Buletin Farmatera最新文献

{"title":"SUDDEN DEATH DUE TO RESPIRATORY TRACT DISEASES","authors":"Abdul Gafar Parinduri","doi":"10.30596/BF.V4I2.2674","DOIUrl":"https://doi.org/10.30596/BF.V4I2.2674","url":null,"abstract":"Sudden death is death that occured within 24 hours since of the onset symptoms. Forensic cases, most occur within minutes or even the first seconds of appearance. Sudden death causes can be applied according to the body system, there are central nervous, respiratory, gastrointestinal, haemopoietic, and the endocrine system. Sudden death from respiratory illness is one of the causes of sudden and natural deaths worldwide. Incidence of sudden death in developing countries has a higher frequency. One of the respiratory ailments that causes sudden death is tuberculosis. Case report:a 35 year-old female has been carried out outside examination and in (autopsy) on the corpse. Autopsy was found that lung attachment with chest cavity. Right and left lung was full of foam mixed with pus. This verification supports that the cause of sudden death was due to chonic lung disease. Keywords: Corpse autopsy, pulmonary tuberculosis, sudden death, respiratory disease","PeriodicalId":206231,"journal":{"name":"Buletin Farmatera","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129698652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MODULATION OF BONE TISSUE HISTOMORPHOMETRY AND MALONDIALDEHYDE EXPRESSION LEVELS BY VITAMIN C IN RODENTS AFTER PRENATAL NOISE EXPOSURE","authors":"Taya Elsa Savista, V. Kalanjati, A. Abdurachman","doi":"10.30596/BF.V4I2.2571","DOIUrl":"https://doi.org/10.30596/BF.V4I2.2571","url":null,"abstract":"Abstract: Vitamin C is proposed as an antioxidant to combat the oxidative stress of prenatal noise exposure in bone tissue of newborn Wistar rats. Thirty-two Wistar mothers were administered oral vitamin C 150 mg/kg BW/day from D1 of pregnancy until delivery; white noise exposure of 95 dB, 4 hr/day was given from D15 of pregnancy until delivery. Newborn rats were divided into 4 groups equally (n=24): K1 (distilled water), K2 (vitamin C), P1 (distilled water + WN), P2 (vitamin C + WN). The osteoblast and osteoclast mean cell numbers, the osteoid volume, and an oxidative stress expression level marker of malondialdehyde (MDA) were calculated from two adjacent longitudinal slices of newborn rats’ tibiae using Cell Sense and ImageJ softwares (4 μ; 400x of light microscope magnification). Data were analyze using either ANOVA and LSD post-test or Brown-Forsythe and Games Howell post- test; significance level if p<0.05. In P2, the mean number of the osteoblast was significantly higher than in P1 (p<0.001); whilst the osteoclast mean number was significantly lower compared to other groups (p=0.03). In P2, the osteoid volume was significantly higher than in P1 (p=0.021); with lower MDA levels than P1 (p=0.074). From this study, vitamin C could protect the newborn rat bones exposed by prenatal noise as an oxidative stressor. Keywords: vitamin C, prenatal noise, osteogenesis, malondialdehyde","PeriodicalId":206231,"journal":{"name":"Buletin Farmatera","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126800272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFECTS OF METHANOL EXTRACT AND N-HEXANE EXTRACT OF PAPAYA LEAVES (CARICA PAPAYA L) ON TOTAL AND DIFFERENTIAL WHITE BLOOD CELL COUNTS IN MALE WISTAR RATS AFTER CARRAGEENAN INDUCTION","authors":"Okto P.E. Marpaung, Datten Bangun, S. Ilyas","doi":"10.30596/BF.V4I2.3016","DOIUrl":"https://doi.org/10.30596/BF.V4I2.3016","url":null,"abstract":"As one of the countries producing medicinal plants, Indonesia has the potential to develop medicinal plants in the future. The anti-inflammatory effects of methanol and n-hexane extract from papaya leaves were seen in this study using a pretest-posttest control group design using 36 male adult Wistar rats divided into 6 groups. All rats received 1 week acclimatization, then blood specimens were taken from the tail, after which they were treated, and intraplantar injections were carried