Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)最新文献_第9页

Aktivitas Antibakteri Ekstrak Kelopak Bunga Rosella Terenkapsulasi Maltodekstrin dan Sinergitasnya dengan Isoniazida dan Rifampisin Terhadap Mycobacterium tuberculosis H37rv 罗塞拉花瓣提取物的抗菌活性与马氏菌素和荨麻疹及结核病结核病的根瘤菌和根茎瘤

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Pub Date : 2019-10-15 DOI: 10.22487/j24428744.0.v0.i0.12946

N. J. N. Djide, M. Djide, M. Amir, Sartini Sartini

{"title":"Aktivitas Antibakteri Ekstrak Kelopak Bunga Rosella Terenkapsulasi Maltodekstrin dan Sinergitasnya dengan Isoniazida dan Rifampisin Terhadap Mycobacterium tuberculosis H37rv","authors":"N. J. N. Djide, M. Djide, M. Amir, Sartini Sartini","doi":"10.22487/j24428744.0.v0.i0.12946","DOIUrl":"https://doi.org/10.22487/j24428744.0.v0.i0.12946","url":null,"abstract":"First-line drugs (Isoniazid and Rifampicin) for the treatment of tuberculosis are known to have experienced resistance to Mycobacterium tuberculosis. The aim of this study was to determine the minimum inhibitory concentration (MIC) of maltodextrin encapsulated rosella calyx extract and its ability to provide a synergistic effect with Isoniazid (INH) and Rifampicin (RIF) on M. tuberculosis R37rv. Rosella calyxs were macerated using 50% ethanol and encapsulated using maltodextrin. Antibacterial activity was carried out by determining MIC value using Microscopic Observation and Direct Susceptibility (MODS) method. The synergistic effect was carried out by calculating the Fractional Inhibition Concentration Index (FICI). The results showed that this extract was able to inhibit M. tuberculosis H37rv with MIC of 10 mg/ ml. The FICI value of the combination of extract with INH and rifampicin was obtained 1.25. This showed that rosella calyx extract is not synergistic with INH and rifampicin, might be due to rosella calyx extract has an antibacterial effect with a different mechanism with INH and Rifampicin.","PeriodicalId":206667,"journal":{"name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115152631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Studi Fisikokimia Betasianin Dalam Kulit Buah Naga dan Aplikasinya Sebagai Pewarna Merah Alami Sediaan Farmasi 龙的果皮中beta氰化物的化学物质研究和它的天然染药制剂

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Pub Date : 2019-10-15 DOI: 10.22487/j24428744.0.v0.i0.13498

Ridho Asra, Rina Desni Yetti, R. Rusdi, Selly Audina, N. Nessa

{"title":"Studi Fisikokimia Betasianin Dalam Kulit Buah Naga dan Aplikasinya Sebagai Pewarna Merah Alami Sediaan Farmasi","authors":"Ridho Asra, Rina Desni Yetti, R. Rusdi, Selly Audina, N. Nessa","doi":"10.22487/j24428744.0.v0.i0.13498","DOIUrl":"https://doi.org/10.22487/j24428744.0.v0.i0.13498","url":null,"abstract":"The rind of dragon fruit (Hylocereus lemairel (Hook.) Britton & Rose) is a waste material that has not been optimally utilized. The rind contains betacyanin pigment that has many benefits in pharmaceutical products. The study aimed to characterize the physicochemical properties, to evaluate the stability and to apply betacyanin in dragon fruit rind as a natural dye. The extraction process was done by using water as solvent which was sonicated at 50 kHz for 30 minutes at 25 °C. Extract was freeze dried for 48 hours. The dried extract was purified by using preparative TLC and physicochemically analyzed by using UV-Vis and FTIR spectrophotometer. The stability of betacyanin extract against pH and temperature was examined and applied as a dye in tablet imprinting. The result of this study indicated that betacyanin was found at Rf value of 0.6 same as the betacyanin standard. The maximum wavelength of betacyanin was obtained at 534 nm and the IR spectra showed similarity with betacyanin standard with the same functional groups between 4000-600 cm-1 although there was a slight shift in the wavenumber but it still in the range. The stability study were stable at temperature below 40 °C and at range pH 4-6. Betacyanin applications as natural dye of tablet have been successfully carried out with good color stability during 3 months of storage at room temperature.","PeriodicalId":206667,"journal":{"name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128843189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Analisis Pektin Albedo Buah Jeruk Pamelo sebagai Adsorben Logam Berat Timbal (Pb), Kadmium (Cd) dan Tembaga (Cu)

