RESEARCH RESULTS IN BIOMEDICINE最新文献

{"title":"Coexistence of Urinary Incontinence and Osteoporosis in Females – A Systematic Review","authors":"Sougata Panda, Seveka Bali, Amrit P. S. Sood, Vishesh Singhal","doi":"10.18413/2658-6533-2022-8-4-0-7","DOIUrl":"https://doi.org/10.18413/2658-6533-2022-8-4-0-7","url":null,"abstract":"Background: Urinary incontinence (UI) is described as the involuntary leakage of urine and is a global problem. The younger age groups have the lowest prevalence (12.0%), while the oldest have the greatest (40.0%); however, there is a surge around the middle age. Osteoporosis (OP) is a medical and socioeconomic hazard characterized by the decrease of bone mass, strength throughout the body resulting in lower bone density and a higher risk of fractures. Females become more vulnerable to these conditions as they grow older. The aim of the study: To assess the available research and find links between coexistence of decreased bone health and urinary incontinence in females. Materials and methods: Electronic databases like, CINAHL, Embase, Trip Medical Database, Cochrane Library and Pub Med were the ones searched for relevant articles from January 2011 to January 2022. The PRISMA Statement for Systematic Reviews and Meta-Analysis was used to conduct this systematic review. Results: There were 416 results found in the databases after eliminating the duplicates and studies that were unrelated to the topic. The review included total of five studies and quality assessment was done by four reviewers. Most studies found a strongly significant link between osteoporosis and urinary incontinence, whereas one study found no association. Conclusion: In this study, the five most common associated risk factors were revealed to be menopause, obesity, smoking, physical inactivity, and hyperlipidemia. Based on recent studies a strong significant link was found between the two health conditions (OP and UI) and coexistence of both conditions was seen in females.","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80792447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social functional activity of patients with diabetic retinopathy","authors":"N. M. Agarkov, I. Lev, M. Tanygin, Evgeniy N. Korovin","doi":"10.18413/2658-6533-2022-8-4-0-9","DOIUrl":"https://doi.org/10.18413/2658-6533-2022-8-4-0-9","url":null,"abstract":"","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78072086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of the exosomal microRNA-126 and microRNA-218 expression profiles in patients with hemorrhagic fever with renal syndrome (HFRS)","authors":"I. Gilyazova, G. Khasanova, Elizaveta A. Ivanova, D. Asadullina, Aliya N. Khasanova, A. Izmailov, G. Gilyazova, Guoqing Wang, Honglan Huang, Jiahui Pan, Tong Shao, Haochen Yao, Wenfang Wang, E. Khusnutdinova","doi":"10.18413/2658-6533-2022-8-4-0-2","DOIUrl":"https://doi.org/10.18413/2658-6533-2022-8-4-0-2","url":null,"abstract":"Background: Hemorrhagic fever with renal syndrome (HFRS), caused by orthohantaviruses, occupies one of the leading places among natural focal human diseases, for which there are no modern accurate and highly sensitive diagnostic methods. To improve this situation, a better understanding of the hantavirus pathogenesis of HFRS is required. The expression levels of circulating microRNAs in the serum or plasma of patients during infection make them potential therapeutic biomarkers for the diagnosis of HFRS. The aim of the study: To analyze the expression levels of miR-126 and miR-218 patients with HFRS at different stages of the disease. Materials and methods: The moderate disease severity group of HFRS patients included 105 RNA samples, severe – 99 and severe with complications – 84 RNA samples. Blood samples of HFRS patients for molecular genetic analysis were collected three times – during the initial febrile period (1-4 days of illness), the polyuric period (15-22 days of illness) and during the convalescence period. Total RNA isolation was performed using the miRNeasy Serum/Plasma Advanced Kit (Qiagen, Germany). Quantitative realtime PCR was performed using the miRCURY LNA SYBR Green PCR Kit (Qiagen, Germany) and the real time PCR product detection system LightCycler96 (Roch). Results: A pairwise comparison of miR-126 and miR-218 expression levels in patients with HFRS at the fever stage and at the polyuric stage of HFRS did not reveal statistically significant results (P>0.05). Conclusion: Further studies of the network of genes that are targets of various microRNAs are needed to clarify the