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Recent advances in studies on cardiac structure and metabolism最新文献

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Properties of membrane-bound and soluble guanylate cyclase of cardiac and skeletal muscle. 心脏和骨骼肌中膜结合和可溶性鸟苷酸环化酶的性质。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
S J Sulakhe, P V Sulakhe
{"title":"Properties of membrane-bound and soluble guanylate cyclase of cardiac and skeletal muscle.","authors":"S J Sulakhe,&nbsp;P V Sulakhe","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Kinetic properties of guanylate cyclase present in the washed particles, plasma membranes, and the soluble cytoplasm of heart and skeletal muscle are described; properties of the enzyme solubilized by Triton X-100 treatment of the particles or membrane fractions are also reported. It is apparent from the data that the membrane-bound guanylate cyclase in the cell may be regulated by acetylcholine, may exist as a metallo-protein with bound Mn2+ (essential for activity), and that Mg2+ regulates, whereas Ca2+ and nucleotides (especially ATP) modulate, guanylate cyclase activity. The findings also suggest that guanylate cyclase, similar to adenylate cyclase and (Na+, K+)-ATPase, is mainly located in the plasma membranes of heart and skeletal muscle.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"11 ","pages":"257-63"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11246435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reduced response of cardiac norepinephrine release to isometric handgrip exercise in heart failure. 心脏去甲肾上腺素释放对心力衰竭患者等距握力运动的反应降低。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
T Haneda, Y Miura, K Miyazawa, T Sato, K Shirato, T Honna, T Nakajima, T Arai, K Kobayashi, H Sakuma, K Yoshinaga, T Takishima
{"title":"Reduced response of cardiac norepinephrine release to isometric handgrip exercise in heart failure.","authors":"T Haneda,&nbsp;Y Miura,&nbsp;K Miyazawa,&nbsp;T Sato,&nbsp;K Shirato,&nbsp;T Honna,&nbsp;T Nakajima,&nbsp;T Arai,&nbsp;K Kobayashi,&nbsp;H Sakuma,&nbsp;K Yoshinaga,&nbsp;T Takishima","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In order to evaluate the relation of cardiac norepinephrine (NE) release to left ventricular function, blood was taken simultaneously from the coronary sinus (CS) and the aorta (A) in 19 patients with heart diseases, at rest and during isometric handgrip exercise (IHG) at 30% of their maximal contraction. Plasma NE was analyzed by Renzini's THI method. The concentrations of plasma NE at rest were 397 +/- 66 (S.E.M.) ng/liter in CS and 292 +/- 50 in A. IHG significantly increased NE to 578 +/- 88 in CS and to 462 +/- 85 in A (p less than 0.001). Estimated NE release from the heart (deltaNE = NECS - NEA) correlated inversely to left ventricular end-diastolic pressure at rest (r = -0.520, p less than 0.05) and during IHG (r= -0.689, p less than 0.01). The changes in deltaNE induced by IHG correlated to the slope of the left ventricular function curve (r=0.618, p less than 0.01). It is concluded that the response of cardiac NE release to exercise is reduced in patients with depressed cardiac function.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"12 ","pages":"383-7"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12213236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronotropic effects of calcium and magnesium ions at different temperatures. 钙、镁离子在不同温度下的变时效应。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
A J Mackaay, W K Bleeker, L N Bouman
{"title":"Chronotropic effects of calcium and magnesium ions at different temperatures.","authors":"A J Mackaay,&nbsp;W K Bleeker,&nbsp;L N Bouman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In the isolated right atrium of rabbit hearts, excess calcium causes an increase of heart rate at 38 degrees C; this effect is absent or even reversed at a temperature of 30 degrees C. From microelectrode studies it seems that when the calcium concentration is increased the pacemaker shifts within the sinoatrial node to cells in which excess calcium causes an acceleration of diastolic depolarization (type A). In fibers where the impulse originates at low calcium (type B), excess calcium causes a deceleration of diastolic depolarization. At low temperature, the effects on type A fibers are completely absent. Excess magnesium has a negative chronotropic effect at both temperatures, mainly by a deceleration of diastolic depolarization in type B fibers.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"11 ","pages":"51-5"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12212439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alteration in calcium metabolism in mitochondria isolated from ischemic and reperfused myocardium. 缺血心肌和再灌注心肌线粒体钙代谢的改变。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
C F Peng, M L Murphy, J J Kane, K D Straub
{"title":"Alteration in calcium metabolism in mitochondria isolated from ischemic and reperfused myocardium.","authors":"C F Peng,&nbsp;M L Murphy,&nbsp;J J Kane,&nbsp;K D Straub","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study determines the effect of ischemia and reperfusion on energy-linked Ca2+ uptake by myocardial mitochondria. The left anterior descending coronary artery was occluded in 14 mature pigs for 2 hr. In seven animals the ligature was released and the ischemic zone reperfused for 2 additional hours. After sacrifice, mitochondrial function was measured in normal and reperfused or ischemic areas of the left ventricle, using a polarographic method. Mitochondria were prepared without EDTA by standard procedures and Ca2+ uptake measured by 45Ca2+ isotope tracer. Uptake of Ca2+ by mitochondria derived from ischemic myocardium is markedly impaired with or without phosphate. Reperfusion may accentuate this impairment. The presence of exogenous Ca2+ inhibits the ability of ischemic or reperfused mitochondria to phosphorylate ADP.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"11 ","pages":"533-8"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12212441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stopping of spontaneous beating of cultured mouse and rat myocardial cells by a toxin (thermostable direct hemolysin) from Vibrio parahaemolyticus. 用副溶血性弧菌毒素(耐热直接溶血素)停止培养小鼠和大鼠心肌细胞的自发跳动。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
