Research journal of pharmaceutical, biological and chemical sciences最新文献_第6页

The effect of an educational intervention in improving hypertension?related adherence to medication and health?related quality of life 教育干预对改善高血压的影响?坚持服药和健康有关吗?相关生活质量

Research journal of pharmaceutical, biological and chemical sciences Pub Date : 2020-12-15 DOI: 10.18231/2320-1924.2018.0018

Hira Iqbal, H. Hussain, F. Zara, Mehrunnisa

{"title":"The effect of an educational intervention in improving hypertension?related adherence to medication and health?related quality of life","authors":"Hira Iqbal, H. Hussain, F. Zara, Mehrunnisa","doi":"10.18231/2320-1924.2018.0018","DOIUrl":"https://doi.org/10.18231/2320-1924.2018.0018","url":null,"abstract":"The objective of this study is to evaluate the effect of educational intervention in improving hypertension?related adherence to medication and health?related quality of life. This study includes the effects of pharmacist interventions on cardiovascular problems, economics, medication issues, medicine adherence, self-prescription, hospitalized patients and discharged patients. The review study shows that pharmacist and physician co management in order to control blood pressure is significant at decreasing blood pressure and rate of blood pressure control is improved. The pharmacist can also improve medication adherence, quality of life and patient knowledge about diseases and medication and give satisfaction to patient. In addition, the use of drugs is reduced. This study emphasizes that intervention of pharmacist in medication management or therapy is health effective. As a member of health care team pharmacist can increase the number of health outcomes. Hypertension is an important risk factor contributes to present epidemic cardiovascular problems with the pharmacist intervention in controlling of blood pressure its risk is going to decrease.\u0000\u0000Keywords: Hypertension, Role of pharmacist, Essential hypertension, Cardio-vascular problems, Adherence.","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82768677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fascinating approach for using metabolites products of living microorganisms as reducing agents for preparing silver nanoparticles 使用活微生物的代谢物产品作为制备纳米银的还原剂的迷人方法

Research journal of pharmaceutical, biological and chemical sciences Pub Date : 2020-12-15 DOI: 10.18231/2320-1924.2018.0017

Mohammad Abdul Rahmman Al-Maeni, Shaymaa Fouad Rasheed

{"title":"Fascinating approach for using metabolites products of living microorganisms as reducing agents for preparing silver nanoparticles","authors":"Mohammad Abdul Rahmman Al-Maeni, Shaymaa Fouad Rasheed","doi":"10.18231/2320-1924.2018.0017","DOIUrl":"https://doi.org/10.18231/2320-1924.2018.0017","url":null,"abstract":"A crucial area of research in nanotechnology is the formation of environmentally benign nanoparticles. Both unicellular and multicellular play an important role in synthesis nanoparticles through the production of inorganic materials either intracellularly or extracellularly. The agents (pigments, siderophores, cell extracted metabolites and reducing compounds) were used to prepare silver nanparticles with different sizes and shapes. The color variations (dark yellow, slightly dark yellow and golden yellow) arising from changes in the composition, size, and shape of nanoparticles, surrounding medium can be monitored using UV-visible spectrophotometer. These effects are due to the phenomena called surface plasmon resonance. The silver nanoparticles have Plasmon resonances ranged between (390, 383 and 365) nm which they are among the limitation of silver nanoparticles (360 – 420 nm). AFM analysis of Ag NP’s showed partially purified big triangular Ag NP having edge length around ~1. mm. Hexagonal particles on the background of a matrix made up of some molecules which may be metabolites products are found. Small spherical nanoparticles embedded in some kind of matrix indicate that this molecule acts as capping agent, which inhibits further growth of nanoparticles. Also ribbons like structures of width around 50 nm which are intertwined are the noble and rare structures which are synthesized by this method. MIC of silver Nanoparticles for. E coli, ranges between 80-90 µg/ml.., Serrtia, ranges between 50-60 µg/ml and Shagilla, ranges between 90-100 µg/ml. \u0000 \u0000Keywords: Metabolites product of microorganisms, silver nanoparticles.","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"136 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80251911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Chloroquine and Hydroxychloroquine in SARS-Cov-2. Repurposing the old drugs against today’s deadly disease 氯喹和羟氯喹在SARS-Cov-2中的作用。重新利用旧药来对付今天的致命疾病

Research journal of pharmaceutical, biological and chemical sciences Pub Date : 2020-08-15 DOI: 10.18231/j.jpbs.2020.001

Kavita M. Jaiswal, S. Dudhgaonkar, Latesh B. Raghute, Mahek S. Kewalramani, Lohit S. Vaishnao

