{"title":"Lessons Learned from MammoGrid for Integrated Biomedical Solutions","authors":"R. McClatchey, D. Manset, T. Solomonides","doi":"10.1109/CBMS.2006.109","DOIUrl":"https://doi.org/10.1109/CBMS.2006.109","url":null,"abstract":"This paper presents an overview of the MammoGrid project and some of its achievements. In terms of the global grid project, and European research in particular, the project has successfully demonstrated the capacity of a grid-based system to support effective collaboration between physicians, including handling and querying image databases, as well as using grid services, such as image standardization and computer-aided detection (CADe) of suspect or indicative features. In terms of scientific results, in radiology, there have been significant epidemiological findings in the assessment of breast density as a risk factor, but the results for CADe are less clear-cut. Finally, the foundations of a technology transfer process to establish a working \"MammoGrid plus\" system in Spain through the company Maat GKnowledge and the collaboration of CIEMAT and hospitals in Extremadura","PeriodicalId":208693,"journal":{"name":"19th IEEE Symposium on Computer-Based Medical Systems (CBMS'06)","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124324571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Using Visual Interpretation of Small Ensembles in Microarray Analysis","authors":"G. Štiglic, M. Mertik, V. Podgorelec, P. Kokol","doi":"10.1109/CBMS.2006.169","DOIUrl":"https://doi.org/10.1109/CBMS.2006.169","url":null,"abstract":"Many different classification models and techniques have been employed on gene expression data. These computational methods are in rapid and continuous evolution and there is no clear consensus on which methods are best to cope with the complex microarray data analysis. Currently ensembles of classifiers are regarded as one of the best classification techniques as they can achieve excellent classification accuracy in comparison to single classifiers methods. One of their main drawbacks is their incomprehensibility. This paper addresses the important issue of the tradeoff between accuracy and comprehensibility when building ensembles and proposes a novel visual technique for interactive interpretation of the knowledge from the small ensembles consisting of only a few decision trees. This way we can achieve better accuracy compared to single classifier, but still maintain a certain level of comprehensibility in small ensembles. The results show that our small ensembles outperform the single classifiers and still retain comprehensibility. Our study also points out that in order to take advantage of our proposed method we need more effective small ensemble building techniques","PeriodicalId":208693,"journal":{"name":"19th IEEE Symposium on Computer-Based Medical Systems (CBMS'06)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114313112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An Aid System to the Medical Diagnosis of Patients with Neurological Problems","authors":"E. Quirino, F. Paraguaçu, G.M.C. Souza","doi":"10.1109/CBMS.2006.36","DOIUrl":"https://doi.org/10.1109/CBMS.2006.36","url":null,"abstract":"The aim of this paper is to approach an interactive learning environments of diagnosis support and aid in the treatment of patients who present neurological problems. This paper proposes an architecture that facilitates the activities of the medical students, in decision-support, giving advice in physiotherapy about patients with cerebral vascular accident","PeriodicalId":208693,"journal":{"name":"19th IEEE Symposium on Computer-Based Medical Systems (CBMS'06)","volume":"357 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114759608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Costa-Santos, J. Bernardes, P. Vitányi, L. Antunes
{"title":"Clustering Fetal Heart Rate Tracings by Compression","authors":"C. Costa-Santos, J. Bernardes, P. Vitányi, L. Antunes","doi":"10.1109/CBMS.2006.68","DOIUrl":"https://doi.org/10.1109/CBMS.2006.68","url":null,"abstract":"Fetal heart rate (FHR) monitoring is widely used regarding the detection of fetuses in danger of death or damage. Thirty one FHR tracings acquired in the antepartum period were clustered by compression in order to identify abnormal ones. A recently introduced approach based on algorithmic information theory was used. The new method can mine patterns in completely different areas, without domain-specific parameters to set, and does not require specific background knowledge. At the highest level the FHR tracings were clustered according to an unanticipated feature, namely the technology used in signal acquisition. At the lower levels all tracings with abnormal or suspicious patterns were clustered together, independently of the technology used","PeriodicalId":208693,"journal":{"name":"19th IEEE Symposium on Computer-Based Medical Systems (CBMS'06)","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130072042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Barla, Bettina Irler, S. Merler, Giuseppe Jurman, S. Paoli, Cesare Furlanello
{"title":"Proteome Profiling without Selection Bias","authors":"A. Barla, Bettina Irler, S. Merler, Giuseppe Jurman, S. Paoli, Cesare Furlanello","doi":"10.1109/CBMS.2006.134","DOIUrl":"https://doi.org/10.1109/CBMS.2006.134","url":null,"abstract":"In this paper, we present a method for predictive profiling of mass spectrometry data. The method integrates a spectra preprocessing pipeline with a complete validation setup aimed at identifying the discriminating peaks and at providing an unbiased estimate of the predictive classification error, based on SVM classifiers and on entropy-based RFE procedure. A particular emphasis is placed upon avoiding selection bias effects throughout all the analysis steps, from preprocessing to peak importance ranking","PeriodicalId":208693,"journal":{"name":"19th IEEE Symposium on Computer-Based Medical Systems (CBMS'06)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130629152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Using Ontology Visualization to Coordinate Cross-species Functional Annotation for Human Disease Genes","authors":"M. Dolan, J. Blake","doi":"10.1109/CBMS.2006.165","DOIUrl":"https://doi.org/10.1109/CBMS.2006.165","url":null,"abstract":"Biomedical ontologies provide representational system to support the integration and retrieval of biological knowledge. The gene ontology (GO) is widely used to annotate molecular attributes of genes and provides a common paradigm for comparative functional analysis research. One way to expand the view of the function of any one gene product is to compare annotations of genes that share close evolutionary