molecular mechanisms that can influence the occurrence and development of HFRS.","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81790132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"The blue zones\" resilience-diet (review)","authors":"A. Martynenko, Nunes P. Sibelli, A. Ilnitski","doi":"10.18413/2658-6533-2022-8-4-0-8","DOIUrl":"https://doi.org/10.18413/2658-6533-2022-8-4-0-8","url":null,"abstract":"Given the progressive aging of the population, the problem of extending healthy longevity while maintaining high vitality is very important. The \"blue zones\" – the regions with the highest life expectancy – are of particular scientific interest. The views of scientists from all over the world are riveted to the lifestyle of the inhabitants of these territories. The available studies demonstrate the important role of nutrition in longevity, but there is not enough information about a single resistance diet based on foods consumed by long-livers of the \"blue zones\". The aim of the study: The purpose of this review is to determine whether the nutrition of long-livers of the \"blue zones\" has the characteristics of a resilience diet. Materials and methods: Literature data were studied based on the following search words: aging, longevity, gerontology, nutrition of centenarians, blue zones, viability, age viability, resilience diet for 2006-2021 in computer databases: NCBI, Google Scholar, Science Direct, PubMed, Scopus, ISI Web of Science, Cyberleninka, Elsevier and SciELO. Results: Analysis of the literature data showed that the eating habits of centenarians of the \"blue zones\" of the USA, Greece and Italy, Japan, Costa Rica, Brazil have similar features. Their diet is dominated by plant foods: cereals, beans, pasta from hard varieties, nuts, fruits, vegetables, fresh herbs, olive oil. People in these countries eat meat, especially red meat, milk and dairy products, eggs very rarely, giving preference to fish and seafood. This diet helps prevent cardiovascular disease, diabetes, colorectal cancer, breast and lung cancer, overweight and obesity, early sarcopenia and dementia, and depression. Due to this, the long-livers of the \"blue zones\" are characterized by high age viability. Conclusion: Based on the analysis of the nutrition of long-livers in the \"blue zones\", it is possible to form a resistance diet. The dominant foods in the diet should include unrefined cereals, durum wheat pasta, fresh vegetables and fruits, herbs, algae, fermented foods (tofu, miso, sauerkraut). It is also necessary to consume nuts and legumes, olive oil, fish and seafood daily. White meat, dairy products, eggs should be consumed no more than 1-2 times a week. We should limit or exclude red meat, potatoes, white bread, sweets as much as possible. These dietary interventions may be useful for the formation of a healthy pattern of aging with high age viability.","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76107943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"olecular cytogenetic and cytopostgenomic analysis of the human genome","authors":"I. Iourov, S. Vorsanova, O. S. Kurinnaia, M. Zelenova, K. Vasin, I. Demidova, Alexey D. Kolotii, V. S. Kravets, Maria E. Iuditskaia, Nikita S. Iakushev, I. V. Soloviev, Y. Yurov","doi":"10.18413/2658-6533-2022-8-4-0-1","DOIUrl":"https://doi.org/10.18413/2658-6533-2022-8-4-0-1","url":null,"abstract":"Despite the achievements of human genomics, comprehensive genome analysis, including acquiring the knowledge about intercellular and interindividual variations at (sub)chromosomal/ cytogenomic level, remains a difficult task. This basically results from a lack of heuristic algorithms for uncovering (cyto)genomic and/or somatic genome variations and the functional outcomes. However, current developments in molecular cytogenetics and “cytopostgenomics” may offer a solution of the problem. The aim of the study: To present a heuristic algorithm for molecular cytogenetic and cytopostgenomic analysis of the human genome to uncover mechanisms of genetic (brain/neurodevelopmental) diseases. Materials and methods: Data on cytogenetic and (cyto)genomic variations (chromosome abnormalities, chromosome/genome instability, copy number variation (CNV) etc.) addressed by original molecular cytogenetic techniques and processed by original bioinformatic (cytopostgenomic) methods were used to develop the algorithm. Karyotyping was performed in 8556 individuals. FISH analysis was applied when required (cases of somatic mosaicism/ chromosome instability). Molecular karyotyping by