{"title":"Chloroquine and Hydroxychloroquine in SARS-Cov-2. Repurposing the old drugs against today’s deadly disease","authors":"Kavita M. Jaiswal, S. Dudhgaonkar, Latesh B. Raghute, Mahek S. Kewalramani, Lohit S. Vaishnao","doi":"10.18231/j.jpbs.2020.001","DOIUrl":"https://doi.org/10.18231/j.jpbs.2020.001","url":null,"abstract":"Introduction: Chloroquine (CQ) and Hydroxychloroquine (HCQ) has received huge momentum as possible treatment for COVID-19. In India the drug is approved for prophylaxis of asymptomatic health workers treating suspected or confirmed COVID-19 cases, and asymptomatic household contacts of confirmed patients. The U.S. Food and Drug Administration (FDA) has issued Emergency Use Authorization (EUA) of HCQ to treat COVID-19.\u0000Materials and Methods: Here we present the database of trials with these compounds in COVID-19.\u0000Discussion: Early 15 registered clinical trials of CQ and HCQ in COVID -19 positive patients in China, showed that the drugs were superior to the control treatment in inhibiting the exacerbation of pneumonia, improving lung imaging findings, promoting a virus-negative conversion, and shortening the disease course. Some studies had no positive results including a multinational registry analysis of HCQ with or without a macrolide for treatment of COVID-19 published online in Lancet on 22nd May 2020.The study showed that there was decreased in-hospital survival and an increased frequency of ventricular arrhythmias when HCQ was used for treatment of COVID-19.In the light of this publication the WHO temporarily paused the HCQ arm of its ‘Solidarity’ global clinical trial on 26th May 2020 and trials with HCQ /CQ for COVID were also suspended. The Lancet paper was in controversy until finally on June 4th 2020 the article was retracted by authors.\u0000Conclusions: Until we get results of WHO fast track ‘Solidarity’ clinical trial and other randomized clinical trials repurposing these drugs remains questionable.\u0000\u0000Keywords: CQVID-19 pandemic, Corona ‘Solidarity’ trial, Severe acute respiratory syndrome","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77873407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Hepatoprotective and antioxidant effects of Commelina diffusa Burm extracts on gentamicin-induced liver damage in rats 白头翁提取物对庆大霉素所致大鼠肝损伤的保护和抗氧化作用

Research journal of pharmaceutical, biological and chemical sciences Pub Date : 2020-08-15 DOI: 10.18231/j.jpbs.2020.004

Kamdem Djoko Serges, P. Laure, Nchouwet Moise Legentil, Kodjio Norbert, Kamanyi Albert, Wansi Ngnokam Sl

引用次数: 3

Quantifying Pharmacoeconomics 量化概述

Research journal of pharmaceutical, biological and chemical sciences Pub Date : 2020-08-15 DOI: 10.18231/j.jpbs.2020.005

S. Chaudhry

引用次数: 0

Anti-Oxidant and Anti Tyrosinase Effect of Zizyphus Spina-Christi Seed Extract 酸枣籽提取物的抗氧化和抗酪氨酸酶作用

Research journal of pharmaceutical, biological and chemical sciences Pub Date : 2020-05-20 DOI: 10.36478/rjbsci.2020.15.21

I. Maina, K. I. Onifade, B. Saidu, A. A. Abubakar, S. Habibullah, Abdullahi Ishaq Jaafar, Y. A. Yabo, Abdurahman Jibreen Hassan

{"title":"Anti-Oxidant and Anti Tyrosinase Effect of Zizyphus Spina-Christi Seed Extract","authors":"I. Maina, K. I. Onifade, B. Saidu, A. A. Abubakar, S. Habibullah, Abdullahi Ishaq Jaafar, Y. A. Yabo, Abdurahman Jibreen Hassan","doi":"10.36478/rjbsci.2020.15.21","DOIUrl":"https://doi.org/10.36478/rjbsci.2020.15.21","url":null,"abstract":": Medicinal plant such as Ziziphus Spina-Christi (ZSC) has been used for the treatment and prevention of several ailments in human and animals.It is recommended for the management of diseases in which free radical species are produced as a result of oxidative stress. However, there is lack of systematic study on the antioxidant and antityrosinase capacities of ZSCF from Nigeria. The present study quantifies the anti-oxidant and anti tyrosinaseability of the ZSCF grown in the Gwaski, Southern Borno state Nigeria. Antioxidant activity was assessed by using 2, 2-Diphenyl-1-Picrylhydrazyl (DPPH), Superoxide-Radical Scavenging Activity (SRSA), Ferric Reducing/Antioxidant Power (FRAP assay). Overall the ZSCF showed strong antioxidant ability and high anti tyrosinase effect. There is variation in the oxidation power (DPPH) with 15.5% at the concentration of 7.8 μ g mL G 1 -88.4% at 1000 μ g mL G 1 and 22.5% at 7.8 μ g mL G 1 as well as 63.5% at 1000 μ g mL G 1 for FRAP assay. The percentage antityrosinase activities varied from 4.1% at 7.8 μ g mL G 1 -70.5% at 1000 μ g mL G 1 for plant crude extract. The observed antioxidantand anti tyrosinase ability of ZSCF may be due to abundant presence of phenolic contents and high electron donating ability to neutralize free radicals.","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79870019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diversity of Endophytic Fungi from Leaves of Cenetlla asiatica L. and Melia azedarach L. 积雪草和苦楝叶内生真菌的多样性。

Research journal of pharmaceutical, biological and chemical sciences Pub Date : 2020-05-20 DOI: 10.36478/rjbsci.2020.22.25

