Radiology最新文献

{"title":"Intra-articular Knee Injections and Progression of Knee Osteoarthritis: Data from the Osteoarthritis Initiative.","authors":"Upasana U Bharadwaj, John A Lynch, Gabby B Joseph, Zehra Akkaya, Michael C Nevitt, Nancy E Lane, Charles E McCulloch, Thomas M Link","doi":"10.1148/radiol.233081","DOIUrl":"10.1148/radiol.233081","url":null,"abstract":"<p><p>Background At least 10% of all patients with knee osteoarthritis (OA) undergo treatment with injectable corticosteroids or hyaluronic acid (HA). Although both have been shown to help with symptomatic pain relief, their long-term effects on knee OA progression remain inconclusive. Purpose To investigate the association between intra-articular knee injections, specifically corticosteroids and HA, and OA progression using a detailed whole-joint semiquantitative MRI evaluation and clinical outcomes for a period of 2 years. Materials and Methods This secondary analysis uses data from the Osteoarthritis Initiative (OAI), a multicenter, longitudinal, prospective study (February 2004 to January 2015). Participants who received a reported injection of corticosteroid or HA and propensity-score-matched controls (on age, sex, body mass index [calculated as weight in kilograms divided by height in meters squared], and clinical variables) were analyzed. Using the Whole-Organ MRI Score (WORMS) system for cartilage, bone marrow lesions, and meniscus, 3-T MRI performed at the time of injection, 2 years prior, and 2 years after were semiquantitatively graded. Postinjection progression was quantified using WORMS difference between time of injection and the 2-year follow-up. Associations with injection type were analyzed using repeated measures of analysis of covariance. Results There were 210 participants analyzed (mean age, 64 years ± 7.9 years [SD]; 126 female participants). Corticosteroids were associated with greater WORMS progression compared with controls (mean difference, 0.39; 95% CI: 0.05, 0.75; <i>P</i> = .02) and HA (0.42; 95% CI: 0.01, 0.84; <i>P</i> = .04). HA was associated with decreased WORMS progression compared with the injection-concurrent time frame (mean difference, -0.42; 95% CI: -1.34, -0.28; <i>P</i> = .003). Both corticosteroids (mean difference in Western Ontario and McMaster Universities Osteoarthritis Index scores, -5.20; 95% CI: -6.91, -3.48; <i>P</i> = .001) and HA injections (-2.15; 95% CI: -4.42, -0.13; <i>P</i> = .04) were associated with reduced pain after injection. Conclusion Corticosteroid injections were associated with higher OA progression than HA injections and controls, whereas HA was associated with decreased progression at MRI for up to 2 years after injection. ClinicalTrials.gov Identifier: NCT00080171 © RSNA, 2025.</p>","PeriodicalId":20896,"journal":{"name":"Radiology","volume":"315 2","pages":"e233081"},"PeriodicalIF":12.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12127947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Field-Cycling MRI for Identifying Minor Ischemic Stroke.","authors":"Ajay Malhotra,Dheeraj Gandhi","doi":"10.1148/radiol.242774","DOIUrl":"https://doi.org/10.1148/radiol.242774","url":null,"abstract":"","PeriodicalId":20896,"journal":{"name":"Radiology","volume":"2 1","pages":"e242774"},"PeriodicalIF":19.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143914791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital Breast Tomosynthesis and Digital Mammography Associated with Similar Rates of Advanced Cancer.","authors":"Karla Kerlikowske,Jeffrey A Tice","doi":"10.1148/radiol.242837","DOIUrl":"https://doi.org/10.1148/radiol.242837","url":null,"abstract":"","PeriodicalId":20896,"journal":{"name":"Radiology","volume":"11 1","pages":"e242837"},"PeriodicalIF":19.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143914841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Floating Aortic Thrombus and Acute Myocardial Infarction.","authors":"Lihua Yu, Jiayin Zhang","doi":"10.1148/radiol.242582","DOIUrl":"https://doi.org/10.1148/radiol.242582","url":null,"abstract":"","PeriodicalId":20896,"journal":{"name":"Radiology","volume":"315 2","pages":"e242582"},"PeriodicalIF":12.