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Pub Date : 2019-10-03 DOI: 10.22487/j24428744.0.v0.i0.12134

Masdiana Tahir, Ineks Safitri, Asriani Suhaenah

{"title":"Analisis Pektin Albedo Buah Jeruk Pamelo sebagai Adsorben Logam Berat Timbal (Pb), Kadmium (Cd) dan Tembaga (Cu)","authors":"Masdiana Tahir, Ineks Safitri, Asriani Suhaenah","doi":"10.22487/j24428744.0.v0.i0.12134","DOIUrl":"https://doi.org/10.22487/j24428744.0.v0.i0.12134","url":null,"abstract":"Pamelo citrus is a fruit plant having the potential to be developed in Indonesia. One of the centers for producing large oranges or Pamelo citrus in South Sulawesi is Pangkep Regency. One of the components of the Pamelo citrus is pectin. Pectin is a polysaccharide compound with a high molecular weight which is widely found in plants and it can absorb metals because they contain carboxylic groups. This study aimed to analyze pectin from albedo pamelo citrus fruit as an adsorbent for heavy metal plumbum (Pb), cadmium (Cd) and copper (Cu). The method used was atomic absorption spectrophotometer with the equation analysis of heavy metal adsorption by pectin of pamelo citrus determined by Langmuir and Freundlich adsorption isothermal method. The results showed that pectin of albedo pamelo citrus following the isothermal of Freundlich adsorption which showed the adsorbent capacity of Pb, Cd and Cu with the KF values 0.561 mg/g, 0.010 mg/g and 0.066 mg/g, respectively. Meanwhile, n values were 0.823 for Pb, 0.321 for Cd and 1.121 for Cu, and in commercial pectin following the isothermal of Freundlich adsorption with the KF values of Pb, Cd and Cu were 0.650 mg/g, Cd 0.015 and Cu of 0.77 mg/g, respectively. Then the n values were 0.641 for Pb, 0.811 for Cd and 1.183 for Cu.","PeriodicalId":206667,"journal":{"name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129594051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Efek Imunomodulator Ekstrak Etanol Spons Melophlus sarasinorum Terhadap Aktivitas Fagositosis Sel Makrofag Pada Mencit Jantan Balb/C 透明海绵乙醇提取物的免疫调节器对大腹滨嘴侧侧化的巨噬细胞活性的影响

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Pub Date : 2019-10-03 DOI: 10.22487/j24428744.0.v0.i0.13611

