Photons Plus Ultrasound: Imaging and Sensing 2019最新文献

{"title":"A light emitting diodes based photoacoustic system and its application in indocyanine green (ICG) enhanced human prostate cancer detection (Conference Presentation)","authors":"Haonan Zhang, Qian Cheng, Shengsong Huang, Yingna Chen, Zhang Mengjiao, Xie Weiya, Jingyue Pan, Guan Xu, Denglong Wu, Xueding Wang","doi":"10.1117/12.2507921","DOIUrl":"https://doi.org/10.1117/12.2507921","url":null,"abstract":"Transrectal ultrasound (TRUS) guided biopsy is the standard procedure for evaluating the presence of prostate cancer. TRUS, however, has limited sensitivity to prostate tumors, nor can it differentiate aggressive cancer from non-aggressive ones. The emerging photoacoustic (PA) imaging combined with TRUS offers a great promise to solve this overarching issue, especially when powered by tumor-targeting contrast agent. In this work, we studied the feasibility of PA imaging to cover the entire prostate by using light illumination via the urethral track. Experiment was conducted on whole human prostates ex vivo. The light source was an array of light emitting diodes (LED) which has many advantages compared to solid state laser. The LED array was placed in the urethra, delivering light with fluence within the ANSI safety limit. A PA and ultrasound (US) dual modality system acquired the images in the same way as in TRUS. The imaging target was a 1-mm tube filled with ICG solution, mimicking the situation of a prostate tumor labeled with ICG contrast agent. The imaging results demonstrated that PA imaging can detect the ICG-filled tube at any place in the prostate, with an imaging depth over 20 mm. This study validated that PA imaging, when performed in a transrectal manner and combined with transurethral light illumination, is capable of molecular level imaging of the entire prostate noninvasively. The high sensitivity offered by PA imaging in detecting aggressive prostate cancer may contribute to prostate cancer management, e.g., enabling more accurate guidance for needle biopsy.","PeriodicalId":206495,"journal":{"name":"Photons Plus Ultrasound: Imaging and Sensing 2019","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126451944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LED based photoacoustic imaging with enhanced sensitivity for human inflammatory arthritis (Conference Presentation)","authors":"Janggun Jo, Guan Xu, Yunhao Zhu, G. Gandikota, E. Schiopu, Xueding Wang","doi":"10.1117/12.2509799","DOIUrl":"https://doi.org/10.1117/12.2509799","url":null,"abstract":"Our previous research has demonstrated that photoacoustic (PA) imaging is capable of evaluating the pathological condition in human peripheral joints affected by inflammatory arthritis. In this work, we tested the performance of a PA imaging system based on the LED light source and its performance for arthritis imaging. The LED-based PA imaging system not only has less cost but also has smaller footprint and, hence, is more portable and convenient for use in rheumatology clinic. 2D B-scan PA and US images of each metacarpophalangeal (MCP) joint were acquired along the sagittal sections. Along the same sections, US Doppler images were also acquired. Images from 12 joints with clinically active arthritis (i.e., positive on Doppler US), 5 joints with subclinically active arthritis (i.e., negative on Doppler US), and 12 joints of normal volunteers were compared. The blood volume in each joint reflecting hyperemia was quantified by counting the density of the color pixels in each pseudo-color PA image. T-tests were conducted to evaluate whether PA imaging can differentiate the three groups. The results from this study suggest that LED-based PA imaging is capable of detecting hyperemia as an important biomarker of joint inflammation. In addition, PA imaging could differentiate the subclinically active arthritis group and the normal group while Doppler US could not, suggesting that PA imaging has higher sensitivity to mildly hyperemia when compared to Doppler US. The imaging technique presented may contribute to rheumatology clinic by providing a new tool for early diagnosis and treatment evaluation of joint inflammation.","PeriodicalId":206495,"journal":{"name":"Photons Plus Ultrasound: Imaging and Sensing 2019","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128270805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-time swept-beam compact photoacoustic/ultrasound imaging system (Conference Presentation)","authors":"Geng-Shi Jeng, S. Yoon, I. Pelivanov, Meng-Lin Li, Liang Gao, David S. Li, M. O’Donnell","doi":"10.1117/12.2509330","DOIUrl":"https://doi.org/10.1117/12.2509330","url":null,"abstract":"Photoacoustic (PA) imaging has had limited clinical applicability for many reasons but one primary barrier to clinical translation is the bulky, expensive, and low repetition-rate laser typically used, resulting in low frame-rate images and a system with a large physical