雷贝拉唑:综合概况。

Q1 Pharmacology, Toxicology and Pharmaceutics

Profiles of drug substances, excipients, and related methodology Pub Date : 2021-01-01 Epub Date: 2020-08-13 DOI:10.1016/bs.podrm.2020.07.003

Ahmed H Bakheit, Hamad M Al-Kahtani, Salem Albraiki

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引用次数: 1

摘要

雷贝拉唑属于抗分泌类药物，与苯并咪唑替代。这些药物通过精确抑制H+/K+- atp酶(酸或质子泵)诱导胃酸分泌。这种效果有助于治疗和预防胃酸直接加重十二指肠溃疡和胃溃疡等症状的情况。本章对雷贝拉唑的命名、理化性质、制备方法和ADME概况进行了综述。此外，本章还包括几种方法的分析雷巴拉唑的剂型和生物液体的审查。

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Rabeprazole: A comprehensive profile.

Rabeprazole belongs to the class of anti-secretory drugs, with benzimidazoles substitution. These drugs induce gastric acid secretion through precise inhibition of the enzyme H⁺/K⁺-ATPase (acid or proton pump). This effect helps to treat and prevent conditions in which gastric acid directly aggravates symptoms such as duodenal and gastric ulcers. This chapter includes a comprehensive review of rabeprazole in terms of nomenclature, its physical-chemical properties, methods of preparation and ADME profiles. In addition, the chapter also includes a review of several methods for analysis of rebeprazole in its dosage forms and biological fluids.

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来源期刊

Profiles of drug substances, excipients, and related methodology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

13.10

自引率

0.00%

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