Ojong Elias Ojong, Omeke Chimene Wosu, Aguma Emenike, Paschal Ateb Ubi
{"title":"Design and simulation of 30 000 tons per year of cumene plant from natural gas field","authors":"Ojong Elias Ojong, Omeke Chimene Wosu, Aguma Emenike, Paschal Ateb Ubi","doi":"10.1515/pac-2023-1135","DOIUrl":"https://doi.org/10.1515/pac-2023-1135","url":null,"abstract":"The research considers the design and simulation of 30 000 tons per year of cumene plant using Aspen HYSYS as the simulation tool. The feed (material content) used is the characterized natural gas from Utorogu Gas Field with composition of 0.9019 methane, 0.0694 ethane, 0.0209 propane, 0.00361 n-butane, 0.00414 i-butane, 0.00005 n-pentane and 0.00007 i-pentane. The cumene plant consist of the cryogenic distillation column, de-hydrogenator (Continuous Stirred Tank Reactor), Alkylator (Plug Flow Reactor), storage tanks, separators, pumps, heat exchanger and mixers. The size/design models of basic plant units such as de-hydrogenator, alkylator, separators, storage tanks and distillation column were developed using the principles of mass and energy balance. The result of design or size specifications in terms of equipment diameter of basic plant units obtained from HYSYS simulation are 0.8 m and 0.319 m for the cryogenic and cumene columns; 1.931 m, 2.244 m and 1.366 m for the propane, propene and cumene storage tanks; 1.868 m and 2.076 m for the de-hydrogenator and alkylator; 1.931 m and 2.146 m for propene and cumene separators respectively. The power or capacity of propane and propene pumps configured in the plant are 0.02 kW and 0.005 kW respectively. The result of the reactor and distillation column thickness specification to withstand corrosion, pressure or stress during plant operation in terms of cylindrical shell and ellipsoidal doomed head are 17.36 mm and 4.31 mm respectively. The economic evaluation (overall cost) including the cost of utilities, catalyst, operating, and maintenance for entire plant is $ 3.004 M.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"46 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140009751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shefali Baweja, Amit Lochab, Shalini Baxi, Reena Saxena
{"title":"Computational investigation of thallium interactions with functionalized multi-walled carbon nanotubes for electrochemical sensing applications","authors":"Shefali Baweja, Amit Lochab, Shalini Baxi, Reena Saxena","doi":"10.1515/pac-2023-1139","DOIUrl":"https://doi.org/10.1515/pac-2023-1139","url":null,"abstract":"Thallium (Tl) is a heavy toxic element which can cause several health issues. WHO and EPA have set a maximum permissible limit for thallium in drinking water above which it is hazardous, so its determination in our environment becomes crucial. Multi-walled carbon nanotubes (MWCNTs) are preferred for use in thallium sensing due to their large surface area and high conductivity, which allow them to be readily functionalized to selective groups. Previous experimental results showed that Tl selectively interacted with the MWCNTs functionalized with 3-amino-1,2,4-triazole-5-thiol (T-MWCNTs) with a limit of detection of 1.29 μg L<jats:sup>−1</jats:sup> and linear range 10–100 μg L<jats:sup>−1</jats:sup> by using voltammetry under optimized conditions. In actual water samples, the electrochemical sensor fabricated with the above-mentioned functionalized MWCNTs nanocomposite demonstrated high reproducibility and recovery. Molecular recognition and the outcomes of chemical and biological processes are shaped by non-covalent interactions among molecules. It is essential to investigate how these interactions impact binding preferences to enhance our understanding of these events. Here, we examine the structures of complexes of Tl and T-MWCNTs using quantum chemical calculations. Our results show that the most favourable complex of Tl-T-MWCNTs involve strong interaction of Tl with the nitrogen lone pair and additional stabilising interaction provided by the oxygen lone pair of amide linkage of T-MWCNTs. Moreover, we observed that the thiol group within T-MWCNTs readily undergoes deprotonation due to its acidic nature. Non-covalent interactions among molecules influence chemical and biological processes and molecular recognition. To improve our knowledge of these events, it is important to explore the ways in which these interactions affect binding preferences The negative value of adsorption energy (−1.53 eV) of this structure suggested that the interaction process between Tl and T-MWCNTs is spontaneous.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"39 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139978269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lihui Yuan, Ping Zhu, Yu Wang, Xia Dong, Dujin Wang
