Psychotherapy and Psychosomatics最新文献

{"title":"Comparative efficacy and safety of benzodiazepines in the treatment of patients with generalized anxiety disorder: a systematic review and network meta-analysis.","authors":"Hélder Fernandes, Catarina Novais, Bernardo Sousa-Pinto, Patrício Soares-da-Silva, Luís Filipe Azevedo","doi":"10.1159/000546269","DOIUrl":"10.1159/000546269","url":null,"abstract":"<p><p>Introduction Guidelines recommend that benzodiazepines (BZD) might be used as an add-on to antidepressant therapy during the first weeks of treatment of generalized anxiety disorder (GAD) or as a first-line and stand-alone. Our aim is to evaluate the comparative efficacy and safety of individual BZD in the treatment of patients with GAD. Methods In this systematic review and network meta-analysis, we included randomized controlled trials including adults (≥18 years) with GAD and comparing BZD against placebo or an active intervention. We assessed the certainty of evidence using the confidence in network meta-analysis (CINeMA) framework. This study is registered with PROSPERO (registration number CRD42022330264). Results We included 56 studies (7556 participants). The certainty of the evidence for the primary outcomes, as measured with CINeMA, varied from high to very low (overall; 40 comparisons scored \"very low\", 7 scored \"low\" and 814 scored \"high\"). Regarding efficacy, all BZD, in general, were significantly better than placebo, but there were no significant differences between the different BZD (high heterogeneity and inconsistency were detected). Regarding treatment discontinuation, with some exceptions, no significant differences were observed in the comparisons against placebo or other BZD (no or low heterogeneity and inconsistency were observed in the different analyses). Regarding treatment tolerability, none of the BZD showed significant differences compared to placebo, except diazepam (RR=1.61; 95%CI=1.32;1.96). Moderate heterogeneity and low inconsistency were observed in the treatment tolerability network meta-analysis. Conclusion BZD are overall efficacious for the treatment of GAD and have a favourable safety profile. No distinctive differences were identified when comparing BZD among themselves.</p>","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":" ","pages":"1-34"},"PeriodicalIF":16.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Videoconference-Based Cognitive Behavioral Therapy in Medication-Treated Adults with Attention-Deficit/Hyperactivity Disorder: A Randomized, Assessor-Blinded, Controlled Trial.","authors":"Aiko Eto, Ayumu Endo, Tokiko Yoshida, Yoichi Seki, Kayoko Taguchi, Minako Hongo, Kohei Takahashi, Yuki Shiko, Yoshiyuki Hirano, Eiji Shimizu","doi":"10.1159/000546539","DOIUrl":"https://doi.org/10.1159/000546539","url":null,"abstract":"<p><strong>Introduction: </strong>Attention-Deficit/Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder that frequently persists into adulthood. Pharmacotherapies are effective but have side effects and dropout risks. Videoconference-based Cognitive Behavioral Therapy (vCBT) has emerged as a promising intervention, particularly for improving treatment accessibility. This study aimed to evaluate the efficacy of vCBT in adults with ADHD compared to treatment-as-usual (TAU) using a randomized, assessor-blinded, controlled trial design.</p><p><strong>Methods: </strong>Thirty participants (aged 18-65 years) with ADHD were randomly assigned to either the 12-session individual vCBT intervention as an adjunct to TAU or TAU group. The primary outcome was the change in the total score on the ADHD Rating Scale-IV(ADHD-RS-IV) with adult prompts by a blinded assessor at 12 weeks from baseline. Secondary outcomes included self-reported measures of ADHD symptoms using the Conners' Adult ADHD Rating-Self-Report, quality of life (QOL) using the Euro QOL 5 Dimension-5 Level, functional impairment using the Sheehan Disability Scale, depression, anxiety, and self-esteem.</p><p><strong>Results: </strong>All of the participants received pharmacotherapy. Participants in the vCBT group (n=15) demonstrated a significantly greater reduction in ADHD-RS-IV total score than those in the TAU group (vCBT -9.02 vs. TAU 0.84, p = 0.0007, effect size -1.46). Significant improvements in self-reported inattention, hyperactivity, impulsivity, QOL, and work/school performance were observed in favor of vCBT.