SNP-array was performed in 600 (~7%) cases. Results: Using our long-term experience of studying chromosomal and genomic variations/instability in neurodevelopmental disorders as well as original developments in (cyto) genomic data processing, we managed to present a heuristic algorithm for molecular cytogenetic and cytopostgenomic analysis of the human genome to uncover mechanisms for brain diseases. Estimated efficiency of the algorithm was established to achieve 84%. Analyzing the dynamics of applying cytogenetic and cytogenomic techniques throughout ~35 years of our diagnostic research we found that the diagnostic efficiency had been increasing from ~7% (exclusive diagnosis by karyotyping) to more than 80% (molecular cytogenetic and cytopostgenomic analysis). Conclusion: Here, we propose a heuristic algorithm for molecular cytogenetic and cytopostgenomic analysis of the human genome to uncover mechanisms for genetic diseases. The efficiency and ability to uncover mechanisms of chromosome instability allows us to conclude that the algorithm may be highly competitive for basic and diagnostic genomic/cyto(post)genomic research.","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83867004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knock-out of α-, β-, and γ-synuclein genes in mice leads to changes in the distribution of several lipids in the liver and blood plasma","authors":"E. Lysikova, K. Chaprov","doi":"10.18413/2658-6533-2022-8-4-0-4","DOIUrl":"https://doi.org/10.18413/2658-6533-2022-8-4-0-4","url":null,"abstract":"In addition to the role of synuclein proteins in synaptic transmission through binding with lipid membranes, the function of synucleins in reactions of the synthesis of lipids and fatty acids is also widely studied. Studying the disruption of lipid metabolism in Parkinson’s disease caused by synuclein dysfunction is particularly interesting. The aim of the study: To determine the effect of the absence of synuclein family proteins on the total lipid content and the ratio of different lipid classes in the liver and blood plasma in transgenic mice. Materials and methods: Measurement of lipid classes of αβγ-synuclein triple knockout mice (N=6) and wild type controls (N=6) was performed by the HPLC on the silica gel plates. Results: A 1.4-fold (P<0.05) increase in the percentage of total polar lipids was detected in the liver of knockout mice compared with the wild type, while the relative content of triglycerides decreased 1.2-fold (P<0.05), respectively. At the same time plasma levels of the polar lipids and triacylglycerols were unaltered. The lack of synucleins causes changes in the levels of fatty acids in comparison to wild type animals: C16:0 levels increased 1.2-fold in the liver (P<0.05) and 1.8-fold in plasma (P<0.05), and C18:1n9 levels increased both 1.4-fold (P<0.05) in plasma and 1.2-fold in the liver (P<0.05). C20:4n6 levels decreased 1.5-fold (P<0.05) in the liver of nonsynuclein mice. C18:2n6 levels decreased 7-fold in plasma (P<0.05), but did not change in liver. Conclusion: Our data demonstrate that the absence of all three members of the synuclein family causes disruption of lipid metabolism and leads to altered synthesis of fatty acids and hepatic lipid accumulation.","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82322687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathological conditions associated with tau protein: mechanisms of development and possible biological targets for pharmacological correction of tau proteinopathy (review)","authors":"E. Kuzubova, A. Radchenko, V. M. Pokrovsky, Evgeny A. Patrakhanov, Alina A. Novikova, Yulia V. Stepenko, A. Deikin","doi":"10.18413/2658-6533-2022-8-4-0-6","DOIUrl":"https://doi.org/10.18413/2658-6533-2022-8-4-0-6","url":null,"abstract":"Background: The pathological process associated with the pathogenic aggregation of tau is called taupathy. The same term is often used to refer to a group of neurodegenerative diseases, an important pathogenetic component of which is the aggregation of tau. A violation in the expression of the MART gene leads to changes in the physicochemical properties of the protein. Modern strategies for the search for therapeutic agents to modulate tau-proteinopathy are aimed at creating drugs that suppress the formation of pathogenic forms of protein and its aggregation, but at the same time do not disrupt the metabolism of normal intracellular tau and its function in stabilizing microtubules. The aim of the study:To consider possible biological targets of pathological conditions