Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)最新文献_第10页

Analisis Biaya Penyakit Diabetes Melitus Sebagai Pertimbangan Perencanaan Pembiayaan Kesehatan 糖尿病的成本分析考虑的是健康融资计划

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Pub Date : 2019-03-31 DOI: 10.22487/J24428744.2019.V5.I1.12071

N. Abror, T. Andayani, Endang Sulistiawaty

{"title":"Analisis Biaya Penyakit Diabetes Melitus Sebagai Pertimbangan Perencanaan Pembiayaan Kesehatan","authors":"N. Abror, T. Andayani, Endang Sulistiawaty","doi":"10.22487/J24428744.2019.V5.I1.12071","DOIUrl":"https://doi.org/10.22487/J24428744.2019.V5.I1.12071","url":null,"abstract":"Disease cost analysis is an important element in the decision making process of chronic disease, because it can evaluate the cost of illness and illustrate diseases that require an increase in resources for the prevention or therapy. This study aims to determine the total cost of diabetes mellitus (DM), so it can be used as a health fund planning considerations related to the effectiveness and efficiency of medication costs for patients in Yogyakarta Regional Public Hospital. The method used is observational prevalence. The data were obtained retrospectively with patients primary diagnosed and secondary diagnosed of diabetes mellitus with or without complications in the period January to June 2014 in Yogyakarta Regional Public Hospital. The Financial perspective used is the hospitals perspective as health care providers to take into account the direct medical costs by using a bottom-up approach. Data analysis was performed using Kruskal-Wallis and Mann-Whitney Whitney to determine differences in the direct medical costs of outpatient diabetic patients in terms of age, the number and type of diabetes complications, as well as to determine the direct medical cost differences hospitalized diabetic patients in terms of age, the number of complications, type of diabetes, duration of hospitalization and inpatient classes.The results of the research showed that the patients who entered the inclusion criteria as much as 1.689 episodes of visits, which consisted of 1.531 episodes of outpatients visits and 158 episodes of inpatients visits. The total cost of DM based on hospital perspective Rp1.203.799.389,00 IDR within six months. There is a significant difference in direct medical costs in outpatients in terms of the number of factors of complications (p=0.004) and a significant differences direct medical costs inpatients in terms of the number of factors of complications, length of stay and inpatient class in hospitalization (p=0.000). ","PeriodicalId":206667,"journal":{"name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124350791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Validasi Metode Analisis Cemaran DNA Babi pada Bakso Sapi Menggunakan Primer Mitokondria D-Loop22 dengan Metode Polymerase Chain Reaction (PCR) 猪肉豆蔻DNA分析方法的验证方法是采用线粒体D-Loop22与多位酶链反应(PCR)方法

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Pub Date : 2019-03-31 DOI: 10.22487/j24428744.2019.v5.i1.12035

Sri Wahyuni, S. Maryam, Aminah Aminah

{"title":"Validasi Metode Analisis Cemaran DNA Babi pada Bakso Sapi Menggunakan Primer Mitokondria D-Loop22 dengan Metode Polymerase Chain Reaction (PCR)","authors":"Sri Wahyuni, S. Maryam, Aminah Aminah","doi":"10.22487/j24428744.2019.v5.i1.12035","DOIUrl":"https://doi.org/10.22487/j24428744.2019.v5.i1.12035","url":null,"abstract":"The frequency of non-halal ingredient mixing, such as porkin on the food processed products of meatballs, has become an issue to the public, especially for moslems. Therefore, a reliable and valid method with high sensitivity is needed to specifically detect the pig contamination. This research aims to obtain a valid and reliable method by proposing polymerase chain reaction (PCR) using mitochondrial D-Loop22 primer as a method in handing halal food authentication. The sample consisted of beef as a negative control, pork and pork meatballs as a positivecontrol, and five samples of meat balls found in Makassar for halal inspection.The method validation assay was conducted by testing the primary specificity on the fresh tissue (beef and pork) and testing the sensitivity by making a series of pig DNA dilution (1:10; 1:102; 1:103; 1:104) and the variations of contaminated pig:cow (%b/b) : 0.05% , 0.1%, 1%, and 5%. The result of PCR amplification on agarose gel electrophoresis of 0.8% showed that method was able to detect the pig DNA contamination specifically in pigs and not amplify other DNA, and could still be detected up to pig contamination specifically in pigs and not amplify the other DNAs and could still be detected up to pig contamination of 0.05% and on DNA dilution of 1:103. Meanwhile, on the five samples analyzed, there were not found pig DNA contamination characterized by no formed amplification bands.","PeriodicalId":206667,"journal":{"name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125442503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Review: Farmasi Sosial dan Administratif 社会和行政制药

