Qom Univ Med Sci J最新文献

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Case Report of Congenital Microtia-Atresia 先天性小闭锁1例
Qom Univ Med Sci J Pub Date : 2021-08-01 DOI: 10.32598/qums.15.5.1975.4
M. Alipour, K. Khashei Varnamkhasti
{"title":"Case Report of Congenital Microtia-Atresia","authors":"M. Alipour, K. Khashei Varnamkhasti","doi":"10.32598/qums.15.5.1975.4","DOIUrl":"https://doi.org/10.32598/qums.15.5.1975.4","url":null,"abstract":"Background and Objectives Microtia-atresia is a rare congenital anomaly, which characterized by a small, abnormally shaped auricle (microtia) accompanied with narrow, blocked or absent ear canal (atresia). Microtia can occur appear either as independent clinical abnormality or as part of a syndrome. Due to hearing loss, 80%–90% of patients are at increasing risk of speech and poor academic performance. This abnormality with genetic predisposition and autosomal dominant or recessive mode of Mendelian hereditary, as well as forms due to chromosomal aberrations, occur in varying degrees from 0.83 to 17.4 per 10,000 births, usually unilateral form with more common in males. Case Presentation In this article, a term male neonate with microtia-atresia, born of a 34-year-old mother, was reported. On initial examination by a pediatrician, not properly formation of external right ear and absence of the ear canal was observed in infant. In a closer examination no craniofacial anomalies and no microtia associated syndrome was not observed.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79601890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of Educational Intervention Based on Extended Health Belief Model With Social Support on Promoting Self-care Behaviors in Patients With Smear Positive Pulmonary TB 基于社会支持的扩展健康信念模型教育干预对促进涂阳肺结核患者自我保健行为的影响
Qom Univ Med Sci J Pub Date : 2021-08-01 DOI: 10.32598/qums.15.5.1829.1
S. Hosseinalipour, A. Mohammadbeigi, A. Rahbar, S. Mohebi
{"title":"The Impact of Educational Intervention Based on Extended Health Belief Model With Social Support on Promoting Self-care Behaviors in Patients With Smear Positive Pulmonary TB","authors":"S. Hosseinalipour, A. Mohammadbeigi, A. Rahbar, S. Mohebi","doi":"10.32598/qums.15.5.1829.1","DOIUrl":"https://doi.org/10.32598/qums.15.5.1829.1","url":null,"abstract":"Background and Objectives: Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. It is the tenth leading cause of death in the world. Despite the implementation of an effective prevention and treatment plan, the expected success in reducing and controlling TB cases has not yet been achieved. The aim of this study was to determine the effect of education based on health belief model developed with social support on the promotion of self-care behaviors of patients with smear-positive pulmonary tuberculosis in Qom province in 2019. Methods: 80 patients with smear-positive pulmonary tuberculosis Patient being treated at Qom Health Center were included in this educational intervention study. Patients were randomly divided into experimental (n= 40) and control (n= 40) groups. The educational intervention was performed in three sessions of 45 minutes. Data were collected using a questionnaire and during a direct interview before the educational intervention and three months after the educational intervention. Data analysis using SPSS software version 20 and descriptive tests (frequency and percentage, mean and standard deviation) and analytical tests (paired t-test, independent t-test and Chi-square) at the significance level of 0.05 done. Results: Before educational intervention, there was no significant difference in the mean scores of self-care behavior, perceived sensitivity, perceived barriers, perceived benefits, perceived self-efficacy and perceived social support between the experimental and control groups (P>0.05 ). However, after the educational intervention, a significant difference was observed between the experimental and control groups in terms of the mean scores of self-care behavior, perceived barriers, perceived benefits, perceived self-efficacy and perceived social support (P<0.05). Conclusion: The results of this study showed that education Based on Extended Health Belief Model can be effective on perceived barriers, perceived benefits, perceived self-efficacy, perceived social support, and self-care by increasing and improving the status of structures. Therefore, by designing educational programs based on this model, it is possible to provide the ground for behavior change in target patients.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80957950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Antimicrobial Effect of Hydroalcoholic Extracts of Oak Jaft (Quercus Persica) and Echium Amoenum on Shigella Flexneri 栎叶水醇提取物和石斛水醇提取物对福氏志贺氏菌的抑菌作用
