David C Saunders,Shosuke Suzuki,Nilofar Vafaie,Michael H Bloch,Hedy Kober
{"title":"Investigator Meditation Practice Predicts Efficacy of Child/Adolescent Mindfulness-Based Interventions: A Meta-Analysis.","authors":"David C Saunders,Shosuke Suzuki,Nilofar Vafaie,Michael H Bloch,Hedy Kober","doi":"10.1159/000548530","DOIUrl":"https://doi.org/10.1159/000548530","url":null,"abstract":"INTRODUCTIONMindfulness has been shown to benefit children and adolescents. However, predictors of treatment effects of mindfulness-based interventions (MBIs) are less well-known.OBJECTIVETest the treatment effect of MBIs in children/adolescents; test for moderation by meditation practice history (MPH) of the investigator(s); compare moderation by MPH to other study- and participant-level variables.METHODSStudies were identified in PubMed and Google Scholar. English-language reports of clinical trials testing an MBI in youth were included. Investigator MPH was collected via online survey distributed to the first, last, and/or corresponding authors of included studies. Data were analyzed using random-effects models. We preformed omnibus, moderator, and multiple publication bias analyses. Treatment efficacy (Hedge's g and r) was the primary outcome. Secondary analyses included tests for moderation by study- and participant-level characteristics, and investigator MPH.RESULTSData were included from 107 studies, including 1,393 statistics and 8,510 participants. We observed a small-to-moderate significant omnibus effect size (g = 0.33, CI: 0.27-0.39). MBI effects were significantly associated with minutes investigators meditated in the past 24 hours (p=0.05) and number of times investigators meditated in the past 7 days (p<0.01), with those meditating >30 minutes (g=0.51 [0.35-0.66]) and more than 7 times (g=0.52 [0.39-0.65]), respectively, displaying the highest effect sizes.CONCLUSIONThese findings confirm the benefit of MBIs in youth. We provide novel evidence that greater investigator MPH is significantly associated with better treatment outcomes. The results may invite a new way of thinking about and evaluating the mental health treatment literature and may motivate similar studies in other populations or interventions.","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":"24 1","pages":"1-19"},"PeriodicalIF":22.8,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145241037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"What is mental pain? A systematic review and metasynthesis of qualitative research on the lived experience of mental pain.","authors":"Samy Kozlowitz,Alexandre Ribeiro,Jordan Sibeoni,Baptiste Brossard,Astrid Chevance","doi":"10.1159/000548567","DOIUrl":"https://doi.org/10.1159/000548567","url":null,"abstract":"INTRODUCTIONMental pain-a pain not primarily felt in the body-is a predictor of suicide and is often described as one of the most distressing aspects of depression. However, the absence of a clear definition hampers both research and clinical practice. This metasynthesis aims to characterize the lived experience of mental pain to inform the future development of a definition.METHODSWe conducted a systematic search in MEDLINE, EMBASE, PsycINFO, CINAHL, and Web of Science to identify qualitative studies reporting first-person accounts of mental pain. Thematic synthesis was used to generate descriptive and analytical themes, drawing on semantic, clinical, and phenomenological insights. The quality of the primary studies was assessed using the Critical Appraisal Skills Programme (CASP), and the Confidence in the Evidence from Reviews of Qualitative Research (GRADE-CERQual) approach was applied to evaluate the findings.RESULTSThe metasynthesis included 49 qualitative studies with 1,467 participants and led to the development of 22 themes and 85 subthemes. Mental pain was defined by five phenomenal features: unpleasant, immediate, identity-disrupting, invisible, and often perceived as worse than physical pain. It is also accompanied by unspecific psychological and physical manifestations. The emergence of mental pain can be conceptualized as a signal of a threatened sense of self in response to bodily, psychological, existential, or social adversity. Confidence in the findings was moderate due to methodological and reporting limitations.CONCLUSIONA clearer understanding of mental pain may enhance clinical practice by helping clinicians better identify, understand, and respond to this form of suffering.","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":"103 1","pages":"1-20"},"PeriodicalIF":22.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Menstrual Cycle Dynamics in Mental Health Demand new Approaches in Psychotherapy and Digital Health.","authors":"Sibel Nayman,Inga Niedtfeld,Bernd Lenz,Alexander Karabatsiakis,Christian Schmahl,Christine Kuehner","doi":"10.1159/000548508","DOIUrl":"https://doi.org/10.1159/000548508","url":null,"abstract":"","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":"56 1","pages":"1-5"},"PeriodicalIF":22.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145083512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tao Zhang,Bryant Pui Hung Hui,Ducasse Ducasse,Ying Li,Yongyi Wang,Jiawei Hu,Willie Tang Chung Tang,Yingzi Ke