W. Wahyuni, M. Yusuf, Fadhliyah Malik, Adryan Fristiohady Lubis, Astrid Indalifiany, I. Sahidin

{"title":"Efek Imunomodulator Ekstrak Etanol Spons Melophlus sarasinorum Terhadap Aktivitas Fagositosis Sel Makrofag Pada Mencit Jantan Balb/C","authors":"W. Wahyuni, M. Yusuf, Fadhliyah Malik, Adryan Fristiohady Lubis, Astrid Indalifiany, I. Sahidin","doi":"10.22487/j24428744.0.v0.i0.13611","DOIUrl":"https://doi.org/10.22487/j24428744.0.v0.i0.13611","url":null,"abstract":"Immunomodulator is an ingredient or drug that can modulate immune system functions and activities. This study was conducted to determine the effect of ethanol extract of Melophlus sarasinorum sponge on macrophage phagocytosis activity. Twenty four male mice balb/c were divided into six groups. The first group received 100 mg/kg of ethanol extract of Melophlus Sarasinorum sponge, the second group received 200 mg/kg of ethanol extract of Melophlus sarasinorum sponge, the third group received 300 mg/kg of ethanol extract of Melophlus Sarasinorum sponge and the fourth group received 400 mg/kg of ethanol extract of Melophlus Sarasinorum sponge. The positive control group received Phyllanthus niruri linn extract (Stimuno®) 0,13 mg/g and the negative control group received NaCMC 0,5%. The extract was orally administered from first day to seventh day. On the eighth day, each of the mice was injected Staphylococcus aureus bacteria (SA) 0.5 mL intraperitoneally. Macrophage cell activity is calculated from smears of peritoneal fluid of mice. Increased doses of ethanol extract of Melophlus sarasinorum sponge increase the amount of macrophage phagocytosis activity that are 25,25% (negative control), 61,5% (positive control), 55,75% (100 mg/kg), 60,75% (200 mg/kg), 62,25% (300 mg/kg) dan 66,25% (400 mg/kg). The results showed that the ethanol extract of Melophlus sarasinorum sponge has the potential as immunomodulator at a doses of 300 mg/kgBB and 400 mg/kg with no significantly different effectiveness with positive control in increasing macrophage cell phagocytosis activity based on the result of post-hoc statistical test of Tukey (sig.> 0,05). \u0000 ","PeriodicalId":206667,"journal":{"name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127882629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Profil Penggunaan Obat Antidotum Di Rumah Sakit Umum Daerah Undata Provinsi Sulawesi Tengah Periode 2016-2018 2016-2018年至2018年期间在苏拉威西省Undata地区总医院使用抗药物的资料

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Pub Date : 2019-10-01 DOI: 10.22487/j24428744.0.v0.i0.13002

Alwiyah Mukaddas, Ingrid Faustine, Putri Hijjah Ulti

{"title":"Profil Penggunaan Obat Antidotum Di Rumah Sakit Umum Daerah Undata Provinsi Sulawesi Tengah Periode 2016-2018","authors":"Alwiyah Mukaddas, Ingrid Faustine, Putri Hijjah Ulti","doi":"10.22487/j24428744.0.v0.i0.13002","DOIUrl":"https://doi.org/10.22487/j24428744.0.v0.i0.13002","url":null,"abstract":"Antidotes drug is indicated in intoxication or poisoning patients, in addition to the antidote drugs, it can also be used as an appropriate therapeutic indication of his own medicine. The high increasing number of the antidote drug used every year in inpatient instalation Undata hospital, for exmple atropine, N-acetylcysteine and pyridoxine (vitamin B6). Therefore, this study aims to determine the percentage of drug use of antidote category indicated as an antidote therapy in Undata hospitals Central Sulawesi Province period 2016-2018. This is a descriptive study with retrospective approach and using purposive sampling techniques.The results showed that the sample size was 75 patients, with the percentage of drug use as antidotes category in Undata Hospital Central Sulawesi province period 2016-2018, namely pyridoxine (vitamin B6) of 49.33%, N-acetylcysteine drug of 42.66% and the atropine drug of 8%. The use of antidotes drug category are indicated as an antidote to the poisoning therapy drugs obtained 0%. It can be concluded that there is no antidote drug category that used as an antidote therapy on patients with drug poisoning in inpatient instalation Undata hospital Central Sulawesi Province Period 2016-2018.","PeriodicalId":206667,"journal":{"name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129277733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mutu Minyak Jelantah Dengan Adsorben Biji Salak (Salacca zalacca (Gaertn.)Voss) menggunakan Parameter Bilangan Peroksida dan Asam Lemak Bebas

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Pub Date : 2019-09-30 DOI: 10.22487/j24428744.0.v0.i0.10070

I. Ihwan, Fadlia Fadlia, S. Anam

引用次数: 2

Mikroenkapsulasi Likopen dari Buah Tomat dengan Metode Penguapan Pelarut 用溶剂蒸发方法对番茄果实进行微浸

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Pub Date : 2019-04-10 DOI: 10.22487/j24428744.2019.v5.i1.12406

