Keira Gaudet, Marc Corbiere, Tianyan Chen, Heloise Cardinal, Marie Achille
{"title":"The Strategies Used to Balance Health and Work Across the Solid Organ Transplantation Trajectory","authors":"Keira Gaudet, Marc Corbiere, Tianyan Chen, Heloise Cardinal, Marie Achille","doi":"10.1177/15269248241239245","DOIUrl":"https://doi.org/10.1177/15269248241239245","url":null,"abstract":"Introduction: Workers who undergo solid organ transplantation report frequent conflicts between the unpredictable demands of their health condition and the rigid requirements of their employer and of health services. The present study aimed to describe the self-management strategies adopted by workers while staying at work before transplantation and during sustainable return-to-work posttransplantation. Methods: Fifteen employed kidney, liver, and lung transplant recipients were recruited from 2 large urban university health centers in Montreal, Canada. Three focus groups were held, and thematic analysis was performed. Findings: Seven strategies were identified: responding promptly and consistently to fatigue-related needs, planning ahead with immediate supervisors while remaining strategic about when to disclose transplantation, requesting work accommodations, requesting flexibility in healthcare provision, consulting physicians about work-related issues, informing co-workers about work limitations and immunosuppression and asking not to be treated differently in the workplace. Conclusion: Access to work accommodations, support from physicians and flexibility in treatment and appointment schedules supported workers’ ability to manage their health while staying at work before and after undergoing solid organ transplantation. In light of findings, it may be useful for healthcare professionals to address workers’ concerns about work limitations and work accommodation implementation, especially when the illness-management burden increases before transplantation and during posttransplantation sick leave. Future studies could describe the strategies used by other important stakeholders when attempting to provide support to workers.","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":"124 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140564181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Angie K Puerto Nino, Fabricio Batistella Zasso, Atina Boonchit, Sabrin Salim, Raza Mirza, Joseph Ferenbok, Istvan Mucsi, Heather Boon, Gary Levy
{"title":"A Qualitative Study on the Effects of the COVID-19 Pandemic on Solid Organ Transplantation.","authors":"Angie K Puerto Nino, Fabricio Batistella Zasso, Atina Boonchit, Sabrin Salim, Raza Mirza, Joseph Ferenbok, Istvan Mucsi, Heather Boon, Gary Levy","doi":"10.1177/15269248231212912","DOIUrl":"10.1177/15269248231212912","url":null,"abstract":"<p><p><b>Introduction:</b> Solid organ transplantation is a lifesaving intervention requiring extensive coordination and communication for timely and safe care. The COVID-19 pandemic posed unique challenges to the safety and management of solid organ transplantation. This descriptive qualitative study aimed to understand how hospital stakeholders were affected by and responded to the COVID-19 pandemic to contribute toward improved healthcare delivery responses and strategies during times of systemic strain on the healthcare system. <b>Methods:</b> One-hour-long semistructured interviews were performed in 3 cohorts: healthcare professionals (N = 6), administrative staff (N = 6), and recipients (N = 4). Interviews were analyzed using conventional thematic content analysis. Thematic saturation was reached within each cohort. <b>Findings:</b> Twelve codes and 6 major themes were identified including the Impact on Clinical Practice, Virtual Healthcare Delivery, Communication, Research, Education and Training, Mental Health and Future Pandemic Planning. Reflecting on these codes and major themes, 4 recommendations were developed (Anticipation and Preparation, Maximizing Existing Resources and Networks, Standardization and the Virtual Environment and Caring for the Staff) to guide transplant programs to optimize healthcare pathways while enhancing the best practices during future pandemics. <b>Conclusion:</b> Transplant programs will benefit from anticipation and preparation procedures using ramping-down strategies, resource planning, and interprofessional collaboration while maximizing existing resources and networks. In parallel, transplant programs should standardize virtual practices and platforms for clinical and educational purposes while maintaining an open culture of mental health discussion and integrating strategies to support staff's mental health.</p>","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"328-334"},"PeriodicalIF":0.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107592115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cynthia L Russell, Steven R Chesnut, Rebecca J Bartlett Ellis, Mary Freiburghaus, Mercedes Madison, Sunny Yoo Ruggeri, Mary B Stephens, Preethi Yerram, Mark R Wakefield