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Pub Date : 2019-03-31 DOI: 10.22487/j24428744.2019.v5.i1.12068

Anshar Saud

{"title":"Review: Farmasi Sosial dan Administratif","authors":"Anshar Saud","doi":"10.22487/j24428744.2019.v5.i1.12068","DOIUrl":"https://doi.org/10.22487/j24428744.2019.v5.i1.12068","url":null,"abstract":"In the health care system, pharmaceutical care systems are one of the core components and pharmacists play a very important role. With the dynamic changes that occur in health services, diseases, communication and regulatory information technology, the roles and responsibilities of pharmacists are becoming increasingly important than before. Pharmacists are dedicated and in a strategic position to maintain and advance public health. Their efforts improve the quality of life of individuals by helping people to live as freely as possible from illness, pain, and suffering. One of the obligations of pharmacists is to educate the public about health and drug use. Pharmacy practices involve pharmacists, patients, other professional health personnel and the public can be conceptualized as a social process. Therefore, understanding the concepts and principles behind social pharmacy disciplines is very essential and useful for a pharmacist and pharmacy student. The purpose of this article review is to briefly review a number of important topics concerning social, behavioral and administrative aspects in pharmacy to achieve a stronger understanding of dynamic and complex interactions between patients, pharmacists, drugs, teams of health workers, organizations and larger social systems. Mastery of students and pharmacists on this issue – asa consequence of the inclusion of social and administrative aspects into the pharmacy's higher education curriculum–willenable them to be professionally responsible for improving patient drug therapy outcomes as individuals, communities, society, and state systems; and have a greater impact on population health through drug-related public policies.","PeriodicalId":206667,"journal":{"name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","volume":"95 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133104251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Peningkatan Kadar Ketoprofen Terdisolusi melalui Pembentukan Dispersi Padat menggunakan Polivinil Alkohol (PVA) 通过使用聚乙烯酒精(PVA)形成固体分散物(PVA)来解决酮含量的增加

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Pub Date : 2019-03-28 DOI: 10.22487/j24428744.2019.v5.i1.12096

Asriana Sultan, N. Ida, I. Ismail

{"title":"Peningkatan Kadar Ketoprofen Terdisolusi melalui Pembentukan Dispersi Padat menggunakan Polivinil Alkohol (PVA)","authors":"Asriana Sultan, N. Ida, I. Ismail","doi":"10.22487/j24428744.2019.v5.i1.12096","DOIUrl":"https://doi.org/10.22487/j24428744.2019.v5.i1.12096","url":null,"abstract":"Ketoprofen is included in the Class II of Biopharmaceutical Classification System (BCS) which has low solubility. Low solubility will affect the dissolution rate and the dissolved concentration, so the absorption and bioavailability are low as well. Several studies have been conducted to improve the solubility and the dissolution of drugs from these group, such as by solid dispersion system. This study aims to determine the effect of polyvinyl alcohol (PVA) on the dissolved concentration of ketoprofen in solid dispersion and in physical mixture, and to decidethe optimum formula.Solid dispersion and physical mixture of ketoprofen - PVA were formulated with the ratio of 1:1, 1:2 and 1:4, and then compared with the standard ketoprofen. Evaluation of solid dispersion was performed by the intervention test of PVA as a matrix on the maximum wavelength of standard ketoprofen using a UV-Vis spectrophotometer and the dissolution test in artificial gastric fluid media without pepsin using a basket stirrer at pH ± 1,2, the temperature of 37 ± 0.5ºC, and device speed of 50 rpm. The sample was collected at 10, 20, 30, 45, and 60 minutes. The amount of dissolved ketoprofen was determined by a UV-Vis spectrophotometer at a wavelength of 260 nm. The results showed that there was no shifting on maximum wavelength point in both solid dispersions and physical mixtures. The dissolved ketoprofen concentration that was represented in solid dispersion was greater than in physical mixture and standard ketoprofen. The highest dissolved ketoprofen concentration was indicated in solid dispersion formula with the ratio of 1:1.","PeriodicalId":206667,"journal":{"name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","volume":"34 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128602872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Korelasi Antara Kadar Total Flavonoid dan Fenolik dari Ekstrak dan Fraksi Daun Jati Putih (Gmelina Arborea Roxb.) Terhadap Aktivitas Antioksidan 葡萄树提取物和白柚叶(Gmelina Arborea Roxb)的总酚含量与表型水平的相关性。对抗氧化剂活性