{"title":"Efficacy of Acceptance and Commitment Therapy for Suicide and Self-harm: A Systematic Review and Meta-analysis.","authors":"Tao Zhang,Bryant Pui Hung Hui,Ducasse Ducasse,Ying Li,Yongyi Wang,Jiawei Hu,Willie Tang Chung Tang,Yingzi Ke","doi":"10.1159/000548398","DOIUrl":"https://doi.org/10.1159/000548398","url":null,"abstract":"INTRODUCTIONSelf-injurious thoughts and behaviors (SITBs) are major public health issues worldwide. In recent years, there has been a growing body of research investigating the application of acceptance and commitment therapy (ACT) for SITBs. This study systematically reviews and meta-analyzes the effectiveness of ACT in reducing SITBs.METHODSWe systematically searched six databases and examined the reference lists of relevant studies. Studies that explored the effectiveness of ACT versus control conditions for reducing SITBs were included. Effect sizes were calculated using Hedges' g with the random effect model. Subgroup analyses and meta-regression were also performed.RESULTSA total of 48 studies (N = 4,719) were included in this review. The results indicated that ACT outperformed control conditions in alleviating suicide ideation (g = -0.64), suicide attempt (g = -0.66), self-harm (g = -1.53), non-suicidal self-injury (g = -0.59), and overall SITBs (g = -0.99) at post-treatment. Also, ACT was effective in reducing suicide ideation (g = -2.15), non-suicidal self-injury (g = -1.18), and overall SITBs (g = -1.52) at follow-up. Moderator analyses revealed that ACT was more successful in mitigating suicide ideation when delivered in a group format or in Eastern countries. Similarly, studies conducted in Eastern countries, or those employing direct interventions, reported greater efficacy in addressing overall SITBs.CONCLUSIONThis review highlights the effectiveness of ACT in reducing SITBs and suggests that it may serve as a promising alternative strategy to standard treatment for SITBs. More high-quality and large-scale randomized controlled trials are required to substantiate our findings.","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":"68 1","pages":"1-28"},"PeriodicalIF":22.8,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Miriam A Schiele,Harry A Fagan,David S Baldwin,Katharina Domschke
{"title":"INTEGRATIVE SYSTEMATIC REVIEW ON PHARMACOLOGICAL, PSYCHOTHERAPEUTIC AND NEUROSTIMULATORY TREATMENT OPTIONS IN TREATMENT-RESISTANT ANXIETY DISORDERS.","authors":"Miriam A Schiele,Harry A Fagan,David S Baldwin,Katharina Domschke","doi":"10.1159/000547926","DOIUrl":"https://doi.org/10.1159/000547926","url":null,"abstract":"Treatment resistance in anxiety disorders (TR-AD) constitutes a major clinical challenge conferring a considerable burden regarding quality of life and societal health costs. This systematic review provides an overview of pharmacological, psychotherapeutic and neurostimulatory treatment options in adults with treatment-resistant generalized anxiety disorder (TR-GAD), panic disorder (TR-PD) / agoraphobia and social anxiety disorder (TR-SAD). A total of 26 randomised controlled trials (RCTs) and 36 open label studies were identified, with, however, mostly small sample sizes and several methodological limitations. According to RCTs, selective serotonin reuptake inhibitors (SSRI) or clomipramine are effective in TR-PD after failure to respond to cognitive behavioral therapy (CBT). In pharmacological TR-SAD, switching from one SSRI to another or to venlafaxine was found helpful in open label trials. RCTs further suggest augmentation with quetiapine, risperidone, olanzapine or pregabalin in TR-GAD, pindolol in TR-PD and clonazepam in TR-SAD. Open label studies in TR-AD provide preliminary evidence for ketamine or augmentation with nefazodone, reboxetine, buspirone, aripiprazole, olanzapine, quetiapine, risperidone, ziprasidone, divalproex sodium, levetiracetam, zonisamide, flumazenil, pregabalin, cannabidiol