Léa Proulx-Bégin, Marianne Jodoin, Daphnée Brazeau, Alberto Herrero Babiloni, Catherine Provost, Dominique M Rouleau, Caroline Arbour, Louis De Beaumont
{"title":"Does a Prolonged Sham Theta Burst Stimulation Intervention Regimen Outperform Standard Care in Terms of Functional Recovery and Pain Relief After an Upper Limb Fracture?","authors":"Léa Proulx-Bégin, Marianne Jodoin, Daphnée Brazeau, Alberto Herrero Babiloni, Catherine Provost, Dominique M Rouleau, Caroline Arbour, Louis De Beaumont","doi":"10.1097/PSY.0000000000001355","DOIUrl":"10.1097/PSY.0000000000001355","url":null,"abstract":"<p><strong>Objective: </strong>In a recent sham-controlled 13-session prolonged continuous theta burst stimulation intervention protocol, recovery from upper limb fracture at both 1 and 3 months was better than anticipated in patients assigned to the sham intervention group. To determine whether potential placebo effect and close patient monitoring affected recovery, the current study aimed to compare clinical outcomes between sham-treated participants who also received standard care with similarly injured patients who only received standard care.</p><p><strong>Methods: </strong>Twenty participants with isolated upper limb fractures from the sham group were seen 13 times post-fracture (1 baseline session, 10 treatments, and 2 follow-ups [1 and 3 months]) over 3 months. They completed the self-reported Disabilities of Arm, Shoulder, and Hand (DASH) questionnaire and the Numerical Rating Scale for pain assessment at 1 and 3 months post-fracture. Two control groups were recruited: 43 participants at 1 month post-fracture and another 40 participants at 3 months post-fracture. These control groups completed the same questionnaires online, without any lab visits.</p><p><strong>Results: </strong>At 1 month, patients from the sham group reported significantly less functional impairments on the DASH (p = .010). At 3 months, significantly more patients from the control group reported functional limitations (72.5% versus sham's 40%, p = .015).</p><p><strong>Conclusions: </strong>Although preliminary, these findings suggest clinically significant beneficial effects of the sham intervention over the standard care groups. This positive sham intervention effect may be attributed to a placebo response that includes the placebo effect associated with sham rTMS, but also the impact of various factors such as the close monitoring of the injury.</p>","PeriodicalId":20918,"journal":{"name":"Psychosomatic Medicine","volume":"87 1","pages":"84-92"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Psychosomatic MedicinePub Date : 2024-11-01Epub Date: 2024-09-03DOI: 10.1097/PSY.0000000000001335
Allison E Gaffey, Kristie M Walenczyk, Joseph E Schwartz, Martica H Hall, Matthew M Burg
{"title":"Ecologically Assessed Sleep Duration and Arterial Stiffness in Healthy Men and Women.","authors":"Allison E Gaffey, Kristie M Walenczyk, Joseph E Schwartz, Martica H Hall, Matthew M Burg","doi":"10.1097/PSY.0000000000001335","DOIUrl":"10.1097/PSY.0000000000001335","url":null,"abstract":"<p><strong>Objective: </strong>Among younger adults, to determine the associations of actigraph- and self-reported sleep duration with arterial stiffness (AS) assessed in clinic and in ecologically valid contexts, and to examine sex-specific associations.</p><p><strong>Methods: </strong>Healthy adults ( n = 282, median age = 29 years, 67% women) completed a state-of-the-art assessment of AS at rest (SphygmoCor; carotid femoral pulse wave velocity [cfPWV]; central augmentation index [cAIx]) and 7 days of actigraphy-assessed sleep with concurrent, momentary cAIx assessment for 36 hours (Oscar-2). Multivariable regressions were conducted on the full sample and sex-stratified to examine cross-sectional linear and quadratic associations of average sleep duration with resting PWV and cAIx, average cAIx while awake and asleep, and nocturnal cAIx dipping, adjusted for demographic and health covariates. Exploratory analyses included self-reported sleep duration with AS, and actigraphy and self-reported sleep duration with the ambulatory arterial stiffness index (AASI; Oscar-2).