Psychiatry Research最新文献

{"title":"SHAPING MINDS: A systematic review and meta-analysis on the effects of structured exercise in schizophrenia spectrum disorders","authors":"Elona Greca ,&nbsp;Valentina Belalcazar-Vivas ,&nbsp;Gerardo F. Ferrer ,&nbsp;Jack J. Michel","doi":"10.1016/j.psychres.2025.116919","DOIUrl":"10.1016/j.psychres.2025.116919","url":null,"abstract":"<div><div>Background: Individuals with schizophrenia spectrum disorders experience impairments across multiple domains, including cognition, quality of life, and social functioning. Structured exercise interventions may improve these outcomes. We hypothesised that aerobic and combined (aerobic plus resistance) exercise programs would enhance cognitive function, reduce symptom severity, and improve well-being. Study Design: A PRISMA-guided search of PubMed, EMBASE, PsycINFO, Web of Science, SciELO, and ClinicalTrials.gov (2009–2024) identified 17 randomized controlled trials. Standardized mean differences (SMDs) were pooled using a random-effects model. Subgroup analyses examined age and gender. Risk of bias was assessed using RoB 2, publication bias with Egger’s test, and certainty of evidence through GRADE.</div><div>Results: Structured exercise produced a moderate-to-large improvement in overall well-being (SMD = 0.68; 95% CI: 0.43–0.93; <em>p</em> &lt; .001). Significant benefits were also observed in cognition (SMD = 0.59), symptom severity (SMD = 0.71), quality of life (SMD = 0.60), and social functioning (SMD = 0.55). Age and gender moderated treatment effects, with the strongest benefits in males and individuals aged 36–45. Sensitivity analyses confirmed the robustness of results. Mechanistic evidence suggests that improvements may be mediated through increased brain-derived neurotrophic factor (BDNF) and reduced inflammatory signaling.</div><div>Conclusions: Structured exercise is an effective adjunctive intervention for schizophrenia spectrum disorders, improving psychiatric and functional outcomes beyond standard care. Findings support the integration of personalized, scalable exercise programs within routine psychiatric treatment.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"357 ","pages":"Article 116919"},"PeriodicalIF":3.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145850132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of war on teachers’ burnout: The moderating role of emotion regulation","authors":"Demetria Hila Neustadter ,&nbsp;Dana Rose Cohen ,&nbsp;Dana Lassri ,&nbsp;Joy Benatov ,&nbsp;Noga Cohen","doi":"10.1016/j.psychres.2026.116942","DOIUrl":"10.1016/j.psychres.2026.116942","url":null,"abstract":"<div><div>Teachers are at high risk of experiencing job-related burnout, especially during times of enduring stress, such as wartime. Therefore, it is essential to understand risk and protective factors among teachers exposed to these stressful situations.</div><div>The current study examined whether cognitive reappraisal, a well-established adaptive emotion regulation strategy, moderates the link between war exposure, war-related stress, and burnout among Israeli Jewish and Arab high school teachers during the Israel-Hamas war that began in October 2023. We hypothesized that teachers who use cognitive reappraisal more frequently would exhibit weaker associations between war exposure, war-related stress, and burnout. A total of 329 high school teachers (73.6 % women, 26.4 % men) participated in an online survey conducted eight months after the war began. Participants completed measures assessing war exposure, war-related stress, habitual use of cognitive reappraisal, and burnout. Correlational analyses revealed that while war-related stress was associated with burnout, war exposure showed no direct correlation with burnout. Supporting our hypothesis, cognitive reappraisal was negatively associated with burnout. Moderation analyses revealed that cognitive reappraisal significantly moderated the link between war exposure and burnout, with simple slopes analyses indicating that the link between war exposure and burnout was weaker among teachers who reported a higher tendency to use cognitive reappraisal. A similar but not significant trend was observed for war-related stress. Findings suggest that cognitive reappraisal serves as a protective factor against teacher burnout during wartime and highlights the importance of promoting emotion regulation strategies to support teachers’ mental health and enhance resilience during major crises.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"357 ","pages":"Article 116942"},"PeriodicalIF":3.