{"title":"A Descriptive, Correlational Study of Perceptions of Adult Kidney Transplant Recipients and Those Waiting for a Kidney Transplant About Managing Their Medications During a Pandemic.","authors":"Cynthia L Russell, Steven R Chesnut, Rebecca J Bartlett Ellis, Mary Freiburghaus, Mercedes Madison, Sunny Yoo Ruggeri, Mary B Stephens, Preethi Yerram, Mark R Wakefield","doi":"10.1177/15269248231212906","DOIUrl":"10.1177/15269248231212906","url":null,"abstract":"<p><p><b>Introduction:</b> Little is known about COVID-19 impact on patient medication management. <b>Research Question:</b> The aim was to describe medication management, healthcare team interactions, and adherence during the COVID-19 pandemic in kidney transplant patients and those on the kidney transplant wait list. <b>Design:</b> Using a descriptive, correlational design 340 adults from a midwestern US transplant program were recruited. The Managing Medications in the Midst of a Pandemic Survey measured healthcare team encounters and medication management. The Basel assessment of adherence to medications scale measured medication adherence. <b>Results:</b> The response rate was 35% (119/340). During the pandemic, 88% had practiced/were currently practicing socially distancing, 85% had worn/were currently wearing a face mask in public, 18% had been/were currently diagnosed with COVID-19 and 82% received the vaccine. Medication management: 76% planned and organized their own medications. Healthcare team interactions: 89% met in the office, 20% via phone, 12% telehealth, and 13% delayed seeing a healthcare provider because of COVID-19 concerns. Pharmacy interactions: 11% changed their method of obtaining medications from pharmacy due to social distancing. Medication adherence implementation was problematic with 19% missing a dose; results from the binary logistic regression suggested that those with higher levels of education were more likely to report missing a dose. <b>Conclusions:</b> Patients acted to prevent COVID-19 but some still contracted the virus. The pandemic changed healthcare team medication management interactions. Adherence implementation problems were nearly 20%. Findings are relevant to the transplant healthcare team to understand the impact of a pandemic on patient/team interactions and medication adherence.</p>","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"318-327"},"PeriodicalIF":0.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107592114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Antonio Ríos, Andrés Balaguer-Román, Joaquín Carrillo, Ana Isabel López-Navas, Marco Antonio Ayala-García, Pablo Ramírez
{"title":"Living Kidney Donation Between African Immigrants.","authors":"Antonio Ríos, Andrés Balaguer-Román, Joaquín Carrillo, Ana Isabel López-Navas, Marco Antonio Ayala-García, Pablo Ramírez","doi":"10.1177/15269248231212909","DOIUrl":"10.1177/15269248231212909","url":null,"abstract":"","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"360-362"},"PeriodicalIF":0.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107592116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexis J Carter, Haiyan Qu, Rhiannon D Reed, A Cozette Killian, Vineeta Kumar, Michael Hanaway, Jayme E Locke
{"title":"Interpersonal Connections Are Important for Virtual Kidney Transplant Educational Program Development.","authors":"Alexis J Carter, Haiyan Qu, Rhiannon D Reed, A Cozette Killian, Vineeta Kumar, Michael Hanaway, Jayme E Locke","doi":"10.1177/15269248231212905","DOIUrl":"10.1177/15269248231212905","url":null,"abstract":"<p><p><b>Introduction:</b> The Living Donor Navigator program is designed to mitigate disparities in living donor kidney transplantation, although geographic disparities in program participation were observed in the initial years of implementation. The purpose of this study was to understand participant perspectives regarding the use of a virtual option/alternative to expand program participation. <b>Methods:</b> Previous participants of the in-person navigator program were purposively sampled. Using the nominal group technique, a well-structured formative methodology to elicit participant perspectives, 2 meetings were conducted among transplant recipients and advocates (N = 13) to identify and prioritize responses to the question \"What things would concern you about participating in a virtual and remote Living Donor Navigator program?\" <b>Findings:</b> Mean participant age was 59.3 (9.3) years, and participants were 54% male and 62% white. Education levels varied from less than high school to master's degrees. Participants generated 70 unique responses, of which 36 (51.4%) received prioritization. The top 5 ranked responses of each nominal group technique meeting received approximately 50 percent (47.6% vs. 66.7%, respectively) of the total votes and described the potentially limited interpersonal connections, time conflicts, and differing content in a virtual navigator program compared to the in-person model. <b>Discussion:</b> These data suggest that previous participants were concerned with upholding the original design of the program, thus, virtual living donor kidney transplantation programs should aim to maintain interpersonal connections and consistency of content to ensure adequate programmatic engagement. Future research will focus on program fidelity independent of delivery modality.</p>","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"301-309"},"PeriodicalIF":0.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10842874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71485267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ashley L Sweet, Christopher R Connelly, Elizabeth N Dewey, David L Scott
