Research journal of pharmaceutical, biological and chemical sciences最新文献

{"title":"Assessment of heavy metal levels in blood of metal forging factory workers in nnewi, Anambra state, Nigeria","authors":"E. Ogbodo, A. Okpogba, E. C. Ugwu, C. Dike, S. O. Nwoko, Human Biochemistry","doi":"10.18231/J.JPBS.2019.006","DOIUrl":"https://doi.org/10.18231/J.JPBS.2019.006","url":null,"abstract":"Background: Heavy metal toxicity has proved to be a major threat to human health as several health risks are associated with it. Materials and Methods : This is a cross sectional study designed to assess the heavy metal levels in blood of metal forging factory workers in Nnewi, Anambra State, Nigeria. A total of eighteen (18) apparently healthy subjects from the exposed group (metal forging factory) aged between 19 and 56 years and 79 control subjects (comprising of 39 control subjects from Nnewi (N) and 40 control from Elele (E) respectively) aged between 18 and 44 years were recruited for the study. The body mass index (BMI) and length of service (LOS) of the subjects were obtained using structured questionnaire and thereafter, 10ml of venous blood sample was collected from each individual for the assessment of heavy metal levels (Pb, Ni, Cu, Zn, As and Se) using atomic absorption spectroscopy (AAS). Results: The result revealed that the body mass index (BMI) of the metal forging factory workers differed significantly compared with control N subjects (24.75±0.38) and E subjects (23.58±0.67) (p<0.05). Factory workers had a length of service (LOS) of 5.74±1.21 years. There were significant increases in the mean levels of Ni, As and Pb and decreases in Cu, Zn and Se levels in the metal forging factory workers compared with control subjects (p<0.05) respectively. Metal levels differed significantly with both age and length of service (LOS) in exposed worker compared with control subjects (p<0.05). Also, Zn level was significantly correlated with LOS of metal forging factory workers (r=0.562; p=0.015). Conclusion: This study showed elevated levels of Ni, As and Pb and decreased levels of Cu, Zn and Se in the blood of metal forging factory workers.","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86181926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angioedema Of Lower Lip And Gingiva Due To Oral Hormonal Therapy: A Case Report","authors":"D. Gabrić, B. L. Brzak, V. Boras, Lada Šumilin, Ivana Škrinjar","doi":"10.33887/RJPBCS/2019.10.3.25","DOIUrl":"https://doi.org/10.33887/RJPBCS/2019.10.3.25","url":null,"abstract":"","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"1 1","pages":"194-197"},"PeriodicalIF":0.0,"publicationDate":"2019-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76812913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Chronic Renal Dialysis on the Level of Thyroid Gland Hormones among Patients with Chronic Renal Failure","authors":"K. Mansi, S. Altamemi, Sami M. Aloush, M. ALBashtawy","doi":"10.31032/ijbpas/2019/8.4.4692","DOIUrl":"https://doi.org/10.31032/ijbpas/2019/8.4.4692","url":null,"abstract":": The purpose of this study was to assess the effect of haemodialysis on thyroxin level in patients with chronic renal failure. The sample of this study included forty nine participants (28 male and 21 female). Eligible participants were patients on regular dialysis for >1 year at the time of enrollment, had no co morbidity and had no known previous thyroid dysfunction. The study was conducted in one educational hospital in Jordan. Serum level of thyroid hormones T4 and T3 were measured prior to the dialysis session and after completion. There was a statistically significant increase in the level of T3 and T4 after completion of dialysis, however, this increase did not go beyond the normal value. Haemodialysis initiate a trend for increase in the level of thyroxin hormones. Patients on chronic dialysis need vigilant assessment for thyroid function in order to prevent future complications.","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86208780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mangiferin a bioactive compound of mangifera indica l on oxidative damage and antioxidant status in n-diethylnitrosoamine induced hepatocellular carcinoma in animal model","authors":"M. Saranya, R. Maheswari","doi":"10.18231/2320-1924.2018.0016","DOIUrl":"https://doi.org/10.18231/2320-1924.2018.0016","url":null,"abstract":"Our study aims at elucidating the antioxidant efficiency of Mangiferin from (Mangifera indica L.) for its protective effect beside NNitrosodiethylamine induced Hepatocellular carcinoma (HCC) in rat liver carcinogenesis. Studies have shown that N-Nitrosodiethylamine induces lipid peroxidation and alters the antioxidant status in non-target organisms. An effort has been made to study the effect of NNitrosodiethylamine induced Hepatocellular carcinoma on biochemical parameters and ameliorating results of Mangiferin. Animals were segregated to six groups. Group A served as control, Group B induced with 0.01% DEN through water for 15 weeks to induce hepatocellular carcinoma. Group C received Mangiferin via intragastric intubation at a daily dose of 30 mg/kg body weight for 16 weeks every day. Groups D to F animals received 0.01% of DEN as in Group B along with Mangiferin via intragastric intubation at a daily dose of 10, 20 and 30 mg/kg body weight for throughout the experimental period for 4 month. The study highlights the effectiveness of Mangiferin as protective molecule against N-Nitrosodiethylamine induced carcinoma. Histological studies of liver tissue too correlated with the above biochemical findings. These results clearly suggest that Mangiferin