Qom Univ Med Sci J Pub Date : 2021-08-01 DOI: 10.32598/qums.15.5.2349.1
Marzieh An'aam, Fatemeh Riyahi Zaniani, Farid Shirmardi Dezaki
{"title":"Antimicrobial Effect of Hydroalcoholic Extracts of Oak Jaft (Quercus Persica) and Echium Amoenum on Shigella Flexneri","authors":"Marzieh An'aam, Fatemeh Riyahi Zaniani, Farid Shirmardi Dezaki","doi":"10.32598/qums.15.5.2349.1","DOIUrl":"https://doi.org/10.32598/qums.15.5.2349.1","url":null,"abstract":"Background and Objectives: Today, because of the spread of drug resistance and the prevalence of infectious diseases, the use of medicinal plants has increased. So, in this study, the antibacterial effect of hydroalcoholic extract of Oak jaft and Echium amoenum was investigated on Shigella flexneri. Methods: In this study, hydroalcoholic extracts were extracted by maceration method and concentrated by rotary evaporator then dried immediately. Next, the antimicrobial effect of different dilutions of extracts on Shigella flexneri was investigated by disk diffusion and micro broth dilution methods and compared with two antibiotics, ciprofloxacin and trimethoprim-sulfamethoxazole. Results: The results showed that in proportion to the increase in the concentration of oak jaft extract, its antibacterial effect on Shigella flexneri also increased and 3.9 and 7.8 mg/ml of the extract were obtained by MIC and MBC dilution micro broth method, respectively. In the case of Echium amoenum extract, bacteria were grown at all dilutions (except the main stock of the extract (250 mg/ml)) and the extract had no antimicrobial effect on Shigella flexneri. Conclusion: According to the results of this study, oak jaft extract had a good inhibitory effect on Shigella flexneri and in comparison, with ciprofloxacin antibiotic, a similar inhibitory effect was observed and in comparison, with trimethoprim sulfamethoxazole, more inhibitory effect was observed.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78114024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effectiveness of Dialectical Behavioral Therapy on Stress and Cognitive Flexibility in Women With Type 2 Diabetes 辩证行为疗法对女性2型糖尿病患者应激和认知灵活性的影响
Qom Univ Med Sci J Pub Date : 2021-08-01 DOI: 10.32598/qums.15.5.2373.1
Fatemeh Khakshoor Shandiz, F. Shahabizadeh, Qasem Ahi, Mahya Mojahedi
{"title":"The Effectiveness of Dialectical Behavioral Therapy on Stress and Cognitive Flexibility in Women With Type 2 Diabetes","authors":"Fatemeh Khakshoor Shandiz, F. Shahabizadeh, Qasem Ahi, Mahya Mojahedi","doi":"10.32598/qums.15.5.2373.1","DOIUrl":"https://doi.org/10.32598/qums.15.5.2373.1","url":null,"abstract":"Background and Objectives: Diabetes has irreversible effects on the physical and mental functioning of people with diabetes, therefore performing psychological interventions for patients with diabetes seems necessary. Accordingly, the present study aimed to determine the effectiveness of dialectical behavioral therapy on stress and cognitive flexibility of women with type 2 diabetes. Methods: The present study was a quasi-experimental one with pre-test and post-test design and with a control group. Among the statistical population, which included all women with diabetes referred to the Diabetes Center of Birjand in the second 6 months of 2018, 30 people were selected by convenience sampling method and randomly divided into experimental and control groups. The dialectical behavior therapy program was performed for the experimental group in eight 60-minute sessions weekly. Data were collected by Stress Questionnaire (Lovibond & Lovibond, 1995) and Cognitive Flexibility Questionnaire (Dennis & Wendrew, 2010) before and after the intervention, and were analyzed using univariate and multivariate analysis of covariance in the environment of SPSS v. 24 at a significance level of 0.05. Results: The results showed that in the post-test stage there was a significant difference between mean scores of stress and cognitive flexibility in experimental and control groups; in other words, dialectical behavior therapy significantly increased cognitive flexibility and reduced stress in patients with type 2 diabetes (P<0.01). Conclusion: Based on the obtained results, in the therapeutic interventions of diabetic patients using effective treatment methods such as dialectical behavior therapy, it is necessary to pay more attention to the improvement of their psychological conditions.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90940244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Investigating the Association Between Health Literacy and Quality of Life Among Patients With Heart Failure Hospitalized in Coronary Care Unit at Selected Hospitals in Tehran, Iran 调查伊朗德黑兰选定医院冠心病监护病房住院心力衰竭患者健康素养与生活质量之间的关系