{"title":"The Effect of Perfusate Temperature on Delayed Graft Function in Deceased Donor Renal Transplantation.","authors":"Ashley L Sweet, Christopher R Connelly, Elizabeth N Dewey, David L Scott","doi":"10.1177/15269248231212920","DOIUrl":"10.1177/15269248231212920","url":null,"abstract":"<p><p><b>Introduction:</b> Renal allograft hypothermic machine perfusion results in a decreased incidence of delayed graft function compared with static cold storage. Ensuring perfusate temperatures remain within the target range of 4-10 °C may impact delayed graft function rates. <b>Project Aims:</b> To identify whether this target was achieved and, if not, whether higher perfusate temperature was associated with delayed graft function. <b>Design:</b> In this retrospective cohort study, transplanted grafts from deceased donors placed on hypothermic machine perfusion pump from June 2019 to August 2020 were analyzed. Measurements were recovered after 5, 15, 60, and 180 min of perfusion. Univariable and multivariable analyses were performed to identify predictors of delayed graft function. <b>Results:</b> A total of 113 grafts from 94 donors were analyzed. Of these, 21 (19%) developed delayed graft function. On univariable logistic regression, variables associated with delayed graft function included older donor age (OR 1.08, <i>P</i> = .002), higher Kidney Donor Profile Index score (OR 1.03, <i>P</i> = .024), and higher 5-min perfusate temperature (T5 min; OR 1.49, <i>P</i> = .014). A higher T5 min was also associated with delayed graft function in multivariable logistic regression models (OR 1.58, <i>P</i> = .005; OR 1.37, <i>P</i> = .08). Grafts with T5 min >10 °C were more likely to experience delayed graft function than those with T5 min <10 °C (OR 4.5, <i>P</i> = .006). <b>Conclusion:</b> Higher early perfusate temperature was an independent predictor of delayed graft function and may be due to inadequate cooling of the circuit prior to placing grafts on pump. Quality improvement initiatives targeting early perfusate temperatures of ≤10 °C may reduce delayed graft function incidence.</p>","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"341-347"},"PeriodicalIF":0.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107592117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Determinants and Consequences of Living Donor Discussion Direction.","authors":"Mary K Roberts, Jonathan Daw","doi":"10.1177/15269248231212913","DOIUrl":"10.1177/15269248231212913","url":null,"abstract":"<p><p><b>Introduction:</b> Living donor discussions in which kidney transplant candidates discuss living kidney donation with their social network are an important step in the living donor kidney transplant process. No prior research has investigated whether who initiates discussion or influences evaluation agreement rates or how these processes may contribute to disparities. <b>Research Questions:</b> This study aimed to determine how common candidate- and potential-donor-initiated discussions were, at what rate each discussion type resulted in agreement to be evaluated for living donation, and what sociodemographic characteristics predicted living donor discussion and agreements. <b>Design:</b> A 2015 cross-sectional survey at a single, large Southeastern US transplant center measured kidney transplant candidates' social networks, including whether they had a donor discussion, who initiated it, and whether the discussion resulted in the donor evaluation agreement. Candidate-network member pairs' probability of having a candidate-initiated discussion, potential-living donor-initiated discussion, or no discussions were compared in multinomial logistic regression, and the probability of the discussion resulted in evaluation agreement was evaluated in multinomial logistic regression. <b>Results:</b> Sixty-six kidney transplant candidates reported on 1421 social network members. Most (80%) candidate/network-member pairs did not have a living donor discussion, with candidate-initiated discussions (11%) slightly more common than potential-donor-initiated discussions (10%). Evaluation agreement was much more common for potential-donor-initiated (72%) than for candidate-initiated discussions (39%). Potential-donor-initiated discussions were more common for White candidates (16%) than for Black candidates (7%). <b>Conclusion:</b> Potential-donor-initiated discussions resulted in evaluation agreement much more frequently than candidate-initiated discussions. This dynamic may contribute to racial living donation disparities.</p>","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"310-317"},"PeriodicalIF":0.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72015205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anne M Sescleifer, Alice Crane, William Teeter, Thomas Scalea, William S Twaddell, Josue Alvarez-Casas, Chandra Bhati, Zurabi Lominadze, Saad Malik, Daniel Maluf, Raphael P H Meier
