Photons Plus Ultrasound: Imaging and Sensing 2019最新文献

Ultrasonically sculpted tunable relay lenses for imaging and photo manipulation through turbid media (Conference Presentation) (Withdrawal Notice) 用于混浊介质成像和照片处理的超声雕刻可调转接镜头(会议报告)(退出通知)

Photons Plus Ultrasound: Imaging and Sensing 2019 Pub Date : 2019-07-19 DOI: 10.1117/12.2510480

M. Scopelliti, Daniele Busacchio, M. Chamanzar, Yasin Karimi

引用次数: 0

Front Matter: Volume 10878 封面:卷10878

Photons Plus Ultrasound: Imaging and Sensing 2019 Pub Date : 2019-04-19 DOI: 10.1117/12.2523398

引用次数: 0

Ten years of k-Wave: a review of the past and a roadmap for the future (Conference Presentation) k-Wave的十年:过去的回顾和未来的路线图(会议报告)

Photons Plus Ultrasound: Imaging and Sensing 2019 Pub Date : 2019-03-13 DOI: 10.1117/12.2507824

B. Treeby, J. Jaros, Filip Vaverka, J. Budisky, Marta Cudova, Kristian Kadlubiak, Petr Kleparnik, Filip Kuklis, Elliott S. Wise, P. Georgiou, E. Martin, James Robertson, F. Lucka, B. Cox

{"title":"Ten years of k-Wave: a review of the past and a roadmap for the future (Conference Presentation)","authors":"B. Treeby, J. Jaros, Filip Vaverka, J. Budisky, Marta Cudova, Kristian Kadlubiak, Petr Kleparnik, Filip Kuklis, Elliott S. Wise, P. Georgiou, E. Martin, James Robertson, F. Lucka, B. Cox","doi":"10.1117/12.2507824","DOIUrl":"https://doi.org/10.1117/12.2507824","url":null,"abstract":"k-Wave is an open-source MATLAB toolbox designed for the time-domain simulation of propagating acoustic waves in 1D, 2D, or 3D. The first release was in 2009, and focused on the simulation of photoacoustic initial value problems and the reconstruction of photoacoustic images from simulated or experimental data. In the ten years since, there have been eight major releases, extending both the functionality and the computational performance of the toolbox. There are now more than 10,000 registered users worldwide, and the toolbox has become the defacto standard for simulation studies in photoacoustic imaging. The development team responsible for k-Wave has also grown, with expertise now spanning physics, mathematics, inverse problems, numerical methods, software engineering, and high-performance computing. In this presentation, the major theoretical, algorithmic, and computational developments of k-Wave will be described, along with the underlying design inputs and decisions that led to these developments. A roadmap for the future development of k-Wave will also be presented. This includes new transducer classes, stair-case free sources, native support for multiple GPUs, adaptive grid refinement using moving mesh methods, gradient-based iterative photoacoustic image reconstruction, performance and accuracy improvements for the elastic wave models, and automatic job-submission to run k-Wave simulations remotely using HPC-as-a-service.","PeriodicalId":206495,"journal":{"name":"Photons Plus Ultrasound: Imaging and Sensing 2019","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126695146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-resolution high-contrast mid-infrared imaging of fresh biological samples with ultraviolet-localized photoacoustic microscopy (Conference Presentation) 利用紫外定位光声显微镜对新鲜生物样品进行高分辨率、高对比度中红外成像(会议报告)

Photons Plus Ultrasound: Imaging and Sensing 2019 Pub Date : 2019-03-04 DOI: 10.1117/12.2515616

Junhui Shi, T. T. Wong, Yun He, Lei Li, Ruiying Zhang, Jeeseong Hwang, K. Maslov, Lihong V. Wang