K Goshima, T Honda, Y Takeda, T Miwatani
{"title":"Stopping of spontaneous beating of cultured mouse and rat myocardial cells by a toxin (thermostable direct hemolysin) from Vibrio parahaemolyticus.","authors":"K Goshima,&nbsp;T Honda,&nbsp;Y Takeda,&nbsp;T Miwatani","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Low concentrations of thermostable direct hemolysin from Vibrio parahaemolyticus stopped the spontaneous beating of cultured mouse and rat myocardial cells. These low concentrations depolarized the maximal diastolic potential and inhibited the generation of action potential of cultured myocardial cells. The toxin lost its activity when preincubated with ganglioside, GT1 or GM1. GT1 was more effective than GM1. High concentrations of the toxin caused morphological damage of cultured mouse and rat myocardial cells, but did not stop the beating, or cause morphological damage of cultured chick myocardial cells.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"11 ","pages":"615-20"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12212449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myocardial fatty acid and cardiac performance. 心肌脂肪酸与心脏性能。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
F Takenaka, S Takeo
{"title":"Myocardial fatty acid and cardiac performance.","authors":"F Takenaka,&nbsp;S Takeo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Isoproterenol enhanced myocardial triglyceride utilization and incorporation of exogenous fatty acid into triglyceride fraction in the perfused rat heart in the presence of glucose. However, in the absence of glucose, cardiac performance was considerably aggravated by isoproterenol. This suggests that glucose might be an essential fuel in the heart stimulated by isoproterenol.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"11 ","pages":"379-84"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12212791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Morphological evidence for neural control of the activity of rat heart pacemaker. 大鼠心脏起搏器活动神经控制的形态学证据。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
M Moravec-Mochet, J Moravec, P Y Hatt
{"title":"Morphological evidence for neural control of the activity of rat heart pacemaker.","authors":"M Moravec-Mochet,&nbsp;J Moravec,&nbsp;P Y Hatt","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"12 ","pages":"71-5"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12212804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Possible mechanism of rate-dependent change of contraction in dog ventricular muscle: relation to calcium movements. 犬心室肌收缩速率依赖性变化的可能机制:与钙运动的关系。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
Y Saeki, A Kamiyama
{"title":"Possible mechanism of rate-dependent change of contraction in dog ventricular muscle: relation to calcium movements.","authors":"Y Saeki,&nbsp;A Kamiyama","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"11 ","pages":"131-5"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12212956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacological protection of hypoxic heart. 缺氧心脏的药理保护。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
W G Nayler, A Grau, C Yepez
{"title":"Pharmacological protection of hypoxic heart.","authors":"W G Nayler,&nbsp;A Grau,&nbsp;C Yepez","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The ability of beta-adrenoceptor antagonists, with and without intrinsic sympathomimetic activity, and of verapamil to protect the heart against hypoxia-induced damage was investigated. Damage was quantitated in terms of a raised end-diastolic resting tension and creatine phosphokinase (CPK) release. The results indicate that both the d and the l isomers act differently, the isomers preventing CPK release and the d isomers preventing the increase in resting tension.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"12 ","pages":"525-30"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12212966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of environmental factors and tissue culture methodology in producing and studying cultured cardiac cells. 环境因素及组织培养方法对体外培养心肌细胞产生与研究的影响。
Recent advances in studies on cardiac structure and metabolism Pub Date : 1976-05-26
P Padieu, C Frelin, F Pinson, F Charbonné, P Athias
{"title":"Effect of environmental factors and tissue culture methodology in producing and studying cultured cardiac cells.","authors":"P Padieu,&nbsp;C Frelin,&nbsp;F Pinson,&nbsp;F Charbonné,&nbsp;P Athias","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Improvement in the method of heart cell cultures is described and justified in relation to environmental factors. The validity of such cardiac cell culture for cardiac research is discussed in light of particular cellular activities: differentiation of lipoprotein lipase, myoglobin biosynthesis, glucose and fatty acid metabolism pleiotypic responses (rotein, RNA, and DNA biosyntheses, substrates transports) to serum stimulation, and the architectonic growth of muscle and nonmuscle cells.</p>","PeriodicalId":21025,"journal":{"name":"Recent advances in studies on cardiac structure and metabolism","volume":"12 ","pages":"609-20"},"PeriodicalIF":0.0,"publicationDate":"1976-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12212976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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