Prostate Cancer最新文献_第5页

The Single-Knot Running Vesicourethral Anastomosis after Minimally Invasive Prostatectomy: Review of the Technique and Its Modifications, Tips, and Pitfalls. 微创前列腺切除术后膀胱尿道单结吻合术:技术综述及其改进、提示和缺陷。

IF 4.2

Prostate Cancer Pub Date : 2016-01-01 Epub Date: 2016-05-31 DOI: 10.1155/2016/1481727

Simone Albisinni, Fouad Aoun, Alexandre Peltier, Roland van Velthoven

引用次数: 13

Systematic Review of Focal Prostate Brachytherapy and the Future Implementation of Image-Guided Prostate HDR Brachytherapy Using MR-Ultrasound Fusion. 聚焦前列腺近距离治疗的系统性综述和使用磁共振-超声波融合的图像引导前列腺 HDR 近距离治疗的未来实施。

IF 4.2

Prostate Cancer Pub Date : 2016-01-01 Epub Date: 2016-05-16 DOI: 10.1155/2016/4754031

M Sean Peach, Daniel M Trifiletti, Bruce Libby

{"title":"Systematic Review of Focal Prostate Brachytherapy and the Future Implementation of Image-Guided Prostate HDR Brachytherapy Using MR-Ultrasound Fusion.","authors":"M Sean Peach, Daniel M Trifiletti, Bruce Libby","doi":"10.1155/2016/4754031","DOIUrl":"10.1155/2016/4754031","url":null,"abstract":"Prostate cancer is the most common malignancy found in North American and European men and the second most common cause of cancer related death. Since the practice of PSA screening has become common the disease is most often found early and can have a long indolent course. Current definitive therapy treats the whole gland but has considerable long-term side effects. Focal therapies may be able to target the cancer while decreasing dose to organs at risk. Our objective was to determine if focal prostate brachytherapy could meet target objectives while permitting a decrease in dose to organs at risk in a way that would allow future salvage treatments. Further, we wanted to determine if focal treatment results in less toxicity. Utilizing the Medline repository, dosimetric papers comparing whole gland to partial gland brachytherapy and clinical papers that reported toxicity of focal brachytherapy were selected. A total of 9 dosimetric and 6 clinical papers met these inclusion criteria. Together, these manuscripts suggest that focal brachytherapy may be employed to decrease dose to organs at risk with decreased toxicity. Of current technology, image-guided HDR brachytherapy using MRI registered to transrectal ultrasound offers the flexibility and efficiency to achieve such focal treatments. ","PeriodicalId":20907,"journal":{"name":"Prostate Cancer","volume":"2016 ","pages":"4754031"},"PeriodicalIF":4.2,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34636610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Salvage Brachytherapy for Biochemically Recurrent Prostate Cancer following Primary Brachytherapy. 原发性近距离治疗后生化复发前列腺癌的补救性近距离治疗。

IF 4.2

Prostate Cancer Pub Date : 2016-01-01 Epub Date: 2016-03-22 DOI: 10.1155/2016/9561494

John M Lacy, William A Wilson, Raevti Bole, Li Chen, Ali S Meigooni, Randall G Rowland, William H St Clair

