p16, weak NANOG expression was found in 11/24 cases with patchy p16 expression while no SOX11 expression was observed. During 10 months of follow-up, additional CIN1 and two CIN3 were identified, and another CIN1 and CIN3 after 5 and 6 years, accordingly.</p><p><strong>Conclusions: </strong>Our study showed that atypical squamous epithelium with patchy p16 expression poses a risk for highgrade precancerous lesions, harbouring high-risk HPV infection. Novel markers may hold diagnostic value in other specific contexts.</p>","PeriodicalId":21034,"journal":{"name":"Radiology and Oncology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In the pursuit of perfect planning: comparison between Lightning Inverse Planning and GammaPlan Wizard for gamma knife radiosurgery.","authors":"Victor Goulenko, Robert J Plunkett, Matthew B Podgorsak, Dheerendra Prasad","doi":"10.2478/raon-2025-0039","DOIUrl":"10.2478/raon-2025-0039","url":null,"abstract":"<p><strong>Background: </strong>The Lightning^® software, was added to the Gamma Knife's Leksell GammaPlan^® as a fully automated inverse planner, differently from the prior software, Wizard^®. In this paper we compare their treatment planning capacity and quality.</p><p><strong>Materials and methods: </strong>Thirty-eight cases were compared under four different planning techniques. First, manual forward planning aided by the Wizard^® optimization tool. Second, inverse planning with Wizard^®. The third and fourth plans used Lightning^® with and without consideration for organs at risk (OAR). They were analysed for: planning time, number of shots, coverage, selectivity, gradient index, bean-on time, and OAR dose. Comparison based on pathology was added due to their idiosyncrasies. For quality comparison, dose-volume histograms (DVH) were compared to plans developed under our treatment standards. Tumor's volume and time to plan were correlated with Pearson's coefficient.</p><p><strong>Results: </strong>Lightning^® had better coverage (8%) and gradient index (15%) but had 12% decrease in selectivity. Planning and delivery times had a reduction of 57% and 5% respectively, despite having three times the number of shots. Only Lightning^® with protection of OAR met the dose constrains in all plans. DVH showed similar plan qualities.</p><p><strong>Conclusions: </strong>Lightning^® allowed the planner to explore different optimization parameters to achieve a plan that suits the clinical problem at hand. It took less time to calculate shots placement, OAR protection and the ideal isodose line than the Wizard^®. This can be useful to plan multiple and complex targets at a faster time, increase the patient's tolerance and, may have a radiobiological advantage by impacting intra-fraction repair.</p>","PeriodicalId":21034,"journal":{"name":"Radiology and Oncology","volume":"59 2","pages":"285-292"},"PeriodicalIF":2.1,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemotherapy for basal cell carcinoma in the head and neck region: 5-year follow-up from the Insp-ECT registry.","authors":"Ales Groselj, Giulia Bertino, Marta Minuti, Anthony James P Clover, Camilla Kjaer Lonkvist, Erika Kis, Christian Kunte, Tobian Muir, Francesco Russano, Francesca de Terlizzi, Joy Odili, Gregor Sersa","doi":"10.2478/raon-2025-0040","DOIUrl":"10.2478/raon-2025-0040","url":null,"abstract":"<p><strong>Background: </strong>Basal cell carcinoma (BCC) is a cutaneous malignancy that typically appears in sun-exposed areas. We analyzed data from the Insp-ECT registry of all patients affected by BCC in the head and neck region. The aim of this study was to evaluate the safety and efficacy of electrochemotherapy (ECT) on a 5-year basis.</p><p><strong>Patients and methods: </strong>A cohort of 132 patients was included. They were treated by ECT according to the current Standard Operating Procedures. The median age was 74 years (range 41-93). There was a median of 1 nodule per patient (range 1-7), and the median size of the lesions was 1.4 cm (range 0.5-5.0 cm).</p><p><strong>Results: </strong>Patients tolerated ECT well, and 96% agreed to repeat it if needed. The side effects were mild and temporary. All patients achieved a complete clinical response after 1 to 3 ECT sessions. During the first year of follow-up, 4 (3%) patients experienced recurrence, which was treated (2 with ECT, 1 with surgery, and 1 with a combination of ECT and surgery), after which they remained free of disease until the end of follow-up at 5 years. Five patients reported recurrence thereafter and were treated according to their condition. At the 5-year follow-up, the disease-free survival (DFS) rate was 92% (95% confidence interval [CI]: 87%-96%). At that time, 3 patients were alive with disease (2%), and 124 patients were free of disease (98%).