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric Imaging 2040.","authors":"Nathan C Hull, Donald P Frush, Winnie C W Chu, Carlos F Ugas Charcape, Joanna Kasznia-Brown, Edward Y Lee","doi":"10.1148/radiol.250378","DOIUrl":"https://doi.org/10.1148/radiol.250378","url":null,"abstract":"","PeriodicalId":20896,"journal":{"name":"Radiology","volume":"315 2","pages":"e250378"},"PeriodicalIF":12.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Spirometry: AI-Driven Chest CT Analysis, a New Frontier in Monitoring Amyotrophic Lateral Sclerosis.","authors":"Amir Ali Rahsepar, Arash Bedayat","doi":"10.1148/radiol.250988","DOIUrl":"https://doi.org/10.1148/radiol.250988","url":null,"abstract":"","PeriodicalId":20896,"journal":{"name":"Radiology","volume":"315 2","pages":"e250988"},"PeriodicalIF":12.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multireader Diagnostic Accuracy of Abbreviated Breast MRI for Screening Women with Extremely Dense Breasts.","authors":"Sophie E L van Grinsven, Ritse M Mann, Evelyn M Monninkhof, Katya Duvivier, Mathijn D F de Jong, Petra K de Koekkoek-Doll, Claudette E Loo, Ruud M Pijnappel, Rogier van der Sluijs, Jeroen Veltman, Carla H van Gils, Wouter B Veldhuis","doi":"10.1148/radiol.241233","DOIUrl":"https://doi.org/10.1148/radiol.241233","url":null,"abstract":"<p><p>Background Abbreviated MRI may reduce costs and time of supplemental breast cancer screening. The Dense Tissue and Early Breast Neoplasm Screening (DENSE) trial provides an opportunity to study this protocol in a true screening population. Purpose To compare multireader diagnostic accuracy of various abbreviated screening breast MRI protocols with that of the full multiparametric protocol in the DENSE trial, focusing on identifying the minimal protocol necessary to maintain high diagnostic accuracy. Materials and Methods In this secondary analysis of a subset from the DENSE trial, seven radiologists performed incremental readings of first-round screening MRI scans in women with extremely dense breasts and findings negative for cancer at mammography. Different sequences were added in four incremental steps. The first step included both high-temporal low-spatial and low-temporal high-spatial dynamic T1-weighted series, up to 120 seconds after contrast agent injection. The final step added all full-protocol sequences. Each radiologist assessed the same MRI scans and provided Breast Imaging Reporting and Data System scores for all four incremental steps. Pooled sensitivity and specificity were calculated across all readers per step using a generalized estimating equation model, and pooled reading time per step was calculated using a linear mixed model. Results The first-round screening included 518 MRI scans from 518 women (median age, 53 years; IQR, 51-59 years), including 83 breast cancers: 68 invasive cancers (82%) and 15 ductal carcinomas in situ (18%). There was no evidence of a difference in sensitivity between abbreviated protocol (84.3%; 95% CI: 77.7, 89.2) and the full multiparametric MRI protocol (85.9%; 95% CI: 80.0, 90.3; <i>P</i> = .68). There was also no evidence of a difference in specificity between abbreviated protocol (73.9%; 95% CI: 70.7, 76.9) and full protocol (75.8%; 95% CI: 72.8, 78.5; <i>P</i> = .39). The abbreviated protocol had a pooled reading time (49.7 seconds; 95% CI: 48.5, 50.9) that was almost 50% shorter than the full protocol (96.4 seconds; 95% CI: 94.3, 98.5; <i>P</i> < .001) with 70%-80% shorter scanning time, depending on hospital and scanner vendor. Conclusion In women in the DENSE trial with extremely dense breasts and findings that were negative for cancer at mammography, abbreviated breast MRI for first-round screening had high diagnostic accuracy that was comparable to full multiparametric protocol, at much shorter reading and scanning times. ClinicalTrials.gov Identifier: NCT01315015 © RSNA, 2025 <i>Supplemental material is available for this article.