Research journal of pharmaceutical, biological and chemical sciences最新文献_第8页

Hypoglycemic, Hypolipidimic and Protective Effects of Arbutus andrachne Extract in Streptozotocin Induced Diabetic Rats 杨梅提取物对链脲佐菌素诱导的糖尿病大鼠的降血糖、降血脂及保护作用

Research journal of pharmaceutical, biological and chemical sciences Pub Date : 2019-10-20 DOI: 10.36478/rjbsci.2019.56.60

A. Abu-zaiton, M. Abu-Samak, S. Oran, Israa Yousef, Yousef M. Abu-Zaitoon, Ayah Algaramseh

引用次数: 2

Influence of Avian Influenza Virus on Human Inflammatory Gene Expression Profile 禽流感病毒对人炎症基因表达谱的影响

Research journal of pharmaceutical, biological and chemical sciences Pub Date : 2019-10-20 DOI: 10.36478/rjbsci.2019.1.6

Abdulrhem Thonnon Al-Ghazal

引用次数: 0

Prediction of Olympic Results in Skiers of Russia on a Distance of Fifty Kilometers 奥运会俄罗斯50公里滑雪项目成绩预测

Research journal of pharmaceutical, biological and chemical sciences Pub Date : 2019-10-20 DOI: 10.36478/rjbsci.2019.52.55

Sivakov Vladimir Ilyich, Belousova Natalya Anatolyevna, Kamskova Yuliana Germanovna, Perepelyukova Elena Viktorovna, Matveeva Polina Alexandrovna, Matveev Vitalyi Vladimirovich

引用次数: 0

Evaluating the Effect of Vitamin D and Calcium on Glucose and Insulin Level of Induced-Diabetic Rats 评价维生素D和钙对诱导糖尿病大鼠葡萄糖和胰岛素水平的影响

Research journal of pharmaceutical, biological and chemical sciences Pub Date : 2019-10-20 DOI: 10.36478/rjbsci.2019.61.65

F. Salem, A. Abu-zaiton

{"title":"Evaluating the Effect of Vitamin D and Calcium on Glucose and Insulin Level of Induced-Diabetic Rats","authors":"F. Salem, A. Abu-zaiton","doi":"10.36478/rjbsci.2019.61.65","DOIUrl":"https://doi.org/10.36478/rjbsci.2019.61.65","url":null,"abstract":"Diabetes Mellitus (DM) is a major health concern all over the world. The number of affected people is increasing every year. Many factors contribute to the disease including diet, genetics, lifestyle and so forth. The disease is characterized by hyperglycemia because of insuffiency of the insulin producing beta cells of the pancreas. There is need for alternatives to the conventional antidiabetic drugs to overcome their shortages vitamin D and calcium intake are thought to protect against DM our research aims to evaluate the effect of administration vitamin D, calcium and combination of both on glucose and insulin levels in diabetic rats. Diabetes mellitus was induced intraperitoneally in male Wister albino rats by injection of alloxan (150 mgkgG bw). Animals were divided into seven groups of eight rats each: group I served as normal control, group II act as diabetic control. The diabetic rats treated groups (III, IV, V, VI and VII) were treated, respectively with metformin at dose of 100 mgkgG, vitamin D3 at dose of 12.5 μgkgG, calcium gluconate at dose of 100 mgkgG both vitamin D3 and calcium gluconate and olive oil at dose of 0.3 mLkgG (serve as vehicle group). The treatments were performed by oral administration once a day for 28 consecutive days. The results showed that vitamin D3 and vitamin D3-calcium combination lowers blood glucose level and calcium alone was not statistically significant decreased glucose level. Supplementation with vitamin D3 with or without calcium increases insulin slightly when compared with normal control.","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88929976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of genome variation in Simple sequence repeat (SSR) of meningococcal isolates 脑膜炎球菌分离株简单重复序列(SSR)基因组变异分析

Research journal of pharmaceutical, biological and chemical sciences Pub Date : 2019-07-28 DOI: 10.18231/j.jpbs.2019.003