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental health of adolescents during times of war","authors":"Lena Lipskaya-Velikovsky,&nbsp;Reut Komemi,&nbsp;Yafit Gilboa,&nbsp;Mor Nahum","doi":"10.1016/j.psychres.2026.116957","DOIUrl":"10.1016/j.psychres.2026.116957","url":null,"abstract":"<div><h3>Objective</h3><div>War-related prolonged stress is associated with poorer adolescent mental health. This cross-sectional study aimed to characterize the mental health of adolescents in Israel during an ongoing war situation and to examine how emotional, cognitive, and occupational factors were associated with their mental health during this period.</div></div><div><h3>Methods</h3><div>Data from 973 Israeli adolescents (ages 13–18, 65.8% female) were collected remotely eight months after the October 7th, 2023, attack and the subsequent war. Participants completed validated self-report questionnaires assessing their mental health, dispositional resilience, subjective executive functions (EFs), sense of coherence, and war-related changes in their daily-life participation.</div></div><div><h3>Results</h3><div>Overall, 40.2% of adolescents scored within the abnormal range for mental health symptoms, exceeding the expected normative 10%. Female and older participants reported worse emotional status. Adolescents reported reduced participation across all occupational domains, with notable individual variability. A regression model explained over 50% of the variance in mental health scores, with greater executive dysfunction and lower resilience showing the strongest associations with poorer mental health. Decision tree analysis indicated that adolescents with better inhibitory control and more stable participation were more likely to report better mental health. Among adolescents with EF difficulties, lower arousal symptoms were associated with better mental health.</div></div><div><h3>Conclusions</h3><div>These findings indicate a substantial and concerning mental health burden among adolescents living under prolonged war-related stress and highlight individual differences linked to internal resources and participation. EFs, patterns of daily-life participation, and arousal symptoms were associated with adolescents’ capacity to cope with war-related stress. Addressing them as potential intervention targets may help mitigate the long-term negative consequences of prolonged conflict-related stress.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"357 ","pages":"Article 116957"},"PeriodicalIF":3.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Home is where my toothbrush is”: An occupational therapy perspective of trauma and PTSD following October 7th and the Iron Swords War","authors":"Moran Shaham Levy,&nbsp;Dorit Loew Goldberg","doi":"10.1016/j.psychres.2025.116918","DOIUrl":"10.1016/j.psychres.2025.116918","url":null,"abstract":"<div><div>This article explores the contribution of occupational therapy (OT) to trauma care in the aftermath of the October 7th attacks and the Iron Swords War, with a focus on post-traumatic stress disorder (PTSD). It examines how traumatic experiences disrupt occupational identity, daily routines, and overall functioning. Drawing on trauma-informed care principles, the paper outlines OT-based interventions that promote recovery by facilitating engagement in meaningful activities that restore agency, coherence, and purpose. Clinical case examples illustrate the therapeutic role of occupation in stabilizing individuals and supporting identity reconstruction. The findings underscore OT’s integrative approach - linking person, environment, and occupation - as a vital component in interdisciplinary trauma recovery and posttraumatic growth.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"357 ","pages":"Article 116918"},"PeriodicalIF":3.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145846765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agitation and anxiety features define a more severe phenotype in unipolar depression","authors":"Maria Luca ,&nbsp;Antonina Luca ,&nbsp;Stefano Barlati ,&nbsp;Lisa Buson ,&nbsp;Valentina Menesello ,&nbsp;Anna Magistrali ,&nbsp;Rosana Carvalho Silva ,&nbsp;Giulia Perusi ,&nbsp;Gabriele Nibbio ,&nbsp;Stefano Bignotti ,&nbsp;Giovanni Battista Tura ,&nbsp;Raffaele Ferri ,&nbsp;Massimo Gennarelli ,&nbsp;Antonio Vita ,&nbsp;Daniel Souery ,&nbsp;Siegfried Kasper ,&nbsp;Joseph Zohar ,&nbsp;Stuart Montgomery ,&nbsp;Panagiotis Ferentinos ,&nbsp;Dan Rujescu ,&nbsp;Edoardo Spina","doi":"10.1016/j.psychres.2025.116928","DOIUrl":"10.1016/j.psychres.2025.116928","url":null,"abstract":"<div><h3>Background</h3><div>Agitated depression, conventionally associated with bipolar disorder, may also constitute a clinically significant subtype within unipolar major depressive disorder (MDD). Nevertheless, the interrelationship between agitation and anxiety symptoms and their clinical implications in unipolar depression remain largely unexamined.