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Profiles of drug substances, excipients, and related methodology最新文献

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Remdesivir. 瑞德西韦
Profiles of drug substances, excipients, and related methodology Pub Date : 2023-01-01 Epub Date: 2023-02-09 DOI: 10.1016/bs.podrm.2022.11.003
Ahmed H Bakheit, Hany Darwish, Ibrahim A Darwish, Ahmed I Al-Ghusn
{"title":"Remdesivir.","authors":"Ahmed H Bakheit, Hany Darwish, Ibrahim A Darwish, Ahmed I Al-Ghusn","doi":"10.1016/bs.podrm.2022.11.003","DOIUrl":"10.1016/bs.podrm.2022.11.003","url":null,"abstract":"<p><p>Remdesivir, marketed under the brand name Veklury, is an antiviral drug with a broad spectrum of activity. There were various countries where the use of Remdesivir for the treatment of COVID-19 was authorized during the pandemic. Remdesivir was first designed to treat hepatitis C, but it was later tested for Ebola virus sickness and Marburg virus infections. Remdesivir is a prodrug designed to facilitate the intracellular transport of GS-441524 monophosphate and its subsequent biotransformation into GS-441524 triphosphate, a ribonucleotide analogue inhibitor of viral RNA polymerase. The objective of this chapter is to provide a comprehensive review of Remdesivir (GS-5734), including its nomenclature, physiochemical properties, preparation methods, identification procedures, numerous qualitative and quantitative analytical techniques, ADME profiles, and pharmacological effects. In addition, the chapter provides a variety of chromatographic and spectroscopic techniques for separating brimonidine from other drugs in combination formulations.</p>","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9331082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmaceutical based cosmetic serums. 基于药物的化妆品血清。
Profiles of drug substances, excipients, and related methodology Pub Date : 2023-01-01 DOI: 10.1016/bs.podrm.2022.11.006
Nimra Khan, Sofia Ahmed, Muhammad Ali Sheraz, Zubair Anwar, Iqbal Ahmad
{"title":"Pharmaceutical based cosmetic serums.","authors":"Nimra Khan,&nbsp;Sofia Ahmed,&nbsp;Muhammad Ali Sheraz,&nbsp;Zubair Anwar,&nbsp;Iqbal Ahmad","doi":"10.1016/bs.podrm.2022.11.006","DOIUrl":"https://doi.org/10.1016/bs.podrm.2022.11.006","url":null,"abstract":"<p><p>The growth and demand for cosmeceuticals (cosmetic products that have medicinal or drug-like benefits) have been enhanced for the last few decades. Lately, the newly invented dosage form, i.e., the pharmaceutical-based cosmetic serum has been developed and widely employed in various non-invasive cosmetic procedures. Many pharmaceutical-based cosmetic serums contain natural active components that claim to have a medical or drug-like effect on the skin, hair, and nails, including anti-aging, anti-wrinkle, anti-acne, hydrating, moisturizing, repairing, brightening and lightening skin, anti-hair fall, anti-fungal, and nail growth effect, etc. In comparison with other pharmaceutical-related cosmetic products (creams, gels, foams, and lotions, etc.), pharmaceutical-based cosmetic serums produce more rapid and incredible effects on the skin. This chapter provides detailed knowledge about the different marketed pharmaceutical-based cosmetic serums and their several types such as facial serums, hair serums, nail serums, under the eye serum, lip serum, hand, and foot serum, respectively. Moreover, some valuable procedures have also been discussed which provide prolong effects with desired results in the minimum duration of time after the few sessions of the serum treatment.</p>","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9315708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Brimonidine. Brimonidine。
Profiles of drug substances, excipients, and related methodology Pub Date : 2023-01-01 DOI: 10.1016/bs.podrm.2022.11.001
Ahmed H Bakheit, Ahmed M Alomar, Hany Darwish, Hamad M Alkahtani
{"title":"Brimonidine.","authors":"Ahmed H Bakheit,&nbsp;Ahmed M Alomar,&nbsp;Hany Darwish,&nbsp;Hamad M Alkahtani","doi":"10.1016/bs.podrm.2022.11.001","DOIUrl":"https://doi.org/10.1016/bs.podrm.2022.11.001","url":null,"abstract":"<p><p>Brimonidine is a highly selective 2-adrenoceptor agonist that lowers intraocular pressure (IOP) by decreasing aqueous humor production and increasing aqueous humor outflow via the uveoscleral route. Brimonidine is used to treat glaucoma and other eye conditions. Brimonidine is a topical medication that is used mainly to treat open-angle glaucoma and ocular hypertension in the eyelids. The purpose of this chapter is to provide a comprehensive discussion of Brimonidine's nomenclature, physiochemical properties, preparation methods, identification procedures, and numerous qualitative and quantitative analytical techniques, as well as its ADME profiles and pharmacological effects. In addition, the chapter contains numerous approaches for separating brimonidine from other medications in combination formulations utilizing chromatographic techniques and other spectroscopic approaches.</p>","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9320806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Vandetanib. 咒骂。
Profiles of drug substances, excipients, and related methodology Pub Date : 2023-01-01 DOI: 10.1016/bs.podrm.2022.11.004
Ahmed I Al-Ghusn, Ahmed H Bakheit, Mohamed W Attwa, Haitham AlRabiah