{"title":"A Case Report of Rescue of Primary Nonfunction following Liver Transplant Using the Molecular Adsorbent Recirculating System (MARS).","authors":"Anne M Sescleifer, Alice Crane, William Teeter, Thomas Scalea, William S Twaddell, Josue Alvarez-Casas, Chandra Bhati, Zurabi Lominadze, Saad Malik, Daniel Maluf, Raphael P H Meier","doi":"10.1177/15269248231212917","DOIUrl":"10.1177/15269248231212917","url":null,"abstract":"","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"358-359"},"PeriodicalIF":0.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71522474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sara Farghaly, Tracy Sparkes, Brian Masters, Abdolreza Haririan, Neha Jakhete, Daniel Maluf, Rolf N Barth, Sari Freedman
{"title":"Impact of Renal Replacement Therapy on Rejection among Liver Transplant Recipients.","authors":"Sara Farghaly, Tracy Sparkes, Brian Masters, Abdolreza Haririan, Neha Jakhete, Daniel Maluf, Rolf N Barth, Sari Freedman","doi":"10.1177/15269248231212915","DOIUrl":"10.1177/15269248231212915","url":null,"abstract":"<p><p><b>Introduction:</b> Renal dysfunction in liver transplant recipients is associated with an increased risk of morbidity and mortality, with an even higher risk among patients requiring renal replacement therapy. There is limited data evaluating rejection outcomes in patients requiring renal replacement therapy after liver transplant. <b>Program evaluation aims:</b> To evaluate the incidence of biopsy-proven acute rejection, recipient and graft survival, infection, renal dysfunction, and immunosuppression practices. <b>Design:</b> This was a single-center, retrospective, cohort study. To be eligible, patients were deceased donor liver transplant recipients ≥18 year of age transplanted between January 2017 and August 2019 who received steroid-only induction and tacrolimus as part of their initial immunosuppression regimen. <b>Results:</b> Recipients that required renal replacement therapy (N = 86) were compared to those who received no renal replacement therapy (N = 158). Biopsy-proven acute rejection at 1-year posttransplant was significantly higher among those requiring renal replacement therapy (36% vs 13%, <i>P</i> < .001). Patient survival at 12 months was 77% for those requiring renal replacement therapy and 94% for those not requiring renal replacement therapy (<i>P</i> < .001). Infection (HR 3.8, 95% CI 1.6-8.8; <i>P</i> < .001), but not rejection (HR 0.7, 95% CI 0.3-1.7; <i>P</i> = .5) was an independent predictor of mortality. The use of renal replacement therapy after liver transplant necessitated careful titration of immunosuppression to balance the detrimental risks of infection versus rejection in this high-risk population.</p>","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"348-355"},"PeriodicalIF":0.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138047821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emily A Vail, Douglas E Schaubel, Vishnu S Potluri, Peter L Abt, Niels D Martin, Peter P Reese, Mark D Neuman
{"title":"Deceased Organ Donor Management and Organ Distribution From Organ Procurement Organization-Based Recovery Facilities Versus Acute-Care Hospitals.","authors":"Emily A Vail, Douglas E Schaubel, Vishnu S Potluri, Peter L Abt, Niels D Martin, Peter P Reese, Mark D Neuman","doi":"10.1177/15269248231212918","DOIUrl":"10.1177/15269248231212918","url":null,"abstract":"<p><p><b>Introduction:</b> Organ recovery facilities address the logistical challenges of hospital-based deceased organ donor management. While more organs are transplanted from donors in facilities, differences in donor management and donation processes are not fully characterized. <b>Research Question:</b> Does deceased donor management and organ transport distance differ between organ procurement organization (OPO)-based recovery facilities versus hospitals? <b>Design:</b> Retrospective analysis of Organ Procurement and Transplant Network data, including adults after brain death in 10 procurement regions (April 2017-June 2021). The primary outcomes were ischemic times of transplanted hearts, kidneys, livers, and lungs. Secondary outcomes included transport distances (between the facility or hospital and the transplant program) for each transplanted organ. <b>Results:</b> Among 5010 deceased donors, 51.7% underwent recovery in an OPO-based recovery facility. After adjustment for recipient and system factors, mean differences in ischemic times of any transplanted organ were not significantly different between donors in facilities and hospitals. Transplanted hearts recovered from donors in facilities were transported further than hearts from hospital donors (median 255 mi [IQR 27, 475] versus 174 [IQR 42, 365], <i>P</i> = .002); transport distances for livers and kidneys were significantly shorter (<i>P</i> < .001 for both). <b>Conclusion:</b> Organ recovery procedures performed in OPO-based recovery facilities were not associated with differences in ischemic times in transplanted organs from organs recovered in hospitals, but differences in organ transport distances exist. Further work is needed to determine whether other observed differences in donor management and organ distribution meaningfully impact donation and transplantation outcomes.</p>","PeriodicalId":20671,"journal":{"name":"Progress in Transplantation","volume":" ","pages":"283-292"},"PeriodicalIF":0.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71522475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}