{"title":"The preparation of permanent antistatic additive based on poly(ether-b-amide) copolymers and its modification effect on polyamide 6","authors":"Lihui Yuan, Ping Zhu, Yu Wang, Xia Dong, Dujin Wang","doi":"10.1515/pac-2023-1132","DOIUrl":"https://doi.org/10.1515/pac-2023-1132","url":null,"abstract":"Conventional polymers have typically been used in the packaging of various electronic devices; however, due to the inherent electrically insulating properties these materials fail to dissipate static charges. To address this issue, novel poly(ether-<jats:italic>b</jats:italic>-amide) (PEBA) segmented copolymers consisting of uniform rigid oxalamide and flexible polyethylene glycol (PEG) were synthesized via melt polycondensation. The influence of PEG molecular weight and the spacer length separating two oxalamide units on the condensed structure, mechanical performance, and antistatic properties was systematically investigated. Fourier-transform infrared (FTIR) demonstrated strongly hydrogen bonded and highly ordered oxalamide hard segments with the degree of ordering between 71 and 85 % even at low levels. Mechanical behavior results showed that segmented copolymers have an obvious yield point, an elastic modulus between 20 and 30 MPa, and strain at break exceeding 2000 %. Meanwhile, such copolymers possessed low surface resistivity, as low as 10<jats:sup>7</jats:sup> Ω, which is significantly less than that of commercial antistatic additives. The antistatic effect of PEBA on polyamide 6 (PA6) was also investigated, revealing that when the content reached 30 wt%, the surface resistivity of the alloys decreased from 10<jats:sup>13</jats:sup> Ω to 10<jats:sup>11</jats:sup> Ω and remained stable after 40 days, even after water washing treatment. Overall, these findings illustrate that the newly synthesized PEBA copolymers demonstrate outstanding long-term antistatic properties and provide valuable insights for the development of polyether-based multiblock copolymer antistatic agents.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"131 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139956214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Noviany Noviany, Hasnah Osman, Suriyati Mohamad, Bambang Irawan, Wisnu Ananta Kusuma, Jhons F. Suwandi, Sutopo Hadi, Nanik S. Aminah
{"title":"Two new naturally dimers constituent from Indonesian Sesbania grandiflora plant and their bioactivity","authors":"Noviany Noviany, Hasnah Osman, Suriyati Mohamad, Bambang Irawan, Wisnu Ananta Kusuma, Jhons F. Suwandi, Sutopo Hadi, Nanik S. Aminah","doi":"10.1515/pac-2023-1112","DOIUrl":"https://doi.org/10.1515/pac-2023-1112","url":null,"abstract":"A new dimer of natural isoflavonoid along with some known flavonoid compounds was successfully isolated from the roots of Indonesian <jats:italic>Sesbania grandiflora</jats:italic> plant using ethyl acetate extraction. The new compound specified as naturally bi-isoflavonoid with (4→6) inter-isoflavanyl linkage and four known flavonoids xenognosin B, liquiritigenin, 7,2′4′-trihydroxyisoflavone, demethylvestitol, and 1,1′-bi-2-naphthol was isolated and the antituberculosis activity of the compounds was studied. The structure of all compounds was elucidated with the aid of 1D and 2D NMR, UV spectroscopy, and HRESI mass spectrometry. The data obtained were also compared with the previous published data. Among compounds, 1,1′-bi-2-naphthol was found to exhibit the highest activity against <jats:italic>Mycobacterium tuberculosis</jats:italic> H37Rv with the MIC’s value of 10.9 µM while the biisoflavonoid with (4→6) inter-isoflavanyl linkage showed moderate activity with the