</p><p><strong>Conclusion: </strong>This study highlights the efficacy of vCBT as a viable and accessible intervention for adults with ADHD, particularly in reducing core symptoms and enhancing QOL and functional outcomes. vCBT is an important alternative treatment, especially for patients who remain symptomatic after pharmacotherapy.</p>","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":" ","pages":"1-25"},"PeriodicalIF":16.3,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biofeedback and Training of Interoceptive Insight and Metacognitive Efficacy Beliefs (InMe) to Improve Adaptive Interoception: A Subclinical Randomised Controlled Trial.","authors":"Michal Tanzer, Marina Bobou, Athanasios Koukoutsakis, Alkistis Saramandi, Paul M Jenkinson, Sam Norton, Caroline Selai, Katerina Fotopoulou","doi":"10.1159/000546298","DOIUrl":"https://doi.org/10.1159/000546298","url":null,"abstract":"<p><p>Introduction Interoception, the sensing, awareness and regulation of physiological states, is crucial for wellbeing and mental health. Behavioural interventions targeting interoception exist, but Randomised Control Trials (RCTs) testing efficacy remain limited. The present, preregistered (ISRCTN16762367) RCT tested the novel Interoceptive iNsight and Metacognitive Efficacy beliefs (InMe) intervention. InMe uses slow-breathing and cardiac biofeedback during stress to train interoceptive self-efficacy beliefs and improve self-reported interoception. Methods Healthy participants aged 18-30 years with low self-reported interoception were randomly assigned (1:1) to the InMe intervention (n=50) or an active control (guided imagery; n=52). Participants blinded to allocation were stratified by gender and disordered eating. Assessments included baseline (T0), post-intervention (T1), and 7-8 weeks post-intervention (T2). The primary outcome was the \"Adaptive Interoception\" factor of the Multidimensional Assessment of Interoceptive Awareness questionnaire. Results Both arms improved in the primary outcome at T1 (InMe:adjusted M difference=5.76; 95%CI[-0.03;11.56], p=0.05; Control:adjusted M difference=7.90; 95%CI[1.92;13.87], p=0.002; Marginal R2=0.09). However, only InMe sustained this improvement at T2 (InMe:adjusted M difference=9.25, 95%CI[3.37;15.13], p<0.001; Control:adjusted M difference=2.94, 95%CI[-3.07; 8.96], p=0.72), as indicated by a significant Time*Arm interaction (b=6.31; SE=2.92, 95%CI[0.56;12.05], p<0.03; Marginal R2=0.12). Secondary outcomes showed a reduction in disordered eating scores across both arms at both time points (T1:b=-1.44, SE=0.37, 95%CI[-2.17;-0.71], p<0.001; T2: b=-1.05, SE=0.37, 95%CI[-1.79; -0.32], p=0.005). Conclusion The InMe intervention selectively improved self-reported interoception at follow-up but did not outperform the Control for secondary outcomes. Future research should explore its efficacy in clinical populations alongside complementary therapies.</p>","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":" ","pages":"1-36"},"PeriodicalIF":16.3,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a Smartphone App Intervention with Telephone Guidance as Transitional Support from Inpatient Treatment to Continuing Care for Individuals with Alcohol Use Disorder: Results from a Randomized Controlled Trial.","authors":"Sebastian Saur,Kiona K Weisel,Catharina Lang,Lukas M Fuhrmann,Niklas Meurer,Daniela Reichl,Mathias Zink,Peter Heepe,Thomas Hillemacher,Wolf-Dietrich Braunwarth,Peter Falkai,Gabriele Koller,Yaroslav Kiderman,Thomas Kraus,Johannes Kornhuber,Philipp Spitzer,Dominikus Bönsch,Mark Stemmler,Anja Hildebrand,Sabine Steins-Loeber,Matthias Berking","doi":"10.1159/000545817","DOIUrl":"https://doi.org/10.1159/000545817","url":null,"abstract":"INTRODUCTIONRelapse rates in individuals with alcohol use disorder (AUD) are particularly high following inpatient treatment. Innovative strategies should specifically target the transitional gap between completion of inpatient treatment and uptake of standard continuing care. This study aimed to determine whether Appstinence, a digital approach that combines a smartphone app intervention with adjunct telephone coaching, more markedly reduces the risk of relapse for 6 months after inpatient AUD treatment in comparison to a control group with access to standard continuing care.METHODSIn this multicenter clinical trial, 356 participants were randomized to the intervention (n=175) or control group (n=181). Eligibility criteria included diagnosis of AUD, smartphone access, no acute suicidality, and no language or