{"title":"Salvage Brachytherapy for Biochemically Recurrent Prostate Cancer following Primary Brachytherapy.","authors":"John M Lacy, William A Wilson, Raevti Bole, Li Chen, Ali S Meigooni, Randall G Rowland, William H St Clair","doi":"10.1155/2016/9561494","DOIUrl":"https://doi.org/10.1155/2016/9561494","url":null,"abstract":"Purpose. In this study, we evaluated our experience with salvage brachytherapy after discovery of biochemical recurrence after a prior brachytherapy procedure. Methods and Materials. From 2001 through 2012 twenty-one patients treated by brachytherapy within University of Kentucky or from outside centers developed biochemical failure and had no evidence of metastases. Computed tomography (CT) scans were evaluated; patients who had an underseeded portion of their prostate were considered for reimplantation. Results. The majority of the patients in this study (61.9%) were low risk and median presalvage PSA was 3.49 (range 17.41-1.68). Mean follow-up was 61 months. At last follow-up after reseeding, 11/21 (52.4%) were free of biochemical recurrence. There was a trend towards decreased freedom from biochemical recurrence in low risk patients (p = 0.12). International Prostate Symptom Scores (IPSS) increased at 3-month follow-up visits but decreased and were equivalent to baseline scores at 18 months. Conclusions. Salvage brachytherapy after primary brachytherapy is possible; however, in our experience the side-effect profile after the second brachytherapy procedure was higher than after the first brachytherapy procedure. In this cohort of patients we demonstrate that approximately 50% oncologic control, low risk patients appear to have better outcomes than others. ","PeriodicalId":20907,"journal":{"name":"Prostate Cancer","volume":"2016 ","pages":"9561494"},"PeriodicalIF":4.2,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/9561494","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34413291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Advances in Radiotherapy for Prostate Cancer Treatment. 前列腺癌放疗治疗进展。

IF 4.2

Prostate Cancer Pub Date : 2016-01-01 Epub Date: 2016-07-25 DOI: 10.1155/2016/3079684

Tarun Podder, Daniel Song, Timothy Showalter, Luc Beaulieu

{"title":"Advances in Radiotherapy for Prostate Cancer Treatment.","authors":"Tarun Podder, Daniel Song, Timothy Showalter, Luc Beaulieu","doi":"10.1155/2016/3079684","DOIUrl":"https://doi.org/10.1155/2016/3079684","url":null,"abstract":"Major categories of radiotherapy (RT) for prostate cancer (CaP) treatment are: (1) external beam RT (EBRT), and (2) brachytherapy (BT). EBRT are performed using different techniques like three-dimensional conformal RT (3D-CRT), intensity modulated RT (IMRT), volumetric modulated arc therapy (VMAT), and stereotactic body radiation therapy (SBRT), stereotactic radiosurgery (SRS) and intensity modulated proton therapy (IMPT), etc., using a variety of radiation delivery machines, such as a linear accelerator (Linac), Cyberknife robotic system, Gamma knife, Tomotherapy and proton beam machine. The primary advantage of proton beam therapy is sparing of normal tissues and organ at risks (OARs) with comparable coverage of the tumor volume. MR-Linac is the latest addition in the image-guided RT. Robot-assisted brachytherapy is one of the latest technological innovations in the field. With the advancement of technology, radiation therapy for prostate cancer can be improved using high quality multimodal imaging, robot-assistance for brachytherapy as well as EBRT. This chapter presents the advances in radiation therapy for the treatment of prostate cancer.","PeriodicalId":20907,"journal":{"name":"Prostate Cancer","volume":"2016 ","pages":"3079684"},"PeriodicalIF":4.2,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/3079684","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34307458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Assessment of the Performance of Magnetic Resonance Imaging/Ultrasound Fusion Guided Prostate Biopsy against a Combined Targeted Plus Systematic Biopsy Approach Using 24-Core Transperineal Template Saturation Mapping Prostate Biopsy. 磁共振成像/超声融合引导前列腺活检与24核经会阴模板饱和定位前列腺活检联合靶向加系统活检方法的性能评估

IF 4.2

Prostate Cancer Pub Date : 2016-01-01 Epub Date: 2016-05-16 DOI: 10.1155/2016/3794738

Francis Ting, Pim J Van Leeuwen, James Thompson, Ron Shnier, Daniel Moses, Warick Delprado, Phillip D Stricker