Qom Univ Med Sci J Pub Date : 2021-07-01 DOI: 10.32598/qums.15.4.230
Mehri Abdi, N. Alaee, R. Norouzadeh
{"title":"Investigating the Association Between Health Literacy and Quality of Life Among Patients With Heart Failure Hospitalized in Coronary Care Unit at Selected Hospitals in Tehran, Iran","authors":"Mehri Abdi, N. Alaee, R. Norouzadeh","doi":"10.32598/qums.15.4.230","DOIUrl":"https://doi.org/10.32598/qums.15.4.230","url":null,"abstract":"Background and Objectives: Symptoms of heart failure and its complications over time cause limitations in the normal life process of patients and may affect their quality of life. Thus, this study aimed to investigate the relationship between health literacy and patients' quality of life with heart failure admitted to the intensive care units in selected hospitals in Tehran City, Iran. Methods: In this study, 105 patients with heart failure were selected. They were admitted to the cardiac ICU in educational hospitals in Tehran. Data collection tools were demographic information, heart failure health literacy, and quality of life questionnaires. Descriptive statistics and statistical methods of correlation and regression were performed using SPSS v. 24. Results: The results showed a significant positive relationship (r= 0.40) between health literacy and quality of life scores in patients with heart failure. Also, health literacy significantly predicted the quality of life score in patients with heart failure (P<0.001). The results of bivariate regression analysis showed that health literacy scores significantly predict the quality of life of patients with heart failure (P<0.001, r2= 0.16). Conclusion: The findings showed that health literacy could predict the quality of life in patients with heart failure. So, it is crucial to consider health literacy in health promotion programs and improve the quality of life of these patients.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79028513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Health Promotion Support Program on Quality of Life in Patients With Type 2 Diabetes 健康促进支持计划对2型糖尿病患者生活质量的影响
Qom Univ Med Sci J Pub Date : 2021-07-01 DOI: 10.32598/qums.15.4.296
Fatemeh Zanjani, Sima Mohammad Khan kermanshahi, M. Gholami Fesharaki
{"title":"The Effect of Health Promotion Support Program on Quality of Life in Patients With Type 2 Diabetes","authors":"Fatemeh Zanjani, Sima Mohammad Khan kermanshahi, M. Gholami Fesharaki","doi":"10.32598/qums.15.4.296","DOIUrl":"https://doi.org/10.32598/qums.15.4.296","url":null,"abstract":"Background and Objectives: Diabetics need to improve their lifestyle. They should control and prevent the complications of diabetes to improve their quality of life. This study aimed to investigate the effect of health promotion support programs on the quality of life in patients with type 2 diabetes. Methods: The present study was a quasi-clinical trial. A total of 60 people were selected by convenience sampling method and then divided purposefully into intervention (n= 30) and control (n= 30) groups. The health promotion support program was implemented in three stages: review and recognition, support planning, and evaluation. The study data were collected by Demographic and Quality of Life Questionnaire of diabetic patients (DQOL-BCI) before and two months after the intervention in the experimental and control groups. Results: The difference between the two groups regarding gender, age, marriage, education, and the job was not significant. The Mean±SD score of quality of life in the intervention group before the intervention was 46.8±8.06 and increased after the intervention to 56.8±6.06 (P <0.001). The Mean±SD score of quality of life in the control group before the intervention was 46.9±6.7 and increased after the intervention to 49.7±5.6, and this difference was statistically significant (P<0.001). The increase in the quality of life score of the intervention group was 10 units, but it was 2.87 units in the control group. Before the intervention, the difference in the quality of life scores of the two groups was not significant (the independent t-test, P=0.98), but after the intervention, this difference was significant (the independent t-test, P<0.001). Conclusion: The results showed that implementing a health promotion support program effectively improved the quality of life of type 2 diabetic patients. Therefore, it is suggested to be used as an effective method in improving the quality of life of diabetic patients and other chronic diseases.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76434780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determining the Components of a Health Information Social Network Based on a Delphi Study 基于德尔菲研究确定健康信息社会网络的组成部分