neurocognitive impairments. The primary outcome was risk of relapse within six months after randomization, as assessed with the Timeline-Follow-Back method. Secondary outcomes included uptake of standard continuing care, hazardous alcohol consumption, craving, depression and anxiety symptom severity, and well-being.RESULTSThe intervention reduced the risk of relapse within six months as indicated by a log-rank test (HR 0.72, 95% CI 0.53-0.98, p=0.04) and Cox regression adjusted for baseline characteristics (HR 0.67, 95% CI 0.48-0.92, p=0.01). This effect increased when participants fully adhered to the intervention protocol (log-rank test: HR 0.61, 95% CI 0.39-0.94, p=0.02). No significant differences were observed in secondary outcomes.CONCLUSIONOur findings provide supportive evidence for digital AUD transition treatment. Specifically, we found that, in comparison with access standard continuing care, the novel intervention more effectively reduced risk of relapse within six months following inpatient treatment.","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":"22 1","pages":"1-24"},"PeriodicalIF":22.8,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of team‑based collaborative care for distressed patients in secondary prevention of chronic coronary heart disease: Results from the multicenter, randomized controlled TEACH trial.","authors":"Monika Sadlonova,Birgit Herbeck Belnap,Ingrid Becker,Kristina Bersch,Franziska Geiser,Viktoria Adenauer,Martin Hellmich,Ingrid Kindermann,Angela Zimmer,Matthias Michal,Jasmin Ghaemi Kerahrodi,Mariel Nöhre,Martina de Zwaan,Astrid Petersmann,Irina Müller-Kozarez,Maja Ehlers,Rolf Wachter,Christian Albus,Christoph Herrmann-Lingen,","doi":"10.1159/000545865","DOIUrl":"https://doi.org/10.1159/000545865","url":null,"abstract":"INTRODUCTIONCoronary heart disease (CHD) has serious implications for patients´ quality of life (QoL). Psychological distress affects 15 to 40% of patients with CHD and is robustly associated with poorer prognosis. Blended collaborative care (BCC), a telephone-delivered intervention involving non-physician care managers that address both psychological and medical factors can be applied for secondary prevention of CHD.METHODSWe conducted the multicenter, randomized controlled TEACH trial that investigated the efficacy of a BCC intervention (TeamCare) in distressed CHD patients. The primary aim was to examine the treatment response rate of TeamCare defined as ≥ 50% improvements in health-related QoL (HRQoL, assessed by HeartQoL) after 12 months compared to usual care (UC). Secondary endpoints were changes in HRQoL, psychological and medical factors, and satisfaction with care.RESULTSIn total, 457 patients (mean age 62.9 ± 9.5 years, 23% females) were randomized to TeamCare (n=230) or UC (n=227). At 12 months, TeamCare patients showed a significantly higher proportion of treatment response on HeartQoL compared to UC (19% vs. 10%, respectively). TeamCare yielded significantly greater improvements in HeartQoL scores: global (d=0.338), physical (d=0.270), and emotional (d=0.382). Further, TeamCare led to a significantly greater decrease in depression (d=-0.329), anxiety (d=-0.300), perceived stress (d=-0.233), and medical risk score (d=-0.235). Finally, BCC patients showed a higher satisfaction with overall treatment and psychosocial care.CONCLUSIONThe TEACH study is the first ever performed BCC trial in distressed CHD patients in Europe. The BCC intervention has the potential to significantly improve secondary prevention in distressed CHD patients.","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":"19 1","pages":"1-32"},"PeriodicalIF":22.8,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A neural signature of touch aversion and interpersonal problems in Borderline Personality Disorder.","authors":"Jella Voelter, Danilo Postin, Ilona Croy, René Hurlemann, Dirk Scheele","doi":"10.1159/000545973","DOIUrl":"https://doi.org/10.1159/000545973","url":null,"abstract":"<p><strong>Introduction: </strong>Patients with borderline personality disorder (BPD) suffer from severe social impairments and interpersonal problems. Social touch can provide comfort and facilitate the maintenance of social bonds, and preliminary evidence indicates a negative evaluation of social touch in patients with BPD. However, the neural mechanisms underlying aberrant touch processing in BPD and its role for social impairments are still unclear.