RESEARCH RESULTS IN BIOMEDICINE最新文献_第9页

Cognitive dysfunction in elderly patients with chronic systolic heart failure 老年慢性收缩期心力衰竭患者的认知功能障碍

RESEARCH RESULTS IN BIOMEDICINE Pub Date : 2021-06-30 DOI: 10.18413/2658-6533-2021-7-2-0-10

A. Zarudsky, E. Perutskaya, D. Perutskiy

引用次数: 1

Association of VEGFA, factor V and prothrombin gene polymorphisms with early pregnancy loss VEGFA，因子V和凝血酶原基因多态性与早期妊娠丢失的关系

RESEARCH RESULTS IN BIOMEDICINE Pub Date : 2021-06-30 DOI: 10.18413/2658-6533-2021-7-2-0-1

A. Ahmed, M. Azova

引用次数: 2

Effects of psychopharmacotherapy and patients’ adherence: interdependence within the biopsychosocial paradigm 精神药物治疗的效果和患者的依从性:生物心理社会范式内的相互依赖

RESEARCH RESULTS IN BIOMEDICINE Pub Date : 2021-06-30 DOI: 10.18413/2658-6533-2021-7-2-0-11

Mikhail Yu Sorokin, N. Lutova, V. Wied, M. Khobeysh, O. Makarevich

{"title":"Effects of psychopharmacotherapy and patients’ adherence: interdependence within the biopsychosocial paradigm","authors":"Mikhail Yu Sorokin, N. Lutova, V. Wied, M. Khobeysh, O. Makarevich","doi":"10.18413/2658-6533-2021-7-2-0-11","DOIUrl":"https://doi.org/10.18413/2658-6533-2021-7-2-0-11","url":null,"abstract":"Background: The expected effects of psychopharmacology in the clinic are mediated by changes in dopamine and serotonin neurotransmission that can determine impaired motivational processes in patients. The aim of the study: To study associations between psychopharmacotherapy and biological, psychological, and social factors of patients` medication adherence. Materials and methods: 83 patients hospitalized due to exacerbation for selection of therapy. Socio-demographic and medical history data were taken from medical records. The original Treatment Motivation Assessment Questionnaire and the Medical Compliance Scale were used. Dispersion analysis with p≤0.05 was performed. Effect sizes (ES) were calculated using Cohen’s d and Cramer’s V. Results: Patients taking atypical antipsychotics were characterized by shorter duration of illness and infrequent hospitalizations (ES=0.68 and 0.47). Only childless and single patients were treated with two antipsychotics (ES=0.32). Past non-compliance varied in subgroups of patients receiving typical and atypical antipsychotics (ES=0.74). The structure of patients' motivation for treatment was objectivized: outpatients treated with typical antipsychotics less often relied on their own knowledge and skills to overcome the disease making a decision about their treatment (ES=0.64) and had lower motivation (ES=0.6). Regardless of their class, the use of antidepressants was associated with better insight. However, unspecific intensification of treatment motivation occurred only when antidepressants were used in combination with mood stabilizers (ES=0.64). Conclusion: Patients' longterm adherence to psychopharmacotherapy is not only a socio-psychological construct, but also a biological process influenced by the neurotropic drugs prescribed in clinical practice. Оригинальная статья Original article Сорокин МЮ, и др. Эффекты психофармакотерапии и ... Sorokin MYu, et al. Effects of psychopharmacotherapy and ... 204","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82236532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Study on the antioxidant capacity of Hibiscus rosa-sinensis decoction in vivo in Mus musculus var. albino 芙蓉水煎液对白化小家鼠体内抗氧化能力的研究

RESEARCH RESULTS IN BIOMEDICINE Pub Date : 2021-06-30 DOI: 10.18413/2658-6533-2021-7-2-0-5

H. N. Thi, Tai Phung Anh, Hien Nguyen Thanh, D. N. Anh, Linh Nguyen Anh, Huyen Nguyen Thi Thuong

引用次数: 0

Changes in the blood complement system in the development of diabetic retinopathy in the elderly 血液补体系统在老年糖尿病视网膜病变发展中的变化