Evi Sulastri, Nurlina Ibrahim, S. Budiarti

{"title":"Mikroenkapsulasi Likopen dari Buah Tomat dengan Metode Penguapan Pelarut","authors":"Evi Sulastri, Nurlina Ibrahim, S. Budiarti","doi":"10.22487/j24428744.2019.v5.i1.12406","DOIUrl":"https://doi.org/10.22487/j24428744.2019.v5.i1.12406","url":null,"abstract":"Lycopene is a carotenoid group easily damaged due to the oxidation process (light, oxygen and temperature) and isomerization during storage. This damage can be minimized by microencapsulation processes. The objective of this study was to develop novel microencapsulation of lycopene extracts from tomato fruit by solvent evaporation method using ethyl cellulose as wall materials and to select the optimum formulation. Three microcapsule formulations were prepared containing the ratio of lycopene and ethyl cellulose (L:ES) of 1:1, 1:2 and 1:3. The morphology of the microcapsules was analysed by optical microscopy and scanning electronic microscopy. The encapsulation efficiency, particle size, recovery yield and moisture content were also examined. The result showed that all microcapsule formula were aggregated and irregular in shape with encapsulation efficiency of 6.13- 19.43%, moisture content of 1,63- 7,52%, recovery yield of 81-98,12% and particle size of 46,2-86µm. Microcapsule with a ratio 1:3 (L:ES) was the most optimum formula based on a maximum encapsulation efficiency than the others","PeriodicalId":206667,"journal":{"name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124739392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uji Aktivitas Antioksidan dan Profil Fitokimia Ekstrak Kayu Beta-beta (Lunasia amara Blanco.) 抗氧化剂活性试验和可提取的植物化学提取物(Lunasia amara Blanco)。

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Pub Date : 2019-04-07 DOI: 10.22487/j24428744.2019.v5.i1.12404

Hasnaeni Hasnaeni, Aminah Aminah

引用次数: 4

Analisis Cemaran DNA Tikus pada Bakso Daging Sapi yang Beredar di Makassar dengan Metode Polymerase Chain Reaction (PCR) 分析Makassar上流传的牛肉肉丸上的小鼠DNA，其方法是多淀粉链反应(PCR)

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Pub Date : 2019-04-07 DOI: 10.22487/j24428744.2019.v5.i1.12036

Aminah Aminah, Ristieyen Ramadini, Tadjuddin Naid

引用次数: 4

Review: Metode Peningkatan Kecepatan Disolusi Dikombinasi Dengan Penambahan Surfaktan 回顾:快速解决方案的方法与添加surfatan

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Pub Date : 2019-04-02 DOI: 10.22487/j24428744.2019.v5.i1.12360

Reynelda Juliani Sagala

{"title":"Review: Metode Peningkatan Kecepatan Disolusi Dikombinasi Dengan Penambahan Surfaktan","authors":"Reynelda Juliani Sagala","doi":"10.22487/j24428744.2019.v5.i1.12360","DOIUrl":"https://doi.org/10.22487/j24428744.2019.v5.i1.12360","url":null,"abstract":"Dissolution and solubility rates are very important parameters in designing a pharmaceutical dosage form, especially for oral drug administration. Oral drugs that have low dissolution rates often require high doses loading to improve the absorption and effectiveness in order to achieve therapeutic concentration. The increasing of drug dose is a less safe alternative solution, therefore researchers have developed physics, chemistry, and other modification in order to increase dissolution rate. These methods such as salt formation, prodrug formation, particle size reduction (micro-crystallization), co-grinding, crystal modification, micellar solubilization and complex formation, solid dispersion and self emulsifying. This review paper will focus on different methods that will be compared with the present of surfactant in these methods. The present of surfactants was able to overcome the limitation of each methods with a mechanism for reducing surface tension, micellar formation, reducing contact angle and increasing of wetting behaviour. Therefore, the present of surfactant in modification of drug dosage form could be considered to increase dissolution rate in order to achieve therapeutic effect.","PeriodicalId":206667,"journal":{"name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133925039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2