Qom Univ Med Sci J Pub Date : 2021-07-01 DOI: 10.32598/qums.15.4.240
Akbar Mohammadi Motlaq, Z. Abazari, F. Sepehr
{"title":"Determining the Components of a Health Information Social Network Based on a Delphi Study","authors":"Akbar Mohammadi Motlaq, Z. Abazari, F. Sepehr","doi":"10.32598/qums.15.4.240","DOIUrl":"https://doi.org/10.32598/qums.15.4.240","url":null,"abstract":"Background and Objectives: In recent years, social networks have been considered by organizations active in the health sector. They have provided many opportunities for consulting, training, and information sharing and held promises to increase the quality and safety of health care and reduce costs. So it is necessary to study their dimensions and requirements. This study aims to identify the components of the health information social network from the perspective of experts. Methods: This research is an analytical survey using the Delphi method. The statistical population included 28 experts in the field of health information technology in Iran. The data collection tool was a questionnaire whose validity was confirmed by experts, and its reliability was 0.96 according to the Cronbach α coefficient. SPSS software version 19 was used for data analysis. Results: According to this research, the health information social network has 6 dimensions, each has several components (a total of 47 components). These dimensions include services, core users, requirements, information security, evaluation and monitoring, and technical features. Conclusion: The dimensions of this network are based on the collective opinion of experts and are a framework for creating a social network of health information. Its use helps in planning and decision making and providing high-quality health services and leads to quality improvement of health indicators.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90770406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Designing and Validating an Instrument for Measuring the Effectiveness of Education in Medical Universities 医学院校教学效果测量工具的设计与验证
Qom Univ Med Sci J Pub Date : 2021-07-01 DOI: 10.32598/qums.15.4.272
Ali Reza Shouri Bidgolili, Gholamreza Vaisi, Gholamreza Sharifi Rad
{"title":"Designing and Validating an Instrument for Measuring the Effectiveness of Education in Medical Universities","authors":"Ali Reza Shouri Bidgolili, Gholamreza Vaisi, Gholamreza Sharifi Rad","doi":"10.32598/qums.15.4.272","DOIUrl":"https://doi.org/10.32598/qums.15.4.272","url":null,"abstract":"Background and Objectives: The objectives of educational systems are missions, ideals, general goals, and behavior. Evaluation and judgment are essential for the training courses. Determining the effectiveness of the courses makes it possible to improve them. Numerous models evaluate training effectiveness, success, performance improvement, and desirability of training programs. Educational planners have always considered medical education and training of an efficient workforce. Because of the importance of education and the need for its continuous effectiveness in medical universities, we designed a tool to measure the effectiveness of medical education. Methods: The study method is a mixed qualitative-quantitative approach. The qualitative part of the content analysis was prepared to design and validate a tool with the statistical community of faculty members using qualitative and quantitative purposeful sampling. In the qualitative phase, 30 people were interviewed using semi-structured interviews. The components found were classified based on research methodology in 4 areas of course curriculum development, training course implementation, educational outcome and performance, and other accompanying factors. Then an effective measurement tool with good validity and reliability was designed. Regarding the face validity of the questionnaire, it was distributed among ten experts. To assess the reliability of the research tool, a questionnaire was distributed among 490 faculty members. Results: The results of measuring the reliability of the instrument by the Cronbach α values in the four domains were as follows: 0.875 in the area of curriculum development, 0.885 in the area of curriculum implementation, 0.890 in the curriculum outcome and performance, and 0.925 in other areas of the effective factors. These figures confirmed the validity of the tool. Also, using the agreement coefficient-test, the responses of faculty members and physicians and all stakeholders of medical universities showed more than 69% agreement. Conclusion: The study's findings showed that all the found components impact the effectiveness of education, and our designed tool was confirmed with appropriate and reliable validity and reliability.