Psychotherapy and Psychosomatics最新文献

{"title":"Adherence to Physical Activity Interventions in Major Depressive Disorder: A Systematic Review and Meta-Analysis.","authors":"Vanessa K Tassone,Qiaowei Lin,Gloria Li,Aarna Rao,Victoria Duscio,Tia Mathur,Harani Uthayakumar,Syeda Zauraiz Sohail,Soha Kar,Danika A Quesnel,Wendy Lou,David Wiljer,Catherine M Sabiston,Benoit Mulsant,Venkat Bhat","doi":"10.1159/000550802","DOIUrl":"https://doi.org/10.1159/000550802","url":null,"abstract":"INTRODUCTIONNon-adherence is a barrier to the effectiveness of physical activity (PA) interventions for major depressive disorder (MDD). This systematic review and meta-analysis identified reported adherence-related outcomes, compared adherence rates of PA and non-PA interventions in MDD, and determined predictors of adherence.METHODSMEDLINE, APA PsycINFO, CINAHL Plus, and SPORTDiscus were searched until September 5th, 2024. Pooled estimated risk differences [RDs] and 95% confidence intervals [CIs] were calculated using fixed-effects or random-effects models. Meta-regression explored predictors of adherence.RESULTSNinety-seven studies were included in this review, and 91 studies in the meta-analysis. Adherence-related outcomes for analyses included rates of intervention receipt, retention, protocol adherence, and session attendance. Retention was the most commonly reported outcome, with no significant difference between PA and non-PA interventions. Similarly, there were no significant differences in intervention receipt and session attendance. However, PA interventions had significantly lower protocol adherence than non-PA interventions (RD = -0.15; 95% CI: -0.23, -0.08). Severe baseline depressive symptoms, longer intervention durations, and in-person delivery predicted retention rates. Longer PA sessions predicted intervention receipt and supervision of activities predicted attendance rates.CONCLUSIONParticipants with MDD demonstrate lower protocol adherence to PA interventions than to interventions without a PA component. This result was based on a paucity of studies. Rates of intervention receipt, retention, and attendance were comparable in PA and non-PA interventions. Studies could benefit from including individuals with greater depressive symptom severity and supervised activity. With replication, findings could improve the design of, and increase adherence to, PA interventions in MDD.","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":"17 1","pages":"1-25"},"PeriodicalIF":22.8,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146089182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidepressants and Risk of Mortality in People with Depressive Disorder and Co-Occurring Type 2 Diabetes Mellitus: A 20-Year Population-Based Cohort Study.","authors":"Matthew Tsz Ho Ho, Joe Kwun Nam Chan, Heidi Ka Ying Lo, Catherine Zhiqian Fang, Corine Sau Man Wong, Krystal Chi Kei Lee, Francisco Tsz Tsun Lai, Amy Pui Pui Ng, William Chi Wai Wong, Wing Chung Chang","doi":"10.1159/000550667","DOIUrl":"10.1159/000550667","url":null,"abstract":"<p><strong>Introduction: </strong>Depression and diabetes often co-occur and worsen clinical outcomes of both conditions. However, mortality risk among depression patients with diabetes exposed to antidepressant is understudied. We investigated whether antidepressant would decrease mortality risk in people with depression and incident diabetes.</p><p><strong>Methods: </strong>This population-based cohort study identified 11,137 depression patients with incident type 2 diabetes between 2002 and 2021 in Hong Kong who were exposed to antidepressants, using territory-wide electronic medical-record database. Association between antidepressant exposure and mortality risk was analyzed by Cox proportional-hazards models for any antidepressant, specific drug classes, and individual agents, with stratified analysis by HbA1c level. A comprehensive array of covariates, including age, sex, calendar-year period, catchment-area, preexisting physical comorbidities, diabetic complications, substance/alcohol use disorders, cardiovascular/antidiabetes medications, and presence of antidepressants other than the specified drug was adjusted. Three sets of sensitivity analyses were conducted by restricting to patients (a) with cumulative drug exposure ≥90 days and ≥180 days, (b) with medication-possession ratio ≥80%, and (c) monotherapy.</p><p><strong>Results: </strong>Lower risk of all-cause mortality was associated with exposure to any antidepressant (hazard ratio 0.79, 95% confidence interval 0.70-0.90) compared with no antidepressant in depression patients with incident diabetes. Lower mortality risk was associated with exposure to noradrenergic and specific-serotonergic antidepressants (0.77 [0.66-0.90]) compared with no antidepressant, and to mirtazapine (0.76 [0.65-0.88]) and trazodone (0.75 [0.63-0.90]). Sensitivity analyses affirmed that lower mortality risk was associated with mirtazapine.