out with 1% carrageenan solution as much as 0.1 ml. Then retrieval of blood specimens from rats' tails at 3 hours and 6 hours afterwards. Then an examination of the number and type of leukocytes was performed on all blood specimens obtained. It was found that the number of male Wistar rat leukocytes after getting methanol extract of papaya leaves was lower but not significant (p> 0.05) compared to those who did not. The increase in the number of leukocytes cannot be restrained significantly by the administration of n-hexane extract. It was found that changes in leukocyte counts in acute inflammatory conditions with the administration of methanol extract and n-hexane extract of Papaya Leaves. The increase number of neutrophils and monocytes in acute inflammatory conditions can be significantly suppressed by the administration of methanol extract of papaya leaves. Key words: inflammation, carrageenan, papaya, Carica papaya l","PeriodicalId":206231,"journal":{"name":"Buletin Farmatera","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129931682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VITAMIN C PREVENTS STRESS INDUCED CARDIOMYOPATHY IN PRENATAL NOISE EXPOSED RODENTS","authors":"Winnie Nirmala Santosa, Viskasari P. Kalajanti, Ni Wajan Tirthaningsih","doi":"10.30596/BF.V4I2.2597","DOIUrl":"https://doi.org/10.30596/BF.V4I2.2597","url":null,"abstract":"Potency of oral vitamin C to prevent cardiomyopathy in prenatal noise exposed newborn Wistar rats was studied by comparing the cardiomyocyte numbers and the extracellular matrix expressions (ECM) to controls. Twenty-four newborns (NR) of 32 pregnant mothers were divided equally into 4 groups: K1 (distilled water [DW]), K2 (150 mg/kg of BW oral vitamin C once daily [VC]), P1 (4 hours daily of white noise at 95 dB [WN]+DW), and P2 (WN+VC). VC and WN were given from D1 till birth and from D15 till birth, respectively. The hearts of NR were harvested, and processed for histology slides (2 midsagittal 4 μ cut slides/ animal) stained with hematoxyllin-eosin and Masson trichrome for the cardiomyocytes and ECM quantification at the ventricles using Image Raster 3.0 and ImageJ, respectively. Pictures from 8 visual fields/ slide were taken and analyzed in duplicate (400x magnifications under a light microscope). Data were analyzed using SPSS 17; significance level of p<0.05. In P1, the cardiomyocite cell numbers was significantly lowest (p<0.001); whilst the ECM was significantly highest than K1, K2, P2 (p<0.001 and p<0.005, respectively). Here, vitamin C could prevent the adverse effect of prenatal noise exposures in the ventricle myocardium of newborn rats. Keywords: cardiomyopathy, hypertrophy, prenatal noise, vitamin C","PeriodicalId":206231,"journal":{"name":"Buletin Farmatera","volume":"2016 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127510434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymorphism TaqIA Gen Dopamine D2 Receptor In Men Aged Start From 40 Years Old With Metabolic Syndrome Compared To Non Metabolic Syndrome","authors":"Muhammad Budi Syahputra","doi":"10.30596/bf.v4i1.2175","DOIUrl":"https://doi.org/10.30596/bf.v4i1.2175","url":null,"abstract":"Introduction : Metabolic syndrome involves heritability , genetic , bad diet and lack of physical activity . One cause of the Metabolic Syndrome is a genetic abnormality in the dopamine D2 receptor gene that causes \" Reward Deficiency Syndrome \". Aim: To investigate the relationship between polymorphisms of the dopamine D2 receptor gene Taq1A in men starting from 40 years of age with metabolic syndrome compared to those without metabolic syndrome. Methods: This research was done as an unpaired analytical research using case control design . The research subject is stored DNA isolates originating from metabolic syndrome 21 and 21 are non metabolic syndrome . Thermal Cycle process performed on isolates DNA using PCR techniques with applications located on a 310 bp band with a 2 % agarose gel , then the application in digestion with enzyme Taq1A ( New England Biolabs ®Inc ) and there are variant polymorphism ( T / C 310 bp , 180 bp , 130 bp ) , ( C / C 180 bp , 130 bp ) , ( T / T 310 bp ) and analyzed statistically using x² test , odds ratio. Result: Based on the metabolic syndrome X ² test was found genotype T / C at most ( 47.6 % ) , T / T ( 19.1 % ) , C / C ( 33.3 % ) with a value of p = 0.500 with a significance of p < 0 , 05 . In no metabolic syndrome T / C ( 61.9 % ) , T / T ( 9.5 % ) , C / C ( 28.6 % ) with a value of p = 0.457 with a significance of p < 0.05. Based on the distribution of allele no significant relationship. Conclusion: Based on the results of the study didn’t relate to the frequency distribution of genotype and allele distribution Taq1A polymorphisms of the dopamine D2 receptor gene in men aged from 40 years with the metabolic syndrome than those without metabolic syndrome","PeriodicalId":206231,"journal":{"name":"Buletin Farmatera","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123508146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Karakteristik Gen Nrf2 ( Nuclear Respiratory Factor 2 ) Dan Gen Actn-3 (R577x) Siswa Sekolah Sepak Bola Di Kota Medan","authors":"K. Surbakti, Martina Evlyn R.H., Gusbakti Rusip, B. Y. M. Sinaga","doi":"10.30596/BF.V4I1.2177","DOIUrl":"https://doi.org/10.30596/BF.V4I1.2177","url":null,"abstract":"Penelusuran genetik dapat menjadi salah satu metode talent profiling pada atlet sepak bola. Gen yang berhubungan dengan performa atletik adalah gen NRF2 dan ACTN3. Gen NRF2  dikenal juga GA-binding protein transcription factor sub unit β (GABPBI)  gen ini terdapat pada DNA mitokondria dan merupakan faktor transkripsi pada biogenesis mitokondria. Gen ACTN-3 merupakan gen yang mengkode sebuah protein sarkomer yang hampir secara keseluruhan diekspresikan dalam serat otot cepat dan menghasilkan daya ledak. Tujuan penelitian ini untuk melihat variasi gen NRF2 dan gen ACTN3 pada siswa sekolah sepak bola yang berusia 11-14 tahun yang berjumlah 33 orang.Identifikasi  gen NRF2 dan gen  ACTN-3 diidentifikasi menggunakan PCR-RFLP dari sampel sel bukal. Hasil studi menunjukkan  varian gen NRF2 secara mayoritas adalah genotip AA ( homozygote ) sebanyak 29 orang (87,90%) sebanyak 29 orang (87,90%), sedangkan genotip AG sebanyak 4 orang (12,12%) (heterozygote ). Varian genotip GG tidak ditemukan dalam penelitian ini. Varian genotif ACTN-3 adalah genotip RX ( heterozygote ) sebanyak 14 orang (42,4%), sedangkan genotip XX sebanyak 13 orang (39,4%) (homozygote ) danvarian genotip RR sebanyak 6 orang (18,2%) (homozygote)","PeriodicalId":206231,"journal":{"name":"Buletin Farmatera","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115511040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hubungan Beberapa Faktor Pengukuran Fungsi Paru Menggunakan Peak Flow Meter Pada Buruh Pabrik Aspal PT. Karya Murni Patumbak Deli Serdang","authors":"Nanda Novziransyah, Faisal Balatif, S. Veronica","doi":"10.30596/BF.V4I1.2321","DOIUrl":"https://doi.org/10.30596/BF.V4I1.2321","url":null,"abstract":"Kesehatan adalah faktor yang sangat penting bagi produktifitas dan peningkatan produktifitas tenaga kerja selaku sumber daya manusia. Tidak ada pekerjaan tanpa bahaya, tetapi dapat dihindari ketika para pekerja sadar akan resiko dan tahu cara menghilangkan atau meminimalkannya. Setiap pekerja harus memahami petunjuk kerja dengan menggunakan alat pelindung diri (APD) seperti ssarung tangan, safety shoes, atau masker. Salah satu faktor resiko yang dapat menurunkan fungsi paru adalah debu. Peak Flow Meter merupakan alat sederhana yang dapat digunakan untuk mengukur kecepatan aliran udara maksimal ketika paru pada keadaan inspirasi maksimal disebut dengan Peak Expiratory Flow Rate (PEFR). Tujuan penelitian ini untuk mengetahui hubungan beberapa faktor dengan pengukuran fungsi paru menggunakan Peak Flow Meter pada buruh pabrik aspal dii PT. Karya Murni Patumbak. Jenis penelitian yang digunakan adalah survei analitik dengan tujuan untuk mengetahui hubungan antar variabel melalui analisis statistik dengan pendekatan cross sectional . Populasi dalam penelitian ini adalah buruh pabrik aspal PT. Karya Murni Patumbak yang berjumlah 43 orang, metode total sampling digunakan untuk mengambil sampel pada penelitian ini sebanyak 43 orang. Data terdiri dari data primer yang diperoleh langsung dari hasil wawancara dan pemeriksaan fungsi paru. Teknik analisa data yang digunakan adalah analisis univariat dan bivariat. Pada hasil penelitian didapat bahwa (1) adanya hubungan antara umur dengan gangguan fungsi paru (RP=1,37); (2) adanya hubungan antara masa kerja dengan gangguan fungsi paru (RP=1,1); (3) adanya hubungan antara penggunaan APD dengan gangguan fungsi paru (RP=1,4); (4) adanya hubungan antara kebiasaan merokok dengan gangguan fungsi paru (RP=2,76) pada buruh pabrik aspal PT. Karya Murni Patumbak. Dari hasil penelitian ini disarankan kepada para buruh pabrik aspal PT. Karya Murni Patumbak agar tetap bekerja sesuai dengan SOP dan menggunakan APD sesuai pada tempatnya sehingga tercipta dunia kerja yang aman dan nyaman bagi diri sendiri, bagi rekan kerja dan lingkungan kerja. Mengurangi atau meminimalisir potensi bahaya di tempat kerja agar terhindar dari penyakit hubungan kerja dan penyakit akibat kerja. Disarankan kepada pihak manajemen PT. Karya Murni Patumbak ikut serta dan mendukung dalam menciptakan budaya K3 di tempat kerja dan lebih memperhatikan hak-hak para pekerja.","PeriodicalId":206231,"journal":{"name":"Buletin Farmatera","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127423155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Khasiat Jus Buah Pepaya Terhadap Kadar Kolesterol Total dan Malondialdehyde pada Tikus Hiperkolesterolemia","authors":"Ilham Hariaji, Hadyanto Lim","doi":"10.30596/BF.V4I1.2101","DOIUrl":"https://doi.org/10.30596/BF.V4I1.2101","url":null,"abstract":"Penelitian ini bertujuan untuk menganalisis khasiat jus buah pepaya ( Carica papaya L.) terhadap efek penurunan kadar kolesterol total dan kadar malondialdehyde (MDA) dalam plasma darah tikus putih ( Rattus norvegicus ) galur Wistar berjenis kelamin jantan  hiperkolesterolemia yang diinduksi kuning telur ayam petelur. Penelitian ini menggunakan pre test and post test with control group design menggunakan 35 ekor tikus yang dibagi dalam 5 kelompok, terdiri dari : K(-) (hanya diberikan pakan standar selama 8 minggu), K(+) (diberikan pakan standar 8 minggu,diinduksi kuning telur 2 minggu), P1 ( diberi pakan standar selama 4 minggu, diinduksi kuning telur 2 minggu dan diberikan jus pepaya selama 2 minggu, diperiksa kadar kolesterol total dan MDA pada minggu ke 4), P2 ( diberi pakan standar 6 minggu,diinduksi kuning telur 2 minggu dan diberikan jus pepaya selama 4 minggu, diperiksa kadar kolesterol total dan MDA pada minggu ke 6), P3 (diberi pakan standar 8 minggu, diinduksi kuning telur 2 minggu dan diberikan jus pepaya selama 6 minggu, diperiksa kadar kolesterol total dan MDA pada minggu ke 8). Semua kelompok dilakukan pengukuran kadar kolesterol total dan MDA sebelum dilakukan perlakuan apapun. Hasil pemeriksaan kadar kolesterol total dan MDA sebelum dan sesudah induksi kuning telur selama dua minggu menunjukan peningkatan yang bermakna ( p <0,05) pada kelompok yang diinduksikan kuning telur. Selanjutnya kadar kolesterol total dan MDA setelah induksi jus buah pepaya menunjukan penurunan yang bermakna ( p <0,05) pada kelompok P1, P2 dan P3. Penelitian ini membuktikan bahwa pemberian jus buah pepaya berkhasiat menurunkan kadar kolesterol total dan kadar malondialdehyde sebagai petanda stres oksidatif di dalam darah.","PeriodicalId":206231,"journal":{"name":"Buletin Farmatera","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124015638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymorphism of Dopamine D2-141C Ins/Del Receptor Gene in Paranoid Schizophrenia and Non Schizophrenia Patients of Batak Ethnicity in Sumatera Utara","authors":"Dede Bisma Kuncara","doi":"10.30596/BF.V4I1.2176","DOIUrl":"https://doi.org/10.30596/BF.V4I1.2176","url":null,"abstract":"Introduction: Schizophrenia is a chronic mental condition which is