treatment prevents liver damage, lipid peroxidation and protects the antioxidant defense system in DEN-induced liver carcinogenesis in rats.","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81311093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of withania somnifera root extracts on serotonin secretion in suiz albino mice","authors":"B. Githaiga, E. Lelmen, E. Mwangi, P. Waithaka","doi":"10.18231/2320-1924.2018.0015","DOIUrl":"https://doi.org/10.18231/2320-1924.2018.0015","url":null,"abstract":"Pain is a common manifestation of presence of disease or physical injury in humans. High levels of serotonin in the plasma has been associated with pain. This study aimed at determining the effect of Withania somnifera root extracts on serotonin levels in Suiz albino mice. W. somnifera root samples were collected and ground to small pieces. Ethanol, n-butanol, xylene and methanol were used to extract metabolites from the ground root materials using hot extraction technique. The mice were injected with the extracts separately and serotonin levels determined over a period of 12 h at 2 h intervals. Serotonin concentration was determined using Beer Lamberts method. Light absorbance by the extracts varied significantly (F = 50.2011 P = 1.25x10. The concentrations of serotonin from mice injected with the metabolites from the selected solvents varied significantly (F = 23.3269 P = 0.0000469. In addition, there was no significant difference in light absorbance values obtained by Panadol, methanol and ethanol extracts. (F = 3.7178 P = 0.089). Extracts from W. somnifera have the ability to reduce serotonin levels in plasma. Further studies on the mechanisms involved in reducing serotonin levels by W. somnifera in blood need to be carried out. There is need for mass production of metabolites from W. somnifera.","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84310817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary metabolism and therapeutic efficacy of medicinal plants","authors":"Abdul Kader Mohiuddin","doi":"10.18231/2320-1924.2018.0014","DOIUrl":"https://doi.org/10.18231/2320-1924.2018.0014","url":null,"abstract":"Medicinal plants constitute main resource base of almost all the traditional healthcare systems. Most of the herbal drugs produced currently in majority of the developing countries lack proper quality specification and standards. Herbal drugs used in traditional medicine may contain a single herb or combinations of several different herbs believed to have complementary and/or synergistic effects. Both the raw drugs and the finished herbal products manufactured contain complex mixtures of organic compounds, such as fatty acids, sterols, alkaloids, flavonoids, polyphenols, glycosides, saponins, tannins, terpenes etc. The quality of the finished product is based on the quality of the raw materials. As many as 35% of the medicinal plants used in Indian systems of medicine are highly cross pollinated which indicate the existence of a wide range of genetic variability in the populations of these medicinal plant species which in turn reflected in the variations in the composition of secondary metabolites. Ecological and edaphic as well as seasonal variations also cause changes in the chemical composition of medicinal plants. These facts have to be considered while developing quality parameters! standards of medicinal plants and their finished products.Purpose of the study: An illustrated review of factors that influence secondary metabolism of plants and their impacts on therapeutic efficacy.Findings: Traditional plants are used from ancient time for various human well-being, both as life-saving and lifestyle drugs. A careful observation may explore facts behind therapeutic efficacy of these plants.Materials and Methods: A comprehensive literature review, consulting books, technical newsletters, herb magazines, journals, and many other sources. Health professionals like qualified doctors, herbal specialists, folk healers, alternative medicine specialists given their valuable suggestions. Research limitations: The limitation lies with the unlimited information about traditional medicines. Validity of those are very hard to prove. Only data obtained from books, newsletters, national and international research-based articles are given here along with surrounding facts mostly visible. A few many plant medicine books consulted earlier but article has fewer scope to add from them.Practical Implication: the article is based on plant medicine which is a specialized topic. Students, researchers and professionals may acquire much from this article.","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"96 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78340887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periapical radiographic technique errors made with digital sensors","authors":"Victória Conterato Dias, A. Morosolli, M. I. Rockenbach","doi":"10.18231/2320-1924.2018.0020","DOIUrl":"https://doi.org/10.18231/2320-1924.2018.0020","url":null,"abstract":"Purpose: The objective of this study was to analyze the errors of technique in periapical radiographs as performed by fourth year students at the Dentistry School of the Pontifical Catholic University of Rio Grande do Sul, Brazil. \u0000Material and Methods: Fifteen students were randomly selected and each one performed a complete periapical examination in a mannequin. A Direct Digital X-Ray System equipped with a size 2 Sensor was used to obtain the radiographic images. A total of 210 periapical radiographs were evaluated and the images were classified according to the errors that were related to the radiographic technique. The