footprint. We have previously demonstrated a fast-scan approach delivering the frame rates required for real-time integrated PA/ultrasound (PAUS) imaging. In this paper, we present a new real-time PAUS system based on a swept-scanning source approach using a compact, recently-developed laser, providing pulse-to-pulse wavelength tuning at kHz rates and a scanning fiber-optic delivery system integrated with a high-frequency (15 MHz) US linear array. An array of fibers spanning the array are arranged on two lateral sides of the transducer and scanned sequentially based on optimized pulse sequences. By coherent compounding of multiple sub-images associated with each fiber light source, PA imaging with sufficient SNR at a frame rate of 50 Hz is achieved. Real-time in vivo multi-spectral imaging of nano-drug delivery to mice is demonstrated. With the same scanner footprint, our compact PAUS system can provide not only conventional high-quality scanned US imaging with all associated modes, but interleaved, multispectral PA imaging at video rates appropriate for real-time clinical applications.","PeriodicalId":206495,"journal":{"name":"Photons Plus Ultrasound: Imaging and Sensing 2019","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131012250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International Photoacoustic Standardisation Consortium (IPASC): recommendations for standardized data exchange in photoacoustic imaging (Conference Presentation)","authors":"J. Gröhl","doi":"10.1117/12.2508317","DOIUrl":"https://doi.org/10.1117/12.2508317","url":null,"abstract":"","PeriodicalId":206495,"journal":{"name":"Photons Plus Ultrasound: Imaging and Sensing 2019","volume":"266 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132780717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual mode photoacoustic and ultrasound imaging system based on a Fabry-Perot scanner (Conference Presentation)","authors":"Khoa Pham, S. Noimark, N. Huynh, E. Zhang, Adrien Desjardins, B. Cox, P. Beard","doi":"10.1117/12.2506922","DOIUrl":"https://doi.org/10.1117/12.2506922","url":null,"abstract":"Compared to piezoelectric based photoacoustic (PA) scanners, the planar Fabry-Perot (FP) scanner has several advantages. It can provide small element size with high sensitivity, a smooth broadband frequency response, and is transparent to excitation light. This enables the FP scanner to provide excellent high-resolution in vivo PA images of soft tissue to depths up to approximately 10 mm. However, unlike piezoelectric scanners, the FP scanner in its current form cannot provide a pulse-echo ultrasound (US) as well as a PA image, which is useful because of the additional tissue contrast it provides. To address this, a dual mode FP scanner-based system that, for the first time, can acquire co-registered 3D PA and US images has been developed.\u0000\u0000In order to provide an optical US generation capability, the FP ultrasound sensor was coated with a novel Gold-Nanoparticle-PDMS composite which was excited with nanosecond laser pulses to generate plane wave US pulses. By modifying the FP sensor in this way, it now acts as an US transmitter as well as a receiver. The coating is highly absorbing at the US generation wavelength (>95%) but transparent at the PA excitation wavelength, the latter to allow the system to also operate in PA imaging mode as before. The generated US pulses exhibited peak pressures in the MPa range, which is comparable to the output of conventional piezoelectric based medical US scanners. The pulses had a broad bandwidth (>40 MHz) and the emitted wavefront was planar to within λ/10 at 10 MHz. PA and pulse-echo US signals were mapped in turn by the FP scanner over centimetre scale areas with a step size of 100 μm and an element size of 64 μm. The -3dB bandwidth of the FP sensor was 30 MHz. Reconstruction methods using a k-space formulation recovered co-registered 3D PA and US images. The system’s lateral spatial resolution was evaluated by imaging a line target at depths up to 10 mm and ranged between 50 and 120 μm for both modes.\u0000\u0000Arbitrarily shaped 3D objects were imaged to demonstrate the volumetric US imaging capability of the scanner. Tissue mimicking phantoms, with impedance mismatches representative of soft tissues, and ex vivo tissue samples were imaged with the system as well as a conventional clinical US scanner for comparison. Finally, the system obtained promising high-resolution 3D dual mode PA-US images for a variety of phantoms with contrast based on both optical absorption and acoustic impedance. This novel all-optical system has the potential to add complementary morphological contrast to photoacoustic vascular images which could aid the clinical assessment of superficial tumours, lymph node disease and other conditions.","PeriodicalId":206495,"journal":{"name":"Photons Plus Ultrasound: Imaging and Sensing 2019","volume":"732 