characterized by reality distortion as well as thought, speech and behavior disorders. Several factors that may cause schizophrenia include genetic abnormalities of dopamine receptors that contribute to disorders in function of the brain, several studies have found an association between schizophrenic and non schizophrenic patients in the dopamine receptor gene polymorphism D2 -141C Ins/Del. Aim: To investigate the relationship of DRD2 -141C Ins/Del gene polymorphism in schizophrenic and non-schizophrenic patients of Batak ethnicity in Sumatera Utara, Indonesia. Methods: This research was done as an unpaired analytical case-control study. The subjects of the study were DNA isolates obtained from 60 patients of paranoid schizophrenia and 54 non-schizophrenia of Batak ethnicity in Sumatera Utara, Indonesia. PCR examination was performed on the DNA isolates to examine D2 -141C Ins/Del dopamine receptor gene polymorphism. The data collected were then analyzed statistically. Result: In this study, three variants of DRD2 gene polymorphism (I/D: 304bp, 160bp, 144bp), (I/I: 160bp, 144bp), (D/D: 304bp) was identified. In both schizophrenic and non-schizophrenic patients, the highest I/D genotypes were identified (71.7%) and (63%) , and the least D/D genotypes were identified (6.7%) and (7.4%) with p = 0.726. Based on the allele distribution there was no difference of risk on allele D and allele I on the cause factor of schizophrenia (OR: 1.13; 95% CI: 0.66-1.92). According to Hardy-Weinberg Equilibrium law, both schizophrenic and non schizophrenic patients of Batak ethnicity in Sumatera Utara is in disequilibrium p = 0.0002 and p = 0.0057 with significance of p <0,05. Conclusion: There is no significant association between genotypic distribution and DRD2 -141C Ins/Del gene alleles in schizophrenic and non schizophrenic patients.","PeriodicalId":206231,"journal":{"name":"Buletin Farmatera","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116739877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalensi Dermatitis Kontak di Satuan Medis Fungsional Kulit dan Kelamin RSUP. H. Adam Malik Periode Januari 2010 – Desember 2010","authors":"Ika Nopa","doi":"10.30596/BF.V4I1.2163","DOIUrl":"https://doi.org/10.30596/BF.V4I1.2163","url":null,"abstract":"Contact dermatitis is a dermatitis caused by the material or substance that sticks to the skin. Data from NIOSH found  from 372,000 work-related illness were reported 12% is a skin disease or disorder and 80% of occupational skin disease is contact dermatitis. To observe the progression of this disease, therefore a research was conducted to observe the latest prevalence of contact dermatitis. The purpose of this research is to find out the prevalence of contact dermatitis at  Dermatology Polyclinik of Haji Adam Malik General Hospital, Medan in January 2010 -December 2010.  This is a descriptive study and the design is cross-sectional study. Population in this research was all medical records of contact dermatitis from January 2010 - December 2010, and samples were taken by simple random sampling method and 97 medical records sampled. All the collected data were calculated with SPSS and presented in distribution tables. Results showed the prevalence of contact dermatitis patients is 660 patients (11.65%) of the entire population, with the highest percentage found in the female as many as 62 patients (63.9%) of the sample. Based on age group, the highest prevalence found in 30-39 years old as many as 28 patients (28.9%) of the sample. Based on the type of work, the highest prevalence found in housewives as many as 31 patients (32%) of the sample. Based on the location of contact dermatitis, the highest prevalence found in the hands of the 35 patients (36.1%) of the sample. Based on the type of work, location of most lesions on housewives found on the hand, and that 18 of 31 patients.","PeriodicalId":206231,"journal":{"name":"Buletin Farmatera","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125543761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}