A. Rani, V. Ambikapathy, A. Panneerselvam

引用次数: 0

The Effect of Applying Partial Root Zone Drying Technique on Growth, Result and Quality of Tomato 应用部分根区干燥技术对番茄生长、结果和品质的影响

Research journal of pharmaceutical, biological and chemical sciences Pub Date : 2020-05-20 DOI: 10.36478/rjbsci.2020.26.32

M. Idris

引用次数: 0

Fungal Pathogens of Postharvest Rot of Groundnut (Arachys hypogaea L.) in Hong Local Government Area of Adamawa State Nigeria 尼日利亚阿达马瓦州洪地方政府区花生采后腐病真菌病原菌研究

Research journal of pharmaceutical, biological and chemical sciences Pub Date : 2020-05-20 DOI: 10.36478/rjbsci.2020.5.14

P. Asama, F. K. Channya

{"title":"Fungal Pathogens of Postharvest Rot of Groundnut (Arachys hypogaea L.) in Hong Local Government Area of Adamawa State Nigeria","authors":"P. Asama, F. K. Channya","doi":"10.36478/rjbsci.2020.5.14","DOIUrl":"https://doi.org/10.36478/rjbsci.2020.5.14","url":null,"abstract":": Fungi such as Aspergillus niger (brasiliensis), Aspergillus flavus, Alterneriadianthocola, Curvularia lunata, Curvulari apellesecens, Fusarium oxysporum, Fusarium equiseti, Microphomina phaseolina, Rhizopus stolonifer, Penicillium digitatumare associated with heavy losses of seeds, fruits, grains, vegetables and other plant products in transit and storage rendering them unfit for human consumption. The research sought to identify fungal pathogens of groundnut rot in storage in Hong Local Government area of Adamawa State, Nigeria a major groundnut producing area. A survey was carried out using random sampling on incidence of groundnut rot in the seven districts of Hong local government area in the month of July 2016. Isolation and identification, frequency of occurrence, virulence, as well as effect of pathogens on germination of groundnut seeds and seedling growth were carried out. Incidence of rot occurred in all seven districts with the highest in Hong, Hildi and Gaya, pathogens associated with the rot were identified as follows; Aspergillus niger (brasilensis), Aspergilus flavus, Penicillium chrysogenum, Rhizopus stolonifer, Paecilomyces lilacinus, Pseudallescheria boydii, Cylindrocarpon lichenicola and Scedosaporium prolificans. The frequent occurring fungi were Aspergillus niger (brasilensis) and Aspergillus flavus while the most virulent was Aspergillus flavus. There was significant reduction in seed germination and seedling growth at 99.99% probability level for both the Valencia(kampala) and Peruvian(kwathrumthrum) from 33.33% for un-inoculated to 11.00% for inoculated.Proper storage practices to reduce groundnut rot as well as enhance seed viability are therefore suggested.","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82162873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Mummy Enhances Chondrocyte Proliferation and the Expression of Extracellular Matrix Components in Monolayer and 3D Culture Conditions 木乃伊在单层和三维培养条件下促进软骨细胞增殖和细胞外基质成分的表达

Research journal of pharmaceutical, biological and chemical sciences Pub Date : 2020-05-20 DOI: 10.36478/rjbsci.2020.33.39

F. Rezaei, Maryam Hassan Famian, H. Shafaei, J. S. Rad, L. Roshangar, A. Montaseri

{"title":"Mummy Enhances Chondrocyte Proliferation and the Expression of Extracellular Matrix Components in Monolayer and 3D Culture Conditions","authors":"F. Rezaei, Maryam Hassan Famian, H. Shafaei, J. S. Rad, L. Roshangar, A. Montaseri","doi":"10.36478/rjbsci.2020.33.39","DOIUrl":"https://doi.org/10.36478/rjbsci.2020.33.39","url":null,"abstract":": To investigate the probable effects of mummy on chondrocyte proliferation and expression of cartilage specific gene. Chondrocytes at the second passage were plated at density of 1×10 6 in monolayer or seeded onto PCL scaffolds. Cells in both conditions were divided into control (received medium) or treated with mummy at concentrations of 500 or 1000 µg mL G 1 for 72 h. The gene expression profile of collagen II, aggrecan, Cartilage Oligomeric Matrix Protein (COMP) and Sox-9 was evaluated using real-time RT-PCR. The ability of mummy to enhance the proliferation of chondrocytes was further evaluated using doubling time. Treatment of chondrocytes with 1000 µg mL G 1 of mummy resulted in a significant increase in expression of Sox-9, COMP and aggrecan genes in both monolayer and 3D culture conditions. Compared to the monolayer cultivated cells, expression of genes in seeded chondrocytes on PCL scaffolds was significantly higher. The highest proliferation rate of chondrocytes was found at a concentration of 1000 µg mL G 1 . The preliminary findings of this study revealed that mummy can be a promoting factor for chondrocyte proliferation and ECM synthesis. The use of mummy at 1000 µg mL G 1","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84310313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0