</p><p><strong>Conclusion: </strong>Depression patients with comorbid type 2 diabetes with exposure to several antidepressant are at decreased mortality risk. Further research is warranted to confirm our findings and clarify the mortality-reducing mechanisms of antidepressant in this vulnerable population.</p>","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":" ","pages":"1-14"},"PeriodicalIF":9.0,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12999188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146053331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modifiers in Effects of Combined Pharmacotherapy and Psychotherapy versus Pharmacotherapy Alone for Adult Depression: An Individual Participant Data Meta-analysis.","authors":"Marketa Ciharova,Eirini Karyotaki,Mathias Harrer,Erica Weitz,Clara Miguel,Arpana Amarnath,Toshi A Furukawa,Constantin Yves Plessen,Ellen Driessen,Claudia Buntrock,Lingyao Tong,David Hellerstein,Lisa W Samstag,Ying Chen,Sreevani Rentala,Curt Hemanny,Irismar Reis de Oliveira,Marc B J Blom,Yvonne Burnand,Antonio Andreoli,Andrea K Wittenborn,Kevin L Delucchi,Nusrat Husain,Robert J DeRubeis,Joel M Town,Frank Röhricht,Han Choi,Jack Dekker,David J A Dozois,Martin B Keller,Raymond W Lam,François Lespérance,Giuseppe Maina,Gianluca Rosso,Jeanette Milgrom,Arun Ravindran,Charles F Reynolds Iii,Nicola Wiles,Brandon A Gaudiano,Livia Hartmann de Souza,Atsuo Nakagawa,Beatriz Rodríguez Vega,Angela Palao,Jaime López Rodríguez,Valerio Villamil Salcedo,Ingo Zobel,Elisabeth Schramm,Steven D Hollon,Heleen Riper,Pim Cuijpers","doi":"10.1159/000550633","DOIUrl":"https://doi.org/10.1159/000550633","url":null,"abstract":"INTRODUCTIONIt is not clear which individual-patient- and study-level variables modify the effects in the comparison of combined treatment versus pharmacotherapy alone for adult depression.METHODSRandomized trials comparing combined treatment with pharmacotherapy alone were identified on September 1st, 2024, and individual participant data (IPD) requested from the authors. One-stage IPD meta-analyses were conducted to estimate effects on depressive symptoms at post-treatment and follow-up, response, remission, and reliable improvement, and to assess effect modifiers.RESULTSOf 75 eligible studies, 31 (41.33%) provided their IPD (3703 participants). Combined treatment was more effective in reducing depressive symptoms at post-treatment (SMD = 0.45, 95%CI: 0.27 to 0.64), six- (SMD = 0.55, 95%CI: 0.25 to 0.85) and twelve-month follow-up (SMD = 0.22, 95%CI: 0.02 to 0.43). The effect size was smaller in studies that provided IPD than in those that did not. No patient-level effect modifiers were identified. No difference between the two arms was found in studies using SSRIs (as opposed to other antidepressants) and recruiting specific target groups (versus unselected adult populations), and the difference between combined treatment and pharmacotherapy alone was larger if pharmacotherapy was not administered adequately, but these findings were not confirmed in sensitivity analyses. Several patient-level characteristics predicted higher depressive symptoms at post-treatment, regardless of treatment condition.CONCLUSIONCombined treatment outperforms pharmacotherapy alone regardless of individual characteristics. Thus, its delivery does not have to be limited to specific patient subgroups. However, IPD were available for only 41% of eligible studies, thus limiting this sample's representativeness.","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":"95 1","pages":"1-23"},"PeriodicalIF":22.8,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146015240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term psychodynamic therapy of obsessive-compulsive disorder - a randomized controlled trial of unmedicated patients.","authors":"Falk Leichsenring,Christiane Steinert,Joachim Biskup,Lila Alina Feix,Nikolas Heim,Britta Nimis,Reinhard Kreische,Fatima Nöske,Christian Ruckes,Heinz Weiss,Günther Reich,Annabelle Starck","doi":"10.1159/000550421","DOIUrl":"https://doi.org/10.1159/000550421","url":null,"abstract":"BACKGROUNDObsessive-compulsive disorder (OCD) is a chronic and disabling mental disorder. Cognitive-behavioral therapy and serotonin-reuptake inhibitors and their combination are first-line treatments. However, about 50% of the patients do not achieve response or remission, although many patients received additional pharmacotherapy. These results highlight the need for additional evidence-based treatment options.METHODSIn a randomized controlled trial (RCT) a manual-guided method of short-term psychodynamic therapy (STPP) for OCD was tested against a waiting list condition. Thirty-seven unmedicated patients were randomly assigned to STPP, 30 to