</p><p><strong>Results: </strong>Overall and by sex, associations of average sleep duration with resting cfPWV, resting cAIx, and awake cAIx were not significant. Sleep duration showed a positive, linear association with sleep cAIx in women (95% confidence interval =1.07 to 5.86, Δ R2 = 0.021). Among women, sleep duration was also inversely associated with cAIx dipping (95% confidence interval = -4.48 to -0.95, Δ R2 = 0.020). Analyses with self-reported sleep duration and AASI as alternate predictors and outcomes were not significant.</p><p><strong>Conclusions: </strong>Certain sleep duration-AS associations may be sex-specific. Assessing sleep and momentary AS in ecologically valid conditions outside the research laboratory is valuable to understand these relations. Although this investigation should be replicated, findings raise the question of whether interventions to target sleep duration also reduce AS.</p>","PeriodicalId":20918,"journal":{"name":"Psychosomatic Medicine","volume":" ","pages":"740-747"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11560491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Psychosomatic MedicinePub Date : 2024-11-01Epub Date: 2024-08-28DOI: 10.1097/PSY.0000000000001343
Adriana Munhoz Carneiro, Kevin Pacheco-Barrios, Maria Fernanda Andrade, Daniela Martinez-Magallanes, Elly Pichardo, Wolnei Caumo, Felipe Fregni
{"title":"Psychological Factors Modulate Quantitative Sensory Testing Measures in Fibromyalgia Patients: A Systematic Review and Meta-Regression Analysis.","authors":"Adriana Munhoz Carneiro, Kevin Pacheco-Barrios, Maria Fernanda Andrade, Daniela Martinez-Magallanes, Elly Pichardo, Wolnei Caumo, Felipe Fregni","doi":"10.1097/PSY.0000000000001343","DOIUrl":"10.1097/PSY.0000000000001343","url":null,"abstract":"<p><strong>Objective: </strong>Considering the growing evidence that psychological variables might contribute to fibromyalgia syndrome (FMS), our study aims to understand the impact of psychological factors in quantitative sensory testing (QST) in FMS patients by performing a systematic review with meta-analysis.</p><p><strong>Methods: </strong>A systematic search was carried out in PubMed/MEDLINE, EMBASE, Web of Science, and PsycINFO databases for records up until January 2024. We included 20 studies ( n = 1623, 16 randomized controlled trials, and 4 nonrandomized controlled trials) with low or moderate risk of bias included.</p><p><strong>Results: </strong>From nonrandomized evidence, our meta-analysis found a baseline relationship between anxiety, depression, and pain catastrophizing and QST measures in FMS patients. Higher pain catastrophizing levels were associated with less efficient conditioned pain modulation. Higher anxiety and depression were associated with lower pain threshold (PT). Randomized evidence showed a statistically significant increase in PT after fibromyalgia treatments (effect size = 0.29, 95% confidence interval = 0.03-0.56). The effect was not influenced by treatment type. Moreover, we found that only anxiety levels before treatment negatively influenced the PT improvements after treatment.</p><p><strong>Conclusion: </strong>FMS patients with higher anxiety levels at baseline showed a smaller increase in PT after the intervention. Depression factor was not significant in either changes in anxiety or depression. Baseline anxiety levels should be monitored as possible confounders of QST measurements. Understanding how psychological factors and QST are related in FMS patients is critical for improving the syndrome's management and treatment.Protocol Registration: CRD42023429397.</p>","PeriodicalId":20918,"journal":{"name":"Psychosomatic Medicine","volume":" ","pages":"781-789"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Psychosomatic MedicinePub Date : 2024-11-01Epub Date: 2024-09-19DOI: 10.1097/PSY.0000000000001345
Lauren Pattyn, Jonas Zaman, Iris van de Pavert, Valentina Jelinčić, Andreas von Leupoldt, Lukas Van Oudenhove, Ilse Van Diest