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Pub Date : 2019-03-22 DOI: 10.22487/j24428744.2019.v5.i1.12034

Syamsuddin Nur, Fitriyanti Jumaetri Sami, Akbar Awaluddin, M. A. Afsari

{"title":"Korelasi Antara Kadar Total Flavonoid dan Fenolik dari Ekstrak dan Fraksi Daun Jati Putih (Gmelina Arborea Roxb.) Terhadap Aktivitas Antioksidan","authors":"Syamsuddin Nur, Fitriyanti Jumaetri Sami, Akbar Awaluddin, M. A. Afsari","doi":"10.22487/j24428744.2019.v5.i1.12034","DOIUrl":"https://doi.org/10.22487/j24428744.2019.v5.i1.12034","url":null,"abstract":"This experiment aims to determine the correlation of total phenolic and flavonoid content of jati putih leaves fraction (Gmelina arborea Roxb.) towards Antioxidant activity . Sample was extracted by maceration method using ethanol 70% to obtain the ethanol extract (EE), followed by liquid-liquid extraction method to obtain fraction of ethyl acetate (EA) and n-Hexane (EH). The phytochemical screening and determination of total phenolic and flavonoid content were done by colorimetric method. Antioxidant activity were done by DPPH, FRAP and ABTS methods. Phytochemical screening showed positive results for flavonoids, phenolic and saponins. The largest total phenolic content was found on EA (11,59 µg/ml ± 0,3 %b/b EAG) and the largest total flavonoid content was on EA (3,88 µg/ml ± 0,02 %b/b EK). The total phenolic and flavonoid content of Jati putih leaves has a correlation with antioxidant activity. The coefficient correlation of activity on reducingDPPH radical was 56,7% (total of phenolic content) and 57,8% (total of flavonoid content) and on iron reduction power in FRAP method was 99,9% (total of phenolics and flavonoids content). The relationship with the activity in reducing radical ABTS obtained coefficient correlation of 57,0% and 58,1% for total phenolic and flavonoids contents, respectively.","PeriodicalId":206667,"journal":{"name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115415641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Fungi Endofit dari Tanaman Secang (Caesalpinia sappan L) Sebagai Penghasil Senyawa Antioksidan 植物内生长真菌是一种抗氧化剂

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Pub Date : 2019-03-20 DOI: 10.22487/J24428744.2019.V5.I1.12013