</p><p><strong>Methods: </strong>We recruited 55 BPD patients and 31 healthy controls and used functional magnetic resonance imaging to probe neural responses to slow (i.e. C-tactile (CT)-optimal; affective) and fast (i.e. CT-suboptimal; discriminative) touch before and after four weeks of a residential dialectical behavior therapy (DBT) program. In addition to assessing BPD symptoms and interpersonal problems, we evaluated touch allowance maps and the attitude towards social touch.</p><p><strong>Results: </strong>BPD patients showed a comprehensive negative bias towards social touch before the DBT, evident in a significantly more negative attitude towards and reduced comfort zones of social touch compared to healthy controls. Activation in the posterior insular cortex in response to CT-optimal touch was significantly reduced and correlated with the severity of interpersonal problems in BPD patients. Despite significant improvements in overall BPD symptom load, dysfunctional social touch processing persisted after four weeks of DBT, indicating trait-like disturbances in BPD.</p><p><strong>Conclusions: </strong>An impaired insula-mediated integration of affective and sensory components of touch may constitute a clinically relevant biological signature of the complex interpersonal problems in BPD.</p>","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":" ","pages":"1-24"},"PeriodicalIF":16.3,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In psychedelic-assisted therapy, the alliance in the psychotherapy component is as important as the drug.","authors":"Christoph Flückiger,Madita Böhme,Ann-Marie Schweizer,Juan-Martín Gómez Penedo,Bruce E Wampold","doi":"10.1159/000546270","DOIUrl":"https://doi.org/10.1159/000546270","url":null,"abstract":"","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":"37 1","pages":"1-5"},"PeriodicalIF":22.8,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term versus long-term mentalization-based therapy for borderline personality disorder (MBT-RCT): 24 months follow-up of a randomized clinical trial.","authors":"Sophie Juul,Janus Christian Jakobsen,Emilie Hestbaek,Caroline Barkholt Kamp,Markus Harboe Olsen,Marie Rishede,Frederik Weischer Frandsen,Sune Bo,Stig Poulsen,Per Sørensen,Anthony Bateman,Sebastian Simonsen","doi":"10.1159/000544934","DOIUrl":"https://doi.org/10.1159/000544934","url":null,"abstract":"Introduction Borderline personality disorder (BPD) is a severe and prevalent psychiatric disorder. Mentalization-based therapy (MBT) is an evidence-based intervention for BPD, which is often delivered as a long-term psychotherapy program for BPD. We previously published a randomized clinical trial assessing short-term versus long-term MBT for BPD 16 months after randomization as the primary follow-up time-point. Objectives To assess the long-term (24 months) results of short-term versus long-term MBT for outpatients with BPD. Methods Adult outpatients (≥18 years) with subthreshold or diagnosed BPD were randomly assigned (1:1) to short-term MBT (5 months) or long-term MBT (14 months). The primary outcome was BPD symptoms assessed with the Zanarini Rating Scale for Borderline Personality Disorder. Secondary outcomes were level of functioning (assessed using the Work and Social Adjustment Scale), quality of life (assessed using Short Form Health Survey, SF-36), global functioning (assessed using the Global Assessment of Functionins scale, GAF), and severe self-harm. All outcomes were assessed at 24 months after randomization. Results Between October 4, 2018, and December 3, 2020, we randomly assigned 166 participants to short-term MBT (n=84) or long-term MBT (n=82). After 24 months, regression analyses showed no evidence of a difference when assessing the primary outcome, BPD symptoms (ZAN-BPD MD -0.56; 95% CI -2.67 to 1.54; p = 0.598), level of functioning (WSAS MD -1.42% CI -5.04 to 2.21; p = 0.440), global functioning (GAF MD 2.51 95% CI: -1.65 to 6.67; p = 0.234), or severe self-harm (RR 1.38; 95% CI 0.88 to 2.21; p = 0.149). Regression analyses showed evidence of a beneficial effect of long-term MBT when assessing.","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":"69 1","pages":"1-14"},"PeriodicalIF":22.8,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143926346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Internet-Delivered Treatment for Stress-Related Disorders: A Randomized Controlled Superiority Trial of Cognitive Behavioral Therapy versus General Health Promotion.","authors":"Victoria