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123855909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depth-resolved biomedical optoacoustic imaging: from early works of 1990s to the latest advances (Conference Presentation)","authors":"A. Oraevsky","doi":"10.1117/12.2516335","DOIUrl":"https://doi.org/10.1117/12.2516335","url":null,"abstract":"","PeriodicalId":206495,"journal":{"name":"Photons Plus Ultrasound: Imaging and Sensing 2019","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122335852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo characterization of cervical remodeling throughout gestation using photoacoustic near-infrared spectra (Conference Presentation)","authors":"Y. Qu","doi":"10.1117/12.2514591","DOIUrl":"https://doi.org/10.1117/12.2514591","url":null,"abstract":"Premature cervical remodeling is an indicator of impending spontaneous preterm birth, however, current clinical measurements of cervical remodeling are mainly obtained by digital examinations, which are subjective and detect only late events, such as cervical effacement and dilation. The incompletely understood mechanisms of cervical remodeling lead to degradation of extracellular matrix proteins and inflammation, and these physiological changes are associated with increased tissue hydration. Near-infrared spectroscopy is routinely used in industrial applications to quantify the water content in various products, because this method does not require sample preparation and is nondestructive. Spectroscopic photoacoustic tomography is an embodiment of near-infrared spectroscopy and has been demonstrated in the quantification of various biochemical constituents. However, the dimensions of those tabletop systems in the previous demonstrations preclude in vivo use in the gastrointestinal tract and urogenital tract. Photoacoustic endoscopy (PAE) incorporates an acoustic detector, optical components, and electronic components in a millimeter-diameter-scale probe to image tissue that is inaccessible by the tabletop systems. Here, we present a near-infrared spectroscopic PAE system. We analyze the measured photoacoustic near-infrared (PANIR) spectra by linear regression. We demonstrate that this method successfully quantifies the water contents of tissue-mimicking phantoms made of gelatin hydrogel. Applying this method to the cervices of pregnant women, we observe their physiological water contents and a progressive increase throughout gestation. The application of this technique in maternal health care may advance our understanding of cervical remodeling and provide a sensitive method for predicting preterm birth.","PeriodicalId":206495,"journal":{"name":"Photons Plus Ultrasound: Imaging and Sensing 2019","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123659618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-wavelength high-speed functional photoacoustic microscopy of mouse brain with a Raman laser at 1-MHz A-line rate (Conference Presentation)","authors":"Yun He, Yun He, Junhui Shi, K. Maslov, Lihong V. Wang","doi":"10.1117/12.2510658","DOIUrl":"https://doi.org/10.1117/12.2510658","url":null,"abstract":"Label-free functional photoacoustic microscopy (fPAM) has become a popular technology in small-animal hemodynamic studies. Here we report a stimulated-Raman-scattering-based (SRS) dual-wavelength high-speed fPAM that has achieved volumetric imaging at a 1 MHz A-line rate with capillary-level resolution. Potassium gadolinium tungstate (KGd(WO4)2) crystal is used as a Raman shifter to convert the pump 532 nm picosecond-pulsed laser to the first order Stokes line at 558 nm through the SRS effect with ~40% efficiency and a much narrower line width compared with previous fiber-based SRS PAMs. We also developed a water-immersible micro-electro-mechanical system scanner for scanning a ~4-mm range at a 500 Hz B-scan rate, while maintaining the optic-acoustic confocal alignment. This scanner is assembled entirely from commercially available components, facilitating replication. The detection sensitivity of our fPAM is also improved by employing a high numerical aperture polyvinylidene fluoride ultrasonic transducer, whose acoustic impedance matches better with tissue coupling medium than traditional ceramic transducers. The high sensitivity combined with ~2.4 µm resolution enabled our fPAM to image single red blood cells with a signal-to-noise ratio of ~27 dB. Compared with our previous laser-pulse-width based fPAM, we achieved simultaneous imaging of hemoglobin concentration and oxygenation with a 5-fold increase in imaging speed. Moreover, our system works in a convenient free-space manner compared to previous SRS-based PAMs. We applied it to imaging vasculature and blood oxygen saturation on mouse brains in both resting and stimulated states.","PeriodicalId":206495,"journal":{"name":"Photons Plus Ultrasound: Imaging and Sensing 2019","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125920874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}