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Profiles of drug substances, excipients, and related methodology最新文献

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Vandetanib. 咒骂。
Profiles of drug substances, excipients, and related methodology Pub Date : 2023-01-01 DOI: 10.1016/bs.podrm.2022.11.004
Ahmed I Al-Ghusn, Ahmed H Bakheit, Mohamed W Attwa, Haitham AlRabiah
{"title":"Vandetanib.","authors":"Ahmed I Al-Ghusn,&nbsp;Ahmed H Bakheit,&nbsp;Mohamed W Attwa,&nbsp;Haitham AlRabiah","doi":"10.1016/bs.podrm.2022.11.004","DOIUrl":"https://doi.org/10.1016/bs.podrm.2022.11.004","url":null,"abstract":"<p><p>Vandetanib is an anti-cancer drug called an antineoplastic kinase inhibitor. The FDA authorized vandetanib on April6, 2011 for the treatment of nonresectable, locally progressed, or metastatic medullary thyroid carcinoma in adults. Because Vandetanib can make the Q-T interval last longer, it shouldn't be given to people with serious heart problems like congenital long QT syndrome or heart failure that hasn't been fixed yet. This chapter provides an overview of Vandetanib's physical and molecular properties, mode of action, pharmacokinetics, and common applications. In furthermore, a detailed summary of the reported techniques of Vandetanib measurement will be provided to assist analysts in selecting the most practical approach for its estimation in routine analysis. This chapter will also explain the synthesis methods developed in the preparation of vandetanib as well as pharmacology of its. In addition, this section summarizes the analytical and characterization techniques utilized to characterize vandetanib row material.</p>","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":"48 ","pages":"109-134"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9320807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Application of chemometrics using direct spectroscopic methods as a QC tool in pharmaceutical industry and their validation. 化学计量学直接光谱法在制药工业中的应用及其验证。
Profiles of drug substances, excipients, and related methodology Pub Date : 2022-01-01 DOI: 10.1016/bs.podrm.2021.10.006
L. Wulandari, R. Idroes, T. R. Noviandy, G. Indrayanto
{"title":"Application of chemometrics using direct spectroscopic methods as a QC tool in pharmaceutical industry and their validation.","authors":"L. Wulandari, R. Idroes, T. R. Noviandy, G. Indrayanto","doi":"10.1016/bs.podrm.2021.10.006","DOIUrl":"https://doi.org/10.1016/bs.podrm.2021.10.006","url":null,"abstract":"","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":"60 1","pages":"327-379"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79860297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Loratadine.
Profiles of drug substances, excipients, and related methodology Pub Date : 2022-01-01 DOI: 10.1016/bs.podrm.2021.10.002
N. AlMasoud, Ahmed H H Bakheit, M. F. Alshammari, H. Abdel‐Aziz, H. Alrabiah
{"title":"Loratadine.","authors":"N. AlMasoud, Ahmed H H Bakheit, M. F. Alshammari, H. Abdel‐Aziz, H. Alrabiah","doi":"10.1016/bs.podrm.2021.10.002","DOIUrl":"https://doi.org/10.1016/bs.podrm.2021.10.002","url":null,"abstract":"","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":"82 1","pages":"55-90"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82162457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lodenafil.
