Lapatinib: A comprehensive profile.

Q1 Pharmacology, Toxicology and Pharmaceutics

Profiles of drug substances, excipients, and related methodology Pub Date : 2023-01-01 DOI:10.1016/bs.podrm.2022.11.005

Ahmed A Abdelgalil, Hamad M Alkahtani

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Abstract

Lapatinib is an anticancer used for treatment of the patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine or with letrozole for the treatment of postmenopausal women with hormone receptor-positive metastatic breast cancer. This comprehensive profile of Lapatinib gives more detailed information about the description, formulae, Elemental Analysis, Uses and application. Furthermore, methods and schemes are outlined for the preparation of the drug substance. The physical properties of the medication include constant of ionization, solubility, X-ray powder diffraction pattern, differential scanning calorimetry, thermal conduct and spectroscopic studies are investigated. The methods employed in bulk medicines and/or in pharmaceutical formulations to analyze the drug substance include spectrophotometric, electrochemical and the chromatographic methods are indicated. Other studies on this drug substance include drug stability, pharmaceutical applications, mechanism of action, pharmacodynamics, and a dosing information are also reviewed.

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拉帕替尼:全面的概况。

拉帕替尼是一种抗癌药物，用于治疗晚期转移性乳腺癌患者，与化疗药物卡培他滨或来曲唑联合用于治疗绝经后激素受体阳性转移性乳腺癌妇女。拉帕替尼的综合简介提供了更详细的信息，包括描述、配方、元素分析、用途和应用。此外，还概述了该原料药的制备方法和方案。研究了药物的物理性质，包括电离常数、溶解度、x射线粉末衍射图、差示扫描量热、热传导和光谱研究。原料药和/或制剂中用于分析原料药的方法包括分光光度法、电化学法和色谱法。对该原料药的其他研究包括药物稳定性、药物应用、作用机制、药效学和给药信息进行了综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Profiles of drug substances, excipients, and related methodology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

13.10

自引率

0.00%

发文量