Learned Symptom-Specific Fear Toward a Visceral Sensation and Its Impact on Perceptual Habituation.

IF 2.9 3区 医学 Q2 PSYCHIATRY
Psychosomatic Medicine Pub Date : 2024-11-01 Epub Date: 2024-09-19 DOI:10.1097/PSY.0000000000001345
Lauren Pattyn, Jonas Zaman, Iris van de Pavert, Valentina Jelinčić, Andreas von Leupoldt, Lukas Van Oudenhove, Ilse Van Diest
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引用次数: 0

Abstract

Objective: Impaired habituation of bodily sensations has been suggested as a contributing factor to chronic pain. We examined in healthy volunteers the influence of fear learning toward a nonpainful sensation in the esophagus on the perceptual habituation of this sensation.

Methods: In a homoreflexive fear learning paradigm, nonpainful electrical sensations in the esophagus were used as a conditioned stimulus (CS). This sensation was presented 42 times before, during, and after fear learning. In the fear learning group ( n = 41), the CS was paired with a painful electrical sensation in the esophagus (unconditioned stimulus [US]). In the control group ( n = 41), the CS was not paired with the US. Ratings for CS intensity, US expectancy, startle electromyogram (EMG), skin conductance responses (SCR), and event-related potentials (ERPs) to the CS were assessed.

Results: Compared to the control group, fear learning was observed in the fear learning group as evidenced by potentiated startle responses after the CS relative to ITI ( t (1327) = 3.231, p = .001) and higher US expectancy ratings ( t (196) = 3.17, p = .002). SCRs did not differ between groups ( F1,817 = 1.241, p = .33). Despite successful fear learning, the fear learning group did not show a distinct pattern of habituation to the visceral CS relative to the control group (intensity ratings: F1,77.731 = 0.532, p = .47; ERPs: F1,520.78 = 0.059, p = .94).

Conclusion: Acquired fear to nonpainful esophageal sensations does not affect their perceptual habituation patterns.

对内脏感觉的症状特异性恐惧及其对知觉习惯化的影响。
目的:身体感觉的习惯化受损被认为是导致慢性疼痛的一个因素。我们在健康志愿者中研究了对食道非疼痛感觉的恐惧学习对这种感觉的知觉习惯化的影响:方法:在同源反射性恐惧学习范式中,食管中的非疼痛性电感觉被用作条件刺激(CS)。这种感觉在恐惧学习前、学习过程中和学习后出现了 42 次。在恐惧学习组(41 人)中,CS 与食管中的疼痛电刺激(非条件刺激;US)配对。在对照组(41 人)中,CS 不与 US 配对。对 CS 强度、US 预期、惊吓肌电图(EMG)、皮肤传导反应(SCR)和 CS 事件相关电位(ERPs)的评分进行了评估:结果:与对照组相比,恐惧学习组观察到了恐惧学习,这表现在 CS 后相对于 ITI 的惊跳反应增强(t(1327) = 3.231,p = .001)和更高的美国预期评级(t(196) = 3.17,p = .002)。各组之间的 SCR 没有差异(F1, 817 = 1.241, p = .33)。尽管恐惧学习取得了成功,但与对照组相比,恐惧学习组对内脏 CS 并未表现出明显的习惯化模式(强度评分:F1, 77.731 = 0.532 p = .47;ERPs:F1,520.78 = 0.059,p = .94):结论:后天对非疼痛性食管感觉的恐惧不会影响其知觉习惯模式。
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来源期刊
Psychosomatic Medicine
Psychosomatic Medicine 医学-精神病学
CiteScore
5.10
自引率
0.00%
发文量
258
审稿时长
4-8 weeks
期刊介绍: Psychosomatic Medicine is the official peer-reviewed journal of the American Psychosomatic Society. The journal publishes experimental, clinical, and epidemiological studies on the role of psychological and social factors in the biological and behavioral processes relevant to health and disease. Psychosomatic Medicine is an interdisciplinary peer-reviewed journal devoted to high-quality science on biobehavioral mechanisms, brain-behavior interactions relevant to physical and mental disorders, as well as interventions in clinical and public health settings. Psychosomatic Medicine was founded in 1939 and publishes interdisciplinary research articles relevant to medicine, psychiatry, psychology, and other health-related disciplines. The print journal is published nine times a year; most articles are published online ahead of print. Supplementary issues may contain reports of conferences at which original research was presented in areas relevant to the psychosomatic and behavioral medicine.
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