{"title":"High-resolution high-contrast mid-infrared imaging of fresh biological samples with ultraviolet-localized photoacoustic microscopy (Conference Presentation)","authors":"Junhui Shi, T. T. Wong, Yun He, Lei Li, Ruiying Zhang, Jeeseong Hwang, K. Maslov, Lihong V. Wang","doi":"10.1117/12.2515616","DOIUrl":"https://doi.org/10.1117/12.2515616","url":null,"abstract":"Label-free mid-infrared (MIR) imaging provides rich chemical and structural information of biological tissues without staining. Conventionally, the long MIR wavelength severely limits the lateral resolution owing to optical diffraction; moreover, the strong MIR absorption of water ubiquitous in fresh biological samples results in high background and low contrast. Here, we present a novel approach, called ultraviolet-localized MIR photoacoustic microscopy (ULM-PAM), to achieve high-resolution and water-background–free MIR imaging of fresh biological samples. In our approach, a pulsed MIR laser thermally excites the sample at the focal spot, and a pulsed ultraviolet (UV) laser photoacoustically detects the resulting transient temperature rise owing to the Gruneisen relaxation effect, thereby reporting the intensity of the MIR absorption by the sample. The imaging resolution of our method is determined by the wavelength of the UV laser, which is one order of magnitude shorter than that of the mid-IR laser (2.5 μm to 12 μm). In addition, in the UV region from 200 nm to 230 nm, most important organic molecules in biological tissues, including proteins, lipids and nuclei acids, have strong absorption, while water is transparent. Therefore, our method can achieve high resolution and water-background free IR imaging of fresh biological samples. For cell cultures, our method achieved high-resolution and high-contrast infrared imaging of lipids, proteins. The capability of label-free histology of this method is also demonstrated in thick biological tissues, such as brain slices. Our approach provides convenient high-resolution and high-contrast MIR imaging, which can benefit diagnosis of fresh biological samples.","PeriodicalId":206495,"journal":{"name":"Photons Plus Ultrasound: Imaging and Sensing 2019","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115130371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Fast label-free photoacoustic-histology (Conference Presentation) 快速无标签光声组织学(会议报告)

Photons Plus Ultrasound: Imaging and Sensing 2019 Pub Date : 2019-03-04 DOI: 10.1117/12.2507837

J. Baik, Jin-Young Kim, Hyojin Kim, Hyosang Ahn, Kyunghee Byun, H. Choi, S. Ryu, Chulhong Kim

{"title":"Fast label-free photoacoustic-histology (Conference Presentation)","authors":"J. Baik, Jin-Young Kim, Hyojin Kim, Hyosang Ahn, Kyunghee Byun, H. Choi, S. Ryu, Chulhong Kim","doi":"10.1117/12.2507837","DOIUrl":"https://doi.org/10.1117/12.2507837","url":null,"abstract":"A Frozen section examination is the conventional intraoperative histology method widely used in cancer surgery for tumor margin assessment. However, this method is necessary to perform complicated process including sectioning and staining, which require approximately 15 minutes. Particularly with the ultraviolet (UV) laser (266 nm), photoacoustic microscopy (PAM) showed the capability to visualize cell nuclei without the time consuming procedures by utilizing superior optical contrast of DNA/RNA at this wavelength, which can be a potential alternative of the frozen section. However, previously developed UV-PAM is limited to be applied in intraoperative scenarios because it has suffered from slow imaging speed because of 2D mechanical scanning with linear stepper motors. To overcome this limitation, we developed a fast UV-PAM system based on a 2-axis waterproof microelectromechanical systems (MEMS) scanner with the specially fabricated optical components for UV light. This MEMS scanner enables to scan 3 × 3 mm2 range and acquire 400 × 400 pixels image within 20 seconds. The measured spatial and axial resolutions of the developed system are 2.2 and 39 μm, respectively. Finally, we acquired the histology-like PA image of the mouse kidney with characteristic tubular structures of kidney epithelial cells. In the mouse brain, distinct microstructures such as hippocampus and dentate gyrus were differentiated with the validation of frozen section sample.","PeriodicalId":206495,"journal":{"name":"Photons Plus Ultrasound: Imaging and Sensing 2019","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123561198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hybrid modality photoacoustic/fluorescence microscopy through a multimodefiber using speckle illumination (Conference Presentation) 使用散斑照明的多模光纤混合光声/荧光显微镜(会议报告)