M. A. R. Al-Maeni

{"title":"Analysis of genome variation in Simple sequence repeat (SSR) of meningococcal isolates","authors":"M. A. R. Al-Maeni","doi":"10.18231/j.jpbs.2019.003","DOIUrl":"https://doi.org/10.18231/j.jpbs.2019.003","url":null,"abstract":"s Alteration of repeat tract length within the SSR of phase variable genes may enhance the persistence of isolates within their host for a long time (a period of months) (Alamro et al.,2014). Alamro et al. (2014) showed there was trend towards selection for OFF state or low expression for five phase variable genes (opc, hmbr, nadA, nalP, hpuAB) in three carriers (V54, V124 and V64) within strains belonging into CC174 and CC167 in first, second and third time points. He concluded that the selection for low or OFF state helped N. meningitidis to persist for a long time (Alamro et al., 2014). The current study aimed to detect the alteration in the repeat tracts of the same five variable genes within the previous three carriers (V54, V124, and V64) but for other strains belonging to CC22, CC269, and CC198 at the fourth time point. There was also a trend towards selection for an OFF state or low expression for three genes which are (opc, hpuAb, nalP) with 2/3 (66.6%) carriers while hmbr gene showed ON state in all carriers (100%). This indicates that antibodies formed against (opc, HpuAb, nalP) genes in strains belonging to CC174 and CC167 in first, second and third time points were able to enhance immunization against the isolates in the current study for CC269 and CC22 resulting in the selection for the OFF state or low expression. Conversely, antibodies formed against hmbr gene in the previous time points on isolates within the CC167 may not show immunization against hmbr gene in the isolates of current study CC22, CC198 and CC269 and so the gene stayed in the ON state. Interestingly, the nadA gene was missing from isolates under the current study. These results may reflect important aspects in the vaccination program especially as nadA is one of the component of Bexsero vaccine.","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76881381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of genome variation in CEs of meningococcal isolates 脑膜炎球菌分离株CEs基因组变异分析

Research journal of pharmaceutical, biological and chemical sciences Pub Date : 2019-07-28 DOI: 10.18231/J.JPBS.2019.002

M. A. R. Al-Maeni

{"title":"Analysis of genome variation in CEs of meningococcal isolates","authors":"M. A. R. Al-Maeni","doi":"10.18231/J.JPBS.2019.002","DOIUrl":"https://doi.org/10.18231/J.JPBS.2019.002","url":null,"abstract":"Important points were concluded from this analysis related with the presence of the same variable CEs within multiple isolates with different time points being under the selection and the location of SNPs within the conserved functional pattern of CEs. In the 40 isolates, 9 out of 39 variable CEs conducted with multiple isolates, each one affected around 20% or more of population. In the same way, the presence same variable CEs within multiple isolates belonging to same CCs or different CCs of 25 pair isolates detected in 12 out of 137 variable CEs, each one affected around 10% or more out of 25 pair isolates. Interestingly, some CEs showed variation within promoters or IHF patterns or were inserted inside the genes, and were associated with genes that coded mainly for different enzymes within metabolism scheme or transporters within outer membrane scheme in both 40 and 25 pair isolates. This variation may change the level of transcription of genes belonging into previous mentioned schemes and this altered expression may help N. meningitidis to resist the immune system. There were 6 out of 39 and 15 out of 137 variable CEs that showed variation within the conserved functional pattern in 40 isolates and 25 pair isolates respectively. Another function of CEs is as a source of variation in N. meningitidis.","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74907718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical, GC-MS and FT-IR Analysis of Papaver somniferum L 木瓜的植物化学、GC-MS和FT-IR分析

Research journal of pharmaceutical, biological and chemical sciences Pub Date : 2019-07-28 DOI: 10.18231/J.JPBS.2019.001