{"title":"Assessment of the Performance of Magnetic Resonance Imaging/Ultrasound Fusion Guided Prostate Biopsy against a Combined Targeted Plus Systematic Biopsy Approach Using 24-Core Transperineal Template Saturation Mapping Prostate Biopsy.","authors":"Francis Ting, Pim J Van Leeuwen, James Thompson, Ron Shnier, Daniel Moses, Warick Delprado, Phillip D Stricker","doi":"10.1155/2016/3794738","DOIUrl":"https://doi.org/10.1155/2016/3794738","url":null,"abstract":"Objective. To compare the performance of multiparametric resonance imaging/ultrasound fusion targeted biopsy (MRI/US-TBx) to a combined biopsy strategy (MRI/US-TBx plus 24-core transperineal template saturation mapping biopsy (TTMB)). Methods. Between May 2012 and October 2015, all patients undergoing MRI/US-TBx at our institution were included for analysis. Patients underwent MRI/US-TBx of suspicious lesions detected on multiparametric MRI +/- simultaneous TTMB. Subgroup analysis was performed on patients undergoing simultaneous MRI/US-TBx + TTMB. Primary outcome was PCa detection. Significant PCa was defined as ≥Gleason score (GS) 3 + 4 = 7 PCa. McNemar's test was used to compare detection rates between MRI/US-TBx and the combined biopsy strategy. Results. 148 patients underwent MRI/US-TBx and 80 patients underwent MRI/US-TBx + TTMB. In the MRI/US-TBx versus combined biopsy strategy subgroup analysis (n = 80), there were 55 PCa and 38 significant PCa. The detection rate for the combined biopsy strategy versus MRI/US-TBx for significant PCa was 49% versus 40% (p = 0.02) and for insignificant PCa was 20% versus 10% (p = 0.04), respectively. Eleven cases (14%) of significant PCa were detected exclusively on MRI/US-TBx and 7 cases (8.7%) of significant PCa were detected exclusively on TTMB. Conclusions. A combined biopsy approach (MRI/US-TBx + TTMB) detects more significant PCa than MRI/US-TBx alone; however, it will double the detection rate of insignificant PCa. ","PeriodicalId":20907,"journal":{"name":"Prostate Cancer","volume":"2016 ","pages":"3794738"},"PeriodicalIF":4.2,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/3794738","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34636609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Evolving Paradigm of Radiotherapy for High-Risk Prostate Cancer: Current Consensus and Continuing Controversies. 高危前列腺癌放射治疗范式的演变：当前共识与持续争议。

IF 4.2

Prostate Cancer Pub Date : 2016-01-01 Epub Date: 2016-05-23 DOI: 10.1155/2016/2420786

Aditya Juloori, Chirag Shah, Kevin Stephans, Andrew Vassil, Rahul Tendulkar

引用次数: 0

Predicting Low-Risk Prostate Cancer from Transperineal Saturation Biopsies. 经会阴饱和活检预测低风险前列腺癌。

IF 4.2

Prostate Cancer Pub Date : 2016-01-01 Epub Date: 2016-04-11 DOI: 10.1155/2016/7105678

Pim J van Leeuwen, Amila Siriwardana, Monique Roobol, Francis Ting, Daan Nieboer, James Thompson, Warick Delprado, Anne-Marie Haynes, Phillip Brenner, Phillip Stricker