Photons Plus Ultrasound: Imaging and Sensing 2019 Pub Date : 2019-03-04 DOI: 10.1117/12.2508865

Antonio Miguel M. Caravaca Aguirre, Sakshi Singh, R. Piestun, E. Bossy

{"title":"Hybrid modality photoacoustic/fluorescence microscopy through a multimode\u0000fiber using speckle illumination\u0000 (Conference Presentation)","authors":"Antonio Miguel M. Caravaca Aguirre, Sakshi Singh, R. Piestun, E. Bossy","doi":"10.1117/12.2508865","DOIUrl":"https://doi.org/10.1117/12.2508865","url":null,"abstract":"We present an ultra-thin endoscope that combines a multimode optical fiber (MMF) attached to\u0000an optical hydrophone for simultaneous optical-resolution photoacoustic microscopy and fluorescence\u0000imaging. The MMF is used for light delivery and fluorescence collection and the hydrophone\u0000for acoustic detection; a digital micro-mirror device (DMD) modulates the amplitude of the optical\u0000wavefront of a pulsed laser coupled into the MMF, controlling the illumination at the distal tip.\u0000The DMD allows for fast calibration approaches to reach calibration and measurement times of a\u0000few seconds.\u0000We obtain optical-diffraction-limited images with full field illumination recording the intensity\u0000of a series of various calibrated speckle patterns produced by different configurations of the DMD\u0000at the input, with no wavefront shaping. The intensity fluctuations from speckle pattern to speckle\u0000pattern encodes for the position at which the signal is emitted. The fluorescence signal from the sample is\u0000collected with the MMF and detected with a PMT at the proximal side. For the acoustic detection,\u0000embedding the ultrasound detection within the device avoids the absorption of high-frequency ultrasound\u0000by the tissue and therefore removes any limitation on the insertion depth. The footprint of\u0000the probe is 250 um x 125 um making it thinner than common GRIN lenses used for endoscopy. \u0000To best of our knowledge, our approach provides the thinnest endoscope head capable\u0000of obtaining optical-resolution photoacoustic and fluorescence images simultaneously.","PeriodicalId":206495,"journal":{"name":"Photons Plus Ultrasound: Imaging and Sensing 2019","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125332564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transvaginal fast-scanning optical-resolution photoacoustic endoscopy imaging of cervical vascular morphology (Conference Presentation) 经阴道快速扫描光学分辨率光声内窥镜成像颈部血管形态(会议报告)

Photons Plus Ultrasound: Imaging and Sensing 2019 Pub Date : 2019-03-04 DOI: 10.1117/12.2513386

Y. Qu

{"title":"Transvaginal fast-scanning optical-resolution photoacoustic endoscopy imaging of cervical vascular morphology (Conference Presentation)","authors":"Y. Qu","doi":"10.1117/12.2513386","DOIUrl":"https://doi.org/10.1117/12.2513386","url":null,"abstract":"Vasculatures enable nutrient transportation, waste disposal, and immune surveillance. Due to these diverse functions, abnormal changes in vascular morphology are commonly associated with the development of various diseases, including tumor growth and metastasis, inflammatory disorders, and pulmonary hypertension. Many models linking vascular morphogenesis to the development of a particular disease have been developed for prognosis, diagnosis, or disease management. To apply these models in clinical assessment, however, a tissue biopsy of the lesion is needed. This procedure is invasive and occasionally clinically infeasible. Photoacoustic endoscopy offers in vivo label-free examination of visceral vascular morphology, but its volumetric imaging process is vulnerable to breathing movement and peristalsis, because its typical B-scan rate is ~ 10 Hz, restricted by the speed of the scanning unit and the laser pulse repetition rate. Here, we present a transvaginal fast-scanning optical-resolution photoacoustic endoscope with a 250 Hz B-scan rate over a 3 mm scanning range. After demonstrating its imaging capability and safety, we not only illustrate the morphological differences in the vasculatures of the human ectocervix, uterine body, and sublingual mucosa, but also show the longitudinal and cross-sectional differences in the cervical vasculatures of pregnant women. This technology is promising for screening the visceral pathological changes associated with angiogenesis.","PeriodicalId":206495,"journal":{"name":"Photons Plus Ultrasound: Imaging and Sensing 2019","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122905167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photoacoustic imaging of RF ablation lesion formation in an ex-vivo passive beating porcine heart model (Conference Presentation) 离体被动跳动猪心脏模型射频消融病变形成的光声成像(会议报告)