</p><p><strong>Conclusions: </strong>This study shows the feasibility and efficacy of ECT treatment in elderly patients with BCC tumors in aesthetically and functionally sensitive areas, with negligible toxicity. Comparable efficacy to other treatment modalities was demonstrated at 1 year and 5 years of follow-up in terms of DFS.</p>","PeriodicalId":21034,"journal":{"name":"Radiology and Oncology","volume":"59 2","pages":"233-243"},"PeriodicalIF":2.1,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mammographically detected spicules associated with malignant breast tumors frequently harbor additional tumor foci.","authors":"Heli Tuomainen, Mazen Sudah, Sarianna Joukainen, Vesa Kärjä, Amro Masarwah, Otto Jokelainen, Hidemi Okuma","doi":"10.2478/raon-2025-0041","DOIUrl":"10.2478/raon-2025-0041","url":null,"abstract":"<p><strong>Background: </strong>On imaging, malignant breast masses are commonly associated with spicules. To the best of our knowledge, the clinical significance of such spiculae has not been previously studied, and no surgical guidelines are available for the management of mammographically detected spiculations.</p><p><strong>Patients and methods: </strong>Between April 2018 and December 2019, all consecutive breast-conserving surgery -patients with invasive malignant lesions, who required intraoperative radiological breast specimen assessment with tomosynthesis, were retrospectively included in this analysis. The tumors were classified into two groups: those with spiculated margins as the dominant feature, and those with other distinct morphological characteristics. Spicule visualization, length, and distribution were evaluated in both groups using pre- and intraoperative imaging and compared with the histopathological features of the spicules.</p><p><strong>Results: </strong>In total, 162 invasive lesions were evaluated. The presence of spicule-associated additional tumor foci was a common finding; 67.6% of the spiculated tumors and 48.9% of the other tumors had additional foci. Most additional tumor foci were within 1 cm of the tumor edge. The mean pathologically measured distance from the main tumor margin to the spicule-associated additional tumor foci was 4.3 ± 2.8 mm. Compared to the maximum spicule length determined from intraoperative images (9.5 ± 5.1 mm), the distance of actual tumor infiltration was much shorter, and a very weak correlation was observed.</p><p><strong>Conclusions: </strong>Breast tumor spicules harbor additional tumor foci, which may lead to margin positivity and potential reoperation. Additional research is necessary to determine the actual tumor burden and clinical significance of spicules.</p>","PeriodicalId":21034,"journal":{"name":"Radiology and Oncology","volume":"59 2","pages":"168-175"},"PeriodicalIF":2.1,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiographic and pathologic response of myxoid liposarcoma treated with preoperative radiotherapy.","authors":"Robert W Gao, Judith As Jebastin, Doris E Wenger, William S Harmsen, Andrew L Folpe, Michael G Haddock, Ivy A Petersen, Safia K Ahmed","doi":"10.2478/raon-2025-0032","DOIUrl":"10.2478/raon-2025-0032","url":null,"abstract":"<p><strong>Background: </strong>We retrospectively assessed volumetric response of myxoid liposarcoma (MLPS) with preoperative radiotherapy (RT) and sought to identify disease and treatment characteristics associated with response.</p><p><strong>Patients and methods: </strong>We identified all patients with a histologic diagnosis of MLPS who received preoperative RT from 2013 to 2021 at our institution. We used cone beam computed tomography (CBCT) to assess changes in tumor volume and greatest dimension during treatment. Tumors were contoured on CBCT images prior to treatment and at the end of each week of RT. Percentage change in tumor volume and greatest dimension were calculated based on pre-treatment and final week contours. Patients with tumors incompletely visualized on CBCT were excluded from volume analysis but included on greatest dimension analysis. Magnetic resonance imaging (MRI) was used to evaluate pre- and post-RT radiographic features. Surgical pathology was reviewed to record pathologic characteristics.</p><p><strong>Results: </strong>Twenty patients met inclusion criteria. Most tumors (18/20) were low grade. The most frequent dose/fractionation scheme was 50 Gy in 25 fractions (16/20), with 3 patients receiving 36 Gy in 18 fractions. Median pre-RT volume and greatest dimension were 120 cc (interquartile range [IQR]: 56-399) and 11.2 cm (IQR: 8.4-14.1), respectively. Median percentage change in volume and greatest dimension were -37% (IQR: -57 to -29) and -10% (IQR: -20 to -7). All evaluable tumors decreased in volume during RT. Between pre- and post-RT MRI, most patients had a decrease in intratumoral (16/20) and peritumoral edema (11/20). Sixteen patients exhibited extensive pathologic response. There were no significant associations between radiographic and pathologic features and volumetric change. Local failure at 3 years was 9% (95% confidence interval: 1-59).