P. Muthukumaran, S. Kumaravel, Nimia Nimia

{"title":"Phytochemical, GC-MS and FT-IR Analysis of Papaver somniferum L","authors":"P. Muthukumaran, S. Kumaravel, Nimia Nimia","doi":"10.18231/J.JPBS.2019.001","DOIUrl":"https://doi.org/10.18231/J.JPBS.2019.001","url":null,"abstract":"The present study was aimed to analysis of bioactive constituents of Papaver somniferum (Poppy seed). The ethanol extract of the seeds were subjected to Phytochemical Screening, Gas chromatographymass spectroscopic (GC-MS) and Fourier transform infrared spectroscopy (FTIR) analysis. GC-MS analysis of the seeds was performed using a Scion 436GC Bruker model nd Interpretation on mass spectrum GC-MS was conducted using the database of National Institute Standard and Technology (NIST) and IR spectrum was recorded in spectrophotometer (Shimadzu, IR Affinity1, Japan). Phytochemical screening for seeds extracts indicated the presence of various secondary metabolites like Alkaloid, Cardiac Glycosides, Flavonoid, Phytosterols and Terpenoids. GC-MS analysis of compounds with totally, Thirty Nine volatile compounds major chemical compounds were identified, such as 9-Octadecynoic acid(30.72%), 9-Tetradecen1-ol, acetate, (E)(24.02%), 9,12-Octadecadienoic acid, methylester, (E,E)(7.82%), cis-9,10-Epoxyoctadecan-1-ol (7.43%) and Undec10-ynoic acid(4.36%). FT-IR analysis of peak values with various functional compounds such as alcohols, phenols, carboxylic acids, aldehydes, amides, amino acids, anhydrides, esters, ketones, Unsaturated aliphatics, aromatics, unsaturated heterocycles, amines, Nitro compound, Alkanes, alkenes, sugars,Sulphur, phosphorus, and fluorine compounds. The present results concluded that the phytochemicals was observed in ethanol extract which revealed that the Papaver somniferum (Poppy seed) is potential use in different fields namely medical and pharmaceuticals and greatly valuable in medicinal practice for the treatment of several human aliments.","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"267 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76278421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Phytochemical screening antioxidant and antimicrobial activity of aeschynomene aspera linn root extract 七香根提取物抗氧化和抗菌活性的植物化学筛选

Research journal of pharmaceutical, biological and chemical sciences Pub Date : 2019-07-28 DOI: 10.18231/j.jpbs.2019.005

M. Akilabalamurugan, K. Iswaryalakshmi

{"title":"Phytochemical screening antioxidant and antimicrobial activity of aeschynomene aspera linn root extract","authors":"M. Akilabalamurugan, K. Iswaryalakshmi","doi":"10.18231/j.jpbs.2019.005","DOIUrl":"https://doi.org/10.18231/j.jpbs.2019.005","url":null,"abstract":"Medicinal plant are the nature’s of gift to human being to make disease free healthy life.It play a vital role to preserve our health. In india different part have been used for curing various diseases from ancient life. In this present study focus on the analysis of priliminary phytochemical in ethanol extract of Asechynomene Aspera Linn root. Among this extract presence of therapeutically important and valuable secondary metabolites flavonoids, alkaloids, trephenoids, steriods and phenol. The antioxidant activity of root sample was evaluvated by using DPPH, ABTS and Nitric oxide reducing activity. The present study showed that good free radical scavenging properties and a clear correlation exist between the antioxidant activity.The ethanolic extract of AsechynomeneAspera Linn root sample was tested for its antibacterial activity against two human bacterial pathogens (E.coli and S.pneumoniae) and using three different concentration by disc diffusion method.The maximum inhibition of antibactrial activity was observed in E.coli. The study concluded that the ethanolic extract of Asechynomene Aspera Linn root has potential antioxidant and antimicrobial action which is responsible for the biological activities that is used for natural health.","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78157104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Preliminary evalution of ayurvedic preprations of taila ’s and churna’s 泰拉和丘纳的阿育吠陀制剂的初步评价

Research journal of pharmaceutical, biological and chemical sciences Pub Date : 2019-07-15 DOI: 10.18231/J.JPBS.2019.004

K. Mohini, Upadhye Mohini, D. Kanchan

引用次数: 0

Anti-Inflammatory activity of seeds extract of datura stramonium against carrageenan induced paw edema on albino wistar rats 曼陀罗籽提取物对卡拉胶诱导的白化wistar大鼠足部水肿的抗炎作用

Research journal of pharmaceutical, biological and chemical sciences Pub Date : 2019-07-15 DOI: 10.18231/J.JPBS.2019.007

R. Agarwal, R. Gupta, R. Yadav, Vivek Asati, J. Rathi

引用次数: 4