</div></div><div><h3>Methods</h3><div>We examined three large, independent cohorts of patients with MDD from the GSRD (<em>n</em> = 1588), STAR*D (<em>n</em> = 1532), and PANDORA (<em>n</em> = 244) studies. A composite agitation–anxiety score was computed by summing relevant items of the retrospective Montgomery-Äsberg depression rating scale (rMADRS) in GSRD, the Hamilton Depression Rating Scale 17-items (HAM-D) in PANDORA and the 30-item Inventory for Depressive Symptomatology, Clinician-rated (IDS-C₃₀) in STAR*D. Patients were then stratified into patients with agitation-anxiety (AA+) and without agitation-anxiety (AA-) based on the median scores of each cluster. Associations between agitation–anxiety features and depression severity, suicidal ideation, disease duration, treatment response, and family history of bipolar disorder were evaluated using univariate and multivariate analyses.</div></div><div><h3>Results</h3><div>A total of 3364 participants were analyzed. AA+ patients showed significantly greater baseline depression severity (independent from agitation–anxiety items) across all datasets. Moreover, agitation–anxiety features correlated with higher rates of suicidal ideation (STAR*D, GSRD), longer disease duration (GSRD), and lower treatment response (STAR*D), independent of age and sex. No significant associations with family history of bipolar disorder were found.</div></div><div><h3>Conclusions</h3><div>Features of agitated depression define a more severe depressive phenotype within depressive episodes and may represent a clinically relevant dimension in unipolar MDD. A transdiagnostic approach may enhance future research and treatment strategies.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"357 ","pages":"Article 116928"},"PeriodicalIF":3.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145886058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of combat intensity and deployment stressors on veteran post-traumatic stress","authors":"Nimrod Hertz-Palmor ,&nbsp;Naama de la Fontaine ,&nbsp;Eden Maharat ,&nbsp;Yael Carmel ,&nbsp;Or Atar ,&nbsp;Nevo Perez ,&nbsp;Anna Bevan ,&nbsp;Tim Dalgleish ,&nbsp;Amit Lazarov ,&nbsp;Roi Sar-El","doi":"10.1016/j.psychres.2026.116944","DOIUrl":"10.1016/j.psychres.2026.116944","url":null,"abstract":"<div><h3>Background</h3><div>Veteran trauma is central to trauma research. Combat exposure, perceived threat, and concerns about disruptions to life and family are key predictors of posttraumatic stress symptoms (PTSS) in veterans. This study examines how various deployment stressors relate to PTSS and other psychological outcomes.</div></div><div><h3>Methods</h3><div>Eighty-six Israeli combat veterans (active duty=60; reserve duty=26) with intense combat exposure reported their combat experiences and deployment-related concerns and completed mental health measures. A cluster analysis identified clusters of co-occurring deployment stressors. Bayesian Graphical Gaussian Models (BGGM) mapped the interrelationships between combat stressors, PTSS, and other psychological outcomes. A subsample of 66 completed a two-month follow-up, enabling analysis of symptom change trajectories.</div></div><div><h3>Results</h3><div>Active-duty soldiers reported more combat exposures, whereas reservists expressed greater concerns about disruptions to life and family. The strongest correlate of PTSS and anxiety was concern over a partner during deployment. Urban operations were also linked to PTSS and specific symptom clusters and vivid trauma memory. Sustaining an injury was associated with more vivid traumatic memories. Longitudinal analyses revealed three symptom trajectories: stable, improvement, and exacerbation, but these were unrelated to sociodemographic factors and unaffected by post-deployment support, unit cohesion, or family functioning.</div></div><div><h3>Conclusions</h3><div>Deployment-related stressors differentially affect veteran mental health. Chronic concerns over partner and family, as well as stressors and exposures involving uncertainty and threat, warrant special attention in clinical and research settings.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"357 ","pages":"Article 116944"},"PeriodicalIF":3.