</p><p><strong>Conclusions: </strong>We report significant decreases in MLPS tumor size during preoperative RT. There may be a role for adaptive RT planning to reduce target volumes and minimize RT-associated morbidity.</p>","PeriodicalId":21034,"journal":{"name":"Radiology and Oncology","volume":"59 2","pages":"176-182"},"PeriodicalIF":2.1,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison of effectiveness of the contrast enhanced computed tomography with magnetic resonance imaging in the differential diagnosis of clear cell renal carcinoma.","authors":"Tomasz Blachura, Julia Radzikowska, Patrycja S Matusik, Aleksander Kowal, Jarosław D Jarczewski, Łukasz Skiba, Tadeusz J Popiela, Robert Chrzan","doi":"10.2478/raon-2025-0033","DOIUrl":"10.2478/raon-2025-0033","url":null,"abstract":"<p><strong>Background: </strong>The incidental detection of indeterminate small renal masses (SRMs) has been rising continuously over the last few decades. The aim of our study was to assess selected contrast enhanced computed tomography (CECT) parameters in the characterization of indeterminate SRMs and compare them with selected magnetic resonance imaging (MRI) data.</p><p><strong>Patients and methods: </strong>Patients with indeterminate SRMs discovered on CECT were included in the study. Selected CECT features have been analyzed as differentiating between clear cell renal cell carcinoma (ccRCC) and other etiologies of SRMs. In 82% of patients, which had available MRI data, a comparison between selected MRI and CECT parameters were performed.</p><p><strong>Results: </strong>Relative washout in CECT had the best accuracy (76.5%), sensitivity (88.9%), as well as satisfactory specificity (69.7%) in ccRCC prediction. The cut-off point determined in receiver operating analysis using the Youden index for this parameter was 11.54. Multivariable analysis showed that only T1 SI ratio < 0.73 from MRI parameters and relative washout > 11.5 from CECT parameters were independent predictors of ccRCC (OR: 30.86, 95% CI: 1.58-600.26, p = 0.024; OR: 15.36, 95% CI: 1.52-155.16, p = 0.021).</p><p><strong>Conclusions: </strong>In clinical practice, the use of both CECT and MRI indicators, especially T1 SI ratio < 0.73 for MRI and relative washout > 11.5 for CECT, can support physicians in diagnosing and treating patients effectively.</p>","PeriodicalId":21034,"journal":{"name":"Radiology and Oncology","volume":"59 2","pages":"193-202"},"PeriodicalIF":2.1,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there a place for ultrasound in diagnosing sarcopenia?","authors":"Tadej Rondaij, Nada Rotovnik Kozjek, Cene Jerele, Taja Jordan","doi":"10.2478/raon-2025-0035","DOIUrl":"10.2478/raon-2025-0035","url":null,"abstract":"<p><strong>Background: </strong>Sarcopenia is a progressive and generalised skeletal muscle disorder which presents as loss of muscle mass and function and is associated with increased likelihood of adverse outcomes, reduced quality of life and increased mortality. In developed countries, the prevalence of sarcopenia is rising due to increasing life expectancy. Still, in many clinical settings, sarcopenia may be overlooked and undertreated. While several tools are available for assessment of muscle mass and quality, there remains a need for safe, reliable and accurate diagnostic methods which can be implemented for both sarcopenia diagnosis and the evaluation of treatment efficacy.</p><p><strong>Conclusions: </strong>Ultrasound is an accessible and non-ionizing imaging technique that can potentially be used for that purpose. Several ultrasound parameters have been identified for their utility to provide assessment of muscle mass, quality and/or muscle function. Ultrasound is gaining recognition as an accurate and reproducible method of muscle mass assessment. However, there are still several limitations that preclude the application of ultrasound in routine clinical practice. Implementing a harmonized measurement protocol and conducting large-scale longitudinal studies on both healthy individuals and various patient cohorts could enable the establishment of clearly defined reference values for individual ultrasound parameters and, in turn, potentially reliable differentiation between normal and sarcopenic states.</p>","PeriodicalId":21034,"journal":{"name":"Radiology and Oncology","volume":"59 2","pages":"153-167"},"PeriodicalIF":2.1,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}