RESEARCH RESULTS IN BIOMEDICINE Pub Date : 2021-06-30 DOI: 10.18413/2658-6533-2021-7-2-0-8

N. M. Agarkov, Tatyana S. Gorko, I. Lev, Alexey A. Shekaturov, A. A. Shabalin

引用次数: 1

Influence of some risk factors and rs1799930 polymorphism of the NAT2-590 G>A gene on the development of chronic pancreatitis 部分危险因素及nat2 - 590g >A基因rs1799930多态性对慢性胰腺炎发生的影响

RESEARCH RESULTS IN BIOMEDICINE Pub Date : 2021-06-30 DOI: 10.18413/2658-6533-2021-7-2-0-4

T. A. Samgina

引用次数: 2

Vaccination against human papillomavirus is a fundamental factor in the prevention of cervical cancer (review) 预防人乳头瘤病毒疫苗是预防子宫颈癌的基本因素(检讨)

RESEARCH RESULTS IN BIOMEDICINE Pub Date : 2021-06-30 DOI: 10.18413/2658-6533-2021-7-2-0-9

Еlena V. Enkova, Еlena V. Kiseleva, O. V. Khoperskaya, S. Shamarin, Ekaterina S. Dukhanina, E.Ya. Sentsova, Voronezh City Clinical Polyclinic No.

引用次数: 0

Estrogens and uterine fibroids: an integrated view 雌激素和子宫肌瘤:综合观点

RESEARCH RESULTS IN BIOMEDICINE Pub Date : 2021-06-30 DOI: 10.18413/2658-6533-2021-7-2-0-6

Hadeel N. AlSudairi, Alanoud T. Alrasheed, V. Dvornyk

{"title":"Estrogens and uterine fibroids: an integrated view","authors":"Hadeel N. AlSudairi, Alanoud T. Alrasheed, V. Dvornyk","doi":"10.18413/2658-6533-2021-7-2-0-6","DOIUrl":"https://doi.org/10.18413/2658-6533-2021-7-2-0-6","url":null,"abstract":"Background: Uterine fibroids or uterine leiomyomata (UL) are common benign tu-mors of the uterine myometrium affecting a significant proportion of women at reproductive age. UL is a disease with complex etiology determined by many genetic and environmental factors. Estrogen is widely acknowledged as one of the main factors contributing to the risk and pathogenesis of UL. The aim of the study: To summarize available literature data about the estrogen-related environmental factors, genes and metabolic pathways, which may play a role in the disease. Materials and methods: The PubMed, Scopus, and Web of Science literature databases were searched for relevant articles using such keywords as ―uterine fibroids‖, ―uterine leiomyoma‖, ―estrogen‖, ―gene‖, ―association‖, ―expression‖, ―epigenetic‖ in various combinations. Results: Estrogen contributes to the risk and pathophysiology of UL in multiple ways. Apart from the well-known effect of estrogen on expression of many genes mediated by estrogen receptors, it increases sensitivity of myometrium to progesterone and thus influences expression of the progesterone-controlled genes. On the other hand, the data about association of various estrogen-related genes with UL are largely inconsistent and inconclusive. Conclusion: The observed heterogene-ity of UL apparently results from the diversity of mechanisms contributing to the disease. This makes identification of the causative genetic variants challenging and prompts for further studies of this problem.","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86890896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Polymorphism of genes associated with the age at menarche and the risk of complications of pregnancy in women in the Central Black Earth Region of Russia 俄罗斯中部黑土地区妇女月经初潮年龄和妊娠并发症风险相关基因多态性

RESEARCH RESULTS IN BIOMEDICINE Pub Date : 2021-06-30 DOI: 10.18413/2658-6533-2021-7-2-0-3

E. Reshetnikov

引用次数: 2

Association of polymorphism of genes STAT3, IL10 and IL12B with a viral load in women with human papillomavirus STAT3、IL10和IL12B基因多态性与人乳头瘤病毒感染女性病毒载量的关系

RESEARCH RESULTS IN BIOMEDICINE Pub Date : 2021-06-30 DOI: 10.18413/2658-6533-2021-7-2-0-2

A. H. Albosale

引用次数: 0