the waiting list. The Y-BOCS total score post-therapy assessed by trained and masked raters was the primary outcome. Secondary outcomes included response, remission, depression, interpersonal problems and obsessive beliefs.RESULTSIn the intention-to-treat sample, STPP achieved a significantly lower Y-BOCS score (p < 0.0001) than the waiting list condition, associated with a large between-group effect size (d=1.04). The mean difference of change in the Y-BOCS between baseline and post-therapy or waiting period assessment was -11.49 (95% CI -14.36, -8.63) for STPP and -1.10 (95% CI -4.29, 2.10) in the waiting-list. Remission rates were 55% vs 17% (p=0.0012), response rates 64% vs 17% (p=0.0003) in favor of STPP.CONCLUSIONIn a first RCT, manual-guided STPP proved to be efficacious in OCD, thereby broadening the spectrum of evidence-based interventions. Of note, our study is one of the few trials using psychotherapy as a monotherapy in OCD, showing effects of psychotherapy alone. Further research is needed to replicate these findings and to compare STPP with other established treatments.","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":"244 1","pages":"1-26"},"PeriodicalIF":22.8,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145937684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression, but Not Fatigue, Improves as Part of Multimodal Post-COVID Rehabilitation.","authors":"Alexa Alica Kupferschmitt, Thilo Hinterberger, Christoph Herrmann, Michael Jöbges, Stefan Kelm, Gerhard Sütfels, Thomas H Loew, Volker Köllner","doi":"10.1159/000549848","DOIUrl":"10.1159/000549848","url":null,"abstract":"<p><strong>Introduction: </strong>Post-COVID syndrome (PCS) can lead to severe restrictions in the ability to work and participate in society and can lead to the development of depressive symptoms. The aim of this study was to investigate how many PCS patients suffer from clinically relevant depressive symptoms and to what extent PCS rehabilitation can modulate psychological symptoms as well as limitations in functional health.</p><p><strong>Methods: </strong>Prospective multicenter cohort study PoCoRe (N = 1,028). Assessment of depressiveness (PHQ-9, PHQ-2), fatigue (FSMC) and functional health and disability (WHO-DAS2.0). Frequency analyses, mean comparisons.</p><p><strong>Results: </strong>At the start of rehabilitation, 71.4% (n = 734) fulfilled the core symptoms of depressive disorders in general in the PHQ-2. In the screening-positive patients, the PHQ-9 total score was on average M = 23.74 (standard deviation = 4.43). As expected the depressive symptom burden was reduced more in depressed PCS patients (d = 0.50) than in nondepressed PCS patients (d = 0.32). Fatigue symptoms did not change. Functional health (WHO-DAS) improved above all in coping with everyday life (d = 0.71, or 1.04), and in the nondepressed patients also in mobility (d = 0.27). In the sociomedical assessment, 24.7% of the total samples were assessed as having an impaired capacity for the reference occupation and 19.5% as having an impaired capacity for the general labor market. Depressive patients had the worse sociomedical outcome.</p><p><strong>Conclusion: </strong>Depressiveness is common and can be well influenced by PCS rehabilitation. Fatigue is less easily influenced, which indicates that they are independent symptoms. Patients with persistent depression and fatigue have a poorer sociomedical prognosis.</p>","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":" ","pages":"1-15"},"PeriodicalIF":9.0,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12912765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145934762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstracts ICPM World Congress 2026.","authors":"","doi":"10.1159/pps/aemag003","DOIUrl":"10.1159/pps/aemag003","url":null,"abstract":"","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":"95 Suppl. 1","pages":"1-162"},"PeriodicalIF":9.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149081673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ConquerFear-HK: A Randomized Controlled Trial of a Metacognition-Based, Manualized Intervention for Fear of Cancer Recurrence among Chinese Cancer Survivors.","authors":"Danielle Wing Lam Ng, Rachel Ng, Ceci Guo, Julia Chan, Richard Fielding, Julia Wei Chun Tang, Wylie Wai Yee Li, Chi Chung Foo, Ava Kwong, Simon Siu-Man Ng, Dacita Suen, Sara Fung, Oi Kwan Chun, Karen Kar Loen Chan, Amy Tien Yee Chang, Phyllis Butow, Wendy Wing Tak Lam","doi":"10.1159/000547888","DOIUrl":"10.1159/000547888","url":null,"abstract":"<p><p><p>Introduction: Fear of cancer recurrence (FCR) is a prominent clinical issue among cancer survivors. This study evaluated the effectiveness of the culturally adapted ConquerFear-HK intervention in reducing FCR among Chinese cancer survivors, compared to standard survivorship care.