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Progress in clinical and biological research最新文献

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Environmental causes and molecular biology of breast cancer: future research directions. 乳腺癌的环境成因与分子生物学:未来研究方向。
Progress in clinical and biological research Pub Date : 1996-01-01
G D Jahnke, J C Barrett
{"title":"Environmental causes and molecular biology of breast cancer: future research directions.","authors":"G D Jahnke, J C Barrett","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20686,"journal":{"name":"Progress in clinical and biological research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19750930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transplacental hormonal carcinogenesis: diethylstilbestrol as an example. 经胎盘激素致癌:以己烯雌酚为例。
Progress in clinical and biological research Pub Date : 1996-01-01
R R Newbold, J A McLachlan
{"title":"Transplacental hormonal carcinogenesis: diethylstilbestrol as an example.","authors":"R R Newbold,&nbsp;J A McLachlan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Prenatal exposure to the potent synthetic estrogen DES has been associated with structural, functional, and long-term alterations, including neoplasia in both male and female offspring. The data summarized in this chapter provide the basis for studying the transplacental carcinogenic effects of other compounds, especially those with known estrogenic activity. Finally, since some of these described prenatal effects are apparently common to different species, experimental results can be predictive and informative in studying mechanisms of transplacentally induced neoplasia.</p>","PeriodicalId":20686,"journal":{"name":"Progress in clinical and biological research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19751739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Estrogen as a carcinogen: the genetics and molecular biology of human endometrial carcinoma. 雌激素作为致癌物:人子宫内膜癌的遗传学和分子生物学。
Progress in clinical and biological research Pub Date : 1996-01-01
J Boyd
{"title":"Estrogen as a carcinogen: the genetics and molecular biology of human endometrial carcinoma.","authors":"J Boyd","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20686,"journal":{"name":"Progress in clinical and biological research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19751740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic variation in susceptibility as a key parameter in risk assessment and risk communication: policy aspects. 易感性的遗传变异作为风险评估和风险沟通的关键参数:政策方面。
Progress in clinical and biological research Pub Date : 1996-01-01
G S Omenn
{"title":"Genetic variation in susceptibility as a key parameter in risk assessment and risk communication: policy aspects.","authors":"G S Omenn","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20686,"journal":{"name":"Progress in clinical and biological research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19861493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms of estrogen-associated carcinogenesis. 雌激素相关癌变机制。
Progress in clinical and biological research Pub Date : 1996-01-01
J C Barrett, T Tsutsui
{"title":"Mechanisms of estrogen-associated carcinogenesis.","authors":"J C Barrett,&nbsp;T Tsutsui","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20686,"journal":{"name":"Progress in clinical and biological research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19751737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic analysis of multistage hepatocarcinogenesis. 多期肝癌发生的遗传学分析。
Progress in clinical and biological research Pub Date : 1996-01-01
T M Poole, T A Chiaverotti, R A Carabeo, N R Drinkwater
{"title":"Genetic analysis of multistage hepatocarcinogenesis.","authors":"T M Poole,&nbsp;T A Chiaverotti,&nbsp;R A Carabeo,&nbsp;N R Drinkwater","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20686,"journal":{"name":"Progress in clinical and biological research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19860411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From host factors to genetic susceptibility. 从宿主因素到遗传易感性。
Progress in clinical and biological research Pub Date : 1996-01-01
P Kleihues, B W Stewart
{"title":"From host factors to genetic susceptibility.","authors":"P Kleihues,&nbsp;B W Stewart","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20686,"journal":{"name":"Progress in clinical and biological research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19861490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diet intervention for modifying cancer risk. 降低癌症风险的饮食干预。
Progress in clinical and biological research Pub Date : 1996-01-01
D F Birt, J C Pelling, S Nair, D Lepley
{"title":"Diet intervention for modifying cancer risk.","authors":"D F Birt,&nbsp;J C Pelling,&nbsp;S Nair,&nbsp;D Lepley","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Considerable evidence suggests that dietary differences between populations account for a significant proportion of the variation in cancer occurrence in different parts of the world. A major problem has been identifying the particular dietary components which predispose or protect individuals against cancer. For example, the high rates of breast and colon cancer in the United States have been associated with numerous dietary patterns including high fat, high dietary energy, and low fruit and vegetable intakes. Our laboratories have attempted to identify mechanisms whereby diet may modify cancer and it is anticipated that future studies will determine which of these potential mechanisms may be relevant in humans. A promising lead in understanding the mechanism of high dietary fat/high dietary energy promotion of cancer was the impact of these diets on cellular protein kinase C (PKC). PKC is important in cellular signaling events which are critical to tumor promotion. Our studies demonstrated increased PKC activity and/or protein expression observed in epidermis and pancreatic epithelial cells of rodents fed high fat/energy diets. The inverse association between cancer at a number of sites and fruit and vegetable intake may be due to both micronutrient and non-nutrient components of fruits and vegetables. We have studied the prevention of skin tumor promotion by apigenin, a plant flavonoid. Apigenin may block several points in the process of tumor promotion, including inhibiting kinases, reducing transcription factors and regulating cell cycle. The complexity of our diets and the multitude of potential dietary effects which may be important in cancer development make this a fertile area for future study.</p>","PeriodicalId":20686,"journal":{"name":"Progress in clinical and biological research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19861492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hormonal influence on hepatocarcinogenesis. 激素对肝癌发生的影响。
Progress in clinical and biological research Pub Date : 1996-01-01
J E Coe
{"title":"Hormonal influence on hepatocarcinogenesis.","authors":"J E Coe","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20686,"journal":{"name":"Progress in clinical and biological research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19750926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time trends in hormone-dependent cancer. 激素依赖性癌症的时间趋势。
Progress in clinical and biological research Pub Date : 1996-01-01
C S Muir, R J Black
{"title":"Time trends in hormone-dependent cancer.","authors":"C S Muir,&nbsp;R J Black","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20686,"journal":{"name":"Progress in clinical and biological research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19751744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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