Profiles of drug substances, excipients, and related methodology Pub Date : 2022-01-01 DOI: 10.1016/bs.podrm.2021.10.004
Yahya M. Alshehri, Abdulrahman A Al-Majed, Mohamed W. Attwa, Ahmed H H Bakheit
{"title":"Lodenafil.","authors":"Yahya M. Alshehri, Abdulrahman A Al-Majed, Mohamed W. Attwa, Ahmed H H Bakheit","doi":"10.1016/bs.podrm.2021.10.004","DOIUrl":"https://doi.org/10.1016/bs.podrm.2021.10.004","url":null,"abstract":"","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":"12 1","pages":"113-147"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75193755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Vinpocetine (A comprehensive profile). 长春西汀(综合概况)。
Profiles of drug substances, excipients, and related methodology Pub Date : 2022-01-01 DOI: 10.1016/bs.podrm.2021.10.001
N. Khalil, A. Bakheit, H. Alkahtani, Turki Al-Muhanna
{"title":"Vinpocetine (A comprehensive profile).","authors":"N. Khalil, A. Bakheit, H. Alkahtani, Turki Al-Muhanna","doi":"10.1016/bs.podrm.2021.10.001","DOIUrl":"https://doi.org/10.1016/bs.podrm.2021.10.001","url":null,"abstract":"","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":"05 1","pages":"1-54"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85976926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Preface. 前言。
Profiles of drug substances, excipients, and related methodology Pub Date : 2022-01-01 DOI: 10.1016/S1871-5125(22)00009-7
Abdulrahman A Al-Majed
{"title":"Preface.","authors":"Abdulrahman A Al-Majed","doi":"10.1016/S1871-5125(22)00009-7","DOIUrl":"https://doi.org/10.1016/S1871-5125(22)00009-7","url":null,"abstract":"","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":"131 1","pages":"ix-x"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76227074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validation of in-vitro bioassay methods: Application in herbal drug research. 体外生物测定方法的验证:在中药研究中的应用。
Profiles of drug substances, excipients, and related methodology Pub Date : 2021-01-01 Epub Date: 2020-08-27 DOI: 10.1016/bs.podrm.2020.07.005
Gunawan Indrayanto, Galih Satrio Putra, Farida Suhud
{"title":"Validation of in-vitro bioassay methods: Application in herbal drug research.","authors":"Gunawan Indrayanto,&nbsp;Galih Satrio Putra,&nbsp;Farida Suhud","doi":"10.1016/bs.podrm.2020.07.005","DOIUrl":"https://doi.org/10.1016/bs.podrm.2020.07.005","url":null,"abstract":"<p><p>This present review described the validation method of in-vitro bioassay for its application in herbal drug research. Seven sequencing steps that can be taken for performing a valid bioassay include: literature survey, sample stability evaluation, Biosystem performance testing, Sample performance evaluation, determination of 50% effective concentration or cytotoxic concentrations, selective index evaluation, and determination of accurate relative potency of sample. Detailed methods and acceptance criteria for each step are described herein. Method calculations of the relative potency of sample using European Pharmacopeia 10.0, 5.3 (2020) were recommended instead of using United States Pharmacopeia 42 (2019). For having reliable data and conclusions, all methods (chemical and bioassay) need to be first validated before any data collection. Absence of any validation method may results in incorrect conclusions and bias.</p>","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":"46 ","pages":"273-307"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.podrm.2020.07.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38833683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 144
Rabeprazole: A comprehensive profile. 雷贝拉唑:综合概况。
Profiles of drug substances, excipients, and related methodology Pub Date : 2021-01-01 Epub Date: 2020-08-13 DOI: 10.1016/bs.podrm.2020.07.003
Ahmed H Bakheit, Hamad M Al-Kahtani, Salem Albraiki
{"title":"Rabeprazole: A comprehensive profile.","authors":"Ahmed H Bakheit,&nbsp;Hamad M Al-Kahtani,&nbsp;Salem Albraiki","doi":"10.1016/bs.podrm.2020.07.003","DOIUrl":"https://doi.org/10.1016/bs.podrm.2020.07.003","url":null,"abstract":"<p><p>Rabeprazole belongs to the class of anti-secretory drugs, with benzimidazoles substitution. These drugs induce gastric acid secretion through precise inhibition of the enzyme H<sup>+</sup>/K<sup>+</sup>-ATPase (acid or proton pump). This effect helps to treat and prevent conditions in which gastric acid directly aggravates symptoms such as duodenal and gastric ulcers. This chapter includes a comprehensive review of rabeprazole in terms of nomenclature, its physical-chemical properties, methods of preparation and ADME profiles. In addition, the chapter also includes a review of several methods for analysis of rebeprazole in its dosage forms and biological fluids.</p>","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":"46 ","pages":"137-183"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.podrm.2020.07.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38833680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Series Page 系列页面
Profiles of drug substances, excipients, and related methodology Pub Date : 2021-01-01 DOI: 10.1016/s1871-5125(21)00004-2
{"title":"Series Page","authors":"","doi":"10.1016/s1871-5125(21)00004-2","DOIUrl":"https://doi.org/10.1016/s1871-5125(21)00004-2","url":null,"abstract":"","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s1871-5125(21)00004-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56843448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Copyright 版权
Profiles of drug substances, excipients, and related methodology Pub Date : 2021-01-01 DOI: 10.1016/s1871-5125(21)00006-6
{"title":"Copyright","authors":"","doi":"10.1016/s1871-5125(21)00006-6","DOIUrl":"https://doi.org/10.1016/s1871-5125(21)00006-6","url":null,"abstract":"","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s1871-5125(21)00006-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56843038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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