Amirullah Amirullah, S. Sartini, Firzan Nainu

{"title":"Fungi Endofit dari Tanaman Secang (Caesalpinia sappan L) Sebagai Penghasil Senyawa Antioksidan","authors":"Amirullah Amirullah, S. Sartini, Firzan Nainu","doi":"10.22487/J24428744.2019.V5.I1.12013","DOIUrl":"https://doi.org/10.22487/J24428744.2019.V5.I1.12013","url":null,"abstract":"Endophytic fungi are microbes that reside symbiotically in the plant tissues with undetected negative impacts to their host plants. These fungi are able to produce elements similar to those produced by their host plants. Secang (Caesalpinia sappan L.) has been known as one of the medicinal plants that contains compounds with antioxidant activity thus promote a hypothesis that its endophytic fungi may yield a similar antioxidant effect. In this study, the isolation of endophytic fungi from Secang as the producer of antioxidant compounds was carried out. At the initial stage, endophytic fungi were isolated from the leaves, the twigs, the stems, and the rootsof Secang using the agar plate method. Pure fungi isolates were then subjected to fermentation process using the PDBgrowth medium supplemented with yeast extractand wereconstantly shaken for 12 days at a speed of 200 rpm to produce secondary metabolites. Fermentatesobtained from all fungi isolates were then extracted using ethyl acetate and further tested for their antioxidant activities. In this study, of 19 isolates that were obtained from four parts of the Secang, five fungi isolates, coded as IFD1, IFD4, IFR5, IFA1, and IFA2 were found to yield antioxidant activities demonstrated by the presence of yellow spots on the chromatogram. elementary schools representatives “not good ranking”, the education did not influence their knowledge with a p value of 0.149. Analysis of the Wilcoxon test in all elementary schools showed a p value p ≤ 0,001, which meant that education had an influence on the knowledge of fifth grade students in elementary schools in Palu City.","PeriodicalId":206667,"journal":{"name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","volume":"60 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114112682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Edukasi Anti Penyalahgunaan Obat Kepada Siswa SD Di Kota Palu Melalui Media Kartu Kuartet 通过媒体季卡，在帕鲁市对小学生进行药物滥用教育

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Pub Date : 2019-03-19 DOI: 10.22487/j24428744.2019.v5.i1.11933

H. Hannan, Pratiwi Wikaningtyas, I. K. Adnyana

{"title":"Edukasi Anti Penyalahgunaan Obat Kepada Siswa SD Di Kota Palu Melalui Media Kartu Kuartet","authors":"H. Hannan, Pratiwi Wikaningtyas, I. K. Adnyana","doi":"10.22487/j24428744.2019.v5.i1.11933","DOIUrl":"https://doi.org/10.22487/j24428744.2019.v5.i1.11933","url":null,"abstract":"Cases of illegal drugs and drug abuse in the elementary school community in Indonesia is increasingly massive and alarming. An innovation to protect elementary school students from that situation is through the colaboration of academics from Bandung Institute of Technology with FDA in Palu in the form education of anti-drug abuse for elementary school students through quartet card media. The aim of the study was to determine the effect of the education on anti-drug abuse knowledge in fifth grade students in Palu City. The research method used pre-experimental design with the design of one group pretest-posttest on three elementary schools which were representatives of three ranks namely; good, quite good and not good based on the results of the Smart-Accurate Quiz FDA in Palu for elementary school level in 2017. The sampling technique used purposive sampling. Observation of knowledge of elementary students using questionnaires that have been tested for validity and reliability had been carried out. The pretest and posttest were conducted before and after education. The comparison of pretest and posttest data in each elementary school was analyzed using paired T test whereas for all elementary school data analyzed using the Wilcoxon test with hypotheses. There was an influence of anti-drug abuse education through quartet card media on anti-drug abuse knowledge in fifth grade students in Palu City. The results showed that there was an influence of education on anti-drug abuse knowledge in fifth grade students from elementary school representatives “good and quite good ranking” with p values of 0.005 and p ≤ 0.001, while in elementary schools representatives “not good ranking”, the education did not influence their knowledge with a p value of 0.149. Analysis of the Wilcoxon test in all elementary schools showed a p value p ≤ 0,001, which meant that education had an influence on the knowledge of fifth grade students in elementary schools in Palu City.","PeriodicalId":206667,"journal":{"name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120961020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Efektivitas Kombinasi Ekstrak Etanol Daun Bunga Matahari dan Tanaman Anting-Anting sebagai Antimalaria Secara In Vivo 葵花籽提取物和耳环的功效可用于体内抗疟疾

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Pub Date : 2019-03-18 DOI: 10.22487/j24428744.2019.v5.i1.11860

Khoirul Ngibad

引用次数: 8

Kajian Heat Shock Protein 90 (HSP90) dalam Pencarian Kandidat Penghambatnya melalui Ekplorasi Bahan Alam Indonesia

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Pub Date : 2019-03-14 DOI: 10.22487/J24428744.2019.V5.I1.12012