{"title":"Predicting Low-Risk Prostate Cancer from Transperineal Saturation Biopsies.","authors":"Pim J van Leeuwen, Amila Siriwardana, Monique Roobol, Francis Ting, Daan Nieboer, James Thompson, Warick Delprado, Anne-Marie Haynes, Phillip Brenner, Phillip Stricker","doi":"10.1155/2016/7105678","DOIUrl":"https://doi.org/10.1155/2016/7105678","url":null,"abstract":"Introduction. To assess the performance of five previously described clinicopathological definitions of low-risk prostate cancer (PC). Materials and Methods. Men who underwent radical prostatectomy (RP) for clinical stage ≤T2, PSA <10 ng/mL, Gleason score <8 PC, diagnosed by transperineal template-guided saturation biopsy were included. The performance of five previously described criteria (i.e., criteria 1-5, criterion 1 stringent (Gleason score 6 + ≤5 mm total max core length PC + ≤3 mm max per core length PC) up to criterion 5 less stringent (Gleason score 6-7 with ≤5% Gleason grade 4) was analysed to assess ability of each to predict insignificant disease in RP specimens (defined as Gleason score ≤6 and total tumour volume <2.5 mL, or Gleason score 7 with ≤5% grade 4 and total tumour volume <0.7 mL). Results. 994 men who underwent RP were included. Criterion 4 (Gleason score 6) performed best with area under the curve of receiver operating characteristics 0.792. At decision curve analysis, criterion 4 was deemed clinically the best performing transperineal saturation biopsy-based definition for low-risk PC. Conclusions. Gleason score 6 disease demonstrated a superior trade-off between sensitivity and specificity for clarifying low-risk PC that can guide treatment and be used as reference test in diagnostic studies. ","PeriodicalId":20907,"journal":{"name":"Prostate Cancer","volume":"2016 ","pages":"7105678"},"PeriodicalIF":4.2,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/7105678","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34458293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prostate cancer patients' refusal of cancer-directed surgery: a statewide analysis. 前列腺癌患者拒绝癌症定向手术:一项全州范围的分析。

IF 4.2

Prostate Cancer Pub Date : 2015-01-01 Epub Date: 2015-04-20 DOI: 10.1155/2015/829439

K M Islam, Jiajun Wen

{"title":"Prostate cancer patients' refusal of cancer-directed surgery: a statewide analysis.","authors":"K M Islam, Jiajun Wen","doi":"10.1155/2015/829439","DOIUrl":"https://doi.org/10.1155/2015/829439","url":null,"abstract":"Introduction. Prostate cancer is the most common cancer among men in USA. The surgical outcomes of prostate cancer remain inconsistent. Barriers such as socioeconomic factors may play a role in patients' decision of refusing recommended cancer-directed surgery. Methods. The Nebraska Cancer Registry data was used to calculate the proportion of prostate cancer patients recommended the cancer-directed surgery and the surgery refusal rate. Multivariate logistic regression was applied to analyze the socioeconomic indicators that were related to the refusal of surgery. Results. From 1995 to 2012, 14,876 prostate cancer patients were recommended to undergo the cancer-directed surgery in Nebraska, and 576 of them refused the surgery. The overall refusal rate of surgery was 3.9% over the 18 years. Patients with early-stage prostate cancer were more likely to refuse the surgery. Patients who were Black, single, or covered by Medicaid/Medicare had increased odds of refusing the surgery. Conclusion. Socioeconomic factors were related to the refusal of recommended surgical treatment for prostate cancer. Such barriers should be addressed to improve the utilization of surgical treatment and patients' well-being. ","PeriodicalId":20907,"journal":{"name":"Prostate Cancer","volume":"2015 ","pages":"829439"},"PeriodicalIF":4.2,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/829439","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33303414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Analysis of Prostate Cancer Susceptibility Variants in South African Men: Replicating Associations on Chromosomes 8q24 and 10q11. 南非男性前列腺癌易感性变异分析:染色体8q24和10q11上的复制关联

IF 4.2

Prostate Cancer Pub Date : 2015-01-01 Epub Date: 2015-08-12 DOI: 10.1155/2015/465184