</p><p><strong>Methods: </strong>This assessor-masked, two-arm parallel randomized controlled trial, was conducted from June 2021 to February 2024. Cantonese- or Mandarin-speaking Chinese cancer survivors scoring ≥13 on the Fear of Cancer Recurrence Inventory Short Form (FCRI-SF) were randomized to either ConquerFear-HK, focusing on attention training, metacognition modification, acceptance, appropriate monitoring behaviour, and goal setting or active control providing standardized, multidisciplinary survivorship care. Primary outcome was changes in FCR assessed by FCRI at prior randomization, immediately post-intervention (T1), 3 months (T2), and 6 months (T3) post-intervention. Intention-to-treat analyses using linear mixed modelling compared outcome changes across time points. This trial was registered at <ext-link ext-link-type=\"uri\" xlink:href=\"http://ClinicalTrials.gov\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">ClinicalTrials.gov</ext-link> (NCT04568226).</p><p><strong>Results: </strong>Of the 175/220 (79.5%) participants recruited, 89 were randomized to ConquerFear-HK and 86 to control. Significant greater FCRI reductions were observed in ConquerFear-HK at T1 (mean difference = -10.66; 95% CI:-20.15, -1.16) and T2 (mean difference = -12.00; 95% CI:-21.90, -2.11) vs. the control (g = 0.33-0.36). No significant between-group differences were found at T3.</p><p><strong>Conclusion: </strong>ConquerFear-HK demonstrates promising short-term (3-month) improvements in FCR among Chinese cancer survivors; however, no sustained benefits were found at 6 months. Possible explanations include the high attrition at 6-month follow-up, a potential early ceiling effect, unconscious therapist bias, or an accelerated adaptation effect in the intervention arm that was achieved later by the control group. </p>.</p>","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":" ","pages":"117-133"},"PeriodicalIF":9.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Self-Reports: Integrating Cortisol Measurement in Psychotherapy Process Research among Adolescents with Borderline Personality Pathology.","authors":"Yasmine Blaha, Marialuisa Cavelti, Silvano Sele, Julian Koenig, Ronan Zimmermann, Klaus Schmeck, Michael Kaess","doi":"10.1159/000547941","DOIUrl":"10.1159/000547941","url":null,"abstract":"<p><p><p>Introduction: Psychotherapy is the primary treatment for adolescent borderline personality pathology (BPP), yet its mechanisms remain unclear. Given potential self-report biases due to alexithymia and impaired interoception, this study examined cortisol responses as a physiological stress marker alongside session ratings from adolescent BPP patients and their therapists to assess its potential as a complementary measure in psychotherapy process research.</p><p><strong>Methods: </strong>N = 56 adolescents (94.6% female) with BPP (≥3 DSM-IV BPD criteria) receiving Adolescent Identity Treatment or Dialectical Behavioral Therapy and their therapists provided pre- and post-session salivary cortisol samples and completed the Session Evaluation Questionnaire. Residual Dynamic Structural Equation Modeling examined associations between cortisol responses and session ratings, with moderation by age, depression, BPP severity, identity diffusion, and trauma.</p><p><strong>Results: </strong>Cortisol responses did not correlate with session ratings in patients. In therapists, higher cortisol responses were associated with lower session smoothness (r = -0.164; p < 0.001) and deepness (r = -0.086; p = 0.004), as well as with lower positivity (r = -0.145; p < 0.001) and higher arousal (r = 0.072; p = 0.012) post-session. Higher depression levels moderated the association between cortisol responses and session deepness in patients (β = -0.009, p = 0.007).</p><p><strong>Conclusion: </strong>While session ratings and cortisol responses correlated in therapists, no such correlation was found in patients. Possible mechanisms include altered interoceptive abilities, dysregulated hypothalamic-pituitary-adrenal (HPA) axis function, or increased variability in self-ratings or cortisol due to BPP. While physiological markers and self-reports offer complementary insights into psychotherapy processes, future studies should include healthy and clinical controls and baseline investigation of HPA axis function (i.e., stress reactivity) in both groups, along with additional hormonal markers. </p>.</p>","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":" ","pages":"92-104"},"PeriodicalIF":9.