and acamprosate. For pharmacological TR, CBT was effective in several RCTs. Following non-response to CBT, first evidence suggests effectiveness of Acceptance and Commitment Therapy and Mindfulness-Based Cognitive Therapy. Only inconclusive support was identified for repetitive transcranial magnetic stimulation (rTMS) in TR-AD. In summary, this integrative review may provide an evidence base for expert recommendations, inform clinical guidelines, and inspire further research into innovative, personalized treatment of TR-AD increasing response rates and lowering the considerable individual and public health burden of anxiety disorders.","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":"16 1","pages":"1-43"},"PeriodicalIF":22.8,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christian Fazekas,Nandu Goswami,Franziska Matzer,Alexander Avian,Julia Lodron,Marc Rijksen,Barbara Hanfstingl,Voyko Kavcic,Andrea Groselj-Strele,Harald Sourij,Harald H Kessler,Evelyn Stelzl,Clarissa Daniela Voegel,Tina Maria Binz,Karin Schmid-Zalaudek,Alexander Wittmann,Stefan Pilz
{"title":"Perceived Chronic Stress prior to SARS-CoV-2 Infection Predicts Ongoing Symptomatic COVID-19: A Prospective Cohort Study.","authors":"Christian Fazekas,Nandu Goswami,Franziska Matzer,Alexander Avian,Julia Lodron,Marc Rijksen,Barbara Hanfstingl,Voyko Kavcic,Andrea Groselj-Strele,Harald Sourij,Harald H Kessler,Evelyn Stelzl,Clarissa Daniela Voegel,Tina Maria Binz,Karin Schmid-Zalaudek,Alexander Wittmann,Stefan Pilz","doi":"10.1159/000547858","DOIUrl":"https://doi.org/10.1159/000547858","url":null,"abstract":"INTRODUCTIONUnderstanding chronic stress as a potential risk factor for COVID-19 progression could inform public health measures and personalized preventive interventions. Therefore, we investigated the influence of chronic stress prior to SARS-CoV-2 infection on symptom persistence 1 month after COVID-19 onset.METHODSThe participants of this prospective cohort study named \"StressLoC\" were adults with COVID-19 who had tested positive for SARS-CoV-2 infection within the last 7 days. Pre-existing perceived chronic stress assessed by the Perceived Stress Scale (PSS-10) was the primary predictor. The number of stressful life events and hair cortisol concentration served as additional measures of pre-existing chronic stress. The main outcome was examined using the Long COVID Symptom and Impact Tool. It was defined as the presence of any new and impactful COVID-19-related symptom at month 1 after inclusion. Accordingly, participants were assigned to either the ongoing symptomatic COVID-19 group (OSC-G) or control group.RESULTSThe study cohort comprised 288 participants (73.3% female), with a median age of 46 years (IQR 35-56). A total of 210 participants (72.9%) were categorized as OSC-G. Multivariate logistic regression showed that allocation to OSC-G was predicted by perceived chronic stress in the month prior to COVID-19 (OR: 1.08, 95% CI: 1.03-1.14; p = 0.002) and the number of pre-existing symptoms (OR: 1.08, 95% CI: 1.03-1.13; p = 0.001). The number of stressful life events and hair cortisol concentration did not predict OSC-G allocation.CONCLUSIONSResults suggest that higher levels of pre-existing perceived chronic stress increase the odds of developing ongoing symptomatic COVID-19.","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":"138 1","pages":"1-12"},"PeriodicalIF":22.8,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145025281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarah Maguire,Francisco J Schneuer,Kelly M Dann,Sarah Barakat,Jane Miskovic-Wheatley,Moin Ahmed,Morgan Sidari,Grant Sara,Kristi Griffiths,Ian B Hickie,Janice Russell,Stephen Touyz,Sloane Madden,Claire Diffey,Michelle Roberton,Warren Ward,Amy Hannigan,Michelle Cunich,Natasha Nassar
{"title":"Mortality in people with eating disorders presenting to the health system: A national population-based record linkage study.","authors":"Sarah Maguire,Francisco J Schneuer,Kelly M Dann,Sarah Barakat,Jane Miskovic-Wheatley,Moin Ahmed,Morgan Sidari,Grant Sara,Kristi Griffiths,Ian B Hickie,Janice Russell,Stephen Touyz,Sloane Madden,Claire Diffey,Michelle Roberton,Warren Ward,Amy Hannigan,Michelle Cunich,Natasha Nassar","doi":"10.1159/000547950","DOIUrl":"https://doi.org/10.1159/000547950","url":null,"abstract":"BACKGROUNDMost previous mortality research in eating disorders involves individuals attending specialist treatment services. Data linkage across jurisdictional health databases at a population level improves the generalisability of findings.AIMSTo investigate