Pedro Fernandez, Muneeb Salie, Danielle du Toit, Andre van der Merwe

{"title":"Analysis of Prostate Cancer Susceptibility Variants in South African Men: Replicating Associations on Chromosomes 8q24 and 10q11.","authors":"Pedro Fernandez, Muneeb Salie, Danielle du Toit, Andre van der Merwe","doi":"10.1155/2015/465184","DOIUrl":"https://doi.org/10.1155/2015/465184","url":null,"abstract":"Genome-wide association studies (GWAS) have implicated single nucleotide polymorphisms (SNPs) on chromosomes 2p15, 6q25, 7p15.2, 7q21, 8q24, 10q11, 10q26, 11q13, 17q12, 17q24, 19q13, and Xp11, with prostate cancer (PCa) susceptibility and/or tumour aggressiveness, in populations of African, European, and Asian ancestry. The objective of this study was to confirm these associations in South African Mixed Ancestry and White men. We evaluated 17 prioritised GWAS SNPs in South African cases (331 Mixed Ancestry and 155 White) and controls (178 Mixed Ancestry and 145 White). The replicated SNP associations for the different South African ethnic groups were rs7008482 (8q24) (p = 2.45 × 10(-5)), rs6983267 (8q24) (p = 4.48 × 10(-7)), and rs10993994 (10q11) (p = 1.40 × 10(-3)) in Mixed Ancestry men and rs10993994 (p = 1.56 × 10(-9)) in White men. No significant associations were observed for the analyses stratified by disease aggressiveness in the individual and the combined population group analysis. The present study demonstrates that a number of known PCa susceptibility variants may contribute to disease susceptibility in South African men. Larger genetic investigations extended to other South African population groups are warranted to confirm the role of these and other SNPs in disease susceptibility. ","PeriodicalId":20907,"journal":{"name":"Prostate Cancer","volume":"2015 ","pages":"465184"},"PeriodicalIF":4.2,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/465184","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34052253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Thioredoxin 1 in Prostate Tissue Is Associated with Gleason Score, Erythrocyte Antioxidant Enzyme Activity, and Dietary Antioxidants. 前列腺组织中的硫氧还蛋白1与Gleason评分、红细胞抗氧化酶活性和膳食抗氧化剂相关

IF 4.2

Prostate Cancer Pub Date : 2015-01-01 Epub Date: 2015-08-18 DOI: 10.1155/2015/728046

Terrence M Vance, Gissou Azabdaftari, Elena A Pop, Sang Gil Lee, L Joseph Su, Elizabeth T H Fontham, Jeannette T Bensen, Susan E Steck, Lenore Arab, James L Mohler, Ming-Hui Chen, Sung I Koo, Ock K Chun

{"title":"Thioredoxin 1 in Prostate Tissue Is Associated with Gleason Score, Erythrocyte Antioxidant Enzyme Activity, and Dietary Antioxidants.","authors":"Terrence M Vance, Gissou Azabdaftari, Elena A Pop, Sang Gil Lee, L Joseph Su, Elizabeth T H Fontham, Jeannette T Bensen, Susan E Steck, Lenore Arab, James L Mohler, Ming-Hui Chen, Sung I Koo, Ock K Chun","doi":"10.1155/2015/728046","DOIUrl":"https://doi.org/10.1155/2015/728046","url":null,"abstract":"Background. Prostate cancer is the most common noncutaneous cancer and second leading cause of cancer-related mortality in men in the US. Growing evidence suggests that oxidative stress is involved in prostate cancer. Methods. In this study, thioredoxin 1 (Trx 1), an enzyme and subcellular indicator of redox status, was measured in prostate biopsy tissue from 55 men from the North Carolina-Louisiana Prostate Cancer Project. A pathologist blindly scored levels of Trx 1. The association between Trx 1 and the Gleason score, erythrocyte antioxidant enzyme activity, and dietary antioxidant intake was determined using Fisher's exact test. Results. Trx 1 levels in benign prostate tissue in men with incident prostate cancer were positively associated with the Gleason score (P = 0.01) and inversely associated with dietary antioxidant intake (P = 0.03). In prostate cancer tissue, Trx 1 levels were associated with erythrocyte glutathione peroxidase activity (P = 0.01). No association was found for other erythrocyte enzymes. Greater Gleason score of malignant tissue corresponds to a greater difference in Trx 1 levels between malignant and benign tissue (P = 0.04). Conclusion. These results suggest that the redox status of prostate tissue is associated with prostate cancer grade and both endogenous and exogenous antioxidants. ","PeriodicalId":20907,"journal":{"name":"Prostate Cancer","volume":"2015 ","pages":"728046"},"PeriodicalIF":4.2,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/728046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34060588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9