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144966297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Walk and Talk: A Randomized Controlled Trial of Multi-Modal Motion-Assisted Memory Desensitization and Reconsolidation Therapy versus Treatment as Usual for Veterans and First Responders with Posttraumatic Stress Disorder.","authors":"Mirjam J Nijdam, Pia Goorden, Irene J M Martens, Rick de Haart, Nicola S Klein, Stijn B Peeters, Martin L Waagemans, Leona Hakkaart-van Roijen, Dorien de Groot, Eric Vermetten","doi":"10.1159/000549158","DOIUrl":"10.1159/000549158","url":null,"abstract":"<p><p><p>Introduction: Posttraumatic stress disorder (PTSD) presents a significant challenge within the treatment of mental health issues, particularly in veterans and first responders who often experience resistance to standard treatments. This study evaluated the effectiveness of a virtual reality exposure-based treatment with motion as compared to treatment as usual (TAU), as first-line treatment for PTSD within these populations.</p><p><strong>Methods: </strong>This multicenter, parallel, single-blind, non-inferiority randomized controlled trial was conducted in three centers across the Netherlands. We included adults diagnosed with occupational or combat-related PTSD, without prior treatment history. Participants were randomized (1:1) to receive either manualized multi-modal motion-assisted memory desensitization and reconsolidation (3MDR) therapy or manualized regular trauma-focused psychotherapy (TAU). 3MDR was applied in fewer sessions than TAU. Primary outcome was self-reported PTSD severity, based on the PTSD Checklist for DSM-5, assessed at baseline, post-treatment, 3 and 6 months post-treatment. Secondary outcomes were clinician-rated PTSD, avoidance, comorbid disorders and symptoms, and functioning. The trial was prospectively registered in the Dutch Trial Register, NL-OMON55588.</p><p><strong>Results: </strong>Between February 15, 2018, and July 22, 2022, 134 participants with PTSD were enrolled, with 67 (50%) randomized to 3MDR and 67 (50%) to TAU of whom 106 (79%) were veterans, and 28 (21%) were first responders. Significant time effects were demonstrated in self-reported and clinician-rated PTSD severity for both groups, as well as in avoidance, comorbid disorders, and functioning. At 6 months post-treatment, 3MDR proved to be non-inferior to TAU in terms of self-reported PTSD (mean difference = -2.91 [95% CI -7.92, 2.10], p = 0.25).</p><p><strong>Conclusion: </strong>3MDR demonstrates to be an effective alternative first-line treatment for PTSD stemming from occupational traumatic events. Even though it leans on infrastructure with a treadmill and other hardware components, it may offer an alternative over conventional trauma-focused psychotherapies for PTSD that yields savings of a quarter of time spent within therapy. </p>.</p>","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":" ","pages":"268-282"},"PeriodicalIF":9.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12707896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145655549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Trauma and Obsessive Compulsive Disorder: Evidence from October 7th, 2023.","authors":"Eyal Kalanthroff, Shir Berebbi, Mor David, Helen Blair Simpson","doi":"10.1159/000548026","DOIUrl":"10.1159/000548026","url":null,"abstract":"<p><p><p>Introduction: Exposure to trauma has been theorized to contribute to the onset and exacerbation of obsessive-compulsive disorder (OCD), yet direct empirical evidence remains limited. This study examined whether individuals directly affected by the trauma of October 7th, 2023, in Israel exhibited higher rates of new-onset or worsening OCD symptoms compared to controls who were not directly affected.</p><p><strong>Methods: </strong>A total of 132 adults participated, including 66 survivors from the Gaza envelope who experienced direct exposure to the attacks and 66 matched controls from other areas of Israel who were not directly affected. Data on OCD and post-traumatic stress disorder (PTSD) symptoms were collected approximately 4-6 months after the events.</p><p><strong>Results: </strong>The data revealed significantly higher OCD symptoms in the directly affected group and PTSD symptom severity partially mediated the relationship between trauma exposure and increased OCD symptoms. Notably, 39% of individuals in the directly affected group met a priori criteria for probable OCD, 24% reported new-onset symptoms after October 7th, and most others reported worsening of existing symptoms.</p><p><strong>Conclusion: </strong>These findings provide the first direct evidence that acute trauma can trigger new-onset and worsening OCD symptoms. Consistent with the diathesis-stress model, the results underscore the role of environmental stressors in OCD etiology and highlight the need for screening for OCD in trauma-exposed populations. </p>.</p>","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":" ","pages":"105-116"},"PeriodicalIF":17.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144966260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}