associated with tau protein and to identify ways of pharmacological correction of tau proteinopath. Materials and methods:We analyzed the literature on the main mechanisms of pathological conditions associated with tau protein and possible biological targets for pharmacological correction of tau-proteinopathy published over the last 10 years. Results: Modern strategies for the search for therapeutic agents to modulate tau-proteinopathy, including Alzheimer's disease, are aimed at creating drugs that suppress the formation of pathogenic forms of tau and its aggregation, but do not disrupt the metabolism of normal intracellular tau protein and its function in stabilizing microtubules. In this regard, the search for therapeutic agents capable of correcting tau-proteinopathy has significantly intensified. Conclusion: There are several approaches to the treatment and prevention of tau-proteinopathy. Stabilization of the microtubule structure, reduction of the activity of full-sized and hyperphosphorylated tau, regulation of pathological phosphorylation of tau, prevention of protein aggregation, inhibition of abnormal aggregation, prevention of oligomerization, inhibition of accumulation inside the cell, specific inhibition of purinoreceptor P2RX7, regulation of AMPA receptors, blocking penetration into cells and transmission of pathogenic protein.","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78665616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the rs10508336 polymor- phism of the TAF3 transcription factor gene with the risk of lower limb arterial disease in the Russian population","authors":"S. Zhabin","doi":"10.18413/2658-6533-2022-8-4-0-3","DOIUrl":"https://doi.org/10.18413/2658-6533-2022-8-4-0-3","url":null,"abstract":"Atherosclerosis obliterans (AO) and diabetic angiopathy (DA) are known to be peripheral artery diseases (PAD) of multifactorial origin, in which genetic and environmental factors play a synergetic role. TAF3 is one of the genes that has been found to be associated with PAD. The aim of the study: To analyze the association of the rs10508336 polymorphism of the TAF3 gene with the risk of PAD in the Russian population. Materials and methods: The study involved 1261 patients, including 642 healthy subjects and 619 PAD patients. All patients were recruited at the Vascular Surgery Division of the Kursk Regional Clinical Hospital. Isolation of genomic DNA was carried out by chloroform extraction and precipitation with ethanol. Genotyping was carried out on the basis of the Research Institute of Genetic and Molecular Epidemiology of KSMU using a MassARRAY-4 time-of-flight genomic mass spectrometer (Agena Bioscience, USA). Results: We found that polymorphism rs10508336 is associated with an increased risk of developing bilateral peripheral atherosclerosis exclusively in smokers (P<0.05). The polymorphism was found to be statistically significantly associated with an increased risk of DA (OR=1.59, 95% CI 1.02-2.46, P=0.045). Furthermore, an association of the rs10508336-A allele with an increase in blood glucose levels in PAD was observed (P=0.01). Conclusion: In the Russian population, an association of the rs10508336 polymorphism of the TAF3 gene with an increased risk of AO, hyperglycemia, and diabetic angiopathy was revealed for the first time. The identified associations point out a possible relationship between carbohydrate metabolism and atherosclerotic processes in the determination of peripheral arterial diseases.","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89934160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of cortisol metabolism in the realization of pathogenetic links in the development of osteoporosis – the rationale for the search for new pharmacotherapeutic targets (review)","authors":"M. Korokin, V. Soldatov, O. Gudyrev, I. S. Koklin, E. I. Taran, M. O. Mishenin, L. Korokina, Alim A. Kochkarov, M. Pokrovskii, M. Varaksin, O. Chupakhin","doi":"10.18413/2658-6533-2022-8-4-0-5","DOIUrl":"https://doi.org/10.18413/2658-6533-2022-8-4-0-5","url":null,"abstract":"Background: Osteoporosis is an important medical and social public health problem in an aging or elderly society. Osteoporosis is caused by an imbalance in bone remodeling, which is a continuous process of destruction of mature bone tissue by osteoclasts (bone resorption) and the formation of new bone tissue by osteoblasts (bone formation). The system of bone homeostasis that regulates the functional activity of osteoclasts and osteoblasts is represented by a wide range of molecules. The