</i> See also the editorial by Kataoka and Honda in this issue.</p>","PeriodicalId":20896,"journal":{"name":"Radiology","volume":"315 2","pages":"e241233"},"PeriodicalIF":12.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved Filtering for CT Perfusion in Stroke: From a Small Step to a Big Leap.","authors":"Alexandre Krainik","doi":"10.1148/radiol.250764","DOIUrl":"https://doi.org/10.1148/radiol.250764","url":null,"abstract":"","PeriodicalId":20896,"journal":{"name":"Radiology","volume":"315 2","pages":"e250764"},"PeriodicalIF":12.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing an Abbreviated MRI Protocol for Women with Dense Breasts.","authors":"Masako Kataoka, Maya Honda","doi":"10.1148/radiol.250981","DOIUrl":"https://doi.org/10.1148/radiol.250981","url":null,"abstract":"","PeriodicalId":20896,"journal":{"name":"Radiology","volume":"315 2","pages":"e250981"},"PeriodicalIF":12.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Outcomes of Interstitial Lung Abnormalities Detected in the Korean National Lung Cancer CT Screening Program.","authors":"Hyungjin Kim, Eunseo Jo, Jinseob Kim, Soon Ho Yoon, Seung Ho Choi, Yoosoo Chang, Seungho Ryu, Jin Mo Goo","doi":"10.1148/radiol.243651","DOIUrl":"https://doi.org/10.1148/radiol.243651","url":null,"abstract":"<p><p>Background Limited evidence exists on the prevalence and outcomes of interstitial lung abnormalities (ILAs) in lung cancer screening populations, particularly Asian populations. Purpose To investigate the prevalence of ILAs and the association of ILAs with lung cancer, idiopathic pulmonary fibrosis (IPF), and mortality outcomes in an Asian population. Materials and Methods In this nationwide, population-based retrospective study, baseline screenings from the Korean National Lung Cancer Screening Program performed between August 2019 and December 2020 were analyzed. ILAs were identified from CT structured reports based on program radiologists' visual assessment, and ILA prevalence was analyzed across age groups. Incidence rate ratios were calculated for lung cancer incidence, IPF, and all-cause mortality comparing individuals with ILAs versus individuals without ILAs, and multivariable Cox regression analyses were performed to examine associations between ILAs and these outcomes. Results Among 125 600 individuals (mean age, 62 years ± 5.3 [SD]; 123 331 men), ILA prevalence was 2.65% (3324 of 125 600) and was strongly associated with older age (<i>P</i> < .001). The lung cancer incidence rate was higher in the ILA group (2009 vs 412 per 100 000 person-years, <i>P</i> < .001; incidence rate ratio, 4.88), as was the all-cause mortality rate (2334 vs 712 per 100 000 person-years, <i>P</i> < .001; incidence rate ratio, 3.28). During a median follow-up of 2.9 years, IPF was diagnosed in 3.55% (118 of 3324) of individuals with ILAs (incidence rate, 1344 per 100 000 person-years in group with ILAs vs 18 per 100 000 person-years in group without ILAs, <i>P</i> < .001; incidence rate ratio, 73.24). In multivariable analyses, individuals with ILAs had a threefold higher risk of lung cancer (adjusted hazard ratio, 3.18 [95% CI: 2.71, 3.73]; <i>P</i> < .001) and twofold higher all-cause mortality (adjusted hazard ratio, 2.37 [95% CI: 2.09, 2.69]; <i>P</i> < .001). Individuals with ILAs showed a markedly higher risk of IPF diagnosis, with more than 60-fold higher risk (adjusted hazard ratio, 63.4 [95% CI: 45.9, 87.7]; <i>P</i> < .001). Conclusion The presence of ILAs was associated with higher risks of lung cancer, IPF, and mortality. © RSNA, 2025 <i>Supplemental material is available for this article.</i> See also the editorial by Baruah and Kabakus in this issue.</p>","PeriodicalId":20896,"journal":{"name":"Radiology","volume":"315 2","pages":"e243651"},"PeriodicalIF":12.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}