relationships and are likely to function in similar ways, such as orthologous genes. We are exploring the power of the GO and orthology sets to provide a comprehensive view of annotations coordinated across species by presenting annotations visualized within the ontology relationship structure. This work describes the application of our ontology visualization approach to a set of model organism genes that are orthologous to human disease genes","PeriodicalId":208693,"journal":{"name":"19th IEEE Symposium on Computer-Based Medical Systems (CBMS'06)","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127887577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Feature Selection for Medical Data Mining: Comparisons of Expert Judgment and Automatic Approaches","authors":"T. Cheng, Chih-Ping Wei, V. Tseng","doi":"10.1109/CBMS.2006.87","DOIUrl":"https://doi.org/10.1109/CBMS.2006.87","url":null,"abstract":"Data mining refers to the process of automatic extracting previously unknown, valid, and actionable patterns or knowledge from large databases for crucial decision support. Among different data mining technique, classification analysis is widely adopted for healthcare applications for supporting medical diagnostic decisions, improving quality of patient care, etc. If a training dataset contains irrelevant features (i.e., attributes), classification analysis may produce less accurate and less understandable results. Two commonly employed feature selection approaches include use of automatic feature selection mechanisms (i.e., data-driven) or expert judgment (i.e., knowledge-driven). Due to differences in their underlying processes, the two prevailing feature selection approaches may have their unique biases that possibly lead to dissimilar classification effectiveness. In this study, we empirically evaluate the classification effectiveness resulted from the two feature selection approaches on a risk prediction of cardiovascular disease dataset. Our evaluation results suggest that the feature subsets selected domain experts improve the sensitivity of a classifier, while the feature subsets selected by an automatic feature selection mechanism improve the predictive power of a classifier on the majority class (i.e., the specificity in this study)","PeriodicalId":208693,"journal":{"name":"19th IEEE Symposium on Computer-Based Medical Systems (CBMS'06)","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126406313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Application of Maximum Entropy-Based Image Resizing to Biomedical Imaging","authors":"P. B. Kao, B. Nutter","doi":"10.1109/CBMS.2006.46","DOIUrl":"https://doi.org/10.1109/CBMS.2006.46","url":null,"abstract":"Subsampling algorithms are applied to resize digital images to a lower resolution for display and transmission applications where the pixel count of the display mechanism is lower than the pixel count of the image acquisition method. Unfortunately, interpolation-based resizing methods change the color information and attenuate a specific range of high-frequency components from which the human visual system derives significant response. The described maximum entropy algorithm (MEA) provides that, as an image goes through subsampling, locally informative pixels are retained by analyzing the pixel neighboringhoods. The selected pixels are inserted directly in the output image, and color information is therefore preserved. From subjective observation and object evaluation using the entropy, contrast, and PSNR, MEA effectively maintains important features and color information and demonstrates better resizing performance than interpolation-based methods for some applications. Furthermore, the computational expense is suitable for real-time implementation","PeriodicalId":208693,"journal":{"name":"19th IEEE Symposium on Computer-Based Medical Systems (CBMS'06)","volume":"2 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114009389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. Syed, Daniel D. Leeds, Dorothy W. Curtis, J. Guttag
{"title":"Audio-Visual Tools for Computer-Assisted Diagnosis of Cardiac Disorders","authors":"Z. Syed, Daniel D. Leeds, Dorothy W. Curtis, J. Guttag","doi":"10.1109/CBMS.2006.50","DOIUrl":"https://doi.org/10.1109/CBMS.2006.50","url":null,"abstract":"The process of interpreting heart sounds is restricted by human auditory limitations. Shortcomings such as insensitivity to frequency changes, slow responses to rapidly occurring changes in acoustic signals and an inability to discriminate the presence of soft pathological sounds are the source of inaccuracies and persist even with experience. This restricts both the practice and teaching of auscultation. In this paper we propose and evaluate a suite of presentation tools for computer-assisted auscultation. We explore the use of digital signal processing techniques to slow down heart sounds while preserving frequency content, differential enhancement across frequency scales to amplify pathological disease signatures, visualization of the signal to measure changes in signal energy across time and presentation of a representative prototypical signal for the patient","PeriodicalId":208693,"journal":{"name":"19th IEEE Symposium on Computer-Based Medical Systems (CBMS'06)","volume":"2015 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128030744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Measurement of Relative Brain Atrophy in Neurodegenerative Diseases","authors":"D. Abdala, A. V. Wangenheim","doi":"10.1109/CBMS.2006.112","DOIUrl":"https://doi.org/10.1109/CBMS.2006.112","url":null,"abstract":"This paper presents a new methodology to be used in measuring brain atrophy on imaging exams of patients with neurodegenerative diseases. The methods foresee the usage of a mean brain that serves as a reference volume. Color maps were created following a cold-hot color scheme where highlighted regions of atrophy based on the standard deviation and mean values voxel-wise of the mean brain. Direct measures of the atrophy grade were obtained by statistical comparisons between the mean brain volume and regions identified as atrophied. The proposed method was evaluated using 35 patients, 16 had been previously diagnosed as Alzheimer cases, 7 as MCI, 2 as vascular dementia and 10 as complainers. The mean brain used in this study was created using affine transformations to drive the necessary volume registration and were composed of healthy patients. All diagnostics followed a neuropsychological protocol","PeriodicalId":208693,"journal":{"name":"19th IEEE Symposium on Computer-Based Medical Systems (CBMS'06)","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114142828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}