Sennerstam,Ludwig Franke Föyen,Evelina Kontio,Frank Svärdman,Mats Lekander,Elin Lindsäter,Erik Hedman-Lagerlöf","doi":"10.1159/000546221","DOIUrl":"https://doi.org/10.1159/000546221","url":null,"abstract":"BACKGROUNDStress-related disorders such as adjustment disorder (AD) and exhaustion disorder (ED) are associated with substantial suffering and high societal costs. Cognitive behavioral therapy (CBT) is a promising treatment for symptom reduction but has not been rigorously compared with other active treatments. This study aimed to investigate the efficacy of CBT compared to an active control treatment (General Health Promotion; GHP) treatment for individuals diagnosed with AD or ED.METHODSA total of 300 adults diagnosed with AD or ED were randomly assigned to a 12-week CBT (n=151) or GHP (n=149), both delivered as therapist-supported online treatments. Primary outcome was post-treatment scores on the 10-item Perceived Stress Scale. Secondary outcomes included several mental health symptom domains and functional impairment. All outcomes were assessed at baseline, post-treatment, and at 1-year follow-up. The trial was pre-registered on Clinicaltrials.gov (NCT04797273).RESULTSThe CBT intervention was not superior to GHP in reducing symptoms of perceived stress and secondary symptoms. Both treatments generated large within-group effect sizes pre- to post-treatment (Cohen's d= 1.19 and 1.06, respectively) and results were maintained to the 1-year follow-up. Diagnostic group moderated the treatment effect pre- to post-treatment and indicated that CBT was superior to GHP for individuals diagnosed with AD but not for those diagnosed with ED.CONCLUSIONSCommon factors likely play an important role in symptom reduction for individuals with stress-related disorders. A refined understanding of the conceptualization of stress-related disorders and which specific mechanisms to target in the respective patient groups is needed to improve treatment outcomes.","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":"68 1","pages":"1-20"},"PeriodicalIF":22.8,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143920979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Yoga on Psychological and Spiritual Outcomes in Cancer Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Meta-Regression.","authors":"Naomi Takemura,Krista Ching-Wai Chung,Jojo Yan-Yan Kwok,Daniel Yee Tak Fong","doi":"10.1159/000545697","DOIUrl":"https://doi.org/10.1159/000545697","url":null,"abstract":"INTRODUCTIONPsycho-spiritual distress remains one of the most prevalent and pressing concerns throughout the cancer survivorship journey, impacting their existential integrity. Various yoga interventions have been examined for their potential to alleviate this distress, but their effects in cancer patients varied.METHODSWe searched seven databases (PubMed, Embase, Cochrane Central Register of Controlled Trials, PsycINFO, CINAHL, SportDiscus, and Web of Science) and two clinical trial registries from their inception to October 2024, without language restriction. The randomized control trials (RCTs) that compared the effects of yoga interventions with controls on psychological, spiritual, and emotional well-being among adults with cancer were included. The random effects pooled estimates (Hedges' g) and 95% confidence intervals (CIs) were calculated. Heterogeneity was assessed using I2. Moderators were identified through meta-regression.RESULTSFifty-five RCTs involving 3,608 participants (2,935 [81.3%] female; mean age range, 46-69 years) were included. Meta-analysis revealed that yoga interventions largely reduced anxiety (Hedges' g, -0.82; 95% CI, -1.33 to -0.31; I2=88%), moderately-to-largely reduced depression (g, -0.62; 95% CI, -1.06 to -0.19; I2=85%), as well as mildly-to-moderately improved spiritual well-being (g, 0.31; 95% CI, 0.17 to 0.46; I2=0%) and emotional well-being (g, 0.23; 95% CI, 0.02 to 0.45; I2=47%).CONCLUSIONYoga effectively reduces anxiety and depression, and improves spiritual well-being and emotional well-being in cancer, underscoring their potential to improve the psychological and spiritual health of this population. More rigorously designed trials are needed to understand the optimal intervention parameters to maximize the effects of yoga on psychological outcomes.","PeriodicalId":20744,"journal":{"name":"Psychotherapy and Psychosomatics","volume":"42 1","pages":"1-22"},"PeriodicalIF":22.8,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}