RESEARCH RESULTS IN BIOMEDICINE最新文献

{"title":"Influence of clinical and biological variants of premature aging on cognitive functionality","authors":"E. Malyutina, E. Fesenko, E. A. Sanches, Viktoriya D. Ismanova, O. Kuzminov, Federal Medical Medical Technologies","doi":"10.18413/2658-6533-2021-7-2-0-7","DOIUrl":"https://doi.org/10.18413/2658-6533-2021-7-2-0-7","url":null,"abstract":"Background: Currently, the development of gerontology as a related medical and biological discipline follows the path of concepts; there are three of them in classical gerontology: frailty, intrinsic capacity and resilience, and in preventive medicine – one – premature aging. The aim of the study: To study the features of cognitive functioning of people with various clinical and biological variants of premature aging. At the same time, insufficient attention is paid to cognitive and psychological functionality, which is largely the basis for the formation of resilience. Materials and methods: The study included 1214 people. All of them were divided into two groups. Subgroups were identified in each group, depending on the presence of a particular clinical and biological variant of premature aging. All patients included in the study underwent cognitive psychological testing. Results: The most risky options of premature aging are cardiac, cerebral, mitochondrial, menopausal (in women), andropausal (in men) and mixed variants of premature aging. Moreover, with increasing age, gender differences increase. In the 55-64-year-old age group with mitochondrial, andropausal, and mixed variants of premature aging, the cognitive vulnerability of men was higher than that of women. So, if in women in the 55-64-year-old age group with the mitochondrial variant in women, the MMSE test score was 28.2±0.08 points, then in men – 24.4±0.07 (p<0.05). In the menopausal variant, the MMSE test score was 27.1±0.04 points, in the andropausal variant in men – 24.2±0.03 (p<0.05). In the mixed variant, the MMSE test score for women was 25.1±0.16 points, while for men it was 23.2±0.16 (p<0.05). Conclusion: 55-64-year-old men and women are most susceptible to cognitive and psychological vulnerability in mitochondrial, menopausal (in women), andropausal (in men) and mixed variants of premature aging, and being a male further increases this vulnerability.","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87766398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of rs2305948 and rs1870377 polymorphic variants of the vascular endothelial growth factor receptor type 2 (KDR) gene with the risk of coronary heart disease","authors":"M. Medvedeva","doi":"10.18413/2658-6533-2020-7-1-0-3","DOIUrl":"https://doi.org/10.18413/2658-6533-2020-7-1-0-3","url":null,"abstract":"Background: According to statistics, the first place among the causes of death worldwide is occupied by cardiovascular diseases (CVD), of which a large proportion are cases of coronary heart disease (CHD). In this regard, to date, research is actively being conducted to study its previously unknown etiological aspects. Especially relevant in modern conditions is the search for genetic markers of the disease, potentially applicable in the future for the early diagnosis of CHD, as well as the establishment of a hereditary predisposition to it. The aim of the study: To study the association of polymorphic variants of rs2305948 and rs1870377 of the KDR gene with the risk of CHD in Central Russia. Materials and methods: The study included 1390 DNA samples: 635 CHD patients and 755 healthy people. DNA was isolated by phenol-chloroform extraction. Genotyping of DNA polymorphisms was performed using real-time PCR with allele discrimination using TaqMan probes. We Оригинальная статья Original article Научные результаты биомедицинских исследований. 2021;7(1):32-43 Research Results in Biomedicine. 2021;7(1):32-43 34 used the CFX96 amplifier and Applied Biosystems kits. Statistical processing of results was carried out using the resources of the SNPstats program. We performed functional annotation of SNPs on the basis of available bioinformatic resources. Results: We found that there is sexual dimorphism in relation to KDR with the development of CHD. We found a statistically significant Association of the a/T rs1870377 genotype of the VDR gene with the risk of CHD in men. Bioinformatic analysis revealed the relationship of rs1870377 polymorphism with increased expression of the SRD5A gene (an enzyme that converts testosterone to dihydrotestosterone), which may be one of the reasons for gender differences in studying the risk of CHD in this particular case. Conclusion: For the first time in the Russian population, the study examined the relationship of polymorphic variants of the KDR gene with the risk of CHD. It was found that the rs1870377 polymorphism of the KDR gene is statistically significantly associated with risk of CHD in males.","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89239647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Induced preterm birth: evaluation of oxidative status, matrix metalloproteinases and their tissue inhibitors in amniotic fluid","authors":"O. V. Remneva, Y. Korenovsky, N. M. Hovalyg, O. V. Kolyado","doi":"10.18413/2658-6533-2020-7-1-0-9","DOIUrl":"https://doi.org/10.18413/2658-6533-2020-7-1-0-9","url":null,"abstract":"Background: Hypoxic brain injury is the most common pathology in newborns. New criteria of viability and progress of perinatal technologies results in high neurological morbidity of surviving very early preterm infants. The aim of the study: To assess the level of oxidative stress, the activity of the system of matrix metalloproteinases (MMP-1 and MMP-9) and their tissue inhibitor (TIMP-1) in the amniotic fluid of low birth weight premature newborns after abdominal delivery. Materials and methods: The study included 142 women, 102 of whom were delivered by caesarian section within 28-33.6 weeks of gestation because of severe obstetric and/or perinatal complications (main group). The comparison group comprised 30 patients with term abdominal delivery, for obstetric indications. In 32 women of the main group and 30 of the comparison group the concentration of thiobarbitate-reactive products (TBRP) in amniotic fluid was determined by the photometric method on the KFC-3 spectrophotometer at 532 nm wavelength by changing the optical density, due to the coloring complex of the malone dialdehyde (MDA) with thiobarbitic acid Оригинальная статья Original article Научные результаты биомедицинских исследований. 2021;7(1):86-95 Research Results in Biomedicine. 2021;7(1):86-95 88 in a ratio of 1:2. The concentrations of matrix metalloprothyinasis and their tissue inhibitors were determined by immunoformation with the vertical photometer Multiscan at 450 nm wavelength. Results: The main indications for induced abdominal delivery are severe pre-eclampsia (38.2%), progress of placental insufficiency (24.5%), placental abruption (17.6%). In premature newborns, severe cerebral ischemia (p<0.05) is more commonly diagnosed after delivery induced for progressive fetal hypoxia (48.9%), and placental abruption (26.7%), while mild/medium cerebral ischemia is diagnosed after delivery for severe pre-eclampsia (54.4%). In the amniotic fluid of premature infants taken immediately after delivery, the concentration of TBRP, MMP-9, and the MMP/TIMMP-1 level was significantly higher and the TIMP-1 level was lower than that in newborns after term abdominal birth. Conclusion: The obtained results demonstrate that premature infants, delivered by caesarian section for maternal indications, underwent antenatal hypoxia induced by lifethreatening situations in the functional system «mother-placenta-fetus», which is confirmed by the presence of oxidative stress, the high activity of the enzymes destroying collagen type IV and low level of tissue inhibitors of matrix metalloprothyinasis.","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78745707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An association study of three polymorphisms in the glutathione synthase (GSS) gene with the risk of ischemic stroke","authors":"Iulia A. Bocharova","doi":"10.18413/2658-6533-2020-6-4-0-4","DOIUrl":"https://doi.org/10.18413/2658-6533-2020-6-4-0-4","url":null,"abstract":"","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86943862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphofunctional changes in the retina when modeling the glaucoma process in rats","authors":"A. Dolzhikov, A. Pobeda, O. Shevchenko, I. Dolzhikova","doi":"10.18413/2658-6533-2020-6-4-0-6","DOIUrl":"https://doi.org/10.18413/2658-6533-2020-6-4-0-6","url":null,"abstract":"","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88620935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PregnancyNutritionandZincDeficiency: Review","authors":"O. Prokhorova, A. Olina","doi":"10.18413/2658-6533-2020-6-4-0-10","DOIUrl":"https://doi.org/10.18413/2658-6533-2020-6-4-0-10","url":null,"abstract":"","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91462115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinformatic analysis of microduplications at 5p15.33: identification of TPPP as a candidate gene for autism and intellectual disability","authors":"K. Vasin, S. Vorsanova, O. S. Kurinnaia, Natalia Shmitova, V. Voinova, I. Iourov","doi":"10.18413/2658-6533-2020-6-4-0-3","DOIUrl":"https://doi.org/10.18413/2658-6533-2020-6-4-0-3","url":null,"abstract":"","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79211559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allele distribution and haploblock structure of matrix metalloproteinase gene polymorphism in patients with H. pylori-negative gastric ulcer and duodenal ulcer","authors":"O. Minyaylo","doi":"10.18413/2658-6533-2020-6-4-0-5","DOIUrl":"https://doi.org/10.18413/2658-6533-2020-6-4-0-5","url":null,"abstract":"","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73048802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychoemotional status of elderly patients with cataracts","authors":"E. Popova","doi":"10.18413/2658-6533-2020-6-4-0-9","DOIUrl":"https://doi.org/10.18413/2658-6533-2020-6-4-0-9","url":null,"abstract":"","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83623398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of first-line anti-TB drugs on the level of toxic plasma phospholipids","authors":"D. S. Riasenskiĭ, A. V. Aseev, G. M. Zubareva","doi":"10.18413/2658-6533-2020-6-4-0-7","DOIUrl":"https://doi.org/10.18413/2658-6533-2020-6-4-0-7","url":null,"abstract":"","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74877755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}