MIC’s value of 92.2 nM, compared with isozianid as a positive control with the MIC’s value of 0.569 nM. It is worth to note that 1,1′-bi-2-naphthol and biisoflavonoid with (4→6) inter-isoflavanyl linkage were isolated for the first time from a natural source. Both compounds have been previously reported as synthetic compounds, which is synonymous with 3,4- <jats:italic>trans</jats:italic>-4-[(3<jats:italic>S</jats:italic>)-7,2′-dihydroxy-4′-methoxyisoflavan-6-yl]-7,2′-dihydroxy-4′-methoxyisoflavan and 1,1′-bi-2-naphthol, respectively. In this respect, the results of this study suggest that the roots of <jats:italic>S. grandiflora</jats:italic> is a potential source of new natural product compounds, with promising bioactivities.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"194 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139924197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unraveling the influence of biomaterial’s functional groups in Cd biosorption: a density functional theory calculation","authors":"Toyese Oyegoke, Chidiebere Millicent Igwebuike, Ademola Oyegoke","doi":"10.1515/pac-2023-1103","DOIUrl":"https://doi.org/10.1515/pac-2023-1103","url":null,"abstract":"Several biomass wastes, including forest wastes, bagasse, algae, and others, have been studied to determine their biosorption capability for adsorbing different ranges of heavy metals in the literature. Most experimental studies have not clearly shown the impact of functional groups in biomaterials discovered by FTIR analysis on the investigated biosorption processes. Because of this, the findings of this study indicate that it is necessary to theoretically investigate the influence of identified functional groups (as determined by FTIR analysis) on the biosorption activities of the sorbent or biomaterial prepared for the removal of cadmium metal from an effluent. Using the most geometrical structure for cadmium (Cd) metal, a series of identified functional groups for the sorbent were analyzed using FTIR to determine their mode and intensity of interaction to computationally understand better how they each influence the biosorption of cadmium. This was done to determine how each functional group contributes to the intensity of the cadmium biosorption, using a ground-state B3LYP density functional theory calculation performed in a Spartan 20 simulation package utilizing the 6-31G* and LANL2DZ > Kr basis sets. According to the study’s findings, carboxylate (–COO*) had the most significant effect on cadmium biosorption activity of all the functional groups studied due to the stronger binding strength obtained for it. Therefore, this research suggests exploring biomaterials with greater intensity for carboxylate function, which would aid cadmium sorption efficiency in an effluent treatment process.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"28 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139756646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shaoyan Fan, Koki Nasu, Yukio Takeuchi, Miho Fukuda, Hirotsugu Arai, Keisuke Taniguchi, Yuichi Onda
{"title":"Transport of radioactive materials from terrestrial to marine environments in Fukushima over the past decade","authors":"Shaoyan Fan, Koki Nasu, Yukio Takeuchi, Miho Fukuda, Hirotsugu Arai, Keisuke Taniguchi, Yuichi Onda","doi":"10.1515/pac-2023-0802","DOIUrl":"https://doi.org/10.1515/pac-2023-0802","url":null,"abstract":"While 20 % of radionuclides released from the Fukushima Daiichi Nuclear Power Plant accident had been deposited in the terrestrial environment, rivers remain the long-term source for <jats:sup>137</jats:sup>Cs, primarily through particulate transfer, from terrestrial to marine ecosystems. In this study, we estimated the suspended <jats:sup>137</jats:sup>Cs flux to the ocean at 11 sites in the coastal area between October 2012 and December 2020 to be 17 TBq, based on our long-term monitoring data of concentrations of suspended <jats:sup>137</jats:sup>Cs and suspended solids. The cumulative loss of suspended <jats:sup>137</jats:sup>Cs from each site to the ocean ranged from 0.1 % to 1.7 % of initial deposition throughout the observation period, depending on the effect of dam lakes and normalized