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145978759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical correlates of individuals with and without misophonia in the U.S.: Results from a population-based study","authors":"Alexandra Freshley ,&nbsp;Heather L. Clark ,&nbsp;Mary J. Schadegg ,&nbsp;Laura J. Dixon","doi":"10.1016/j.psychres.2026.116941","DOIUrl":"10.1016/j.psychres.2026.116941","url":null,"abstract":"<div><div>Misophonia is a disorder characterized by strong negative affective, physiological, cognitive, and behavioral reactions to specific sounds (e.g., chewing, swallowing). Studies have begun to investigate co-occurring psychological and audiological disorders with misophonia, but are limited by methodology and generalizability. This study investigated the rate of comorbid disorders in a sample of individuals with and without misophonia using a nationally representative sample in the United States. Data were collected through Ipsos KnowledgePanel—a large, probability-based web panel that is representative of the United States. Participants were invited to complete a brief self-report survey of previous and current psychological and auditory-sensory symptoms and diagnoses. Over half (62.5%) of the misophonia sample reported they had received at least one psychological disorder diagnosis, wherein depression (48.9%) and anxiety disorders (46.7%) were the most commonly reported. Separate hierarchical multivariate binary logistic regression results demonstrate individuals with misophonia (<em>n</em> = 185) are more likely to report current mental health and auditory-sensory symptoms compared to individuals without misophonia (<em>n</em> = 1644) regardless of demographic factors. Further, hierarchical multivariate binary logistic results show individuals with misophonia are more likely to report lifetime diagnoses of all psychological, auditory-sensory, and communication disorders except hyperacusis, autism spectrum disorders, and certain behavior disorders compared to individuals without misophonia. Comorbidity rates were higher in the misophonia sample, and misophonia status was significantly associated with the presence of other clinical syndromes. Findings advance characterization of misophonia by highlighting the elevated co-occurrence rates of psychological and auditory-sensory disorders compared to individuals without misophonia.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"357 ","pages":"Article 116941"},"PeriodicalIF":3.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145927662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and neurobiological effects of real-life and virtual animal-assisted interventions for patients with depression","authors":"Julien Willms,&nbsp;Alice Sader,&nbsp;Georg Juckel,&nbsp;Paraskevi Mavrogiorgou","doi":"10.1016/j.psychres.2025.116917","DOIUrl":"10.1016/j.psychres.2025.116917","url":null,"abstract":"<div><h3>Background</h3><div>Animal-assisted interventions (AAIs) have been shown to exert beneficial effects on various mental disorders. However, organizational, hygienic, and ethical challenges often limit their implementation. As a result, virtual alternatives are gaining increasing relevance. Initial findings suggest that digital interactions with animals may also elicit affective and physiological responses, although systematic, controlled studies are lacking. This study aimed to systematically compare the effects of real and virtual AAIs on depressive symptoms and peripheral oxytocin concentrations in patients with depression and healthy controls.</div></div><div><h3>Methods</h3><div>In a mixed factorial design (<em>N</em> = 66), patients with depression and healthy controls each underwent three conditions in randomized order: interaction with a live therapy dog, a virtual therapy dog, and a virtual reality (VR)-based fantastical creature. Depressive symptoms (per the DASS) and salivary oxytocin concentrations were assessed.</div></div><div><h3>Results</h3><div>All interventions significantly reduced depressive symptoms in patients, with the strongest effects observed for the live therapy dog and the VR-based fantastical creature. Oxytocin levels increased significantly across all conditions, regardless of participant group.</div></div><div><h3>Conclusion</h3><div>Virtual animal interactions can evoke psychophysiological effects comparable to real-life AAIs. They appear promising as accessible, technology-supported interventions for psychiatric populations, particularly when access to live animals is limited.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"357 ","pages":"Article 116917"},"PeriodicalIF":3.