Transplacental hormonal carcinogenesis: diethylstilbestrol as an example.

R R Newbold, J A McLachlan
{"title":"Transplacental hormonal carcinogenesis: diethylstilbestrol as an example.","authors":"R R Newbold,&nbsp;J A McLachlan","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Prenatal exposure to the potent synthetic estrogen DES has been associated with structural, functional, and long-term alterations, including neoplasia in both male and female offspring. The data summarized in this chapter provide the basis for studying the transplacental carcinogenic effects of other compounds, especially those with known estrogenic activity. Finally, since some of these described prenatal effects are apparently common to different species, experimental results can be predictive and informative in studying mechanisms of transplacentally induced neoplasia.</p>","PeriodicalId":20686,"journal":{"name":"Progress in clinical and biological research","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in clinical and biological research","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Prenatal exposure to the potent synthetic estrogen DES has been associated with structural, functional, and long-term alterations, including neoplasia in both male and female offspring. The data summarized in this chapter provide the basis for studying the transplacental carcinogenic effects of other compounds, especially those with known estrogenic activity. Finally, since some of these described prenatal effects are apparently common to different species, experimental results can be predictive and informative in studying mechanisms of transplacentally induced neoplasia.

经胎盘激素致癌:以己烯雌酚为例。
产前暴露于强效合成雌激素DES与结构、功能和长期改变有关,包括雄性和雌性后代的肿瘤。本章总结的数据为研究其他化合物,特别是已知具有雌激素活性的化合物的经胎盘致癌作用提供了基础。最后,由于所描述的一些产前影响在不同物种中显然是共同的,因此实验结果可以预测和研究经胎盘诱导的肿瘤形成机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信