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75619265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A Case Report of Neonatal Pemphigus Vulgaris 新生儿寻常型天疱疮1例报告
Qom Univ Med Sci J Pub Date : 2021-07-01 DOI: 10.32598/qums.15.4.306
M. Alipour, K. Khashei Varnamkhasti, Marzieh Eslami Moghaddam
{"title":"A Case Report of Neonatal Pemphigus Vulgaris","authors":"M. Alipour, K. Khashei Varnamkhasti, Marzieh Eslami Moghaddam","doi":"10.32598/qums.15.4.306","DOIUrl":"https://doi.org/10.32598/qums.15.4.306","url":null,"abstract":"Background and Objectives: Pemphigus vulgaris (PV) is a chronic, rare mucocutaneous autoimmune bullous disease characterized by flaccid blisters and or pustules, with secondary erosions of the mucous membranes or skin. PV threatens the patient life by forming splits within the epidermis, accompanied by acantholysis (separating keratinocytes from each other). Case Presentation: Our case is a term female neonate with PV, born of a 31-year-old mother. On initial examination by a pediatrician, several thin-walled flaccid blisters and burst blisters accompanied with open sores were observed on the skin of hands, feet, face, and mucosa of the oral cavity, tongue, and throat. A positive Nikolsky's sign confirmed her involvement with the disease.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73682528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Sperm and Morphometric Parameters of Testicular Tissue Following Curcumin Administration in Rats After Varicocele Induction 姜黄素对大鼠精索静脉曲张诱导后精子及睾丸组织形态参数的影响
Qom Univ Med Sci J Pub Date : 2021-07-01 DOI: 10.32598/qums.15.4.284
Mohammadreza Sadraie, M. Tavalaee, M. Nasr-Esfahani, M. Forouzanfar
{"title":"Evaluation of Sperm and Morphometric Parameters of Testicular Tissue Following Curcumin Administration in Rats After Varicocele Induction","authors":"Mohammadreza Sadraie, M. Tavalaee, M. Nasr-Esfahani, M. Forouzanfar","doi":"10.32598/qums.15.4.284","DOIUrl":"https://doi.org/10.32598/qums.15.4.284","url":null,"abstract":"Background and Objectives: Varicocele is the abnormal dilation and twisting of the veins of the pampiniform network, the spermatic cord of the testis. This event is associated with increased oxidative stress and decreased antioxidant capacity. The consequence of varicocele is a reduction in the quality of sperm parameters and defects in spermatogenesis. Curcumin has been introduced as an antioxidant with multiple and modulating potentials in biological activities. This study investigates the effect of curcumin on sperm parameters and the histological status of testicular tissue in rats with varicocele. Methods: For this study, 50 male Wistar rats were examined in 5 different groups: control, sham, varicocele, varicocele treated with curcumin 50 mg/kg, and varicocele treated with curcumin 100 mg/kg. Varicocele was induced through partial occlusion of the left renal vein. Then, sperm parameters and histological status of testicular tissue were assessed and analyzed using ANOVA test after 2 months of curcumin administration in varicocele rats. Results: This study showed that varicocele led to a significant decrease in motility percentage (P= 0.007), sperm concentration (P= 0.036), and a significant increase in abnormal sperm morphology (P≥0.05) compared to the control group. Although administration of curcumin in varicocele rats with concentrations of 50 and 100 mg/kg led to an improvement in sperm parameters, only in varicocele rats received 100 mg/kg curcumin, the concentration (P= 0.032) and total sperm motility (P= 0.04) significantly improved compared to varicocele group. In addition, curcumin improved the tissue damage caused by varicocele and increased the spermatogenesis index. Conclusion: The present study showed that curcumin improves the low quality of sperm parameters and can be a treatment strategy for future male infertility.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76569456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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