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Phagocytosis. 吞噬作用。
Progress in clinical and biological research Pub Date : 2020-02-07 DOI: 10.32388/cpl0wy
T. Stossel
{"title":"Phagocytosis.","authors":"T. Stossel","doi":"10.32388/cpl0wy","DOIUrl":"https://doi.org/10.32388/cpl0wy","url":null,"abstract":"Tentative conclusions concerning the role of recognition and ingestion of microorganisms by phagocytes in host defense and the consequences of disorders of phagocytosis can be derived by correlating a) knowledge about recognition and ingestion derived from studies in vitro, b) investigations of the clearance of particulate matter from the circulation of animals and man, and c) analyses of the behavior of phagocytes in patients susceptible to recurrent pyogenic infections. Deficiency of the major serum recognition-conferring agents (immunoglobulins and complement proteins that deposit a fragment of C3 on microbes) prevents the optimal clearance of virulent encapsulated pathogens by fixed mononuclear phagocytes. Confrontation of phagocytes with particulate matter appearing in pathologic states (viruses, immune complexes, damaged ervthrocvtes in sickle cell anemia and other hemoglobinopathies) diverts them from their normal task of clearing opsonized encapsulated microorganisms. Corticosteroids impair the phagocytic capacity by an unknown mechanism. Major impediments to progress in this field are inadequate assays for phagocytosis and the difficulty in measuring phagocytosis in the intact organism. (Am J Pathol 88:741-752, 1977)","PeriodicalId":20686,"journal":{"name":"Progress in clinical and biological research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90375010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leukoregulin. Leukoregulin .
Progress in clinical and biological research Pub Date : 2020-02-07 DOI: 10.32388/ecnv4d
C. Evans
{"title":"Leukoregulin.","authors":"C. Evans","doi":"10.32388/ecnv4d","DOIUrl":"https://doi.org/10.32388/ecnv4d","url":null,"abstract":"","PeriodicalId":20686,"journal":{"name":"Progress in clinical and biological research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78017674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radical prostatectomy. 根治性前列腺切除术。
Progress in clinical and biological research Pub Date : 2020-02-02 DOI: 10.32388/f261uh
D. Paulson
{"title":"Radical prostatectomy.","authors":"D. Paulson","doi":"10.32388/f261uh","DOIUrl":"https://doi.org/10.32388/f261uh","url":null,"abstract":"","PeriodicalId":20686,"journal":{"name":"Progress in clinical and biological research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88620014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatitis A virus. 甲型肝炎病毒。
Progress in clinical and biological research Pub Date : 2012-01-01 DOI: 10.1007/978-90-313-9129-5_67
J. Balen, A. Demeulemeester, M. Frölich, K. Mohrmann, L. M. Harms, W. C. H. V. Helden, L. Mostert, J. Souverijn
{"title":"Hepatitis A virus.","authors":"J. Balen, A. Demeulemeester, M. Frölich, K. Mohrmann, L. M. Harms, W. C. H. V. Helden, L. Mostert, J. Souverijn","doi":"10.1007/978-90-313-9129-5_67","DOIUrl":"https://doi.org/10.1007/978-90-313-9129-5_67","url":null,"abstract":"","PeriodicalId":20686,"journal":{"name":"Progress in clinical and biological research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85450527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Electrostatic interactions in proteins. 蛋白质中的静电相互作用。
Progress in clinical and biological research Pub Date : 2002-01-01 DOI: 10.1007/0-306-46934-0_5
Barry Honig, Kim A. Sharp, Michael K. Gilson
{"title":"Electrostatic interactions in proteins.","authors":"Barry Honig, Kim A. Sharp, Michael K. Gilson","doi":"10.1007/0-306-46934-0_5","DOIUrl":"https://doi.org/10.1007/0-306-46934-0_5","url":null,"abstract":"","PeriodicalId":20686,"journal":{"name":"Progress in clinical and biological research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80061834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Interaction of lipopolysaccharide with a mammalian lyso-phosphatidate acyltransferase (LPAAT) transfected into E. coli, and effect of lisofylline on LPAAT transfected into mammalian cells. 脂多糖与转染大肠杆菌的哺乳动物溶磷脂酰基转移酶(LPAAT)的相互作用以及异茶碱对转染哺乳动物细胞的LPAAT的影响。
Progress in clinical and biological research Pub Date : 1998-01-01
S L Bursten