Photons Plus Ultrasound: Imaging and Sensing 2019 Pub Date : 2019-03-04 DOI: 10.1117/12.2506871

S. Iskander-Rizk, P. Kruizinga, R. Beurskens, Geert Springeling, P. Knops, F. Mastik, N. Groot, A. Steen, G. Soest

{"title":"Photoacoustic imaging of RF ablation lesion formation in an ex-vivo passive beating porcine heart model (Conference Presentation)","authors":"S. Iskander-Rizk, P. Kruizinga, R. Beurskens, Geert Springeling, P. Knops, F. Mastik, N. Groot, A. Steen, G. Soest","doi":"10.1117/12.2506871","DOIUrl":"https://doi.org/10.1117/12.2506871","url":null,"abstract":"During RF ablation for atrial fibrillation, undesired tissue conductivity is interrupted by inducing lesions through applying RF current. Feedback on lesions formed is currently indirect, leading to unpredictable outcomes for patients. Previously we have shown that two-wavelengths photoacoustic imaging can distinguish between scarred and healthy tissue (Iskander-Rizk et al. BOE 2018). This principle may be translated to clinical imaging by integrating an optical fiber in the ablation catheter to generate photoacoustic signals of lesions using commonly present intracardiac echo (ICE) probe as a receiver. \u0000We modified a commercially available ablation catheter to fit a 400µm, 0.39 NA multi-mode optical fiber through the flushing channel. In a porcine passive beating heart model (Lifetec, Eindhoven), we inserted the modified ablation catheter and a St Jude ViewFlex ICE probe through the jointly tied pulmonary vein into the left atrium. We ablated around the mitral valve, and we used a 100Hz laser source (Innolas Spitlight EVO-OPO) constantly toggling between 790 and 930 nm to generate photoacoustic signals at the ablation site. The signals were digitized and processed with a Verasonics vantage 256 system. One acquisition frame consisted of 5 tilted diverging wave ultrasound acquisitions and 1 photoacoustic acquisitions per wavelength. \u0000We monitored lesion progression and continuity in a beating heart addressing motion artefacts concerns. In addition to that, the dual wavelength photoacoustic images successfully eliminate undesirable signals from the catheter tip, blood and healthy tissue, leaving only signals from lesions, enabling real-time intracardiac ablation monitoring that is readily translatable to an in vivo setting.","PeriodicalId":206495,"journal":{"name":"Photons Plus Ultrasound: Imaging and Sensing 2019","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129451853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Quantitative inversion of 3D multiwavelength photoacoustic images using an adjoint radiance Monte Carlo model (Conference Presentation) 基于伴随辐射蒙特卡罗模型的三维多波长光声图像定量反演(会议报告)

Photons Plus Ultrasound: Imaging and Sensing 2019 Pub Date : 2019-03-04 DOI: 10.1117/12.2509797