{"title":"Learned Symptom-Specific Fear Toward a Visceral Sensation and Its Impact on Perceptual Habituation.","authors":"Lauren Pattyn, Jonas Zaman, Iris van de Pavert, Valentina Jelinčić, Andreas von Leupoldt, Lukas Van Oudenhove, Ilse Van Diest","doi":"10.1097/PSY.0000000000001345","DOIUrl":"10.1097/PSY.0000000000001345","url":null,"abstract":"<p><strong>Objective: </strong>Impaired habituation of bodily sensations has been suggested as a contributing factor to chronic pain. We examined in healthy volunteers the influence of fear learning toward a nonpainful sensation in the esophagus on the perceptual habituation of this sensation.</p><p><strong>Methods: </strong>In a homoreflexive fear learning paradigm, nonpainful electrical sensations in the esophagus were used as a conditioned stimulus (CS). This sensation was presented 42 times before, during, and after fear learning. In the fear learning group ( n = 41), the CS was paired with a painful electrical sensation in the esophagus (unconditioned stimulus [US]). In the control group ( n = 41), the CS was not paired with the US. Ratings for CS intensity, US expectancy, startle electromyogram (EMG), skin conductance responses (SCR), and event-related potentials (ERPs) to the CS were assessed.</p><p><strong>Results: </strong>Compared to the control group, fear learning was observed in the fear learning group as evidenced by potentiated startle responses after the CS relative to ITI ( t (1327) = 3.231, p = .001) and higher US expectancy ratings ( t (196) = 3.17, p = .002). SCRs did not differ between groups ( F1,817 = 1.241, p = .33). Despite successful fear learning, the fear learning group did not show a distinct pattern of habituation to the visceral CS relative to the control group (intensity ratings: F1,77.731 = 0.532, p = .47; ERPs: F1,520.78 = 0.059, p = .94).</p><p><strong>Conclusion: </strong>Acquired fear to nonpainful esophageal sensations does not affect their perceptual habituation patterns.</p>","PeriodicalId":20918,"journal":{"name":"Psychosomatic Medicine","volume":" ","pages":"790-799"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142352766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Psychosomatic MedicinePub Date : 2024-11-01Epub Date: 2024-07-02DOI: 10.1097/PSY.0000000000001329
Derek P Spangler, Harry T Reis, Chiu-Hsieh Hsu, Wojciech Zareba, Richard D Lane
{"title":"Emotional Awareness Is Correlated With Ambulatory Heart Rate Variability: A Replication and Extension.","authors":"Derek P Spangler, Harry T Reis, Chiu-Hsieh Hsu, Wojciech Zareba, Richard D Lane","doi":"10.1097/PSY.0000000000001329","DOIUrl":"10.1097/PSY.0000000000001329","url":null,"abstract":"<p><strong>Objective: </strong>In healthy volunteers, a positive association has previously been observed between emotional awareness (EA), the ability to identify and describe emotional experiences in oneself and others, and resting heart rate variability (HRV), which is dominated by vagus nerve activity. The current study aimed to investigate the EA-HRV association across multiple assessments in a \"real-world\" ambulatory context in patients with long QT syndrome (LQTS) who are at genetic risk for sudden cardiac death.</p><p><strong>Methods: </strong>Participants (157 LQTS patients; Mean Age = 35.1, SD Age = 10.4; 115 women) completed the levels of emotional awareness scale (LEAS) on one occasion, which served as our measure of EA. In an ecological momentary assessment study involving 10 assessments per day over 3 days, multiple 5-minute ECG assessments (mean = 24.6, SD = 5.1) were obtained in each patient using a Holter monitor, from which high-frequency HRV (HF-HRV) was computed on each occasion.</p><p><strong>Results: </strong>There was a significant positive association between LEAS scores and HF-HRV controlling for biobehavioral covariates. We also detected a similar inverse relation between EA and mean heart rate.</p><p><strong>Conclusion: </strong>These findings suggest that, in patients with a well-defined genetic risk for ventricular arrhythmia and sudden death, the ability to experience emotions in a complex and differentiated way covaries with greater parasympathetic influences on the heart. These findings are consistent with the overlapping neural substrates of EA and HRV and their common contribution to adaptive emotional responding, consistent with the Neurovisceral Integration Model.</p>","PeriodicalId":20918,"journal":{"name":"Psychosomatic Medicine","volume":" ","pages":"768-773"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11699878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141555413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}