姜黄素对大鼠精索静脉曲张诱导后精子及睾丸组织形态参数的影响

Mohammadreza Sadraie, M. Tavalaee, M. Nasr-Esfahani, M. Forouzanfar
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引用次数: 1

摘要

背景和目的:精索静脉曲张是睾丸精索旁系网静脉的异常扩张和扭曲。这一事件与氧化应激增加和抗氧化能力下降有关。精索静脉曲张的后果是精子质量的下降和精子发生的缺陷。姜黄素是一种具有多种生物活性的抗氧化剂。本研究探讨姜黄素对精索静脉曲张大鼠精子参数及睾丸组织组织学状态的影响。方法:将50只雄性Wistar大鼠分为对照组、假手术组、精索静脉曲张组、精索静脉曲张组(姜黄素50 mg/kg)和精索静脉曲张组(姜黄素100 mg/kg)。通过左肾静脉部分闭塞诱导精索静脉曲张。采用方差分析方法对精索静脉曲张大鼠姜黄素给药2个月后的精子参数和睾丸组织组织学状态进行评价和分析。结果:本研究显示精索静脉曲张组与对照组相比,运动率(P= 0.007)显著降低,精子浓度(P= 0.036)显著降低,精子形态异常显著增加(P≥0.05)。虽然在精索静脉曲张大鼠中给药浓度为50和100 mg/kg的姜黄素可以改善精子参数,但与精索静脉曲张组相比,只有在精索静脉曲张大鼠中给药浓度为100 mg/kg的姜黄素显著改善了精子浓度(P= 0.032)和总精子活力(P= 0.04)。此外,姜黄素还能改善精索静脉曲张引起的组织损伤,提高精子发生指数。结论:本研究表明姜黄素可改善低质量精子参数,可作为未来男性不育症的治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of Sperm and Morphometric Parameters of Testicular Tissue Following Curcumin Administration in Rats After Varicocele Induction
Background and Objectives: Varicocele is the abnormal dilation and twisting of the veins of the pampiniform network, the spermatic cord of the testis. This event is associated with increased oxidative stress and decreased antioxidant capacity. The consequence of varicocele is a reduction in the quality of sperm parameters and defects in spermatogenesis. Curcumin has been introduced as an antioxidant with multiple and modulating potentials in biological activities. This study investigates the effect of curcumin on sperm parameters and the histological status of testicular tissue in rats with varicocele. Methods: For this study, 50 male Wistar rats were examined in 5 different groups: control, sham, varicocele, varicocele treated with curcumin 50 mg/kg, and varicocele treated with curcumin 100 mg/kg. Varicocele was induced through partial occlusion of the left renal vein. Then, sperm parameters and histological status of testicular tissue were assessed and analyzed using ANOVA test after 2 months of curcumin administration in varicocele rats. Results: This study showed that varicocele led to a significant decrease in motility percentage (P= 0.007), sperm concentration (P= 0.036), and a significant increase in abnormal sperm morphology (P≥0.05) compared to the control group. Although administration of curcumin in varicocele rats with concentrations of 50 and 100 mg/kg led to an improvement in sperm parameters, only in varicocele rats received 100 mg/kg curcumin, the concentration (P= 0.032) and total sperm motility (P= 0.04) significantly improved compared to varicocele group. In addition, curcumin improved the tissue damage caused by varicocele and increased the spermatogenesis index. Conclusion: The present study showed that curcumin improves the low quality of sperm parameters and can be a treatment strategy for future male infertility.
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