Rehmadanta Sitepu

{"title":"Kajian Heat Shock Protein 90 (HSP90) dalam Pencarian Kandidat Penghambatnya melalui Ekplorasi Bahan Alam Indonesia","authors":"Rehmadanta Sitepu","doi":"10.22487/J24428744.2019.V5.I1.12012","DOIUrl":"https://doi.org/10.22487/J24428744.2019.V5.I1.12012","url":null,"abstract":"Exploration on anticancer candidates on inhibition of Heat Shock Protein (HSP) activity are increasing in the past ten years. Some of HSP90 inhibitor candidates were in third phase of clinical trials. However, this issue is not followed by the emergency of HSP90 inhibitor research in Indonesia, not only study on natural source but also on synthetic candidates. This study aims to look the development of tracking HSP90 inhibitor candidates globally so that it can initiate the related research in Indonesia. Study of HSP90 and its inhibitors were taken from scientific articles in the range from 2009 to 2018. HSP90 and its inhibitors have important values in the dynamics of functions and stability of proteins to maintain survival of cells. This also include the oncogene proteins that involve in cell proliferation such as tyrosine kinases, transcription factors, and regulatory proteins that expression and interaction depend on HSP90. Expression of the transcription factor p53, Alk gene, Wnt gene, glucocorticoid receptors have also links with HSP90 protein activity. Some candidates for inhibitor of HSP90 have been entering clinical trials such as geldanamycin analogues, resorcinol derivatives, and purines analog. Candidates from natural sources that are also being developed such as luteolin, licochalcone A, oleochantal, novobiocin, epigallocathecin gallat, silybin, deguelin, and celastrol from terpenoid class, Apigenin from flavon class, Curcumin, and Gambogat Acid. HSP90 inhibitors which are entering the third phase of clinical trial are ganetespib from the resorcinol derivative and retaspimycin from geldanamisin analog group. Exploration of HSP90 inhibitors from Indonesia natural resources still have great potential to be developed because they have high impact values as anticancer candidates.","PeriodicalId":206667,"journal":{"name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","volume":"248 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130541981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analisis Zerumbone Dalam Zingiber zerumbet Dan Aktivitas Penghambatannya Terhadap Bakteri Mycobacterium tuberculosis 对Zingiber Zerumbone的分析及其对结核病杆菌的抗药性

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Pub Date : 2018-11-13 DOI: 10.22487/j24428744.2018.v4.i2.11138

Subehan Lallo, Syaharuddin Kasim, Rosany Tayeb, Asril Damiyanto Hasan, Hartina Sere, I. Ismail, Tamsil Arifin

{"title":"Analisis Zerumbone Dalam Zingiber zerumbet Dan Aktivitas Penghambatannya Terhadap Bakteri Mycobacterium tuberculosis","authors":"Subehan Lallo, Syaharuddin Kasim, Rosany Tayeb, Asril Damiyanto Hasan, Hartina Sere, I. Ismail, Tamsil Arifin","doi":"10.22487/j24428744.2018.v4.i2.11138","DOIUrl":"https://doi.org/10.22487/j24428744.2018.v4.i2.11138","url":null,"abstract":"Zerumbone has been reported for their several biological activities. In our interest to this compound, we have identified and analyzed its content in Zingiber zerumbet, a medicinal plant from Indonesian traditional medicine and investigated its inhibitory activity against Mycobacterium tuberculosis, a known infection bacteria of tuberculosis. Analysis of zerumbone was performed with densitometry to leave, rhizome, flower, and stem of Z. zerumbet which was extracted with various solvent system and extraction methods to determine the best method to isolate zerumbone from Z. zerumbet. Result showed that the highest zerumbone was in rhizome while was not observed in other part. Analysis with various solvent and extraction methods showed the highest yield of zerumbone can be extracted by n-hexane (maceration) and reflux extraction method (methanol). Furthermore, inhibitory activity of zerumbone against M. tuberculosis was tested using Lowenstein Jensen medium by counting the number of M. tuberculosis colony growth in medium. Resulted inhibitory activity of zerumbone at all test concentration (0.5, 0.1, 0.05, 0.01, 0.005%) with the growth of 10, 12, 14, 15, and 50 colonies of M. tuberculosis was observed, respectively. This is indicate that zerumbone can be used as an alternative choice for treatment tuberculosis in the future.","PeriodicalId":206667,"journal":{"name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126379236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2