{"title":"Interaction of lipopolysaccharide with a mammalian lyso-phosphatidate acyltransferase (LPAAT) transfected into E. coli, and effect of lisofylline on LPAAT transfected into mammalian cells.","authors":"S L Bursten","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>1. Lipid A and LPS stimulate LPAAT activity (and hence unsaturated PA formation) in RMC membranes and whole cells. 2. This correlates with cell phenotypic and membrane changes associated with small G proteins. 3. Unsaturated PA and Lipid A have similar effects on cells when given exogenously. 4. Human LPAAT-alpha and -beta isoforms were cloned and transfected into E. coli, demonstrating the ability to restore PA synthesis and reduce lyso-PA accumulation in plsC strains (LPAAT deficient mutants), as well as restoring growth at high temperatures. 5. LPAAT transfection into E. coli plsC (JC201) strains results in an increase in LPS content, suggesting stimulation of LPS synthesis. 6. LPAAT transfection into human A549 lung epithelial carcinoma and endothelial ECV304 cells results in increased cytokine mRNA transcription at baseline, and a significant increase in stimulated cytokine mRNA transcription. In addition, LPAAT transfection also results in increased cytokine release in response to IL-1 beta. 7. LSF, which reduces rodent deaths in sepsis models, reduces unsaturated acyl incorporation into PA in monoblastic cell lines, and reduces serum FFA increase in human sepsis, also reduces unsaturated acyl incorporation into PA in ECV304 cells. LPAAT-alpha transfection increases linolenate incorporation into PA at the expense of linoleate incorporation, which is reversed by LSF. LPAAT-beta increases both linoleate and linolenate incorporation into PA, which is also reduced by LSF. We conclude that LPAAT and PA remodeling may play a role in diffuse renal toxicity in sepsis due to induction of cellular phenotype changes associated with PA induction by Lipid A and/or LPS. Two human isoforms of LPAAT have been cloned, and apparently address C18 unsaturated acyl chains somewhat selectively. LSF causes functional reduction in LPAAT activity in transfected systems. This does not yet imply a direct effect of LSF on LPAAT. LPAAT and LPS may interact in the membrane in a not-yet-understood manner.</p>","PeriodicalId":20686,"journal":{"name":"Progress in clinical and biological research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20495698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CD14 dependent mechanisms of cell activation. 细胞活化的CD14依赖性机制。
Progress in clinical and biological research Pub Date : 1998-01-01
J Han, J Bohuslav, Y Jiang, V V Kravchenko, J D Lee, Z J Li, J Mathison, B Richter, P Tobias, R J Ulevitch
{"title":"CD14 dependent mechanisms of cell activation.","authors":"J Han,&nbsp;J Bohuslav,&nbsp;Y Jiang,&nbsp;V V Kravchenko,&nbsp;J D Lee,&nbsp;Z J Li,&nbsp;J Mathison,&nbsp;B Richter,&nbsp;P Tobias,&nbsp;R J Ulevitch","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20686,"journal":{"name":"Progress in clinical and biological research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20497103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detoxification of lipopolysaccharide by lysozyme. 溶菌酶解毒脂多糖。
Progress in clinical and biological research Pub Date : 1998-01-01
N Ohno, K Takada, T Kurasawa, A Liang, T Yadomae
{"title":"Detoxification of lipopolysaccharide by lysozyme.","authors":"N Ohno,&nbsp;K Takada,&nbsp;T Kurasawa,&nbsp;A Liang,&nbsp;T Yadomae","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20686,"journal":{"name":"Progress in clinical and biological research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20497105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Apoptotic cell death in response to LPS. LPS对凋亡细胞死亡的影响。
Progress in clinical and biological research Pub Date : 1998-01-01
T Yokochi, A Morikawa, Y Kato, T Sugiyama, N Koide
{"title":"Apoptotic cell death in response to LPS.","authors":"T Yokochi,&nbsp;A Morikawa,&nbsp;Y Kato,&nbsp;T Sugiyama,&nbsp;N Koide","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20686,"journal":{"name":"Progress in clinical and biological research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20497111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enzymes of lipid A biosynthesis: targets for the design of new antibiotics. 脂质A生物合成酶:设计新抗生素的靶点。
Progress in clinical and biological research Pub Date : 1998-01-01
C R Raetz
{"title":"Enzymes of lipid A biosynthesis: targets for the design of new antibiotics.","authors":"C R Raetz","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20686,"journal":{"name":"Progress in clinical and biological research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20497193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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