understanding of the molecular mechanisms of bone homeostasis achieved today makes it possible to significantly change and expand the paradigms of treatment and prevention of osteoporosis. The aim of the study: To consider the main pathogenetic pathways through which the effect of the cortisol metabolism system on the development of osteoporosis is realized and to identify ways to find new therapeutic approaches to the treatment and prevention of this pathology. Materials and methods: To achieve this goal, we analyzed the literature on the influence of cortisol metabolism on the development of osteoporosis published in the last 10 years. Results: To date, there are significant prerequisites in the literature for a direct connection of disorders of steroid hormone metabolism with the development of osteoporosis and a violation of osteoreparative processes. This literature review presents the main pathogenetic pathways that cause the processes leading to a decrease in bone density in disorders of cortisol metabolism. The enzyme 11b-hydroxysteroid dehydrogenase (11b-HSD), represented by two isoforms, performs the mutual conversion of cortisone and cortisol in tissues. Using the methods of reverse genetics, we have established the systemic consequences of knockout of both isoforms. Convincing evidence demonstrates that both enzymes are involved in the pathogenesis of osteoporosis. Since animals with type 11b-HSD deficiency are characterized by proinflammatory activation of the endothelium, we assume that further study of the interaction between the endothelium and bone tissue is of particular interest. Conclusion: The effects of glucocorticoids on eNOS expression seem to be significantly modulated by 11ß-HSD isoenzymes. The established relationship between 11ß-HSD and NO can be considered a promising pharmacotherapeutic target. In this regard, a pharmacotherapeutic approach aimed at restoring the balance of nitric oxide in bone and endothelial tissues, currently considered as one of the most relevant ways to correct osteoporosis, may also be relevant in case of cortisol metabolism disorders due to 11ß-HSD2 deficiency.","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77626259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual deficit and geriatric status of rural patients with various ophthalmic pathologies","authors":"E. Yaroshevich, A. Chernov, Vitaly V. Aksenov","doi":"10.18413/2658-6533-2022-8-4-0-10","DOIUrl":"https://doi.org/10.18413/2658-6533-2022-8-4-0-10","url":null,"abstract":"Background: Diseases of the visual organ negatively affect the quality of life of the elderly. A comprehensive study of the pathology of the visual organ among the elderly population of the Voronezh region has not been conducted. The aim of the study: Analysis of visual deficit and geriatric status of rural patients with various ophthalmic pathologies. Materials and methods: The data were obtained retrospectively from medical records and case histories of 842 elderly patients (≥60 years old) who sought inpatient medical care in the \"ophthalmology\" profile in the period from 2018 to 2020. The extracted data included: age, gender, marital status, occupation, visual acuity, primary and concomitant ophthalmological diagnoses, medications, surgical interventions on the eyes. Results: The average age of patients was 69.8±7,5 years, 524 (62.2%) women. The most common were cataracts and glaucoma, there were also patients with AMD, DARP, refractive disorders, retinal detachment, senile pathology of the eyelids. Anti-glaucomatous drugs had a predominant share (57.1%) among all drugs used for the treatment of eye diseases. 66.4% were hospitalized for surgery, and 18.1% had previously undergone eye surgery. 61.4% of patients had a decrease in visual acuity of less than 40% in both eyes on admission, while 8.1% had poor vision or blindness in 1 or both eyes. Age and glaucoma were factors largely associated with severe visual deficits and blindness. Certain geriatric syndromes are associated with age in patients with visual deficits, among which the greatest prevalence is characteristic of falls syndrome, anxiety-depressive syndrome and cognitive impairment syndrome. Conclusion: The most common age-related eye diagnoses are glaucoma, cataract, and AMD. It is necessary to popularize the promotion of prevention and timely treatment of preventable causes of low vision and geriatric syndromes in the elderly.","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85660218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}