river discharge. The higher loss is also thought to be the large outflow of runoff during the typhoon. The current level of the suspended <jats:sup>137</jats:sup>Cs concentrations was lowered to 1/10–1/100 of those immediately after the accident. The average value of the decreasing trend for each site was approximated using the equation<jats:italic>: y</jats:italic> = <jats:italic>a</jats:italic>1 <jats:italic>e</jats:italic> −<jats:italic>k</jats:italic> <jats:sub>1</jats:sub> <jats:italic>t</jats:italic> + <jats:italic>a</jats:italic>2 <jats:italic>e</jats:italic> −<jats:italic>k</jats:italic> <jats:sub>2</jats:sub>t. The rate constant <jats:italic>k</jats:italic> <jats:sub>1</jats:sub> is higher in areas with intensive land use, such as pastures, bare land, and water surfaces, and <jats:italic>k</jats:italic> <jats:sub>2</jats:sub> is lower in urban areas.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"17 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139756650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Empowering women in science through role models, mentors, and support groups: a personal perspective","authors":"Ann Van der Jeugd, Tatjana N. Parac-Vogt","doi":"10.1515/pac-2023-1205","DOIUrl":"https://doi.org/10.1515/pac-2023-1205","url":null,"abstract":"In this personal perspective, we reflect on our personal journey, highlighting the significance that role models and mentoring played in them, and explore how they benefit early-career researchers, promote academic success, and contribute to the overall growth of the academic community. We – the co-authors of this article (Prof. Tatjana Parac-Vogt and Dr. Ann van der Jeugd) – share some special connections: we were both presidents of Belgium Women in Science (BeWiSe), a non-profit association that promotes the role and position of women in science in Belgium (Tatjana from 2012 to 2016; Ann from 2020 to 2024), and we have a thriving mentor/mentee relationship, which started in 2015 through the BeWiSe mentoring programme.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"17 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139756908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis, characterization, and bioactivity test of dibutyltin(IV) dihydroxyibenzoate as disinfectant agent","authors":"Sutopo Hadi, Hidayatul Mustafidah, Yandri Yandri, Wasinton Simanjuntak, Tati Suhartati","doi":"10.1515/pac-2023-1102","DOIUrl":"https://doi.org/10.1515/pac-2023-1102","url":null,"abstract":"In this work, three organotin (IV) derivatives namely dibutyltin(IV) di-2-hydroxybenzoate (DBT2-HBz) (2), dibutyltin(IV) di-3-hydroxybenzoate (DBT3-HBz) (3) and dibutyltin(IV) di-4-hydroxybenzoate (DBT4-HBz)) (4) were synthesized and tested as disinfectant against pathogenic bacteria, <jats:italic>Staphylococcus aureus</jats:italic>. Compounds 2–4 were prepared by reacting dibutyltin(IV) oxide (DBTO) (1) with 2-hydroxybenzoic acid (2-HHBz), 3-hydroxybenzoic acid (3-HHBz) and 4-hydroxybenzoic acid (4-HHBz). The synthesized compounds were characterized by spectroscopic techniques including UV–Vis, FT-IR, <jats:sup>1</jats:sup>H NMR, and <jats:sup>13</jats:sup>C NMR, and micro-elemental analyzer. The optical density (OD) of compounds was measured by UV–Vis at 600 nm, which showed good bioactivity against the <jats:italic>S. aureus</jats:italic>. The data obtained indicated that compound 4 has higher bioactivity than compound 2 and 3, and the positive control using a commercial disinfectant containing 5 % benzalkonium chloride. The optimum bioactivity of compound 4 was observed at a concentration of 5 × 10<jats:sup>−4</jats:sup> M with a contact time of 10 min, as shown by the decrease in absorbance from 0.6092 to 0.4005. Compound 2 was optimal at a concentration of 5 × 10<jats:sup>−4</jats:sup> M with a contact time of 10 min, and the absorbance decreased from 0.6092 to 0.4416. Compound 3 and positive control showed a smaller decrease in absorbance compared to compound 4 and 2. Overall, the results obtained indicated that the compounds synthesized have promising potential as disinfectant against pathogenic bacteria.