mortality risk and causes of death for people with an eating disorder across a large geographic region using administrative health datasets.METHODUsing linked hospital, mental health and death records, a retrospective cohort study was conducted including individuals aged 10-59 years who received an eating disorder diagnosis during hospital-based encounters in Australia, over a 10-year period between 2010 and 2019. A contemporary cohort of people accessing community care only were also evaluated. Mortality rates and standardised morality ratios (SMR) compared to the general population were calculated for each state, and by sex and age groups. Cox regression models were used to assess the risk of sociodemographic characteristics on mortality.RESULTSMortality in people hospitalised with an eating disorder (N=19,697) was more than four times higher than the general population (SMR: 4.54), and highest in people aged 30-39 years (SMR: 13.32). Men hospitalised for eating disorders had a higher risk of death. Mortality rates in anorexia nervosa were not higher than other eating disorder diagnoses. Almost three-quarters of deaths were caused by suicide/self-harm or cardio/respiratory illness.CONCLUSIONSPeople accessing hospital care with eating disorders in Australia have a higher risk of premature death regardless of age, sex or eating disorder diagnosis. Gender and age group disparities can inform policy and resource allocation and support the development of targeted interventions.","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":"24 1","pages":"1-20"},"PeriodicalIF":22.8,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Enhancing Yoga Interventions in Oncology: Addressing Heterogeneity and Long-Term Sustainability.","authors":"Jianing Miao, Jun Li, Yaling Li","doi":"10.1159/000548052","DOIUrl":"10.1159/000548052","url":null,"abstract":"","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":" ","pages":"1-2"},"PeriodicalIF":17.4,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144966334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Beyond Self-Reports: Integrating Cortisol Measurement in Psychotherapy Process Research among Adolescents with Borderline Personality Pathology.","authors":"Yasmine Blaha,Marialuisa Cavelti,Silvano Sele,Julian Koenig,Ronan Zimmermann,Klaus Schmeck,Michael Kaess","doi":"10.1159/000547941","DOIUrl":"https://doi.org/10.1159/000547941","url":null,"abstract":"Psychotherapy is the primary treatment for adolescent Borderline Personality Pathology (BPP), yet its mechanisms remain unclear. Given potential self-report biases due to alexithymia and impaired interoception, this study examined cortisol responses as a physiological stress marker alongside session ratings from adolescent BPP patients and their therapists to assess its potential as a complementary measure in psychotherapy process research. N = 56 adolescents (94.6% female) with BPP (≥ 3 DSM-IV BPD criteria) receiving Adolescent Identity Treatment or Dialectical Behavioral Therapy and their therapists provided pre- and post-session salivary cortisol samples and completed the Session Evaluation Questionnaire. Residual Dynamic Structural Equation Modelling examined associations between cortisol responses and session ratings, with moderation by age, depression, BPP severity, identity diffusion, and trauma. Cortisol responses did not correlate with session ratings in patients. In therapists, higher cortisol responses were associated with lower session smoothness (r = -.164; p < .001) and deepness (r = -.086; p = .004), as well as with lower positivity (r = -.145; p < .001) and higher arousal (r = .072; p = .012) post-session. Higher depression levels moderated the association between cortisol responses and session deepness in patients (β = -.009, p = .007). While session ratings and cortisol responses correlated in therapists, no such correlation was found in patients. Possible mechanisms include altered interoceptive abilities, dysregulated hypothalamic-pituitary-adrenal (HPA) axis function, or increased variability in self-ratings or cortisol due to BPP. While physiological markers and self-reports offer complementary insights into psychotherapy processes, future studies should include healthy and clinical controls and baseline investigation of HPA axis function (i.e. stress reactivity) in both groups, along with additional hormonal markers.","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":"11 1","pages":"1-25"},"PeriodicalIF":22.8,"publicationDate":"2025-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}