J. Buchmann, B. Kaplan, S. Powell, S. Prohaska, J. Laufer

{"title":"Quantitative inversion of 3D multiwavelength photoacoustic images using an adjoint radiance Monte Carlo model (Conference Presentation)","authors":"J. Buchmann, B. Kaplan, S. Powell, S. Prohaska, J. Laufer","doi":"10.1117/12.2509797","DOIUrl":"https://doi.org/10.1117/12.2509797","url":null,"abstract":"Quantitative photoacoustic (PA) tomography aims to recover absolute chromophore concentrations from multiwavelength PA images. Challenges include the accurate prediction of the fluence, the accuracy of the initial pressure distribution reconstructed from measured data, and the large scale of the inverse problem involving high resolution 3D images. In this study, a radiance Monte-Carlo (RMC) light model was used to predict the fluence inside tissue phantoms. Gradients of the scattering coefficient and the chromophore concentrations were calculated using the adjoint formalism. The gradient descent efficiency was significantly improved by using adaptive moment estimation. 3D maps of chromophore concentrations and the scattering coefficient were recovered from measured PA images. The inversion scheme was validated on measured images of a tissue phantom consisting of a scattering liquid and chromophore-filled polymer tubes immersed at different depths. The images were acquired at visible and near-infrared wavelengths using a Fabry-Perot scanner with a planar detection geometry. Amplitude mismatches in the reconstructed initial pressure images due to limited view detection were corrected using an ad hoc correction method. The inversion was stabilized by introducing a calibrated absorber in the imaged volume, or an absolute calibration of the setup. 3D maps of absolute chromophore concentrations, their ratios, and the global scattering coefficient were accurately recovered. The recovery of chromophore concentrations in the image background where SNR is low was identified as a significant new challenge for quantitative PA imaging.","PeriodicalId":206495,"journal":{"name":"Photons Plus Ultrasound: Imaging and Sensing 2019","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126709860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plane wave and synthetic transmit aperture echography using laser-induced ultrasound (Conference Presentation) 激光诱导超声的平面波和合成透射孔径超声(会议报告)

Photons Plus Ultrasound: Imaging and Sensing 2019 Pub Date : 2019-03-04 DOI: 10.1117/12.2509690

D. Thompson, L. Demi, E. Kruit, D. Gasteau, Marieke Olsman, S. Manohar

{"title":"Plane wave and synthetic transmit aperture echography using laser-induced ultrasound (Conference Presentation)","authors":"D. Thompson, L. Demi, E. Kruit, D. Gasteau, Marieke Olsman, S. Manohar","doi":"10.1117/12.2509690","DOIUrl":"https://doi.org/10.1117/12.2509690","url":null,"abstract":"We present laser-induced ultrasound (LIUS) imaging, using a conventional linear ultrasound probe as a receiver. The LIUS source consists of a 40 μm thick film of Carbon Black-doped PDMS. Illumination of this LIUS transmitter with a 10 ns pulsed Nd:YAG laser with a 10 Hz repetition rate leads to the generation of a short, unipolar ultrasound pulse as a consequence of the photoacoustic effect. Two synthetically focused imaging techniques will be presented: coherently compounded multi-angled plane wave imaging (PWI) and synthetic transmit aperture imaging (SAI) . In the PWI case a planar LIUS transmitter, matched in size to the conventional probe aperture, is used. In the SAI case, the same film is illuminated sequentially at different locations along the aperture by an array of multimode optical fibres. For both PWI and SAI a comparison between conventionally acquired and LIUS images is made, as well as a cross-comparison between PWI and SAI. Images of wire phantoms, speckle analysis and finally images of tissue-mimicking phantoms demonstrate the image quality and advantages offered by LIUS sources. Aside from generating shorter pulses for enhanced resolution, the continuous nature of the absorber and the illumination spot provides a cleaner, more homogeneous plane wave field. The outlook for these unconventional US sources and their relative advantages and disadvantages are discussed.","PeriodicalId":206495,"journal":{"name":"Photons Plus Ultrasound: Imaging and Sensing 2019","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129213796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0