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145857552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerated intermittent theta burst stimulation effectively and rapidly reduces suicidal ideation in depression patients: A randomized, sham-controlled study","authors":"Li-Fen Chen ,&nbsp;Wei-Chou Chang ,&nbsp;Chi-Hsiang Chung ,&nbsp;Alexander T. Sack ,&nbsp;Ching-En Lin ,&nbsp;Hsin-An Chang","doi":"10.1016/j.psychres.2025.116926","DOIUrl":"10.1016/j.psychres.2025.116926","url":null,"abstract":"<div><h3>Background</h3><div>Suicidal ideation is common among patients with treatment-resistant depression (TRD), underscoring the need for rapid and safe therapeutic options.</div></div><div><h3>Objective</h3><div>This study examined whether accelerated intermittent theta burst stimulation (iTBS) can rapidly reduce suicidal ideation in TRD inpatients while maintaining pharmacological stability and cognitive safety.</div></div><div><h3>Methods</h3><div>In a randomized, double-blind, placebo-controlled trial, 100 TRD inpatients with suicidal ideation received either active or sham accelerated iTBS over two weeks. The primary outcome was change in Beck Scale for Suicide Ideation (BSS) scores; secondary outcomes included depressive symptoms and cognitive performance.</div></div><div><h3>Results</h3><div>Active accelerated iTBS produced significantly greater reductions in suicidal ideation than sham beginning at week 2 (mean ± SD: 10.0 ± 7.4 vs. 13.2 ± 8.8, <em>p</em> = 0.036), with effects sustained through week 6. Response rates on the BSS were also higher in the active group at week 2 (50% vs. 18%, <em>p</em> &lt; 0.001). Antidepressant effects emerged as early as week 1. Importantly, these clinical improvements occurred without changes in concomitant medications and without any adverse effects on cognitive function, supporting the specificity and safety of the intervention.</div></div><div><h3>Conclusions</h3><div>Accelerated iTBS is a rapid-acting, safe, and cognitively neutral treatment for reducing suicidal ideation and depressive symptoms in TRD inpatients, highlighting its potential utility in acute psychiatric care.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"357 ","pages":"Article 116926"},"PeriodicalIF":3.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145878567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Categories, symptom characteristics and factors influencing depression and anxiety in pregnant women: latent profile analysis and network analysis","authors":"Haiyan Liu ,&nbsp;Youjing Kong ,&nbsp;Xiuyun Cao ,&nbsp;Jingjing Liu ,&nbsp;Rufang Zhou ,&nbsp;Qianzhi Lin ,&nbsp;Wenting Liu ,&nbsp;Yu Chen","doi":"10.1016/j.psychres.2025.116912","DOIUrl":"10.1016/j.psychres.2025.116912","url":null,"abstract":"<div><div>Comorbid prenatal depression and anxiety are prevalent among pregnant women and pose significant risks to maternal and infant health. Previous research has focused on linear associations between depression and anxiety among pregnant women, with limited exploration of subgroup characteristics and symptom heterogeneity. This study examines the categories, symptom characteristics and factors influencing depression and anxiety in pregnant women via latent profile analysis and network analysis. A cross-sectional survey was conducted from June 2021 to August 2023 at hospital obstetric clinics in Guangzhou and Zhongshan, Guangdong Province. A total of 1683 pregnant women completed the Edinburgh Postpartum Depression Scale, the seven-item Generalized Anxiety Disorder Scale, the Cognitive Fusion Questionnaire-Fusion, the Simplified Coping Style Questionnaire and the General Function of Family Assessment Device. Subgroups of patients with depression and anxiety symptoms were identified through latent profile analysis. Multiple regression and network analyses were used to reveal subgroup characteristics. The participants were divided into three subgroups: low depression and anxiety symptom groups (n = 809, 48.07%), medium depression and anxiety symptom groups (n = 756, 44.92%), and high depression and anxiety symptom groups (n = 118, 7.01%). There were significant differences among these three subgroups in terms of age, positive coping, negative coping, cognitive fusion, and family function. The core symptoms of the low and moderate depression and anxiety symptom groups were \"sad or miserable\" and \"anxious or worried\", whereas those of the high depression and anxiety symptom group were \"crying\" and \"uncontrollable worry\". Our study highlights the need for stratified interventions tailored to symptom severity and subgroup characteristics.</div></div>","PeriodicalId":20819,"journal":{"name":"Psychiatry Research","volume":"356 ","pages":"Article 116912"},"PeriodicalIF":3.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145805259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}