students were also asked to report on their experience with the direct digital system. \u0000Results: The absence of a safety margin was the most frequent error on the radiographs that were performed by the students, while elongated image errors were not found. Regarding the radiographed regions, the highest frequency of errors was found in the upper canine region on the left side. \u0000Conclusion: The need for a greater training of the students of dentistry, in order to better perform the radiographic technique and to decrease the occurrence of technique errors in periapical radiographs when using a digital receptor, is emphasized. \u0000 \u0000Keywords:Digital radiography, Diagnostic imaging, Learning, Students.","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89863769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cinnamon Chewing Gum Induced Oral Allergic Contact Stomatitis","authors":"D. Gabrić, V. Boras, L. Vuletić, M. Vuletić, B. Pavelić, A. Glavina","doi":"10.33887/RJPBCS/2019.10.3.4","DOIUrl":"https://doi.org/10.33887/RJPBCS/2019.10.3.4","url":null,"abstract":"","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"9 1","pages":"29-31"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86967631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facile green synthesis of graphene metal nanocomposites and their promising applications","authors":"A. G. Patil, P. Patil, Mahesh P. More, Prashant K. Deshmukh, Sanchita S. Mahale","doi":"10.18231/2320-1924.2018.0007","DOIUrl":"https://doi.org/10.18231/2320-1924.2018.0007","url":null,"abstract":"Graphene, a 2D carbon sheet, has attracted tremendous attention in the scientific fraternity. Recently, graphene based metal nanocomposites (GO@Me-NCs) have opened an exciting avenue amongst researchers worldwide, owing to its exceptional properties. Graphene has a high electrical conductivity, exceptional chemical tolerance and large surface-to-volume ratio, which makes it an obvious template for nanocomposites. As a result, incorporation of graphene with inorganic materials such as metal has been the spotlight of research in recent years for their multi-functionalities. From the perspective of chemistry and materials, this account presents an overview of the green and benign processes for fabrication of GO@Me-NCs and their wide range of applications in various fields. Present review highlights the fabrication of GO@Me-NCs by green techniques using plant extracts, carbohydrates, vitamins, amino acids, etc. Finally a concluding remarks are also provided for the researchers, who are interested in designing advanced green strategies for the fabrication of graphene based metal nanocomposites. \u0000 \u0000Keywords: Green synthesis, Graphene, Metal Nanocomposites","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85935572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between issues related to occupational attachment of nurses in health and medical centers of Estahban City","authors":"D. Ranjbar, A. Yazdanpanah, A. KhaniJeihooni","doi":"10.18231/2320-1924.2018.0003","DOIUrl":"https://doi.org/10.18231/2320-1924.2018.0003","url":null,"abstract":"Purpose: Occupational attachment is one of the variables that can be seen by the employees in creating positive consequences for the organization. Career-minded employees form spiritual relationships with their jobs and invest specific resources in their current jobs, and this is one of the important factors in the lives of individuals. The individual's attitude toward his work reflects a negative or positive evaluation that he has in relation to an aspect of his work environment. Among various job attitudes, attachment to a job is a measure that a person likes to match with his job or the extent to which the occupation of the person's identity center is of particular importance. Methods: The research method is applied in terms of purpose and descriptive-applied method. Correlation method has been used. The research sample was 145 nurses of the hospital and health centers of Estahban city who were selected by available sampling method. To evaluate the variables, two questionnaires were used by researcher and occupational attachment questionnaire. Data analysis was done using descriptive statistics using spss software. Results: There is a significant positive relationship between personal factors with occupational attachment (226 / r = r). The higher the individual factors of the nurses, the higher the level of job attachment. There is a significant positive relationship between economic factors with occupational attachment (212.0 r =). The higher the economic factors of nurses, the higher the job attachment. There is a significant positive relationship between organizational factors with occupational attachment (r = .231). The higher the organizational factors in nurses, the higher the level of occupational attachment. There is a significant positive relationship between environmental factors with occupational attachment (r = .249). The higher the nurses' environmental factors, the higher the level of occupational attachment. Conclusion: Therefore, nurses' attachment to their jobs is one of the most important research topics in the field of health systems, since in many countries nurses form one of the largest groups of health professionals. Therefore, the nature and quality of services provided to Patients are highly dependent on their function. Key words: occupational attachment, individual factors, economic factors, organizational factors, environmental factors","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75154753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}