{"title":"Vandetanib.","authors":"Ahmed I Al-Ghusn,&nbsp;Ahmed H Bakheit,&nbsp;Mohamed W Attwa,&nbsp;Haitham AlRabiah","doi":"10.1016/bs.podrm.2022.11.004","DOIUrl":"https://doi.org/10.1016/bs.podrm.2022.11.004","url":null,"abstract":"<p><p>Vandetanib is an anti-cancer drug called an antineoplastic kinase inhibitor. The FDA authorized vandetanib on April6, 2011 for the treatment of nonresectable, locally progressed, or metastatic medullary thyroid carcinoma in adults. Because Vandetanib can make the Q-T interval last longer, it shouldn't be given to people with serious heart problems like congenital long QT syndrome or heart failure that hasn't been fixed yet. This chapter provides an overview of Vandetanib's physical and molecular properties, mode of action, pharmacokinetics, and common applications. In furthermore, a detailed summary of the reported techniques of Vandetanib measurement will be provided to assist analysts in selecting the most practical approach for its estimation in routine analysis. This chapter will also explain the synthesis methods developed in the preparation of vandetanib as well as pharmacology of its. In addition, this section summarizes the analytical and characterization techniques utilized to characterize vandetanib row material.</p>","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9320807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Application of chemometrics using direct spectroscopic methods as a QC tool in pharmaceutical industry and their validation. 化学计量学直接光谱法在制药工业中的应用及其验证。
Profiles of drug substances, excipients, and related methodology Pub Date : 2022-01-01 DOI: 10.1016/bs.podrm.2021.10.006
L. Wulandari, R. Idroes, T. R. Noviandy, G. Indrayanto
{"title":"Application of chemometrics using direct spectroscopic methods as a QC tool in pharmaceutical industry and their validation.","authors":"L. Wulandari, R. Idroes, T. R. Noviandy, G. Indrayanto","doi":"10.1016/bs.podrm.2021.10.006","DOIUrl":"https://doi.org/10.1016/bs.podrm.2021.10.006","url":null,"abstract":"","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79860297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Loratadine.
Profiles of drug substances, excipients, and related methodology Pub Date : 2022-01-01 DOI: 10.1016/bs.podrm.2021.10.002
N. AlMasoud, Ahmed H H Bakheit, M. F. Alshammari, H. Abdel‐Aziz, H. Alrabiah
{"title":"Loratadine.","authors":"N. AlMasoud, Ahmed H H Bakheit, M. F. Alshammari, H. Abdel‐Aziz, H. Alrabiah","doi":"10.1016/bs.podrm.2021.10.002","DOIUrl":"https://doi.org/10.1016/bs.podrm.2021.10.002","url":null,"abstract":"","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82162457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lodenafil.
Profiles of drug substances, excipients, and related methodology Pub Date : 2022-01-01 DOI: 10.1016/bs.podrm.2021.10.004
Yahya M. Alshehri, Abdulrahman A Al-Majed, Mohamed W. Attwa, Ahmed H H Bakheit
{"title":"Lodenafil.","authors":"Yahya M. Alshehri, Abdulrahman A Al-Majed, Mohamed W. Attwa, Ahmed H H Bakheit","doi":"10.1016/bs.podrm.2021.10.004","DOIUrl":"https://doi.org/10.1016/bs.podrm.2021.10.004","url":null,"abstract":"","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75193755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Vinpocetine (A comprehensive profile). 长春西汀(综合概况)。
Profiles of drug substances, excipients, and related methodology Pub Date : 2022-01-01 DOI: 10.1016/bs.podrm.2021.10.001
N. Khalil, A. Bakheit, H. Alkahtani, Turki Al-Muhanna
{"title":"Vinpocetine (A comprehensive profile).","authors":"N. Khalil, A. Bakheit, H. Alkahtani, Turki Al-Muhanna","doi":"10.1016/bs.podrm.2021.10.001","DOIUrl":"https://doi.org/10.1016/bs.podrm.2021.10.001","url":null,"abstract":"","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85976926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Preface. 前言。
Profiles of drug substances, excipients, and related methodology Pub Date : 2022-01-01 DOI: 10.1016/S1871-5125(22)00009-7
Abdulrahman A Al-Majed
{"title":"Preface.","authors":"Abdulrahman A Al-Majed","doi":"10.1016/S1871-5125(22)00009-7","DOIUrl":"https://doi.org/10.1016/S1871-5125(22)00009-7","url":null,"abstract":"","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76227074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validation of in-vitro bioassay methods: Application in herbal drug research. 体外生物测定方法的验证:在中药研究中的应用。
Profiles of drug substances, excipients, and related methodology Pub Date : 2021-01-01 Epub Date: 2020-08-27 DOI: 10.1016/bs.podrm.2020.07.005
Gunawan Indrayanto, Galih Satrio Putra, Farida Suhud
{"title":"Validation of in-vitro bioassay methods: Application in herbal drug research.","authors":"Gunawan Indrayanto,&nbsp;Galih Satrio Putra,&nbsp;Farida Suhud","doi":"10.1016/bs.podrm.2020.07.005","DOIUrl":"https://doi.org/10.1016/bs.podrm.2020.07.005","url":null,"abstract":"<p><p>This present review described the validation method of in-vitro bioassay for its application in herbal drug research. Seven sequencing steps that can be taken for performing a valid bioassay include: literature survey, sample stability evaluation, Biosystem performance testing, Sample performance evaluation, determination of 50% effective concentration or cytotoxic concentrations, selective index evaluation, and determination of accurate relative potency of sample. Detailed methods and acceptance criteria for each step are described herein. Method calculations of the relative potency of sample using European Pharmacopeia 10.0, 5.3 (2020) were recommended instead of using United States Pharmacopeia 42 (2019). For having reliable data and conclusions, all methods (chemical and bioassay) need to be first validated before any data collection. Absence of any validation method may results in incorrect conclusions and bias.</p>","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.podrm.2020.07.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38833683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 144
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