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"28 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139756689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"MTT assay of human anti-breast cancer cells (MCF-7) in vitro potentials and phytochemicals screening of the root bark extracts from Cassia sieberiana","authors":"Labaran Abdulkadir Magashi","doi":"10.1515/pac-2023-1108","DOIUrl":"https://doi.org/10.1515/pac-2023-1108","url":null,"abstract":"Medicinal plant <jats:italic>Cassia sieberiana</jats:italic> root bark was investigated for phytochemicals and Anti-Breast Cancer cells (MCF-7) properties, using Chemical Separations and MTT assay <jats:italic>in vitro</jats:italic>. The <jats:italic>C. sieberiana</jats:italic> root bark was extracted with soxhlet extractor using different solvents based on polarity guided method and the respective extracts were concentrated under reduced pressure. These extracts were screened for their phytochemicals qualitatively using standard methods. Percentage Yields and Physico-Chemical Evaluation of the Extracts from the various fractions were recorded. The results of phytochemicals screening revealed the presence of some secondary metabolites of pharmacological significance in the Methyl acetate, MeOH and 70 % MeOH root bark extracts including <jats:italic>Saponins, Quinones, Phenolic, Steroids, Tannins, Flavounoids, Terpenoids, Anthraquinones, Cardiac-glycosides, Alkaloids, Carbohydrates, Glycosides and Coumarins</jats:italic>. Results obtained from MTT assay revealed that Extracts of MeOH and 70 % MeOH samples shown a certain degree of inhibition towards MCF-7 cell line. IC<jats:sub>50</jats:sub> were calculated using Graph Pad Prism 6 and results shown that IC<jats:sub>50</jats:sub> of 245.3 μg/ml and 239.6 μg/ml dose dependent inhibitions in MCF-7 cells respectively, compared to <jats:italic>Oxaliplatin</jats:italic> IC<jats:sub>50</jats:sub> of 38.04 μg/ml. Therefore, 70 % MeOH sample with IC<jats:sub>50</jats:sub> of 239.6 μg/ml have shown more potential of inhibiting breast cancer cell, MCF-7 cells line. The inhibition of the root bark is attributed to some of the phytochemicals present in the plant.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"18 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139756643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tati Suhartati, Andi Irawan, Hendri Ropingi, Yandri Yandri, Sutopo Hadi
{"title":"Antidiabetic and antibacterial activities of artocarpin: a flavonoid compound isolated from the root wood of the Pudau plant (Artocarpus kemando Miq.)","authors":"Tati Suhartati, Andi Irawan, Hendri Ropingi, Yandri Yandri, Sutopo Hadi","doi":"10.1515/pac-2023-1131","DOIUrl":"https://doi.org/10.1515/pac-2023-1131","url":null,"abstract":"In this study, artocarpin compound was successfully isolated from the root wood of the Pudau plant (<jats:italic>Artocarpus kemando</jats:italic> Miq.) and subsequently tested as antidiabetic and antibacterial agent against <jats:italic>Staphylococcus aureus</jats:italic> and <jats:italic>Salmonella typhi</jats:italic>. The procedure applied for isolation involved maceration using methanol followed by partition and purification using column chromatography. The purity of the compound was determined using thin layer chromatography and melting point measurement. The compound was subsequently characterized via UV–vis and IR spectroscopy. The compound isolated was obtained as a yellow amorphous solid and has melting point of 168.7–173.6 °C. The antidiabetic tests were performed against α-amylase enzyme, using the compound with the concentrations of 250, 500, 750, and 1000 ppm. The highest inhibition percentage of 43.33 ± 0.02 % was achieved with the use of 750 ppm of the compound and the IC<jats:sub>50</jats:sub> value is 32 661.08 ppm. Antibacterial tests were performed with concentration variations of 0.3, 0.4, and 0.5 mg/disc. <jats:italic>S. aureus</jats:italic> and <jats:italic>S. typhi</jats:italic> bacteria showed high inhibition at a concentration of 0.5 mg/disc with inhibition zone diameters of 8 and 7 mm, respectively (moderate category).","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"17 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139756647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}